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Choroidal thickness after phacoemulsification; a non-randomized comparison of postoperative topical ketorolac versus dexamethasone versus a combination of ketorolac-dexamethasone eye drops.

Abstract：

PURPOSE:To compare the effect of topical dexamethasone versus ketorolac versus combined dexamethasone-ketorolac after phacoemulsification on choroidal thickness (CT). SETTING:A tertiary university-based hospital Design: Prospective non-randomized comparative case series METHODS:: Ninety-two eyes of 92 patients were assigned to the three groups after uneventful phacoemulsification. Group 1, dexamethasone; group 2, ketorolac; group 3, combined dexamethasone-ketorolac that applied topically. Choroidal thickness (CT) at subfoveal (SFCT), nasal and temporal as primary and central retinal thickness (CRT) as secondary outcomes were measured preoperatively, and 1, 3, and 6 months postoperatively using enhanced depth imaging optical coherence tomography. RESULTS:Preoperative CT were similar between the groups (all P>0.05). The groups differed in pattern of changes in nasal and temporal CT (both P<0.001) although their changes of CRT (P=0.13) and SFCT (P=0.55) over time were similar. The mean of SFCT at months 1, 3 and 6 was significantly higher than baseline in dexamethasone (P<0.001 for all follow-ups) and combined (P<0.001 for both month 1 and 3 and P=0.03 for month 6) groups while it was not significant in the ketorolac group (P=0.07). There was an increase in the nasal and temporal CT in three groups, persisted at month 6 in dexamethasone (both P<0.001) and ketorolac (both P<0.001) groups while the change was not statistically significant at month 6 in combined group. CONCLUSION:Dexamethasone and combined groups had statistically significant changes of SFCT after phacoemulsification however, the ketorolac group did not. The pattern of SFCT changes was similar between three groups.

journal_name

J Cataract Refract Surg

journal_title

Journal of cataract and refractive surgery

authors

Ghiasian L,Aghdam KA,Azizi E,Abdolalizadeh P,Janani L,Grzybowski A,Falavarjani KG

doi

10.1097/j.jcrs.0000000000000477

subject

Has Abstract

pub_date

2020-11-12 00:00:00

eissn

0886-3350

issn

1873-4502

pub_type

杂志文章

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Choroidal thickness after phacoemulsification; a non-randomized comparison of postoperative topical ketorolac versus dexamethasone versus a combination of ketorolac-dexamethasone eye drops.