Abstract:
PURPOSE:To determine and compare the amount of apoptosis and changes in rabbit corneal endothelial cell morphology after intracameral administration of different anesthetic agents. SETTING:Department of Ophthalmology, Baskent University Medical Faculty, Ankara, Turkey. METHODS:Right eyes of 64 Vienna white rabbits were injected intracamerally with preservative-free lidocaine hydrochloride 2%, ropivacaine 1%, levobupivacaine 0.75%, or fortified balanced salt solution (BSS Plus) (control). Animals were humanely killed 1 day or 7 days later. Terminal deoxynucleotidyl transferase deoxy-UTP-nick end labeling was used to detect apoptosis. Corneal endothelial cells and apoptotic cells were counted by light microscopy. The morphologic appearance was determined by transmission electron microscopy (TEM). RESULTS:Apoptotic cell density was high in the anesthetic groups on day 1 (P<.01); there was no significant difference between groups at 7 days. Apoptotic cell density declined significantly between 1 day and 7 days in the anesthetic groups (P<.05) but not in the control group. There was no difference in endothelial cell density between the 4 groups at 1 or 7 days. All anesthetic groups showed degenerative changes on TEM, with the least change in the preservative-free lidocaine hydrochloride 2% group. CONCLUSIONS:Intracameral injections of preservative-free lidocaine, ropivacaine, and levobupivacaine induced significantly more apoptotic endothelial cell loss than BSS Plus and led to morphologic changes in the corneal endothelial cells in the early period. This effect was temporary, with recovery by 7 days. Considering the limited proliferative capacity in human eyes, the induced apoptosis might result in the permanent cell loss and enlargement in human corneal endothelium.
journal_name
J Cataract Refract Surgjournal_title
Journal of cataract and refractive surgeryauthors
Borazan M,Karalezli A,Oto S,Akova YA,Karabay G,Kocbiyik A,Celasun B,Demirhan Bdoi
10.1016/j.jcrs.2008.12.016subject
Has Abstractpub_date
2009-04-01 00:00:00pages
753-8issue
4eissn
0886-3350issn
1873-4502pii
S0886-3350(09)00058-3journal_volume
35pub_type
杂志文章abstract:PURPOSE:To evaluate the clinical feasibility of the prototype version of a commercial partial coherence interferometry instrument (axial length measurement, ALM, Carl Zeiss Jena) for noninvasive, high-precision biometry in cataractous eyes. SETTING:Department of Ophthalmology, Vienna General Hospital, and Institute of...
journal_title:Journal of cataract and refractive surgery
pub_type: 临床试验,杂志文章
doi:10.1016/s0886-3350(01)01272-x
更新日期:2002-02-01 00:00:00
abstract::Nonsteroidal anti-inflammatory drugs (NSAIDs) produce potent analgesic, antipyretic, and anti-inflammatory effects. We studied postoperative pain in 97 consecutive patients having photorefractive keratectomy (PRK) by an excimer laser with different topical NSAID protocols. Treatment with topical homatropine hydrobromi...
journal_title:Journal of cataract and refractive surgery
pub_type: 杂志文章
doi:10.1016/s0886-3350(13)80756-0
更新日期:1994-03-01 00:00:00
abstract:PURPOSE:To assess the effect of folding procedures on modulation transfer function (MTF) and resolving power (RP) in soft acrylic intraocular lenses (IOLs). SETTING:Faculty of Engineering, Chiba University, Chiba, Japan. METHODS:Folding procedures and other manipulations were performed on +18.0 diopter soft acrylic l...
journal_title:Journal of cataract and refractive surgery
pub_type: 杂志文章
doi:10.1016/s0886-3350(96)80098-8
更新日期:1996-01-01 00:00:00
abstract:PURPOSE:To evaluate the change in higher-order aberrations (HOAs) after implantation of a foldable iris-claw phakic intraocular lens (pIOL) in myopic eyes. SETTING:Department of Ophthalmology, Johannes Gutenberg-University, Mainz, Germany. METHODS:This prospective nonrandomized comparative self-controlled trial inclu...
journal_title:Journal of cataract and refractive surgery
pub_type: 杂志文章
doi:10.1016/j.jcrs.2005.12.036
更新日期:2006-02-01 00:00:00
abstract:PURPOSE:To investigate the effect of hinge width on corneal sensation and dry-eye syndrome after laser in situ keratomileusis (LASIK). SETTING:TLC Laser Eye Center, Garden City, New York, USA. METHODS:Fifty-four patients at least 18 years of age had bilateral LASIK with a narrow nasal hinge microkeratome flap in 1 ey...
journal_title:Journal of cataract and refractive surgery
pub_type: 杂志文章
doi:10.1016/j.jcrs.2003.09.043
更新日期:2004-04-01 00:00:00
abstract:PURPOSE:To compare corneal endothelial cell density (ECD) and morphology between flap creation with a femtosecond laser and flap creation with a mechanical microkeratome 5 years after laser in situ keratomileusis (LASIK). SETTING:Mayo Clinic, Rochester, Minnesota, USA. DESIGN:Prospective randomized masked paired-eye ...
journal_title:Journal of cataract and refractive surgery
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.jcrs.2012.07.034
更新日期:2012-12-01 00:00:00
abstract:UNLABELLED:Left ventricular assist devices (LVADs) have been increasingly used for 20 years in terminally ill patients with advanced heart failure or awaiting cardiac transplantation. Despite improvement in morbidity and mortality from use of these devices, quality of life may be limited by cataract. Access to cataract...
journal_title:Journal of cataract and refractive surgery
pub_type: 杂志文章
doi:10.1016/j.jcrs.2014.01.024
更新日期:2014-04-01 00:00:00
abstract::In February 2001, a questionnaire on the practice of refractive surgery was sent worldwide to all 8196 members of the American Society of Cataract and Refractive Surgery; 1511 responses (18.4%) were received. Although laser in situ keratomileusis (LASIK) was the most common refractive procedure reported, phakic intrao...
journal_title:Journal of cataract and refractive surgery
pub_type: 杂志文章
doi:10.1016/s0886-3350(01)01318-9
更新日期:2002-02-01 00:00:00
abstract::Lens manufacturers do not usually supply information about the central thickness of an intraocular lens optic. This paper describes a method to calculate the central lens thickness from variables normally supplied by the manufacturer, i.e., the total lens power in situ, the edge thickness, the optic diameter, and some...
journal_title:Journal of cataract and refractive surgery
pub_type: 杂志文章
doi:10.1016/s0886-3350(13)80278-7
更新日期:1993-01-01 00:00:00
abstract:PURPOSE:To analyze the changes in higher-order aberrations (HOAs) that occur after wavefront-optimized photorefractive keratectomy (PRK) and laser in situ keratomileusis (LASIK). SETTING:Emory Eye Center and Emory Vision, Atlanta, Georgia, USA. METHODS:This retrospective analysis comprised eyes that had PRK or LASIK ...
journal_title:Journal of cataract and refractive surgery
pub_type: 杂志文章
doi:10.1016/j.jcrs.2008.10.032
更新日期:2009-02-01 00:00:00
abstract::We present the case of a 56-year-old woman with moderate myopia and bilateral cataract who had cataract extraction and intraocular lens (IOL) implantation. Due to the patient's desire for spectacle independence, a trifocal IOL with toric correction for astigmatism was implanted. During the follow-up, it became obvious...
journal_title:Journal of cataract and refractive surgery
pub_type: 杂志文章
doi:10.1016/j.jcrs.2016.02.001
更新日期:2016-03-01 00:00:00
abstract::We report 3 cases of globe rupture after peribulbar anesthesia. We discuss the predisposing factors, presenting features, and visual outcome after this complication. Globe explosion is a severe complication of inadvertent intraocular injection during peribulbar anesthesia. Visual outcome after vitrectomy is generally ...
journal_title:Journal of cataract and refractive surgery
pub_type: 杂志文章
doi:10.1016/s0886-3350(01)01034-3
更新日期:2002-03-01 00:00:00
abstract:PURPOSE:To demonstrate the use of polar value analysis of surgically induced astigmatism (SIA). SETTING:Department of Ophthalmology, Arhus University Hospital, Arhus, Denmark. METHODS:Univariate polar value analysis of SIA was demonstrated for a single patient and for aggregate data. Bivariate polar value analysis wa...
journal_title:Journal of cataract and refractive surgery
pub_type: 杂志文章
doi:10.1016/s0886-3350(00)00799-9
更新日期:2001-01-01 00:00:00
abstract::Horizontal chopping is effective for endocapsular nucleofractis. We describe pop and chop, a variant of chopping that enables an easy first crack and initial segment removal. It involves partial extracapsular prolapse of the nucleus prior to the initial chop. It is particularly useful when hydrodissection results in p...
journal_title:Journal of cataract and refractive surgery
pub_type: 杂志文章
doi:10.1016/s0886-3350(03)00339-0
更新日期:2003-11-01 00:00:00
abstract:PURPOSE:To study the results of simultaneous photorefractive keratectomy (PRK) and corneal collagen crosslinking (CXL) in keratoconus after previous intrastromal corneal ring segment (ICRS) implantation. SETTING:Enaim Laser Center, Jerusalem, Israel. DESIGN:Case series. METHODS:This study comprised patients with mod...
journal_title:Journal of cataract and refractive surgery
pub_type: 杂志文章
doi:10.1016/j.jcrs.2012.05.033
更新日期:2012-10-01 00:00:00
abstract:PURPOSE:To determine whether preoperative assessment of posterior capsule integrity using anterior segment optical coherence tomography (AS-OCT) can predict posterior capsule dehiscence in patients with posterior polar cataract having phacoemulsification. SETTING:Aravind Eye Hospital and Postgraduate Institute of Opht...
journal_title:Journal of cataract and refractive surgery
pub_type: 杂志文章
doi:10.1016/j.jcrs.2018.07.056
更新日期:2018-12-01 00:00:00
abstract:UNLABELLED:Presbyopia is the most common refractive disorder for people older than 40 years. It is characterized by a gradual and progressive decrease in accommodative amplitude. Many surgical procedures for the correction of presbyopia exist, with additional procedures on the horizon. This review describes the prevale...
journal_title:Journal of cataract and refractive surgery
pub_type: 杂志文章,评审
doi:10.1016/j.jcrs.2016.05.003
更新日期:2016-06-01 00:00:00
abstract:PURPOSE:To report clinical and confocal microscopy characteristics of haze-like opacities in corneas after laser in situ keratomileusis (LASIK). SETTING:Department of Ophthalmology, Johann Wolfgang Goethe-University, Frankfurt am Main, Germany. METHODS:Eighteen eyes of 11 patients with clinically apparent corneal clo...
journal_title:Journal of cataract and refractive surgery
pub_type: 杂志文章
doi:10.1016/s0886-3350(02)02050-3
更新日期:2003-09-01 00:00:00
abstract::A technique is described in which a posterior chamber intraocular lens (IOL) is implanted in eyes with partial loss of posterior capsule or zonular support. The IOL's inferior haptic is placed over the residual capsule and the superior haptic is fixated to the ciliary sulcus with a polypropylene suture. In 17 eyes tha...
journal_title:Journal of cataract and refractive surgery
pub_type: 杂志文章
doi:10.1016/s0886-3350(97)80278-7
更新日期:1997-06-01 00:00:00
abstract::The ocular response analyzer (ORA) (Reichert, Inc.) was used in the case of a middle-aged man who developed unilateral corneal ectasia after bilateral laser in situ keratomileusis (LASIK). The preoperative refraction was similar in the 2 eyes. Post-LASIK ectasia was central in the left eye; topography was oblate in th...
journal_title:Journal of cataract and refractive surgery
pub_type: 杂志文章
doi:10.1016/j.jcrs.2007.11.018
更新日期:2008-03-01 00:00:00
abstract:PURPOSE:To examine the impact of cataract surgery on older adults' self-reported visual difficulties and compare them with those of patients with cataract who declined surgery over the same period. SETTING:Twelve area practices. METHODS:This was a consecutive chart review over a 6-month period. Primary inclusion crit...
journal_title:Journal of cataract and refractive surgery
pub_type: 杂志文章,多中心研究
doi:10.1016/s0886-3350(02)01846-1
更新日期:2003-05-01 00:00:00
abstract:PURPOSE:To compare the performance of the Marco Nidek ARK-530A autorefractor pupillometer function and the Keeler PupilScan II pupillometer (study pupillometer) against the clinical standard NeurOptics PLR-200 pupillometer (standard pupillometer) for measurement of the dark-adapted pupil diameter. SETTING:Department o...
journal_title:Journal of cataract and refractive surgery
pub_type: 杂志文章
doi:10.1016/j.jcrs.2010.10.059
更新日期:2011-04-01 00:00:00
abstract::Extracapsular cataract extraction with posterior chamber intraocular lens implantation was performed in five phakic eyes filled with silicone oil following vitreoretinal surgery. Silicone oil migration was prevented during surgery using an anterior chamber maintaining system and a self-sealed corneoscleral tunnel inci...
journal_title:Journal of cataract and refractive surgery
pub_type: 杂志文章
doi:10.1016/s0886-3350(96)80032-0
更新日期:1996-05-01 00:00:00
abstract:PURPOSE:To report a case series of anterior uveitis after laser in situ keratomileusis (LASIK) and the incidence of anterior uveitis at a mean of 3 years. SETTING:Centro Medico Docente La Trinidad and Clinica Oftalmologica Centro Caracas, Caracas, Venezuela. METHODS:Five refractive surgeons and 18488 eyes that had su...
journal_title:Journal of cataract and refractive surgery
pub_type: 杂志文章
doi:10.1016/s0886-3350(02)01364-0
更新日期:2002-10-01 00:00:00
abstract::Two patients had uneventful phacoemulsification. After initial improvement, vision deteriorated because of cystoid macular edema (CME). In 1 patient, treatment with systemic nonsteroidal antiinflammatory drugs showed significant improvement in visual acuity but had to be discontinued because of side effects and a rela...
journal_title:Journal of cataract and refractive surgery
pub_type: 杂志文章
doi:10.1016/j.jcrs.2004.12.067
更新日期:2005-07-01 00:00:00
abstract:PURPOSE:To assess the repeatability and validity of lens densitometry derived from the Pentacam Scheimpflug imaging system. SETTING:Eye Clinic, Queensland University of Technology, Brisbane, Australia. METHODS:This prospective cross-sectional study evaluated 1 eye of subjects with or without cataract. Scheimpflug mea...
journal_title:Journal of cataract and refractive surgery
pub_type: 杂志文章
doi:10.1016/j.jcrs.2009.03.017
更新日期:2009-07-01 00:00:00
abstract:PURPOSE:To study the intraoperative performance and postoperative outcomes of Cionni modified capsule tension ring (CTR) and intraocular lens (IOL) implantation in the capsular bag in pediatric eyes with ectopia lentis. SETTING:John A. Moran Eye Center, Salt Lake City, Utah, USA. METHODS:Thirty-five eyes (22 children...
journal_title:Journal of cataract and refractive surgery
pub_type: 杂志文章
doi:10.1016/j.jcrs.2008.04.044
更新日期:2008-09-01 00:00:00
abstract:PURPOSE:To study contrast sensitivity in eyes that had flying-spot excimer laser photorefractive keratectomy (PRK) and to compare a subjective method (Vision Contrast Test System [VCTS] 6500) and an objective method (visual evoked potential [VEP]) of measuring contrast sensitivity. SETTING:Istituto Clinica Oculistica,...
journal_title:Journal of cataract and refractive surgery
pub_type: 杂志文章
doi:10.1016/s0886-3350(00)00405-3
更新日期:2000-06-01 00:00:00
abstract:PURPOSE:To evaluate the intraocular pressure (IOP)-lowering efficacy and safety of incisional goniotomy as an adjunct to phacoemulsification in primary angle-closure glaucoma (PACG) patients. METHODS:In this prospective interventional case series, consecutive patients with PACG (high or borderline IOP) deemed fit for ...
journal_title:Journal of cataract and refractive surgery
pub_type: 杂志文章
doi:10.1097/j.jcrs.0000000000000481
更新日期:2020-11-19 00:00:00
abstract:PURPOSE:To quantify the cyclorotation occurring between wavefront measurement and laser refractive surgery. SETTING:LaserVue Eye Center Ophthalmic Clinic, Santa Rosa, California, USA. METHODS:The pupil camera of the Visx WaveScan wavefront device was used to obtain images of 51 eyes (26 patients) from 5 to 20 minutes...
journal_title:Journal of cataract and refractive surgery
pub_type: 杂志文章
doi:10.1016/j.jcrs.2003.08.022
更新日期:2004-03-01 00:00:00