当前位置： SCI文献检索 > JOURNAL OF CATARACT AND REFRACTIVE SURGERY期刊下所有文献 > Corneal endothelial cell changes 5 years after laser in situ keratomileusis: femtosecond laser versus mechanical microkeratome.

Corneal endothelial cell changes 5 years after laser in situ keratomileusis: femtosecond laser versus mechanical microkeratome.

Abstract：

PURPOSE:To compare corneal endothelial cell density (ECD) and morphology between flap creation with a femtosecond laser and flap creation with a mechanical microkeratome 5 years after laser in situ keratomileusis (LASIK). SETTING:Mayo Clinic, Rochester, Minnesota, USA. DESIGN:Prospective randomized masked paired-eye study. METHODS:In this study of LASIK for myopia or myopic astigmatism, fellow eyes were randomized by ocular dominance to flap creation by a femtosecond laser or by a mechanical microkeratome. Central endothelial images were analyzed before and 3 years and 5 years after LASIK; endothelial cell variables were compared between treatments at each examination. Relationships between endothelial cell loss and contact lens wear, residual bed thickness, and preoperative refractive error were evaluated. RESULTS:There were no differences in the ECD, percentage of hexagonal cells, or coefficient of variation of cell area between treatments at any examination (all P = .99); the smallest detectable differences were 120 cells/mm(2), 5%, and 2%, respectively. The mean annual rate of corneal endothelial cell loss was -0.1% ± 1.2% (SD) and -0.1% ± 1.0% for the femtosecond laser and the mechanical microkeratome, respectively. Endothelial cell loss was not associated with contact lens wear, residual bed thickness, or preoperative refractive error. CONCLUSIONS:The energy delivered to the cornea during femtosecond laser flap creation did not affect the corneal endothelium 5 years after LASIK when compared with flap creation with a mechanical microkeratome. Corneas that have had either method of flap creation could be accepted as donor tissue for endothelial keratoplasty from the standpoint of endothelial health. FINANCIAL DISCLOSURE:No author has a financial or proprietary interest in any material or method mentioned.

journal_name

J Cataract Refract Surg

journal_title

Journal of cataract and refractive surgery

authors

Klingler KN,McLaren JW,Bourne WM,Patel SV

doi

10.1016/j.jcrs.2012.07.034

subject

Has Abstract

pub_date

2012-12-01 00:00:00

pages

2125-30

issue

eissn

0886-3350

issn

1873-4502

pii

S0886-3350(12)01286-2

journal_volume

pub_type

杂志文章,随机对照试验

在线工具

Corneal endothelial cell changes 5 years after laser in situ keratomileusis: femtosecond laser versus mechanical microkeratome.