After-cataract formation in newborn rabbits implanted with intraocular lenses.

Abstract:

PURPOSE:Comparison of the after-cataract formation in newborn rabbits implanted with a heparin-surface-modified (HSM) intraocular lens (IOL), a silicone IOL, or no IOL. METHODS:Two groups of 3-week-old rabbits were used. In Group 1 (n = 11), lensectomy was performed in both eyes. One eye was selected at random and an HSM IOL was implanted in the capsular bag; the other eye was left aphakic. In Group 2 (n = 13), lensectomy was performed in both eyes. An HSM IOL was implanted in one eye, a silicone IOL in the other. The wet mass of the dissected after-cataract was determined 3 months after surgery in both groups. RESULTS:In Group 1, the wet mass of the dissected after-cataract was 17.0 +/- 6.5 mg (mean +/- SEM) in eyes implanted with an HSM IOL and 159.7 +/- 17.0 mg in aphakic eyes. This difference was statistically significant (P < .01). In Group 2, the wet mass of the dissected after-cataract was 18.3 +/- 4.3 mg in eyes implanted with an HSM IOL and 25.7 +/- 5.2 mg in eyes implanted with a silicone IOL. No statistically significant difference was found. CONCLUSIONS:In young rabbits, implantation of an IOL in the capsular bag following lensectomy reduced cell proliferation.

authors

Zetterström C,Kugelberg U,Lundgren B,Syrén-Nordqvist S

doi

10.1016/s0886-3350(96)80275-6

subject

Has Abstract

pub_date

1996-01-01 00:00:00

pages

85-8

issue

1

eissn

0886-3350

issn

1873-4502

pii

S0886-3350(96)80275-6

journal_volume

22

pub_type

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