Abstract：
:Intoxication with an acute dose of carbofuran (1.5 mg/kg, sc) in male Sprague-Dawley rats evoked severe toxic manifestations characteristic of hypercholinergic preponderance with profound muscle fasciculations and convulsions during 30-60 min, lasting for about 2 h. Lactate dehydrogenase, a "biomarker" cytoplasmic enzyme catalyzing the reversible reaction of lactate-pyruvate, was represented by five electrophoretically distinct isoenzymes in the serum and tissues. The amounts of each isoenzyme in different tissues were widely varied and consequently the patterns were tissue specific. A 24-h time-course following carbofuran administration indicated a two-fold increase in the activity of total LDH in serum and more than 30% in hemidiaphragm and liver. The patterns of LDH isoenzymes in serum revealed a significant (P less than 0.01) increase in all the isoenzymes except LDH-4 (64% decrease). Analysis of each tissue revealed characteristic changes in LDH isoenzyme patterns indicating organ-specific tissue damage. These alterations in LDH and its isoenzymes, in addition to acetylcholinesterase inhibition, may be directly or indirectly related to the mechanism(s) of the toxic action, and also provide insight into the site/organ(s) of toxic injury, thus providing an early prognostic indicator.
journal_name
Arch Environ Contam Toxicoljournal_title
Archives of environmental contamination and toxicologyauthors
Gupta RC,Goad JT,Kadel WLdoi
10.1007/BF01055345subject
Has Abstractpub_date
1991-08-01 00:00:00pages
263-9issue
2eissn
0090-4341issn
1432-0703journal_volume
21pub_type
杂志文章abstract：:Pollution of surface soils by traffic, especially along major highways, can be a significant issue. Numerous studies have demonstrated traffic to be an important source of particulate matter and gas-phase organic air pollutants that produce many types of deleterious effects. This article brings original information ab...
journal_title：Archives of environmental contamination and toxicology
pub_type： 杂志文章
doi：10.1007/s00244-009-9345-4
更新日期：2009-11-01 00:00:00
abstract：:Juvenile rainbow trout (Oncorhynchus mykiss) were exposed to 0, 10, 30, and 70% (v/v) of a secondary-treated, integrated thermomechanical-bleached kraft pulp and paper mill effluent. The immunological parameters oxidative burst and phagocytosis of head kidney macrophages and total and differential circulating leukocyt...
journal_title：Archives of environmental contamination and toxicology
pub_type： 杂志文章
doi：10.1007/s00244-004-0093-1
更新日期：2005-05-01 00:00:00
abstract：:The quantitative determination in organs of Oncorhynchus mykiss W. of a premetallized dye (C.I. Acid Violet 66) and the azoic base (C.I. Acid Red 217), used in wool dyeing, is studied in this paper. UV-VIS Spectrophotometry was used for the chromatic quantification and atomic absorption spectrophotometry for the detec...
journal_title：Archives of environmental contamination and toxicology
pub_type： 杂志文章
doi：10.1007/BF00212276
更新日期：1992-08-01 00:00:00
abstract：:Herons and egrets are ideal organisms to use asindicators of heavy metal exposure in an ecosystem because different speciesfeed at different levels of the food chain and live in both coastal andinland habitats. This paper reports on the concentration of heavy metals andselenium in the feathers of cattle egrets Bubulcu...
journal_title：Archives of environmental contamination and toxicology
pub_type： 杂志文章
doi：10.1007/s002449900178
更新日期：1997-02-01 00:00:00
abstract：:The morphological alterations of hepatocytes of female zebrafish, Brachydanio rerio, and fingerling rainbow trout, Salmo gairdneri, following prolonged exposure to 0.04, 0.2 and 1 mg/L of 4-chloroaniline were investigated by means of light and electron microscopy. Changes in peroxisomes were visualized by cytochemical...
journal_title：Archives of environmental contamination and toxicology
pub_type： 杂志文章
doi：10.1007/BF01054986
更新日期：1990-05-01 00:00:00
abstract：:We examined possible adverse effects of heavy metals on microbial activity, biomass, and community composition using the simultaneously extracted metals (SEM)/acid-volatile sulfide (AVS)-based approach and measurements of exchangeable metal concentrations in three paddy soils (wastewater-contaminated soil, mine-contam...
journal_title：Archives of environmental contamination and toxicology
pub_type： 杂志文章
doi：10.1007/s00244-017-0387-8
更新日期：2017-04-01 00:00:00
abstract：:Bisphenol A (BPA) glucuronide and sulfate conjugates are major products of Phase II metabolism of BPA in humans. In the past, their determination in body fluids usually involves tedious enzymatic hydrolysis and multiresidual analysis. The recent availability of authentic standards of these conjugates enables our bette...
journal_title：Archives of environmental contamination and toxicology
pub_type： 杂志文章
doi：10.1007/s00244-017-0438-1
更新日期：2017-10-01 00:00:00
abstract：:Retinol-binding protein (RBP) in the Rhesus monkey had the same electrophoretic mobility, molecular weight, and common antigens as human RBP; beta 2-microglobulin protein (MG) had similar electrophoretic mobility and partial common antigens to human MG. After a prolonged oral administration of cadmium chloride to 10 m...
journal_title：Archives of environmental contamination and toxicology
pub_type： 杂志文章
doi：10.1007/BF01055631
更新日期：1981-01-01 00:00:00
abstract：:An experimental model was designed to study the acute lesions caused by a continuous exposure to 2,4-dichlorophenoxyacetic acid (2,4-D) disolved in water (400 mg/L) in hematopoietic kidney tissue in tench (Tinca tinca L). Fifty fish were used in this study, 15 for calculating LC50 and 35 were euthanized 1, 2, 5, 8, an...
journal_title：Archives of environmental contamination and toxicology
pub_type： 杂志文章
doi：10.1007/s002449900405
更新日期：1998-10-01 00:00:00
abstract：:Twenty-seven pesticide workers with elevated blood levels of dieldrin (greater than or equal to 15 ppb) were involved in a case-control study which included history and physical examination, comprehensive neurological evaluation, laboratory tests, and psychological and psychomotor testing. No clinically important diff...
journal_title：Archives of environmental contamination and toxicology
pub_type： 杂志文章
doi：10.1007/BF01057573
更新日期：1981-01-01 00:00:00
abstract：:The Tinto and Odiel river basins (SW Spain) are known worldwide for their unique water characteristics. Such uniqueness is a consequence of their flow through the Iberian Pyrite Belt (an area rich in metal sulphides) and the mining activities in the basins. A process of sulphide oxidation occurs in this region, which ...
journal_title：Archives of environmental contamination and toxicology
pub_type： 杂志文章
doi：10.1007/s00244-017-0409-6
更新日期：2018-01-01 00:00:00
abstract：:A test system was developed to examine the effects of environmental contaminants on thiamine homeostasis in bird embryos. This system employs fresh chicken egg yolk lipids as a vehicle for use in egg injection studies. Furazolidone, an antibiotic suspected to interfere with thiamine metabolism, was used as a positive ...
journal_title：Archives of environmental contamination and toxicology
pub_type： 杂志文章
doi：10.1007/s002440010119
更新日期：2000-10-01 00:00:00
abstract：:In addition to survival and hatching parameters, cytological alterations in liver and kidney of 4- and 6-d old zebrafish larvae (Brachydanio rerio) following single microinjection of fertilized eggs at the germ-ring stage with 5, 12.5, and 25 ng 4-chloroaniline/egg were investigated by means of electron microscopy. Wh...
journal_title：Archives of environmental contamination and toxicology
pub_type： 杂志文章
doi：10.1007/BF00212299
更新日期：1996-03-01 00:00:00
abstract：:Insecticides are increasingly being used in hot arid ecosystems. The evaluation of the ecological risk these insecticides may pose, however, is based largely on data derived from temperate organisms and ecosystems. The major differences in the composition, structure, and functioning of desert animal communities when c...
journal_title：Archives of environmental contamination and toxicology
pub_type： 杂志文章,评审
doi：10.1007/s002449900150
更新日期：1997-01-01 00:00:00
abstract：:The effect of oxyfluorfen was investigated when alga Scenedesmus obliquus has been exposed to different concentrations (7.5, 15, and 22.5 microg x L(-1)) at 12, 24, and 48 hours of exposure. Toxicity test was done by using 13 biomarkers concerning growth rate, chlorophyll content and indicators of photosynthetic and a...
journal_title：Archives of environmental contamination and toxicology
pub_type： 杂志文章
doi：10.1007/s00244-003-2217-4
更新日期：2003-11-01 00:00:00
abstract：:Acute toxicity tests of selenium dioxide were conducted for 96 to 336 hr in intermittent-flow bioassay systems using six species of freshwater fish. The decreasing order of species sensitivity was: fathead minnow, flagfish, brook trout, channel catfish, goldfish, and bluegil. Curves relating median lethal concentratio...
journal_title：Archives of environmental contamination and toxicology
pub_type： 杂志文章
doi：10.1007/BF02221018
更新日期：1976-01-01 00:00:00
abstract：:Nitrous oxide (N2O) emissions from a rice-duck cultivation system in the subtropical region of China and its regulating factors were investigated by using a static chambers technique during rice growth seasons in 2006 and 2007. The experimental field was equally divided into six plots for two different treatments: One...
journal_title：Archives of environmental contamination and toxicology
pub_type： 杂志文章
doi：10.1007/s00244-008-9159-9
更新日期：2009-01-01 00:00:00
abstract：:A total of 208 samples of water, sediment, tomato crops, blood, and mothers' breast milk were collected from the environs of Akumadan, a prominent vegetable-farming community in Ghana. The samples were analyzed for organochlorine (OC) pesticide residues. Lindane and endosulfan were found in water and sediment, while o...
journal_title：Archives of environmental contamination and toxicology
pub_type： 杂志文章
doi：10.1007/s002440010210
更新日期：2001-05-01 00:00:00
abstract：:The acute effects of both untreated and dispersant-treated Prudhoe Bay crude oil on the early life-stages of three marine species were investigated. Identification of which water-accommodated fraction (undispersed or chemically dispersed) was considered "more toxic" was dependent on species, time, and endpoint (and by...
journal_title：Archives of environmental contamination and toxicology
pub_type： 杂志文章
doi：10.1007/s002449900302
更新日期：1998-02-01 00:00:00
abstract：:Copper, mercury, and zinc levels were determined in muscle and liver (N = 163) of seven fish species caught in coastal waters off Montevideo and Piriapolis (control site): Odontesthes spp., Mugil platanus, Micropogonias furnieri, Urophycis brasiliensis, Cynoscion guatucupa, Menticirrhus americanus, and Mustelus schmit...
journal_title：Archives of environmental contamination and toxicology
pub_type： 杂志文章
doi：10.1007/s00244-004-0100-6
更新日期：2005-05-01 00:00:00
abstract：:Acid rain is a serious environmental problem in the world and is of a particular concern in southern China where most of the soils are acidic. This study investigated the dynamics of cations, phosphorus (P), and soil organic matter (SOM) in the Latosol (acidic red soil) from south China under the influences of simulat...
journal_title：Archives of environmental contamination and toxicology
pub_type： 杂志文章
doi：10.1007/s00244-006-0004-8
更新日期：2007-01-01 00:00:00
abstract：:Mercury, cadmium, zinc, and copper concentrations were analyzed in three samples of common guillemot (in April, June, and November). Levels measured were uniformly low, and not enough to have any toxic effects. Adult guillemots had significantly more cadmium in their livers and kidneys than juveniles, with juvenile le...
journal_title：Archives of environmental contamination and toxicology
pub_type： 杂志文章
doi：10.1007/BF00214259
更新日期：1994-08-01 00:00:00
abstract：:Seed germination and early stage seedling growth tests were conducted to determine the ecotoxicological threshold of 2,4, 6-trinitrotoluene (TNT) in two soils of different properties. Soils were amended up to 1,600 mg TNT kg-1 soil and four representative species of higher plants, two dicotyledons (Lepidium sativum L....
journal_title：Archives of environmental contamination and toxicology
pub_type： 杂志文章
doi：10.1007/s002449900455
更新日期：1999-02-01 00:00:00
abstract：:The effect of mercury as Hg2Cl2 and HgCl2 on the antioxidant enzyme levels and its toxicity was investigated in an insect model comprised of adult females of the common housefly, Musca domestica, and fourth-instar larvae of the cabbage looper moth, Trichoplusia ni. HgCl2 was found to be more toxic than Hg2Cl2 to both ...
journal_title：Archives of environmental contamination and toxicology
pub_type： 杂志文章
doi：10.1007/BF00212802
更新日期：1994-01-01 00:00:00
abstract：:The effects of zinc (Zn) deficiency and repeated exposure to cadmium (Cd) on the accumulation and distribution of metallothionein (MT), Cd and Zn in the liver and kidney were studied. Male Sprague-Dawley rats were fed either a Zn-deficient (1 ppm) or a Zn-adequate (40 ppm) diet during the experiment, and the rats were...
journal_title：Archives of environmental contamination and toxicology
pub_type： 杂志文章
doi：10.1007/BF01055026
更新日期：1989-07-01 00:00:00
abstract：:A battery of in vitro bioassays, including a Neutral Red (NR) assay using MCF-7 cells for predicting cytotoxic chemicals, an ethoxy resorufin-O-deethylase (EROD) activity assay using H4IIE cells to check for dioxin-like chemicals, and a recombinant gene yeast assay for screening estrogenic chemicals, was conducted to ...
journal_title：Archives of environmental contamination and toxicology
pub_type： 杂志文章
doi：10.1007/s00244-004-0204-z
更新日期：2005-11-01 00:00:00
abstract：:Soil organisms play a crucial role in the terrestrial ecosystem. Plant protection products (PPPs) are known to affect soil organisms and might have negative impacts on soil functions influenced by these organisms. Little research has been performed to date on the impact of PPPs on tropical soil ecosystems. Therefore, ...
journal_title：Archives of environmental contamination and toxicology
pub_type： 杂志文章
doi：10.1007/s00244-006-0219-8
更新日期：2007-11-01 00:00:00
abstract：:Chemical elimination rate constants (k2) were determined for 41 polychlorinated biphenyl (PCB) congeners in dosed freshwater mussels, Elliptio complanta, following a 150-day laboratory depuration period. Congener-specific elimination rates were inversely dependent on the n-octanol/water partition coefficient (K(ow)) o...
journal_title：Archives of environmental contamination and toxicology
pub_type： 杂志文章
doi：10.1007/s00244-004-2295-y
更新日期：2004-07-01 00:00:00
abstract：:Using the growth response of the green alga Chlorella vulgaris as a model system, the effects of combinations of the environmentally active cations Cd, Co, and Cu were evaluated. The 96-h static EC50 for these cations to C. vulgaris were, respectively, 0.89 microM, 9.0 microM, and 2.8 microM, yielding a toxicity serie...
journal_title：Archives of environmental contamination and toxicology
pub_type： 杂志文章
doi：10.1007/BF01061084
更新日期：1993-01-01 00:00:00
abstract：:This report describes a study of exposure to omethoate during manual operations with ornamental plants in two intensive cultivation tunnels (tunnel 8 and tunnel 5). Airborne concentrations of omethoate were in the range 1.48-5.36 nmol/m(3). Total skin contamination in the range 329.94-12,934.46 nmol/day averaged 98.1 ...
journal_title：Archives of environmental contamination and toxicology
pub_type： 杂志文章
doi：10.1007/s00244-005-8025-2
更新日期：2005-11-01 00:00:00
