Retinol-binding protein and beta 2-microglobulin in urine of cadmium-fed rhesus monkeys.

Abstract:

:Retinol-binding protein (RBP) in the Rhesus monkey had the same electrophoretic mobility, molecular weight, and common antigens as human RBP; beta 2-microglobulin protein (MG) had similar electrophoretic mobility and partial common antigens to human MG. After a prolonged oral administration of cadmium chloride to 10 monkeys over a period of 55 weeks, one monkey of the 30 mg Cd/day group indicated RBPuria and MGuria with the use of anti-human RBP and MG sera when proteinuria appeared. The immunological assay of low-molecular-weight proteins in urine was not applicable for the early detection of cadmium health effects in monkeys.

authors

Nomiyama K,Yotoriyama M,Nomiyama H

doi

10.1007/BF01055631

subject

Has Abstract

pub_date

1981-01-01 00:00:00

pages

297-304

issue

3

eissn

0090-4341

issn

1432-0703

journal_volume

10

pub_type

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