Effects of pesticides on isolated rat hepatocytes, mitochondria, and microsomes.

Abstract:

:Twenty-seven pesticides, with which people are concerned, especially as residues in food, were examined in vitro for their effects on hepatocytes, mitochondria, and microsomes isolated from male rats. Nineteen pesticides returned non-protein sulfhydryl (NPSH) contents in hepatocytes to less than 80% of control at concentrations from 10(-3) to 10(-5) M after 90 min incubation. Among them, only dichlofluanid was reactive with glutathione non-enzymatically. Lipid peroxidation in hepatocytes was stimulated by five pesticides at 10(-3) M, with edifenphos being the most potent peroxidant. Cell viability was considerably decreased by incubation with chlorobenzilate, edifenphos, dichlofluanid, and chinomethionat at 10(-3) M, and in these cases, depletion of cellular adenosine 5'-triphosphate (ATP) contents proceeded to cell death. With respect to isolated mitochondrial respiration, six pesticides inhibited state 3 and/or state 4 respiration rates at concentrations from 10(-3) to 10(-5) M, whereas three pesticides uncoupled state 4 respiration at 10(-3) M. With respect to isolated microsomal lipid peroxidation, seven pesticides, five of which were organophosphorus compounds, were peroxidative at concentrations from 10(-3) to 10(-5) M, whereas seven pesticides were antioxidative at concentrations from 10(-3) to 10(-7) M. Only three pesticides, aldicarb, maleic hydrazide, and chlormequat chloride had no effect on any parameters tested at 10(-3) M. Pesticides that affected isolated mitochondria or microsomes did not necessarily have any effect on isolated hepatocytes.

authors

Yamano T,Morita S

doi

10.1007/BF00212141

subject

Has Abstract

pub_date

1993-08-01 00:00:00

pages

271-8

issue

2

eissn

0090-4341

issn

1432-0703

journal_volume

25

pub_type

杂志文章
  • Effects of inorganic lead on delta-aminolevulinic acid dehydratase activity and hematological variables in the rainbow trout, Salmo gairdnerii.

    abstract::The activity of the enzyme delta-aminolevulinic acid dehydratase (ALA-D) was strongly depressed in erythrocytes, spleen and renal tissue of rainbow trouts (Salmo gairdnerii) exposed to sublethal levels of inorganic lead (10, 75 and 300 microgram Pb2+/L) for 30 days. The fish exposed to the highest lead concentration a...

    journal_title:Archives of environmental contamination and toxicology

    pub_type: 杂志文章

    doi:10.1007/BF01056348

    authors: Johansson-Sjöbeck ML,Larsson A

    更新日期:1979-01-01 00:00:00

  • Biomarkers study for sediment quality assessment in spanish ports using the crab Carcinus maenas and the clam Ruditapes philippinarum.

    abstract::Intermolt crab Carcinus maenas and clam Ruditapes philippinarum were used to determine the toxicity of sediments collected in four Spanish ports (Cádiz, Huelva, Pasajes, and Bilbao) under laboratory conditions during 28 days. Sediment samples were analyzed to determine chemical concentration of metals (As, Cd, Cr, Cu,...

    journal_title:Archives of environmental contamination and toxicology

    pub_type: 杂志文章

    doi:10.1007/s00244-006-0121-4

    authors: Martín-Díaz ML,Blasco J,Sales D,Delvalls TA

    更新日期:2007-07-01 00:00:00

  • Combined effects of UV-B, nitrate, and low pH reduce the survival and activity level of larval cascades frogs (Rana cascadae).

    abstract::We investigated interactions between low pH, high nitrate level, and ultraviolet-B (UV-B) light on the survival and activity level of larval Cascades frogs (Rana cascadae). We used a fully factorial experimental design, with pH levels of 5 and 7; initial "pulse" nitrate exposure levels of 0, 5, and 20 mg/L; and UV-B p...

    journal_title:Archives of environmental contamination and toxicology

    pub_type: 杂志文章

    doi:10.1007/s002440010132

    authors: Hatch AC,Blaustein AR

    更新日期:2000-11-01 00:00:00

  • Effects of elevated foodborne selenium on growth and reproduction of the fathead minnow (Pimephales promelas).

    abstract::Several field studies of selenium-contaminated lakes and reservoirs have indicated the possibility of selenium-induced reproductive failure in important populations of fish. These investigators have hypothesized that bioaccumulation of selenium through the food chain led to fish selenium levels high enough to elicit t...

    journal_title:Archives of environmental contamination and toxicology

    pub_type: 杂志文章

    doi:10.1007/BF01160293

    authors: Ogle RS,Knight AW

    更新日期:1989-11-01 00:00:00

  • Increase of the behavioral response to kairomones by the parasitoid wasp Leptopilina heterotoma surviving insecticides.

    abstract::Hymenopterous parasitoids are key species involved in the regulation of insect populations. Kairomone perception is an important step leading to host parasitization. The massive use of insecticides induces environmental pollution that can interact with the reproduction of parasitoids. In this work, we have determined ...

    journal_title:Archives of environmental contamination and toxicology

    pub_type: 杂志文章

    doi:10.1007/s00244-004-0158-1

    authors: Delpuech JM,Bardon C,Boulétreau M

    更新日期:2005-08-01 00:00:00

  • Residues of PCB's and DDT in the western Lake Superior ecosystem.

    abstract::Fish from western Lake Superior (1972-73) contained DDT and PCB residues at concentrations greater than o.1 ppm. The most predominant PCB's were those containing 3 to 6 chlorine atoms per molecule, and GLC data indicated that the mixtures were most like the commercial product Aroclor 1254(2). Other chlorinated contimi...

    journal_title:Archives of environmental contamination and toxicology

    pub_type: 杂志文章

    doi:10.1007/BF02220927

    authors: Veith GD,Kuehl DW,Puglisi FA,Glass GE,Eaton JG

    更新日期:1977-01-01 00:00:00

  • Physiological and ultrastructural effects of cadmium on wheat (Triticum aestivum L.) leaves.

    abstract::The effects of a 7-day exposure of 3-day-old wheat plantsto increasing Cd concentrations are described, with special attention beinggiven to chloroplast ultrastructural changes, chlorophyll fluorescenceresponses, chlorophyll and nutrient concentration changes as well as growthchanges of the whole plant. The plants tre...

    journal_title:Archives of environmental contamination and toxicology

    pub_type: 杂志文章

    doi:10.1007/s002449900168

    authors: Ouzounidou G,Moustakas M,Eleftheriou EP

    更新日期:1997-02-01 00:00:00

  • Neurodevelopment outcomes in children exposed to organic mercury from multiple sources in a tin-ore mine environment in Brazil.

    abstract::Methylmercury (from fresh-water fish) and ethylmercury [from thimerosal-containing vaccines (TCVs)] are the most prevalent source of neurotoxic exposure during early life in families consuming fish and using these vaccines. But children living in Amazonian mining environments are exposed to additional toxic metals in ...

    journal_title:Archives of environmental contamination and toxicology

    pub_type: 杂志文章

    doi:10.1007/s00244-014-0103-x

    authors: Marques RC,Bernardi JV,Abreu L,Dórea JG

    更新日期:2015-04-01 00:00:00

  • Chromatographic determination of dicofol and metabolites in egg yolks.

    abstract::Egg yolk was spiked with p,p'-dicofol (p,p'-DCF) (0.1-2.0 micrograms/gm), p,p'-dichlorobenzophenone (p,p'-DCBP) (0.1-2.0 micrograms/gm), and 1,1-bis(4-chlorophenyl)-2,2-dichloroethylene (p,p'-DDE) (0.05-1.0 micrograms/gm). The fortified egg yolk (2-5 g) was mixed with acetonitrile to extract non-fat organic materials....

    journal_title:Archives of environmental contamination and toxicology

    pub_type: 杂志文章

    doi:10.1007/BF01059825

    authors: Mourer CR,Hall GL,Whitehead WE,Shibamoto T,Shull LR,Schwarzbach SE

    更新日期:1990-01-01 00:00:00

  • Occurrence of endocrine-disrupting phenols and estrogens in water and sediment of the Songhua river, northeastern China.

    abstract::Concentrations of six phenolic endocrine-disrupting chemicals [4-tert-octylphenol (OP), 4-t-nonylphenol (4-t-NP), 4-n-nonylphenol (4-n-NP), nonylphenol mono- to di-ethoxylates (NP1EO, NP2EO), and bisphenol A (BPA)] and five estrogens [estrone (E1), β-estradiol (E2), estriol (E3) 17α-ethynylestradiol (EE2), and diethyl...

    journal_title:Archives of environmental contamination and toxicology

    pub_type: 杂志文章

    doi:10.1007/s00244-014-9998-5

    authors: Zhang Z,Ren N,Kannan K,Nan J,Liu L,Ma W,Qi H,Li Y

    更新日期:2014-04-01 00:00:00

  • Sub-lethal Effects of Chlorpyrifos on Big Brown Bats (Eptesicus fuscus).

    abstract::We determined dose-response curves for sublethal effects of the organophosphorus (OP) insecticide, chlorpyrifos, on bats. Big brown bats (Eptesicus fuscus, n = 64) were given a single dose of chlorpyrifos (nominal concentrations) of 0, 5, 10, 15, 20, 25, 30, or 60 µg/g body weight and examined at 12 or 24 h after dosi...

    journal_title:Archives of environmental contamination and toxicology

    pub_type: 杂志文章

    doi:10.1007/s00244-016-0307-3

    authors: Eidels RR,Sparks DW,Whitaker JO Jr,Sprague CA

    更新日期:2016-10-01 00:00:00

  • In vitro lead bioaccessibility and phosphate leaching as affected by surface application of phosphoric acid in lead-contaminated soil.

    abstract::Phosphate treatment of lead-contaminated soil may be a cost-effective remedial alternative for in situ stabilizing soil Pb and reducing Pb toxicology to human. The leaching behaviors of the P added to soil surface and the effect on subsurface Pb bioaccessibility must be addressed for this remedial technology to be acc...

    journal_title:Archives of environmental contamination and toxicology

    pub_type: 杂志文章

    doi:10.1007/s00244-002-1197-0

    authors: Yang J,Mosby DE,Casteel SW,Blanchar RW

    更新日期:2002-11-01 00:00:00

  • Effect of subacute benzene exposure on the activity of two neuropeptide-degrading enzymes in the rat brain.

    abstract::Benzene (Bz) is an important industrial chemical, a petroleum by-product, a component of unleaded gas, and thus a ubiquitous environmental pollutant. It is well established that this organic solvent possesses neurotoxic and behavioral effects. However, the neurochemical mechanism of the solvent action remains obscure....

    journal_title:Archives of environmental contamination and toxicology

    pub_type: 杂志文章

    doi:10.1007/BF00212097

    authors: de Gandarias JM,Casis O,Irazusta J,Echevarría E,Casis L

    更新日期:1992-04-01 00:00:00

  • Acute toxicity and sublethal effects of white phosphorus in mute swans, Cygnus olor.

    abstract::Among the waterfowl affected by white phosphorus (P4) at a military base in Alaska are tundra (Cygnus columbianus) and trumpeter (C. buccinator) swans. To estimate the toxicity of P4 to swans and compare the toxic effects to those of mallards (Anas platyrhynchos), we dosed 30 juvenile mute swans (C. olor) with 0 to 5....

    journal_title:Archives of environmental contamination and toxicology

    pub_type: 杂志文章

    doi:10.1007/s002449900477

    authors: Sparling DW,Day D,Klein P

    更新日期:1999-04-01 00:00:00

  • Effects of the fungicide benomyl on earthworms in laboratory tests under tropical and temperate conditions.

    abstract::Soil organisms play a crucial role in the terrestrial ecosystem. Plant protection products (PPPs) are known to affect soil organisms and might have negative impacts on soil functions influenced by these organisms. Little research has been performed to date on the impact of PPPs on tropical soil ecosystems. Therefore, ...

    journal_title:Archives of environmental contamination and toxicology

    pub_type: 杂志文章

    doi:10.1007/s00244-006-0219-8

    authors: Römbke J,Garcia MV,Scheffczyk A

    更新日期:2007-11-01 00:00:00

  • A Simple Approach to the Toxicity Prediction of Anilines and Phenols Towards Aquatic Organisms.

    abstract::Chemicals pollution in the environment has attracted attention all over the world, and the toxicity prediction of chemical pollutants has become quite important. In this paper, we introduce a simple approach to predict the toxicity of some chemical components, in which the Tchebichef image moment (TM) method was emplo...

    journal_title:Archives of environmental contamination and toxicology

    pub_type: 杂志文章

    doi:10.1007/s00244-019-00703-z

    authors: Muhire J,Li BQ,Zhai HL,Li SS,Mi JY

    更新日期:2020-05-01 00:00:00

  • Toxicity of 4-chloroaniline in early life-stages of zebrafish (Brachydanio rerio): I. cytopathology of liver and kidney after microinjection.

    abstract::In addition to survival and hatching parameters, cytological alterations in liver and kidney of 4- and 6-d old zebrafish larvae (Brachydanio rerio) following single microinjection of fertilized eggs at the germ-ring stage with 5, 12.5, and 25 ng 4-chloroaniline/egg were investigated by means of electron microscopy. Wh...

    journal_title:Archives of environmental contamination and toxicology

    pub_type: 杂志文章

    doi:10.1007/BF00212299

    authors: Oulmi Y,Braunbeck T

    更新日期:1996-03-01 00:00:00

  • Inhibition of binding of thyroxin to transthyretin by outdoor and indoor airborne particulate matter and effects on thyroid hormone and vitamin A metabolism in rats.

    abstract::Previous studies have indicated that chemicals, e.g., hydroxylated polychlorinated biphenyls (PCBs) decrease plasma thyroxin levels through interaction with transthyretin. As a consequence, plasma vitamin A and thyroxin are depleted. Both thyroxin and vitamin A are important regulators of normal epithelial differentia...

    journal_title:Archives of environmental contamination and toxicology

    pub_type: 杂志文章

    doi:10.1007/BF00225989

    authors: Heussen GA,Hikspoors ML,Spenkelink A,Brouwer A,Koeman JH

    更新日期:1992-07-01 00:00:00

  • Spatial and Temporal Distributions of Air Pollutants and Size Distribution of Aerosols over Central and Eastern China.

    abstract::The origins and spatial and temporal distributions of air pollutants (PM2.5, PM10, CO, SO2, NO2 and O3) during May to June of 2015 were investigated using data from 1490 monitoring sites in China. Aerosol number concentrations and meteorological data from Shijiazhuang, Nanjing, and Suzhou were combined with the MIX As...

    journal_title:Archives of environmental contamination and toxicology

    pub_type: 杂志文章

    doi:10.1007/s00244-017-0401-1

    authors: Wang H,Shen L,Zhu B,Kang H,Hou X,Miao Q,Yang Y,Shi S

    更新日期:2017-05-01 00:00:00

  • Concentrations, sources, and risk assessment of polychlorinated biphenyls in vegetables near a waste-incinerator site, South China.

    abstract::Numerous studies have reported polychlorinated biphenyl (PCB) concentrations in soil, root, and aerial parts of vegetables. However, few studies have measured the contribution of PCBs bound to particles in air in relation to uptake by vegetables. In the present study, PCB concentrations were measured in five types of ...

    journal_title:Archives of environmental contamination and toxicology

    pub_type: 杂志文章

    doi:10.1007/s00244-014-0045-3

    authors: Zeng L,Li N,Shao D,Kang Y,Zhang Q,Lu P,Li L,Luo J,Guo X

    更新日期:2014-07-01 00:00:00

  • Effects of aerially applied fenthion on survival and reproduction of the panacea sand fiddler, Uca panacea, in laboratory habitats.

    abstract::Sand fiddler crabs, Uca panacea, were exposed in laboratory habitats to measured concentrations of ULV-grade fenthion via simulated aerial spray at 5% and 50% of field rate application of 6-12 mg fenthion/m(2) (0.05-0.10 lbs fenthion/acre). Two habitats served as controls, and two habitats served as replicates for eac...

    journal_title:Archives of environmental contamination and toxicology

    pub_type: 杂志文章

    doi:10.1007/s002449910043

    authors: Schoor WP,Middaugh DP,Marcovich DT

    更新日期:2000-04-01 00:00:00

  • Sources and a Health Risk Assessment of Potentially Toxic Elements in Dust at Children's Playgrounds with Artificial Surfaces: A Case Study in Belgrade.

    abstract::The focus of this research on children's playgrounds with artificial surfaces aimed to establish levels of potentially toxic elements (PTEs) in dust, their origin, and impact on children at 15 playgrounds: 9 on school grounds and 6 on day nurseries in Belgrade (Serbia). Soil samples were taken from the immediate vicin...

    journal_title:Archives of environmental contamination and toxicology

    pub_type: 杂志文章

    doi:10.1007/s00244-019-00702-0

    authors: Čakmak D,Perović V,Kresović M,Pavlović D,Pavlović M,Mitrović M,Pavlović P

    更新日期:2020-02-01 00:00:00

  • Short-term bioassay responses to sludge products and leachate.

    abstract::Recycling of sewage sludge is needed in a sustainable society. Quality aspects of sludge include hygiene (pathogens), nutrients (N and P), and toxicants (metals and organics). Metals are of particular concern because they are not degradable, but their hazards are related to their bioavailability and chemical speciatio...

    journal_title:Archives of environmental contamination and toxicology

    pub_type: 杂志文章

    doi:10.1007/s00244-005-0037-4

    authors: Fjällborg B,Gustafsson N

    更新日期:2006-10-01 00:00:00

  • Exposure to omethoate during stapling of ornamental plants in intensive cultivation tunnels: influence of environmental conditions on absorption of the pesticide.

    abstract::This report describes a study of exposure to omethoate during manual operations with ornamental plants in two intensive cultivation tunnels (tunnel 8 and tunnel 5). Airborne concentrations of omethoate were in the range 1.48-5.36 nmol/m(3). Total skin contamination in the range 329.94-12,934.46 nmol/day averaged 98.1 ...

    journal_title:Archives of environmental contamination and toxicology

    pub_type: 杂志文章

    doi:10.1007/s00244-005-8025-2

    authors: Aprea C,Centi L,Santini S,Lunghini L,Banchi B,Sciarra G

    更新日期:2005-11-01 00:00:00

  • Comparison of Toxicities of Metal Pyrithiones Including Their Degradation Compounds and Organotin Antifouling Biocides to the Japanese Killifish Oryzias latipes.

    abstract::Japanese killifish Oryzias latipes were exposed to three levels (0, 1, and 10 µg l-1) of copper pyrithione (CuPT2), zinc pyrithione (ZnPT2), six of their degradation products, and the organotin compounds tributyltin (TBT) and triphenyltin (TPT) for 48 h at 20 °C. All individual fish exposed to 1 and 10 µg l-1 of CuPT2...

    journal_title:Archives of environmental contamination and toxicology

    pub_type: 杂志文章

    doi:10.1007/s00244-017-0367-z

    authors: Ohji M,Harino H

    更新日期:2017-08-01 00:00:00

  • Assessment of Ecological Risk and Environmental Behavior of Pesticides in Environmental Compartments of the Formoso River in Tocantins, Brazil.

    abstract::Anthropogenic interference the ecosystem unavoidably changes the physical and biological environment. The biodiversity of the Amazon region has been threatened by increased agricultural production and pesticide use. Considering that monitoring pesticides in environments close to their application is one of the ways to...

    journal_title:Archives of environmental contamination and toxicology

    pub_type: 杂志文章

    doi:10.1007/s00244-020-00770-7

    authors: Guarda PM,Pontes AMS,Domiciano RS,Gualberto LDS,Mendes DB,Guarda EA,da Silva JEC

    更新日期:2020-11-01 00:00:00

  • In vivo and in vitro effects of metals in reactive oxygen species production, protein carbonylation, and DNA damage in land snails Eobania vermiculata.

    abstract::Heavy metals are known to induce oxidative damage by way of enhancement of intracellular reactive oxygen species (ROS) production, which often preludes the onset of alterations, such as protein carbonylation and DNA damage. In this study, our aim was to examine the early responses of land snails Eobania vermiculata to...

    journal_title:Archives of environmental contamination and toxicology

    pub_type: 杂志文章

    doi:10.1007/s00244-010-9583-5

    authors: Itziou A,Kaloyianni M,Dimitriadis VK

    更新日期:2011-05-01 00:00:00

  • Assessment of urinary metabolite excretion after rat acute exposure to perfluorooctanoic acid and other peroxisomal proliferators.

    abstract::Perfluorooctanoic acid (PFOA) is a persistent environmental contaminant. Activation of the peroxisome proliferator activated receptor alpha (PPARα) resulting from exposure to PFOA has been extensively studied in rodents. However, marked differences in response to peroxisome proliferators prevent extrapolation of roden...

    journal_title:Archives of environmental contamination and toxicology

    pub_type: 杂志文章

    doi:10.1007/s00244-014-0058-y

    authors: Rigden M,Pelletier G,Poon R,Zhu J,Auray-Blais C,Gagnon R,Kubwabo C,Kosarac I,Lalonde K,Cakmak S,Xiao B,Leingartner K,Ku KL,Bose R,Jiao J

    更新日期:2015-01-01 00:00:00

  • Multi-metals Measured at Sediment-Water Interface (SWI) by Diffusive Gradients in Thin Films (DGT) Technique for Geochemical Research.

    abstract::Diffusive gradients in thin films (DGT) technique was used to determine pore water profile and to assess remobilization character of metals at sediment/water interface. The remobilization of Mn was due to redox reaction in profile, which engendered two large peaks: one with DGT concentration of 1355 µg L(-1) at depth ...

    journal_title:Archives of environmental contamination and toxicology

    pub_type: 杂志文章

    doi:10.1007/s00244-015-0184-1

    authors: Wu Z,Jiao L,Wang S,Xu Y

    更新日期:2016-02-01 00:00:00

  • A Multidisciplinary Assessment of River Surface Water Quality in Areas Heavily Influenced by Human Activities.

    abstract::The present study could serve as a multidisciplinary approach for the assessment of river surface water quality with the use of chemical and biological methods. Specifically, physicochemical parameters, heavy metals, and pesticides were measured in water samples from three different stations (sampling station S1, S2, ...

    journal_title:Archives of environmental contamination and toxicology

    pub_type: 杂志文章

    doi:10.1007/s00244-015-0152-9

    authors: Charalampous N,Kindou A,Vlastos D,Tsarpali V,Antonopoulou M,Konstantinou I,Dailianis S

    更新日期:2015-08-01 00:00:00