Abstract：
:Perfluorooctanoic acid (PFOA) is a persistent environmental contaminant. Activation of the peroxisome proliferator activated receptor alpha (PPARα) resulting from exposure to PFOA has been extensively studied in rodents. However, marked differences in response to peroxisome proliferators prevent extrapolation of rodent PPARα activation to human health risks and additional molecular mechanisms may also be involved in the biological response to PFOA exposure. To further explore the potential involvement of such additional pathways, the effects of PFOA exposure on urinary metabolites were directly compared with those of other well-known PPARα agonists. Male rats were administered PFOA (10, 33, or 100 mg/kg/d), fenofibrate (100 mg/kg/d), or di(2-ethylhexyl) phthalate (100 mg/kg/d) by gavage for 3 consecutive days and allowed to recover for 4 days, and overnight urine was collected. Greater urinary output was observed exclusively in PFOA-treated rats as the total fraction of PFOA excreted in urine increased with the dose administered. Assessment of urinary metabolites (ascorbic acid, quinolinic acid, 8-hydroxy-2'-deoxyguanosine, and malondialdehyde) provided additional information on PFOA's effects on hepatic glucuronic acid and tryptophan-nicotinamide adenine dinucleotide (NAD) pathways and on oxidative stress, whereas increased liver weight and palmitoyl-CoA oxidase activity indicative of PPARα activation and peroxisomal proliferation persisted up to day five after the last exposure.
journal_name
Arch Environ Contam Toxicoljournal_title
Archives of environmental contamination and toxicologyauthors
Rigden M,Pelletier G,Poon R,Zhu J,Auray-Blais C,Gagnon R,Kubwabo C,Kosarac I,Lalonde K,Cakmak S,Xiao B,Leingartner K,Ku KL,Bose R,Jiao Jdoi
10.1007/s00244-014-0058-ysubject
Has Abstractpub_date
2015-01-01 00:00:00pages
148-58issue
1eissn
0090-4341issn
1432-0703journal_volume
68pub_type
杂志文章abstract：:Pollution of surface soils by traffic, especially along major highways, can be a significant issue. Numerous studies have demonstrated traffic to be an important source of particulate matter and gas-phase organic air pollutants that produce many types of deleterious effects. This article brings original information ab...
journal_title：Archives of environmental contamination and toxicology
pub_type： 杂志文章
doi：10.1007/s00244-009-9345-4
更新日期：2009-11-01 00:00:00
abstract：:In this study, we examine the relative contribution of water and live prey (Tubifex tubifex) as sources of nickel (Ni) and thallium (Tl) in juvenile fathead minnows (Pimephales promelas). Overall, both water and prey were important sources of metals for our fish, although only approximately 35% of the metal estimated ...
journal_title：Archives of environmental contamination and toxicology
pub_type： 杂志文章
doi：10.1007/s00244-009-9298-7
更新日期：2009-10-01 00:00:00
abstract：:Demographic characteristics of a white-footed mouse (Peromyscus leucopus) population inhabiting a woodland containing a low level of PCBs contamination were compared to an uncontaminated reference site. Although population density was higher on the PCBs-contaminated grid, the population exhibited greater temporal vari...
journal_title：Archives of environmental contamination and toxicology
pub_type： 杂志文章
doi：10.1007/BF00214844
更新日期：1994-11-01 00:00:00
abstract：:Polycyclic aromatic hydrocarbons (PAH) have become an ubiquitous upper soil component as a consequence of industrialization involving a multitude of combustion processes. Ingestion of PAH contaminated soil is considered to be a major exposure route, specifically for small children living on these soils. Health risk as...
journal_title：Archives of environmental contamination and toxicology
pub_type： 杂志文章
doi：10.1007/s002449900259
更新日期：1997-10-01 00:00:00
abstract：:In this study, ice and water samples were collected from seven sites along the Baotou section of the Yellow River during winter 2013. Total polycyclic aromatic hydrocarbon (PAH) concentrations in the ice and in the water under the ice ranged from 21.3 to 59.4 ng L(-1), and from 38.3 to 222.4 ng L(-1), respectively. Th...
journal_title：Archives of environmental contamination and toxicology
pub_type： 杂志文章
doi：10.1007/s00244-015-0135-x
更新日期：2015-08-01 00:00:00
abstract：:Six prairie grain farmers were monitored for pesticide exposure and related adverse effects while they mixed and/or sprayed carbofuran (Furadan 480F) with ground rig application equipment to control grasshoppers in southern Alberta, Canada. Dermal exposure was estimated with Tegaderm patches placed at seventeen locati...
journal_title：Archives of environmental contamination and toxicology
pub_type： 杂志文章
doi：10.1007/BF01056087
更新日期：1990-03-01 00:00:00
abstract：:A life table response experiment (LTRE) was used to quantify the population-level effects of continuous, multigeneration cadmium exposure on two strains of the freshwater gastropod, Biomphalaria glabrata: the parasite-resistant BS90 and parasite-susceptible NMRI strains. Snails were exposed to waterborne cadmium for t...
journal_title：Archives of environmental contamination and toxicology
pub_type： 杂志文章
doi：10.1007/s00244-008-9203-9
更新日期：2009-05-01 00:00:00
abstract：:Metallothioneins with differing Cd/Zn ratios were prepared in vitro from rat liver zinc-thionein by replacing zinc with cadmium and were injected intraperitoneally to female rats. The distribution of cadmium, zinc, and copper in the kidney supernatant fraction was determined using a Sephadex G-75 column. The distribut...
journal_title：Archives of environmental contamination and toxicology
pub_type： 杂志文章
doi：10.1007/BF01055143
更新日期：1979-01-01 00:00:00
abstract：:A battery of in vitro bioassays, including a Neutral Red (NR) assay using MCF-7 cells for predicting cytotoxic chemicals, an ethoxy resorufin-O-deethylase (EROD) activity assay using H4IIE cells to check for dioxin-like chemicals, and a recombinant gene yeast assay for screening estrogenic chemicals, was conducted to ...
journal_title：Archives of environmental contamination and toxicology
pub_type： 杂志文章
doi：10.1007/s00244-004-0204-z
更新日期：2005-11-01 00:00:00
abstract：:Persistent organochlorines such as DDT and its metabolites (DDTs), hexachlorocyclohexane isomers (HCHs), chlordane compounds (CHLs), hexachlorobenzene (HCB), and polychlorinated biphenyls (PCBs) were determined in whole-body homogenates of resident and migratory birds collected from South India. Organochlorine contami...
journal_title：Archives of environmental contamination and toxicology
pub_type： 杂志文章
doi：10.1007/s002449900335
更新日期：1998-05-01 00:00:00
abstract：:This report summarizes a study of the chemical and biological characteristics of three oligotrophic lakes located in a region that receives a moderately acidic precipitation (mean annual pH 4.5-4.6), and a sulfate deposition of about 20 kg/ha/yr. The two brownwater lakes are relatively acidic (pH 4.5 and 4.8), and muc...
journal_title：Archives of environmental contamination and toxicology
pub_type： 杂志文章
doi：10.1007/BF01056203
更新日期：1989-01-01 00:00:00
abstract：:We investigated interactions between low pH, high nitrate level, and ultraviolet-B (UV-B) light on the survival and activity level of larval Cascades frogs (Rana cascadae). We used a fully factorial experimental design, with pH levels of 5 and 7; initial "pulse" nitrate exposure levels of 0, 5, and 20 mg/L; and UV-B p...
journal_title：Archives of environmental contamination and toxicology
pub_type： 杂志文章
doi：10.1007/s002440010132
更新日期：2000-11-01 00:00:00
abstract：:Using a conditioned proboscis extension response (PER) assay, honeybees (Apis mellifera L.) can be trained to associate an odor stimulus with a sucrose reward. Previous studies have shown that observations of conditioned PER were of interest for assessing the behavioral effects of pesticides on the honeybee. In the pr...
journal_title：Archives of environmental contamination and toxicology
pub_type： 杂志文章
doi：10.1007/s00244-003-0262-7
更新日期：2005-02-01 00:00:00
abstract：:Occurrence of traditional (PBDEs) and novel (HBB, PBEB, DBDPE) brominated flame retardants, as well as the natural compounds of MeO-PBDEs, were studied in a shellfish species (Hexaplex trunculus) sampled from Bizerte Lagoon. PBDE and MeO-PBDE mean concentrations in murex soft tissues were 187 and 264 ng g-1 lw respect...
journal_title：Archives of environmental contamination and toxicology
pub_type： 杂志文章
doi：10.1007/s00244-019-00694-x
更新日期：2020-04-01 00:00:00
abstract：:During their formation, fish eggs receive a load of contaminants including polychlorinated biphenyls (PCBs) from their mother and then, after spawning, are exposed to pesticides present in water. This is the first study investigating the interaction between PCBs and organophosphorous pesticides in fish. The effect of ...
journal_title：Archives of environmental contamination and toxicology
pub_type： 杂志文章
doi：10.1007/s00244-007-9030-4
更新日期：2008-02-01 00:00:00
abstract：:Single-point Tenax extractions (SPTEs) of hydrophobic organic contaminants provide estimates of bioaccessibility through consistent measures of the chemical concentration initially in the rapidly desorbing fraction in sediment (C rapT0), such that a constant ratio is expected between SPTE and C rapT0 (C T /C rapT0, wh...
journal_title：Archives of environmental contamination and toxicology
pub_type： 杂志文章
doi：10.1007/s00244-017-0395-8
更新日期：2017-05-01 00:00:00
abstract：:Soil organisms play a crucial role in the terrestrial ecosystem. Plant protection products (PPPs) are known to affect soil organisms and might have negative impacts on soil functions influenced by these organisms. Little research has been performed to date on the impact of PPPs on tropical soil ecosystems. Therefore, ...
journal_title：Archives of environmental contamination and toxicology
pub_type： 杂志文章
doi：10.1007/s00244-006-0219-8
更新日期：2007-11-01 00:00:00
abstract：:Laboratory studies of algicide toxicity to algal species provide information to improve the efficacy and efficiency of copper-containing algicides in actual field situations. The objectives of this study were (1) to measure the influence of copper form, initial concentration, and duration of exposure on the response o...
journal_title：Archives of environmental contamination and toxicology
pub_type： 杂志文章
doi：10.1007/s00244-002-1135-1
更新日期：2002-07-01 00:00:00
abstract：:Children living in Coatzacoalcos, Veracruz, and in nearby surrounding areas are exposed to a mixture of pollutants from different sources. Previous studies in the area have reported genotoxic and haematotoxic compounds, such as lead (Pb), benzene, toluene, and polycyclic aromatic hydrocarbons (PAHs), in environmental ...
journal_title：Archives of environmental contamination and toxicology
pub_type： 杂志文章
doi：10.1007/s00244-014-9999-4
更新日期：2014-07-01 00:00:00
abstract：:With the increasingly growing global production of sewage sludge, evaluation of its applicability in agriculture and land restoration is essential. This study assessed the potential effects of composting process and fly ash amendment on soil-ameliorating properties of sewage sludge. The metal availability and phytotox...
journal_title：Archives of environmental contamination and toxicology
pub_type： 杂志文章
doi：10.1007/s002440010162
更新日期：2001-02-01 00:00:00
abstract：:Neonates from CD-1 mice, which were treated during gestation with 100 mg/kg of 2,4,5-T, were studied from day 1 to 30 postpartum (pp) for effects on cardiac development by determining total cardiac activities and isozyme profiles of LDH and CK. On day 1pp, the total activities and isozyme profiles of LDH of the neonat...
journal_title：Archives of environmental contamination and toxicology
pub_type： 杂志文章
doi：10.1007/BF01054881
更新日期：1981-09-01 00:00:00
abstract：:There is continuing concern that release of certain chemicals into the environment leads to human exposure to toxins, particularly through contaminated ground and surface waters. The triazine herbicide atrazine (2-chloro-4-ethylamine-6-isopropylamino-S-triazine) is routinely found as a contaminant in many surface and ...
journal_title：Archives of environmental contamination and toxicology
pub_type： 杂志文章
doi：10.1007/s00244-003-3087-5
更新日期：2004-05-01 00:00:00
abstract：:Mink were fed diets that contained 0, 34, or 102 ppb (micrograms/kg) aflatoxins with or without 0.5% hydrated sodium calcium aluminosilicate (HSCAS) and/or 1.0% activated charcoal (AC) for 77 days. Consumption of the diet that contained 34 ppb aflatoxins was lethal to 20% of the mink, while 102 ppb dietary aflatoxins ...
journal_title：Archives of environmental contamination and toxicology
pub_type： 杂志文章
doi：10.1007/BF01064418
更新日期：1991-04-01 00:00:00
abstract：:This work aimed to use seabirds as bioindicators of trace element levels in the tropical waters and food webs of the Western Indian Ocean. The accumulation patterns of selected toxic (Cd and Hg) and essential (Cu, Fe, Mn, Se, and Zn) elements were determined in liver, kidney, and pectoral muscle of 162 marine birds be...
journal_title：Archives of environmental contamination and toxicology
pub_type： 杂志文章
doi：10.1007/s00244-005-0225-2
更新日期：2007-04-01 00:00:00
abstract：:Dissipation processes are described for a combination of commonly used pesticides-atrazine (6-chloro-4-ethylamino-6-isopropylamino- s-triazine), metolachlor (2-chloro- N-[2-ethyl-6-methyl-phenyl]- N-[2-methoxy-1-methylethyl] acetamide), and chlorpyrifos ( O-O diethyl O-[3,5,6-trichloro-2-pyridinyl] phosphorothioate)-i...
journal_title：Archives of environmental contamination and toxicology
pub_type： 杂志文章
doi：10.1007/s00244-002-1259-3
更新日期：2003-01-01 00:00:00
abstract：:Recent studies have examined mercury accumulation in crocodilians. However, though most researchers have focused on tissue concentrations, few have examined mercury levels in crocodilian eggs. In July 1995, we analyzed mercury in 31 nonviable Morelet's crocodile ( Crocodylus moreletii) eggs collected from eight nests ...
journal_title：Archives of environmental contamination and toxicology
pub_type： 杂志文章
doi：10.1007/s00244-001-0020-7
更新日期：2002-04-01 00:00:00
abstract：:The purpose of this study was to determine if wetlands influence mercury concentrations in brook trout (Salvelinus fontinalis), benthic macroinvertebrates, and stream water. On September 26, 2005, water samples, benthic macroinvertebrates, and brook trout were collected from four streams in western Maryland under low-...
journal_title：Archives of environmental contamination and toxicology
pub_type： 杂志文章
doi：10.1007/s00244-006-0057-8
更新日期：2007-01-01 00:00:00
abstract：:Several field studies of selenium-contaminated lakes and reservoirs have indicated the possibility of selenium-induced reproductive failure in important populations of fish. These investigators have hypothesized that bioaccumulation of selenium through the food chain led to fish selenium levels high enough to elicit t...
journal_title：Archives of environmental contamination and toxicology
pub_type： 杂志文章
doi：10.1007/BF01160293
更新日期：1989-11-01 00:00:00
abstract：:Chironomid mouthpart deformities and aberrations of their polytenic chromosomes are sublethal responses to toxic stress. These endpoints have been used in several cases as bioindications for sediment pollution. In the present study we aimed to establish whether there was an association between mouthpart deformities an...
journal_title：Archives of environmental contamination and toxicology
pub_type： 杂志文章
doi：10.1007/s00244-001-0040-3
更新日期：2002-05-01 00:00:00
abstract：:Marine edible fish samples were collected from two important nearshore fishing sites in the eastern Guangdong Province, China: Shantou Harbor and Haimen Bay. In the mixed edible muscle tissues of marine fish samples, the concentrations of polychlorinated biphenyls, dichlorodiphenyltrichloroethanes (DDTs), hexachlorocy...
journal_title：Archives of environmental contamination and toxicology
pub_type： 杂志文章
doi：10.1007/s00244-012-9862-4
更新日期：2013-05-01 00:00:00
