Low-level atrazine exposure decreases cell proliferation in human fibroblasts.

Abstract:

:There is continuing concern that release of certain chemicals into the environment leads to human exposure to toxins, particularly through contaminated ground and surface waters. The triazine herbicide atrazine (2-chloro-4-ethylamine-6-isopropylamino-S-triazine) is routinely found as a contaminant in many surface and groundwaters. Little is known of the long-term effects of atrazine exposure on human cells. The objective of this research was to examine whether low-level exposure of atrazine to normal human fibroblast cells in culture had measurable deleterious effects. We show that low-level, short-term exposure of atrazine to normal fibroblasts results in decreased cell proliferation. In two separate assays to measure cell proliferation, either a 1.5-fold decrease in the cell number occurred (saturation density analysis) or a 2-fold decrease in cell proliferation was found (MTT analysis). Experiments to measure apoptosis in cells exposed to low levels of atrazine did not show DNA fragmentation or increased caspase activity. Thus, this analysis shows that short-term exposure to environmentally relevant, low levels of atrazine can be assessed by a decrease in cellular proliferation of normal human cells.

authors

Manske MK,Beltz LA,Dhanwada KR

doi

10.1007/s00244-003-3087-5

subject

Has Abstract

pub_date

2004-05-01 00:00:00

pages

438-44

issue

4

eissn

0090-4341

issn

1432-0703

journal_volume

46

pub_type

杂志文章
  • Trace elements in three marine birds breeding on Reunion Island (Western Indian ocean): part 1-factors influencing their bioaccumulation.

    abstract::This work aimed to use seabirds as bioindicators of trace element levels in the tropical waters and food webs of the Western Indian Ocean. The accumulation patterns of selected toxic (Cd and Hg) and essential (Cu, Fe, Mn, Se, and Zn) elements were determined in liver, kidney, and pectoral muscle of 162 marine birds be...

    journal_title:Archives of environmental contamination and toxicology

    pub_type: 杂志文章

    doi:10.1007/s00244-005-0225-2

    authors: Kojadinovic J,Le Corre M,Cosson RP,Bustamante P

    更新日期:2007-04-01 00:00:00

  • Relation Between Age and Heavy Metal Content in the Otoliths ofPomadasys stridens Forskal 1775 Collected from the Arabian Gulf

    abstract::A total of 216 otolith samples (89 male, 127 female) fromPomadasys stridens (Forskal 1775), a common fish of the ArabianGulf, were analyzed for the concentrations of heavy metals. Standard length,age, sex, body, and otolith weight were recorded for each fish. Otolithweight from male fish was found in the range of 0.04...

    journal_title:Archives of environmental contamination and toxicology

    pub_type: 杂志文章

    doi:10.1007/s002449900189

    authors: Ahmad S,Al-Ghais SM

    更新日期:1997-04-01 00:00:00

  • Seasonal and geographical variation of organochlorine residues in birds from northwest Mexico.

    abstract::Eight species of birds (129 individuals) were collected from three agricultural areas with long histories of pesticide use in northwestern Mexico. Plucked carcasses were analyzed for organochlorine (OC) pesticides and polychlorobiphenyls (PCBs). DDE was found in all of the samples and at higher levels than other OCs. ...

    journal_title:Archives of environmental contamination and toxicology

    pub_type: 杂志文章

    doi:10.1007/BF01183876

    authors: Mora MA,Anderson DW

    更新日期:1991-11-01 00:00:00

  • Anticoagulant rodenticides in three owl species from Western Canada, 1988-2003.

    abstract::Anticoagulant rodenticides are widely used to control rodent infestations. Previous studies have shown that nontarget organisms, such as birds, are at risk for both primary and secondary poisoning. This paper presents rodenticide residue information on the livers from 164 strigiformes which included barn owls (Tyto al...

    journal_title:Archives of environmental contamination and toxicology

    pub_type: 杂志文章

    doi:10.1007/s00244-009-9402-z

    authors: Albert CA,Wilson LK,Mineau P,Trudeau S,Elliott JE

    更新日期:2010-02-01 00:00:00

  • Developmental instability in a riparian population of the Algerian mouse(Mus spretus) associated with a heavy metal-polluted area in central Portugal.

    abstract::The adverse effects of heavy metals (mostly Cr, Mn, Fe, Cu, Zn, and Se) on the environment were appraised by comparing fluctuating asymmetry of dental characters (molars) in Algerian mice (Mus spretus) from polluted (Oeiras) and reference (Xévora) riparian areas, in central Portugal. The size of tooth traits was shown...

    journal_title:Archives of environmental contamination and toxicology

    pub_type: 杂志文章

    doi:10.1007/s002440010279

    authors: Nunes AC,Auffray JC,Mathias ML

    更新日期:2001-11-01 00:00:00

  • Toxicology of Marine Mammals: New Developments and Opportunities.

    abstract::It is widely recognized that marine mammals are exposed to a wide variety of pollutants, with a weight of evidence indicating impacts on their health. Since hundreds of new chemicals enter the global market every year,the methods, approaches and technologies used to characterize pollution levels or impacts are also in...

    journal_title:Archives of environmental contamination and toxicology

    pub_type: 杂志文章,评审

    doi:10.1007/s00244-015-0233-9

    authors: Weijs L,Zaccaroni A

    更新日期:2016-01-01 00:00:00

  • Assessment of metals in fish from Lake Macquarie, New South Wales, Australia.

    abstract::The concentrations of the metals cadmium, copper, mercury, lead, silver, selenium and zinc were measured in the muscle and gonad tissues of five species of fish, yellowfin bream (Acanthopagrus australis), silverbiddy (Gerres subfasciatus) and trumpeter whiting (Sillago maculata), southern log finned goby (Favonigobiou...

    journal_title:Archives of environmental contamination and toxicology

    pub_type: 杂志文章

    doi:10.1007/s00244-007-9027-z

    authors: Roach AC,Maher W,Krikowa F

    更新日期:2008-02-01 00:00:00

  • Metabolism of 4-chlorobiphenyl by lichens.

    abstract::Eighteen lichens from a variety of habitats were treated with 4-chlorobiphenyl (4-CB). All, as determined by means of radioactive tracers, were shown to partially convert 4-CB to 4-chloro-4'-hydroxybiphenyl. Only one species (Pseudocyphellaria crocata) produced a further major metabolite not previously reported, namel...

    journal_title:Archives of environmental contamination and toxicology

    pub_type: 杂志文章

    doi:10.1007/BF02220817

    authors: Maass WS,Hutzinger O

    更新日期:1975-01-01 00:00:00

  • Comparison of microbial tests for the detection of heavy metal genotoxicity.

    abstract::Heavy metal genotoxicity was evaluated by using different microbial tests. Four genotoxicity assays were employed: the Ames test, the E. coli WP2 test, the Mutatox test detecting mutagenicity, and the SOS assay with E. coli-detecting enzyme induction. All the metals tested (cadmium, chromium, copper, mercury, nickel, ...

    journal_title:Archives of environmental contamination and toxicology

    pub_type: 杂志文章

    doi:10.1007/BF00212978

    authors: Codina JC,Pérez-Torrente C,Pérez-García A,Cazorla FM,de Vicente A

    更新日期:1995-08-01 00:00:00

  • Detection of toxic organometallic complexes in wastewaters using algal assays.

    abstract::Chlorella (a unicellular green alga) and Cladophora (a filamentous alga) were used in algal assays to identify the presence and toxicity of organometallic complexes in four industrial wastewaters. Toxicities of inorganic Pb and organometallic compounds (trimethyl, tetramethyl and tetraethyl leads, cacodylic acid and C...

    journal_title:Archives of environmental contamination and toxicology

    pub_type: 杂志文章

    doi:10.1007/s002449900197

    authors: Wong SL,Nakamoto L,Wainwright JF

    更新日期:1997-05-01 00:00:00

  • Assessing the genotoxic potential of chlorothalonil drift from potato fields in Prince Edward Island, Canada.

    abstract::Chlorothalonil, a broad-spectrum nonsystemic foliar fungicide, is one of the most extensively used pesticide active ingredients on Prince Edward Island, Canada, for blight control on potatoes. In ambient air-sampling programs conducted in 1998 and 1999 and from 2002 to 2004, chlorothalonil was measured in 97% of air s...

    journal_title:Archives of environmental contamination and toxicology

    pub_type: 杂志文章

    doi:10.1007/s00244-011-9699-2

    authors: Garron C,Knopper LD,Ernst WR,Mineau P

    更新日期:2012-02-01 00:00:00

  • Neurodevelopment outcomes in children exposed to organic mercury from multiple sources in a tin-ore mine environment in Brazil.

    abstract::Methylmercury (from fresh-water fish) and ethylmercury [from thimerosal-containing vaccines (TCVs)] are the most prevalent source of neurotoxic exposure during early life in families consuming fish and using these vaccines. But children living in Amazonian mining environments are exposed to additional toxic metals in ...

    journal_title:Archives of environmental contamination and toxicology

    pub_type: 杂志文章

    doi:10.1007/s00244-014-0103-x

    authors: Marques RC,Bernardi JV,Abreu L,Dórea JG

    更新日期:2015-04-01 00:00:00

  • Sublethal lead affects pituitary function of rainbow trout during exogenous vitellogenesis.

    abstract::Sexually maturing female rainbow trout, Oncorhynchus mykiss, were exposed to 10 microg/L of waterborne lead Pb(NO(3))(2) for 12 days during endogenous vitellogenesis and 12 days during exogenous vitellogenesis. Lead had no significant effect on either gonadosomatic indices or mean maximum diameters of developing oocyt...

    journal_title:Archives of environmental contamination and toxicology

    pub_type: 杂志文章

    doi:10.1007/s002449910006

    authors: Ruby SM,Hull R,Anderson P

    更新日期:2000-01-01 00:00:00

  • Determination of polycyclic aromatic hydrocarbons (PAH) and their metabolites in blood, feces, and urine of rats orally exposed to PAH contaminated soils.

    abstract::Polycyclic aromatic hydrocarbons (PAH) have become an ubiquitous upper soil component as a consequence of industrialization involving a multitude of combustion processes. Ingestion of PAH contaminated soil is considered to be a major exposure route, specifically for small children living on these soils. Health risk as...

    journal_title:Archives of environmental contamination and toxicology

    pub_type: 杂志文章

    doi:10.1007/s002449900259

    authors: van Schooten FJ,Moonen EJ,van der Wal L,Levels P,Kleinjans JC

    更新日期:1997-10-01 00:00:00

  • Bioaccumulation and subchronic physiological effects of waterborne iron overload on whitefish exposed in humic and nonhumic water.

    abstract::One-year-old whitefish, Coregonus lavaretus, were exposed to three types of iron-rich water, two dilutions for each, in a subchronic (30-day) experiment. In natural iron-rich humic water, both the bioaccumulation and physiological effects of iron exposure were negligible. In humic-free water with high amount of additi...

    journal_title:Archives of environmental contamination and toxicology

    pub_type: 杂志文章

    doi:10.1007/s002449900506

    authors: Lappivaara J,Kiviniemi A,Oikari A

    更新日期:1999-08-01 00:00:00

  • Postimpoundment time course of increased mercury concentrations in fish in hydroelectric reservoirs of northern Manitoba, Canada.

    abstract::Mercury (Hg) concentrations in fish in boreal reservoirs have been shown to be increased for up to 3 decades after impoundment. However, the time course of increased concentrations is not well known. The purpose of this study was to determine the evolution of Hg concentrations in fish in the boreal reservoirs of north...

    journal_title:Archives of environmental contamination and toxicology

    pub_type: 杂志文章

    doi:10.1007/s00244-006-0113-4

    authors: Bodaly RA,Jansen WA,Majewski AR,Fudge RJ,Strange NE,Derksen AJ,Green DJ

    更新日期:2007-10-01 00:00:00

  • Toxicity of Guthion and Guthion 2S to Xenopus laevis embryos.

    abstract::The development of Xenopus laevis (African clawed frog) embryos exposed to the pesticide Guthion (technical grade) and Guthion 2S (commercial formulation) was evaluated in modified Frog Embryo Teratogenesis Assay--Xenopus (FETAX) tests. The embryos were exposed to five or six increasing concentrations of pesticide in ...

    journal_title:Archives of environmental contamination and toxicology

    pub_type: 杂志文章

    doi:10.1007/BF00214270

    authors: Schuytema GS,Nebeker AV,Griffis WL

    更新日期:1994-08-01 00:00:00

  • Organochlorines in stranded pilot whales (Globicephala melaena) from the coast of Massachusetts.

    abstract::Pilot whales strand periodically along the U.S. coast, and these strandings offer an opportunity for the collection of tissues for biomonitoring of contaminant exposure in cetaceans, as well as for specimen archiving. Concentrations of organochlorine (OC) contaminants (e.g., PCB congeners, pesticides, DDTs) were measu...

    journal_title:Archives of environmental contamination and toxicology

    pub_type: 杂志文章

    doi:10.1007/s002449900497

    authors: Tilbury KL,Adams NG,Krone CA,Meador JP,Early G,Varanasi U

    更新日期:1999-07-01 00:00:00

  • Effects of xenoestrogenic environmental pollutants on the proliferation of a human breast cancer cell line (MCF-7).

    abstract::A human breast cancer cell line (MCF-7) was used to develop an in vitro screening assay for the detection of xenoestrogenic environmental pollutants. MCF-7 cells were cultured in DMEM containing 5% fetal bovine serum (FBS). An estrogenic response was defined as an increase in the frequency of proliferating MCF-7 cells...

    journal_title:Archives of environmental contamination and toxicology

    pub_type: 杂志文章

    doi:10.1007/s002449900322

    authors: Blom A,Ekman E,Johannisson A,Norrgren L,Pesonen M

    更新日期:1998-04-01 00:00:00

  • Comparative evaluation on the biological monitoring of exposure to parathion and its methyl analog.

    abstract::The effects of both parathion and methyl parathion on the inhibition of plasma cholinesterase were elaborated in a rat model employing a modified isocratic reverse-phase HPLC method coupled with UV detection for the determination of the urinary metabolite p-nitrophenol (U-4NP). A linearity of r2 > 0.995 was found for ...

    journal_title:Archives of environmental contamination and toxicology

    pub_type: 杂志文章

    doi:10.1007/s002449900207

    authors: Chang MJ,Chen YC,Yang HJ

    更新日期:1997-05-01 00:00:00

  • Evaluating Hair as a Predictor of Blood Mercury: The Influence of Ontogenetic Phase and Life History in Pinnipeds.

    abstract::Mercury (Hg) biomonitoring of pinnipeds increasingly utilizes nonlethally collected tissues such as hair and blood. The relationship between total Hg concentrations ([THg]) in these tissues is not well understood for marine mammals, but it can be important for interpretation of tissue concentrations with respect to ec...

    journal_title:Archives of environmental contamination and toxicology

    pub_type: 杂志文章

    doi:10.1007/s00244-015-0174-3

    authors: Peterson SH,McHuron EA,Kennedy SN,Ackerman JT,Rea LD,Castellini JM,O'Hara TM,Costa DP

    更新日期:2016-01-01 00:00:00

  • Acute and chronic effects of perfluorobutane sulfonate (PFBS) on the mallard and northern bobwhite quail.

    abstract::Perfluorobutane sulfonate (PFBS) can be a final degradation product of perfluorobutane sulfonyl fluoride (PBSF)-based chemicals. Surfactants based on this chemistry are potential replacements for perfluorooctane sulfonate (PFOS)-related products and have many potential applications in industrial and commercial process...

    journal_title:Archives of environmental contamination and toxicology

    pub_type: 杂志文章

    doi:10.1007/s00244-007-9039-8

    authors: Newsted JL,Beach SA,Gallagher SP,Giesy JP

    更新日期:2008-04-01 00:00:00

  • The effects of water quality and age on the acute toxicity of copper to the Florida apple snail, Pomacea paludosa.

    abstract::Copper (Cu)-containing compounds have been used in Florida as fungicides, herbicides, and soil amendments, resulting in elevated Cu in the aquatic ecosystem. The Florida apple snail (Pomacea paludosa), a key species in south Florida, may be adversely affected by Cu. Water-quality parameters, such as hardness, dissolve...

    journal_title:Archives of environmental contamination and toxicology

    pub_type: 杂志文章

    doi:10.1007/s00244-007-9106-1

    authors: Rogevich EC,Hoang TC,Rand GM

    更新日期:2008-05-01 00:00:00

  • Organochlorine pollutants and stable isotopes in resident and migrant passerine birds from northwest Michoacán, Mexico.

    abstract::Although concentrations of organochlorine compounds (OCs) in birds from most of the United States and Canada have decreased over the last 30 years, there is still concern that migrant birds might be exposed to elevated concentrations of OCs during migration in Latin America. The Lerma-Chapala Basin in west-central Mex...

    journal_title:Archives of environmental contamination and toxicology

    pub_type: 杂志文章

    doi:10.1007/s00244-007-9124-z

    authors: Mora MA

    更新日期:2008-10-01 00:00:00

  • The Extent of the Impact of a Fluorochemical Industrial Park in Eastern China on Adjacent Rural Areas.

    abstract::High levels of perfluoroalkyl substances (PFASs) were observed in rural areas near a fluorochemical industrial park (FCIP) in the Yangtze River Delta region. The concentrations of total PFAS (∑PFASs) in soil, surface water, groundwater, and rainwater were in the range of 0.6-64.6 ng/g dry weight, 15.6-480.9, 4.8-614.6...

    journal_title:Archives of environmental contamination and toxicology

    pub_type: 杂志文章

    doi:10.1007/s00244-017-0458-x

    authors: Lu GH,Jiao XC,Piao HT,Wang XC,Chen S,Tan KY,Gai N,Yin XC,Yang YL,Pan J

    更新日期:2018-04-01 00:00:00

  • Effects of polyhalogenated aromatic hydrocarbons and related contaminants on common tern reproduction: integration of biological, biochemical, and chemical data.

    abstract::In eight Dutch or Belgian common tern (Sterna hirundo) colonies, breeding biology and food choice were determined, and 15 second eggs were collected from three-egg clutches for artificial incubation, biochemical analysis and analysis of yolk-sac polyhalogenated hydrocarbon (PHAH) levels. Results from these analyses we...

    journal_title:Archives of environmental contamination and toxicology

    pub_type: 杂志文章

    doi:10.1007/BF00203917

    authors: Murk AJ,Boudewijn TJ,Menninger PL,Bosveld AT,Rossaert G,Ysebaert T,Meire P,Dirksen S

    更新日期:1996-07-01 00:00:00

  • Typical Endocrine Disrupting Compounds in Rivers of Northeast China: Occurrence, Partitioning, and Risk Assessment.

    abstract::Liao River Basin (LRB), located in northeast China, is one of seven largest river basins in China. The Daliao River Watershed (DLRW) is severely disturbed by human activities in the LRB. In this study, three rivers within the DLRW-Xi River (XR), Hun River (HR), and Daliao River (DLR)-were selected as sampling location...

    journal_title:Archives of environmental contamination and toxicology

    pub_type: 杂志文章

    doi:10.1007/s00244-017-0482-x

    authors: Tan R,Liu R,Li B,Liu X,Li Z

    更新日期:2018-08-01 00:00:00

  • Effects of lead-contaminated sediment on Rana sphenocephala tadpoles.

    abstract::We exposed larval southern leopard frogs (Rana sphenocephala) to lead-contaminated sediments to determine the lethal and sublethal effects of this metal. Tadpoles were laboratory-raised from early free-swimming stage through metamorphosis at lead concentrations of 45, 75, 180, 540, 2360, 3940, 5520, and 7580 mg/kg dry...

    journal_title:Archives of environmental contamination and toxicology

    pub_type: 杂志文章

    doi:10.1007/s00244-005-0243-0

    authors: Sparling DW,Krest S,Ortiz-Santaliestra M

    更新日期:2006-10-01 00:00:00

  • Comparison of persistent organic pollutant residues in serum and adipose tissue in a female population in Belgium, 1996-1998.

    abstract::This study was performed to determine and compare persistent organic pollutant (POP) levels in different matrices in a female population. A total of 96 serum and 46 adipose tissue samples were collected from infertile women (n = 101) attending Centers for Reproductive Medicine in Belgium from 1996 to 1998. Gas chromat...

    journal_title:Archives of environmental contamination and toxicology

    pub_type: 杂志文章

    doi:10.1007/s002440010104

    authors: Pauwels A,Covaci A,Weyler J,Delbeke L,Dhont M,De Sutter P,D'Hooghe T,Schepens PJ

    更新日期:2000-08-01 00:00:00

  • Distribution of selected PCB congeners in the Babcock Street sewer district: a multimedia approach to identify PCB sources in combined sewer overflows (CSOs) discharging to the Buffalo River, New York.

    abstract::To evaluate sources of PCBs in combined sewer overflows (CSOs) to the Buffalo River, New York, combined sewage, sanitary flow, atmospheric wet and dry depositions, and street dust samples were collected from the Babcock Street sewer district and analyzed. Total PCB concentrations (sum of the PCB congeners quantitated)...

    journal_title:Archives of environmental contamination and toxicology

    pub_type: 杂志文章

    doi:10.1007/s002449900234

    authors: Loganathan BG,Irvine KN,Kannan K,Pragatheeswaran V,Sajwan KS

    更新日期:1997-08-01 00:00:00