Abstract：
:This work focuses on the synthesis and characterization of a novel bioresorbable glass ceramic phosphate-based material (GC-ICEL). More specifically, its solubility in different aqueous media (water, Tris-HCl and acellular simulated body fluid) and the response of human stromal cells cultured on it were investigated. X-ray diffraction analysis showed the presence of two crystalline phases identified as Na(2)Mg(PO(4))(3) and Ca(2)P(2)O(7) and dissolution tests highlighted a preferential dissolution of the Na(2)Mg(PO(4))(3) phase and of the residual amorphous phase in all the chosen media. Soaking tests in simulated body fluid showed precipitation of a hydroxyapatite layer, demonstrating the bioactivity of GC-ICEL, which is partially due to the reported bioactivity of Ca(2)P(2)O(7). The effect of GC-ICEL on adhesion, proliferation and osteoblastic gene expression of human bone marrow-derived stromal cells was also studied. Combining molecular and biochemical analyses, it was found that bone marrow cell differentiation was stimulated over proliferation on GC-ICEL. Moreover, the expression of bone-related genes in cells cultured on GC-ICEL confirmed the bioactivity of this phosphate-based glass ceramic, which might have a stimulatory effect on osteogenesis.
journal_name
Acta Biomaterjournal_title
Acta biomaterialiaauthors
Leonardi E,Ciapetti G,Baldini N,Novajra G,Verné E,Baino F,Vitale-Brovarone Cdoi
10.1016/j.actbio.2009.07.017subject
Has Abstractpub_date
2010-02-01 00:00:00pages
598-606issue
2eissn
1742-7061issn
1878-7568pii
S1742-7061(09)00304-3journal_volume
6pub_type
杂志文章abstract：:Surgical suture is a strand of biocompatible material designed for wound closure, and therefore can be a medical device potentially suitable for local drug delivery to treat pain at the surgical site. However, the preparation methods previously introduced for drug-delivery sutures adversely influenced the mechanical s...
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journal_title：Acta biomaterialia
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doi：10.1016/j.actbio.2009.02.026
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journal_title：Acta biomaterialia
pub_type： 杂志文章
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pub_type： 杂志文章
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pub_type： 杂志文章
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journal_title：Acta biomaterialia
pub_type： 杂志文章
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journal_title：Acta biomaterialia
pub_type： 杂志文章
doi：10.1016/j.actbio.2014.02.041
更新日期：2014-06-01 00:00:00
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journal_title：Acta biomaterialia
pub_type： 杂志文章
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更新日期：2016-10-01 00:00:00
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journal_title：Acta biomaterialia
pub_type： 杂志文章
doi：10.1016/j.actbio.2008.08.001
更新日期：2009-01-01 00:00:00
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journal_title：Acta biomaterialia
pub_type： 杂志文章
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更新日期：2008-01-01 00:00:00
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pub_type： 杂志文章
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journal_title：Acta biomaterialia
pub_type： 杂志文章
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更新日期：2012-11-01 00:00:00
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pub_type： 杂志文章
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更新日期：2011-05-01 00:00:00
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journal_title：Acta biomaterialia
pub_type： 杂志文章
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更新日期：2011-07-01 00:00:00
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journal_title：Acta biomaterialia
pub_type： 杂志文章
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更新日期：2012-12-01 00:00:00
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journal_title：Acta biomaterialia
pub_type： 杂志文章
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更新日期：2016-06-01 00:00:00
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journal_title：Acta biomaterialia
pub_type： 杂志文章
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更新日期：2016-12-01 00:00:00
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pub_type： 杂志文章
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更新日期：2016-11-01 00:00:00
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pub_type： 杂志文章
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更新日期：2012-02-01 00:00:00
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pub_type： 杂志文章
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更新日期：2019-12-01 00:00:00
