Exposed hydroxyapatite particles on the surface of photo-crosslinked nanocomposites for promoting MC3T3 cell proliferation and differentiation.

abstract：:Copper-containing bioactive glass nanoparticles (Cu-BG NPs) with designed compositions and sizes were synthesized and incorporated into chitosan (CH)/silk fibroin (SF)/glycerophosphate (GP) composites to prepare injectable hydrogels for cell-free bone repair. The resulting Cu-BG/CH/SF/GP gels were found to exhibit wel...

journal_title：Acta biomaterialia

authors： Wu J,Zheng K,Huang X,Liu J,Liu H,Boccaccini AR,Wan Y,Guo X,Shao Z

更新日期：2019-06-01 00:00:00

abstract：:Bone morphogenetic protein-2 (BMP-2) involved therapy is of great potential for bone regeneration. However, its clinical application is restricted due to the undesirable bioactivity and relevant complications in vivo. Immobilization of recombinant BMP-2 (rhBMP-2) is an efficient strategy to mimic natural microenvironm...

journal_title：Acta biomaterialia

authors： Chen R,Yu Y,Zhang W,Pan Y,Wang J,Xiao Y,Liu C

更新日期：2018-10-15 00:00:00

abstract：UNLABELLED:Myofibroblasts are critical for connective tissue remodeling and wound healing since they can close wound beds and shape tissues rapidly by generating high traction forces and secreting abundant extracellular matrix proteins and matrix metalloproteinases. However, their presence in excessive numbers is assoc...

journal_title：Acta biomaterialia

authors： Kural MH,Billiar KL

更新日期：2016-03-01 00:00:00

abstract：:Cartilage lacks basic repair mechanisms and thus surgical interventions are necessary to treat lesions. Minimally-invasive arthroscopic procedures require the development of injectable biomaterials to support chondrogenesis of implanted cells. However, most cartilage tissue engineering approaches rely on pre-culture o...

journal_title：Acta biomaterialia

authors： Levinson C,Lee M,Applegate LA,Zenobi-Wong M

更新日期：2019-11-01 00:00:00

abstract：:This study assessed the role of immobilized cell adhesion moieties on controlling the cellular attachment, adhesion and phenotype of cardiac muscle cells towards developing scaffolds for cardiac muscle tissue engineering. Collagen I, laminin and the cell-adhesive oligopeptide, arginine-glycine-aspartic acid (RGD) at c...

journal_title：Acta biomaterialia

authors： LaNasa SM,Bryant SJ

更新日期：2009-10-01 00:00:00

abstract：:Nanofibre-based structures and their composites are increasingly being studied for many biomedical applications, including tissue engineering scaffolds. These materials enable architectures resembling the extracellular matrix to be obtained. The search for optimized supports and carriers of cells is still a major chal...

journal_title：Acta biomaterialia

authors： Pinho ED,Martins A,Araújo JV,Reis RL,Neves NM

更新日期：2009-05-01 00:00:00

abstract：:Flax seeds produce mucilage after wetting. The mucilage due to its ability to absorb and maintain water is responsible for specific surface properties which are essential for seed dispersal in different ways. In the present paper, we asked how the hydration level affects the adhesive and frictional properties of the m...

journal_title：Acta biomaterialia

authors： Kreitschitz A,Kovalev A,Gorb SN

更新日期：2015-04-01 00:00:00

abstract：:Cardiac fibrosis, an important pathological feature of structural remodeling, contributes to ventricular stiffness, diastolic dysfunction, arrhythmia and may even lead to sudden death. Matrix stiffness, one of the many mechanical factors acting on cells, is increasingly appreciated as an important mediator of myocardi...

journal_title：Acta biomaterialia

authors： Xie J,Zhang Q,Zhu T,Zhang Y,Liu B,Xu J,Zhao H

更新日期：2014-06-01 00:00:00

abstract：:This study investigated whether a novel alkali-based surface modification enhances in vitro mineralization as well as in vivo bone formation around titanium (Ti) implants in a femoral condyle model of 36 male Wister rats. All implant surfaces were grit-blasted and then received either acid-etching treatment, alkali-ba...

journal_title：Acta biomaterialia

authors： Camargo WA,Takemoto S,Hoekstra JW,Leeuwenburgh SCG,Jansen JA,van den Beucken JJJP,Alghamdi HS

更新日期：2017-07-15 00:00:00

abstract：:Intervertebral disc (IVD) disorders and age-related degeneration are believed to contribute to lower back pain. There is significant interest in cell-based strategies for regenerating the nucleus pulposus (NP) region of the disc; however, few scaffolds have been evaluated for their ability to promote or maintain an im...

journal_title：Acta biomaterialia

authors： Francisco AT,Hwang PY,Jeong CG,Jing L,Chen J,Setton LA

更新日期：2014-03-01 00:00:00

abstract：:Mesenchymal stromal cell (MSC)-derived extracellular vesicles (EVs) (MSC-EVs) exhibit protective effects in damaged or diseased tissues. However, the role of EVs secreted by MSC in hypoxia-ischemic (HI) injury in neonatal mice remains unknown. Systemic administration of MSC-EVs attenuated acute brain damage and neuroi...

journal_title：Acta biomaterialia

authors： Xin D,Li T,Chu X,Ke H,Yu Z,Cao L,Bai X,Liu D,Wang Z

更新日期：2020-09-01 00:00:00

abstract：:To overcome clinical issues caused by large bone defects and subsequent nonunion, various approaches to bone regeneration have been researched, including tissue engineering, biomaterials, stem cells and drug screening. Previously, we developed a free-standing biodegradable polymer nanosheet composed of poly(L-lactic a...

journal_title：Acta biomaterialia

authors： Murahashi Y,Yano F,Nakamoto H,Maenohara Y,Iba K,Yamashita T,Tanaka S,Ishihara K,Okamura Y,Moro T,Saito T

更新日期：2019-02-01 00:00:00

abstract：:Lysosomal entrapment and liver accumulation are the two main obstacles faced by many anticancer drugs for achieving satisfactory therapeutic outcomes. Here, we develop a facile one-step hydrothermal synthetic route to prepare trace metal (M)-, N-, and O-doped carbon-dominated nanoparticles (termed as MNOCNPs, M = Ni, ...

journal_title：Acta biomaterialia

authors： Bao YW,Hua XW,Li YH,Jia HR,Wu FG

更新日期：2019-04-01 00:00:00

abstract：UNLABELLED:Quercetin (3,3',4',5,7-pentahydroxy-flavone) is a flavonoid known for its pharmacological activities, which include antioxidant and anti-inflammatory properties, as well as possible beneficial action on diseases involving bone loss. In this work, we explored the possibility to functionalize hydroxyapatite (H...

journal_title：Acta biomaterialia

authors： Forte L,Torricelli P,Boanini E,Gazzano M,Rubini K,Fini M,Bigi A

更新日期：2016-03-01 00:00:00

abstract：:The aim of the present study was to evaluate the biological properties of a collagen-phospholipid polymer hybrid gel (MiC30 gel) designed for use as a tissue membrane. The following four types of collagen gels were synthesized and tested in vitro and in vivo: physically cross-linked collagen gel (Uc gel), N-(3-dimethy...

journal_title：Acta biomaterialia

authors： Nam K,Kimura T,Funamoto S,Kishida A

更新日期：2010-02-01 00:00:00

abstract：:Tissue-derived extracellular matrix (ECM) biomaterials to regenerate the meniscus have gained increasing attention in treating meniscus injuries and diseases, particularly for aged persons and athletes. However, ECM scaffold has poor cell infiltration and can only be implanted using surgical procedures. To overcome th...

journal_title：Acta biomaterialia

authors： Wu J,Ding Q,Dutta A,Wang Y,Huang YH,Weng H,Tang L,Hong Y

更新日期：2015-04-01 00:00:00

abstract：:The active and passive mechanical behavior of a cosmetic tightening product for skin anti-aging is investigated based on a wide range of in vivo and in vitro measurements. The experimental data are used to inform a numerical model of the attained cosmetic effect, which is then implemented in a commercial finite-elemen...

journal_title：Acta biomaterialia

authors： Pensalfini M,Rotach M,Hopf R,Bielicki A,Santoprete R,Mazza E

更新日期：2020-10-01 00:00:00

abstract：:Engineered tissues are highly limited by poor vascularization in vivo, leading to hypoxia. In order to overcome this challenge, we propose the use of photosynthetic biomaterials to provide oxygen. Since photosynthesis is the original source of oxygen for living organisms, we suggest that this could be a novel approach...

journal_title：Acta biomaterialia

authors： Schenck TL,Hopfner U,Chávez MN,Machens HG,Somlai-Schweiger I,Giunta RE,Bohne AV,Nickelsen J,Allende ML,Egaña JT

更新日期：2015-03-01 00:00:00

abstract：:Since most antibacterial coatings reported to fight biomaterial-associated infections (BAI) fail in completely preventing bacterial colonization, it is crucial to know the impact of that small fraction of adhered bacteria in BAI recrudescence. This study aims to understand the fate of Staphylococcus aureus able to adh...

journal_title：Acta biomaterialia

authors： Alves DF,Magalhães AP,Neubauer D,Bauer M,Kamysz W,Pereira MO

更新日期：2018-09-15 00:00:00

abstract：:Globally, chronic wounds impose a notable burden to patients and healthcare systems. Such skin wounds are readily subjected to bacteria that provoke inflammation and hence challenge the healing process. Furthermore, bacteria induce infection impeding re-epithelialization and collagen synthesis. With an estimated globa...

journal_title：Acta biomaterialia

authors： Homaeigohar S,Boccaccini AR

更新日期：2020-04-15 00:00:00

abstract：:Bone-like materials comprise carbonated-hydroxyapatite nanocrystals (c-Ap) embedding a fibrillar collagen matrix. The mineral particles stiffen the nanocomposite by tight attachment to the protein fibrils creating a high strength and toughness material. The nanometer dimensions of c-Ap crystals make it very challengin...

journal_title：Acta biomaterialia

authors： Forien JB,Uzuhashi J,Ohkubo T,Hono K,Luo L,Schwarcz HP,Deymier AC,Krywka C,Fleck C,Zaslansky P

更新日期：2021-01-15 00:00:00

abstract：:Modification of a biomedical-grade stainless steel 316LS surface by electrochemical cyclic potentiodynamic passivation (CPP) and the response of fibrinogen (Fg), platelets, endothelial cells (ECs) and smooth muscles cells (SMCs) to this surface was investigated. Polarization modulation infrared reflection absorption s...

journal_title：Acta biomaterialia

authors： Shahryari A,Azari F,Vali H,Omanovic S

更新日期：2010-02-01 00:00:00

abstract：:In this study, the Cu-doping mechanism of Biphasic Calcium Phosphate (BCP) was thoroughly investigated, as was its ionic release behavior, in order to elucidate cytotoxicity features of these bioceramics. BCP are composed of hydroxyapatite (Ca10(PO4)6(OH)2) and β-TCP (Ca3(PO4)2). The two phases present two different d...

journal_title：Acta biomaterialia

authors： Gomes S,Vichery C,Descamps S,Martinez H,Kaur A,Jacobs A,Nedelec JM,Renaudin G

更新日期：2018-01-01 00:00:00

abstract：UNLABELLED:Recently, photodynamic therapy (PDT) is one of the new clinical options by generating cytotoxic reactive oxygen species (ROS) to kill cancer cells. However, the optical approach of PDT is limited by tissue penetration depth of visible light. In this study, we propose that a ROS-enhanced nanoparticle, hafnium...

journal_title：Acta biomaterialia

authors： Chen MH,Hanagata N,Ikoma T,Huang JY,Li KY,Lin CP,Lin FH

更新日期：2016-06-01 00:00:00

abstract：:Despite the rapid progress which has been made in hepatocellular carcinoma (HCC) chemotherapeutics, recurrence of liver cancer still remains a barrier to achieve satisfying prognosis. Herein, we aimed to decipher the role of berberine (BER) in chemotherapy-exacerbated HCC repopulation via developing a nanocarrier co-d...

journal_title：Acta biomaterialia

authors： Zhang F,Jia Y,Zheng X,Shao D,Zhao Y,Wang Z,Dawulieti J,Liu W,Sun M,Sun W,Pan Y,Cui L,Wang Y,He K,Zhang M,Li J,Dong WF,Chen L

更新日期：2019-12-01 00:00:00

abstract：:Since its discovery, numerous biotechnological approaches have aimed to explore the silica-polymerizing catalytic activity of the enzyme silicatein. In vivo, silicatein catalyzes polymerization of amorphous silica nanospheres from soluble precursors. In vitro, it directs the formation of nanostructured biosilica. This...

journal_title：Acta biomaterialia

authors： Natalio F,Link T,Müller WE,Schröder HC,Cui FZ,Wang X,Wiens M

更新日期：2010-09-01 00:00:00

abstract：:Viscoelasticity is a fundamental property of virtually all biological materials, and proteinaceous, fibrous materials that constitute the extracellular matrix (ECM) are no exception. Viscoelasticity may be particularly important in the ECM since cells can apply mechanical stress resulting from cell contractility over ...

journal_title：Acta biomaterialia

authors： Bradshaw MJ,Hoffmann GA,Wong JY,Smith ML

更新日期：2019-04-01 00:00:00

abstract：UNLABELLED:Novel photo-reactive phospholipid polymers were synthesized for use in the preparation of nonfouling surfaces with protein conjugation capacity. Poly[2-methacryloyloxyethyl phosphorylcholine (MPC)-ran-N-methacryloyl-(l)-tyrosinemethylester (MAT)] (P(MPC/MAT)) was synthesized by conventional radical polymeriz...

journal_title：Acta biomaterialia

authors： Tanaka M,Iwasaki Y

更新日期：2016-08-01 00:00:00

abstract：UNLABELLED:Despite advances in polymeric nanoparticles (NPs) as effective delivery systems for anticancer drugs, rapid clearance from blood and poor penetration capacity in heterogeneous tumors still remain to be addressed. Here, a dual coating of poly (ethylene glycol)-poly (d,l-lactic acid) (PEG-PDLLA) and water-solu...

journal_title：Acta biomaterialia

authors： Wang G,Chen Y,Wang P,Wang Y,Hong H,Li Y,Qian J,Yuan Y,Yu B,Liu C

更新日期：2016-01-01 00:00:00

abstract：:CRISPR gene editing technology is strategically foreseen to control diseases by correcting underlying aberrant genetic sequences. In order to overcome drawbacks associated with viral vectors, the establishment of an effective non-viral CRISPR delivery vehicle has become an important goal for nanomaterial scientists. H...

journal_title：Acta biomaterialia

authors： Noureddine A,Maestas-Olguin A,Saada EA,LaBauve AE,Agola JO,Baty KE,Howard T,Sabo JK,Espinoza CRS,Doudna JA,Schoeniger JS,Butler KS,Negrete OA,Brinker CJ,Serda RE

更新日期：2020-09-15 00:00:00