当前位置： SCI文献检索 > Acta Biomaterialia期刊下所有文献 > A modular design strategy to integrate mechanotransduction concepts in scaffold-based bone tissue engineering.

A modular design strategy to integrate mechanotransduction concepts in scaffold-based bone tissue engineering.

Abstract：

:Repair or regeneration of load-bearing bones has long been an incentive for the tissue engineering community to develop a plethora of synthetic bone scaffolds. Despite the key role of physical forces and the mechanical environment in bone regeneration, the mechanotransduction concept has rarely been incorporated in structural design of bone tissue scaffolds, particularly those made of bioactive materials such as hydrogels and bioceramics. Herein, we introduce a modular design strategy to fabricate a load bearing device that can support a wide range of hydrogel- and ceramic-based scaffolds against complex in-vivo loading conditions to induce desirable mechanical strains for bone regeneration within the scaffolds. The device is comprised of a fenestrated polymeric shell and ceramic structural pillars arranged in a sophisticated configuration to provide ample internal space for the scaffold, also enabling it to purposely regulate the levels of strains and stresses within the scaffolds. Utilizing this top-down design approach, we demonstrate that the failure load of alginate hydrogels increases 3200-fold in compression, 300-fold in shear and 75-fold in impact, achieving the values that enable them to withstand physiological loads in weight-bearing sites, while allowing generation of osteoinductive strains (i.e., 0.2-0.4%) in the hydrogel. This modular design approach opens a broad range of opportunities to utilize various bioactive but mechanically weak scaffolds for the treatment of load-bearing defects and exploiting mechanobiology strategies to improve bone regeneration.

journal_name

Acta Biomater

journal_title

Acta biomaterialia

authors

Entezari A,Swain MV,Gooding JJ,Roohani I,Li Q

doi

10.1016/j.actbio.2020.10.012

subject

Has Abstract

pub_date

2020-12-01 00:00:00

pages

100-112

eissn

1742-7061

issn

1878-7568

pii

S1742-7061(20)30601-2

journal_volume

118

pub_type

杂志文章

相关文献

Acta Biomaterialia文献大全
  • A semi-synthetic whole parasite vaccine designed to protect against blood stage malaria.

    abstract：UNLABELLED:Although attenuated malaria parasitized red blood cells (pRBCs) are promising vaccine candidates, their application in humans may be restricted for ethical and regulatory reasons. Therefore, we developed an organic microparticle-based delivery platform as a whole parasite malaria-antigen carrier to mimic pRB...

    journal_title：Acta biomaterialia

    pub_type： 杂志文章

    doi：10.1016/j.actbio.2016.08.020

    authors： Giddam AK,Reiman JM,Zaman M,Skwarczynski M,Toth I,Good MF

    更新日期：2016-10-15 00:00:00

  • Melt-spun shaped fibers with enhanced surface effects: fiber fabrication, characterization and application to woven scaffolds.

    abstract：:Scaffolds with a high surface-area-to-volume ratio (SA:V) are advantageous with regard to the attachment and proliferation of cells in the field of tissue engineering. This paper reports on the development of novel melt-spun fibers with a high SA:V, which enhanced the surface effects of a fiber-based scaffold while ma...

    journal_title：Acta biomaterialia

    pub_type： 杂志文章

    doi：10.1016/j.actbio.2013.05.001

    authors： Park SJ,Lee BK,Na MH,Kim DS

    更新日期：2013-08-01 00:00:00

  • Improving chitosan-mediated gene transfer by the introduction of intracellular buffering moieties into the chitosan backbone.

    abstract：:Chitosan was functionalized with imidazole moieties (CHimi) with the aim of improving its buffering capacity and promoting the endosomal escape ability of chitosan-DNA complexes, ultimately increasing their transfection efficiency. 5.6%, 12.9% and 22.1% of the glucosamine residues of chitosan were substituted. Complex...

    journal_title：Acta biomaterialia

    pub_type： 杂志文章

    doi：10.1016/j.actbio.2009.04.021

    authors： Moreira C,Oliveira H,Pires LR,Simões S,Barbosa MA,Pêgo AP

    更新日期：2009-10-01 00:00:00

  • Evaluation of composition and crosslinking effects on collagen-based composite constructs.

    abstract：:Vascular grafts are widely used for a number of medical treatments. Strength, compliance, endothelialization and availability are issues of most concern for vascular graft materials. With current approaches, these requirements are difficult to satisfy simultaneously. To explore an alternative approach, the present stu...

    journal_title：Acta biomaterialia

    pub_type： 杂志文章

    doi：10.1016/j.actbio.2009.09.028

    authors： Madhavan K,Belchenko D,Motta A,Tan W

    更新日期：2010-04-01 00:00:00

  • Multi-layered PLLA-nanosheets loaded with FGF-2 induce robust bone regeneration with controlled release in critical-sized mouse femoral defects.

    abstract：:To overcome clinical issues caused by large bone defects and subsequent nonunion, various approaches to bone regeneration have been researched, including tissue engineering, biomaterials, stem cells and drug screening. Previously, we developed a free-standing biodegradable polymer nanosheet composed of poly(L-lactic a...

    journal_title：Acta biomaterialia

    pub_type： 杂志文章

    doi：10.1016/j.actbio.2018.12.031

    authors： Murahashi Y,Yano F,Nakamoto H,Maenohara Y,Iba K,Yamashita T,Tanaka S,Ishihara K,Okamura Y,Moro T,Saito T

    更新日期：2019-02-01 00:00:00

  • Microelastic properties of lung cell-derived extracellular matrix.

    abstract：:The mechanical properties of the extracellular microenvironment regulate cell behavior, including migration, proliferation and morphogenesis. Although the elastic moduli of synthetic materials have been studied, little is known about the properties of naturally produced extracellular matrix. Here we have utilized atom...

    journal_title：Acta biomaterialia

    pub_type： 杂志文章

    doi：10.1016/j.actbio.2010.07.021

    authors： Soucy PA,Werbin J,Heinz W,Hoh JH,Romer LH

    更新日期：2011-01-01 00:00:00

  • Biphasic calcium phosphate ceramics for bone reconstruction: A review of biological response.

    abstract：:Autologous bone graft is considered as the gold standard in bone reconstructive surgery. However, the quantity of bone available is limited and the harvesting procedure requires a second surgical site resulting in severe complications. Due to these limits, scientists and clinicians have considered alternatives to auto...

    journal_title：Acta biomaterialia

    pub_type： 杂志文章,评审

    doi：10.1016/j.actbio.2017.01.076

    authors： Bouler JM,Pilet P,Gauthier O,Verron E

    更新日期：2017-04-15 00:00:00

  • The effect of albumin and cholesterol on the biotribological behavior of hydrogels for contact lenses.

    abstract：UNLABELLED:The irritation/discomfort associated with the use of contact lenses (CLs) is often related to the eyelid-lens friction. Although the use of such devices is widespread, the information about the influence of the lacrimal fluid biomolecules on the tribological behavior of the CLs hydrogels is scarce. In this w...

    journal_title：Acta biomaterialia

    pub_type： 杂志文章

    doi：10.1016/j.actbio.2015.08.011

    authors： Silva D,Fernandes AC,Nunes TG,Colaço R,Serro AP

    更新日期：2015-10-01 00:00:00

  • Molecular analysis of muscle progenitor cells on extracellular matrix coatings and hydrogels.

    abstract：:Development of an ex vivo culture system to expand satellite cells, the resident muscle stem cell population, will be necessary for the development of their use as therapeutics. The loss of the niche environment is often cited as the reason that culture results in both the loss of myogenic potential and low re-engraft...

    journal_title：Acta biomaterialia

    pub_type： 杂志文章

    doi：10.1016/j.actbio.2019.08.019

    authors： Palade J,Pal A,Rawls A,Stabenfeldt S,Wilson-Rawls J

    更新日期：2019-10-01 00:00:00

  • Prediction of permeability of regular scaffolds for skeletal tissue engineering: a combined computational and experimental study.

    abstract：:Scaffold permeability is a key parameter combining geometrical features such as pore shape, size and interconnectivity, porosity and specific surface area. It can influence the success of bone tissue engineering scaffolds, by affecting oxygen and nutrient transport, cell seeding efficiency, in vitro three-dimensional ...

    journal_title：Acta biomaterialia

    pub_type： 杂志文章

    doi：10.1016/j.actbio.2011.12.021

    authors： Truscello S,Kerckhofs G,Van Bael S,Pyka G,Schrooten J,Van Oosterwyck H

    更新日期：2012-04-01 00:00:00

  • A new approach in biomimetic synthesis of calcium phosphate coatings using lactic acid-Na lactate buffered body fluid solution.

    abstract：:The main objective of this study was to investigate calcium phosphate (CaP) coatings on Ti6Al4V substrates by using the biomimetic technique. To this purpose, a new solution was developed to coat CaP on Ti6Al4V alloy substrates. The newly formulated body fluid (Lac-SBF) contained appropriate amounts of sodium lactate ...

    journal_title：Acta biomaterialia

    pub_type： 杂志文章

    doi：10.1016/j.actbio.2009.12.013

    authors： Pasinli A,Yuksel M,Celik E,Sener S,Tas AC

    更新日期：2010-06-01 00:00:00

  • Preparation and characterization of a novel tobramycin-containing antibacterial collagen film for corneal tissue engineering.

    abstract：:Corneal disease is a major cause of blindness and keratoplasty is an effective treatment method. However, clinical treatment is limited due to a severe shortage of high-quality allogeneic corneal tissues and the bacterial infection after corneal transplantation. In this study, we develop a novel artificial and antibac...

    journal_title：Acta biomaterialia

    pub_type： 杂志文章

    doi：10.1016/j.actbio.2013.08.033

    authors： Liu Y,Ren L,Long K,Wang L,Wang Y

    更新日期：2014-01-01 00:00:00

  • Chemical surface alteration of biodegradable magnesium exposed to corrosion media.

    abstract：:The understanding of corrosion processes of metal implants in the human body is a key problem in modern biomaterial science. Because of the complicated and adjustable in vivo environment, in vitro experiments require the analysis of various physiological corrosion media to elucidate the underlying mechanism of "biolog...

    journal_title：Acta biomaterialia

    pub_type： 杂志文章

    doi：10.1016/j.actbio.2011.03.004

    authors： Willumeit R,Fischer J,Feyerabend F,Hort N,Bismayer U,Heidrich S,Mihailova B

    更新日期：2011-06-01 00:00:00

  • Evaluation of antibacterial and remineralizing nanocomposite and adhesive in rat tooth cavity model.

    abstract：:Antibacterial and remineralizing dental composites and adhesives were recently developed to inhibit biofilm acids and combat secondary caries. It is not clear what effect these materials will have on dental pulps in vivo. The objectives of this study were to investigate the antibacterial and remineralizing restoration...

    journal_title：Acta biomaterialia

    pub_type： 杂志文章

    doi：10.1016/j.actbio.2014.02.033

    authors： Li F,Wang P,Weir MD,Fouad AF,Xu HH

    更新日期：2014-06-01 00:00:00

  • Steroid-eluting contact lenses for corneal and intraocular inflammation.

    abstract：:Ocular inflammation is one of the leading causes of blindness worldwide, and steroids in topical ophthalmic solutions (e.g. dexamethasone eye drops) are the mainstay of therapy for ocular inflammation. For many non-infectious ocular inflammatory diseases, such as uveitis, eye drops are administered as often as once ev...

    journal_title：Acta biomaterialia

    pub_type： 杂志文章

    doi：10.1016/j.actbio.2020.08.013

    authors： Bengani LC,Kobashi H,Ross AE,Zhai H,Salvador-Culla B,Tulsan R,Kolovou PE,Mittal SK,Chauhan SK,Kohane DS,Ciolino JB

    更新日期：2020-10-15 00:00:00

  • Chitosan layered gold nanorods as synergistic therapeutics for photothermal ablation and gene silencing in triple-negative breast cancer.

    abstract：UNLABELLED:Small interfering RNAs (siRNAs) are extensively studied due to their promising potential as therapeutic agents for a wide variety of diseases, including cancer. However, efficient delivery of siRNAs to target cells and tissues is problematic due to a lack of suitable delivery vehicles. In this work, we devel...

    journal_title：Acta biomaterialia

    pub_type： 杂志文章

    doi：10.1016/j.actbio.2015.07.026

    authors： Yang Z,Liu T,Xie Y,Sun Z,Liu H,Lin J,Liu C,Mao ZW,Nie S

    更新日期：2015-10-01 00:00:00

  • Ultra-low friction between boundary layers of hyaluronan-phosphatidylcholine complexes.

    abstract：:The boundary layers coating articular cartilage in synovial joints constitute unique biomaterials, providing lubricity at levels unmatched by any human-made materials. The underlying molecular mechanism of this lubricity, essential to joint function, is not well understood. Here we study the interactions between surfa...

    journal_title：Acta biomaterialia

    pub_type： 杂志文章

    doi：10.1016/j.actbio.2017.06.043

    authors： Zhu L,Seror J,Day AJ,Kampf N,Klein J

    更新日期：2017-09-01 00:00:00

  • Cathodic voltage-controlled electrical stimulation of titanium for prevention of methicillin-resistant Staphylococcus aureus and Acinetobacter baumannii biofilm infections.

    abstract：:Antibiotic resistance of bacterial biofilms limits available treatment methods for implant-associated orthopaedic infections. This study evaluated the effects of applying cathodic voltage-controlled electrical stimulations (CVCES) of -1.5V and -1.8V (vs. Ag/AgCl) to coupons of commercially pure titanium (cpTi) incubat...

    journal_title：Acta biomaterialia

    pub_type： 杂志文章

    doi：10.1016/j.actbio.2016.11.056

    authors： Canty M,Luke-Marshall N,Campagnari A,Ehrensberger M

    更新日期：2017-01-15 00:00:00

  • Staphylococcus epidermidis originating from titanium implants infects surrounding tissue and immune cells.

    abstract：:Infection is a major cause of failure of inserted or implanted biomedical devices (biomaterials). During surgery, bacteria may adhere to the implant, initiating biofilm formation. Bacteria are also observed in and recultured from the tissue surrounding implants, and may even reside inside host cells. Whether these bac...

    journal_title：Acta biomaterialia

    pub_type： 杂志文章

    doi：10.1016/j.actbio.2014.08.012

    authors： Riool M,de Boer L,Jaspers V,van der Loos CM,van Wamel WJB,Wu G,Kwakman PHS,Zaat SAJ

    更新日期：2014-12-01 00:00:00

  • Microstructural quantification of collagen fiber orientations and its integration in constitutive modeling of the porcine carotid artery.

    abstract：BACKGROUND:Mechanical characteristics of vascular tissue may play a role in different arterial pathologies, which, amongst others, requires robust constitutive descriptions to capture the vessel wall's anisotropic and non-linear properties.Specifically, the complex 3D network of collagen and its interaction with other ...

    journal_title：Acta biomaterialia

    pub_type： 杂志文章

    doi：10.1016/j.actbio.2016.01.030

    authors： Sáez P,García A,Peña E,Gasser TC,Martínez MA

    更新日期：2016-03-01 00:00:00

  • Microporous scaffolds support assembly and differentiation of pancreatic progenitors into β-cell clusters.

    abstract：:Human pluripotent stem cells (hPSCs) represent a promising cell source for the development of β-cells for use in therapies for type 1 diabetes. Current culture approaches provide signals to mimic a temporal control of organogenesis to drive the differentiation towards β-cells. However, spatial control may represent an...

    journal_title：Acta biomaterialia

    pub_type： 杂志文章

    doi：10.1016/j.actbio.2019.06.032

    authors： Youngblood RL,Sampson JP,Lebioda KR,Shea LD

    更新日期：2019-09-15 00:00:00

  • Porous silicon as a potential electrode material in a nerve repair setting: Tissue reactions.

    abstract：:We compared porous silicon (pSi) with smooth Si as chip-implant surfaces in a nerve regeneration setting. Silicon chips can be used for recording neural activity and are potential nerve interface devices. A silicon chip with one smooth and one porous side inserted into a tube was used to bridge a 5 mm defect in rat sc...

    journal_title：Acta biomaterialia

    pub_type： 杂志文章

    doi：10.1016/j.actbio.2009.02.010

    authors： Johansson F,Wallman L,Danielsen N,Schouenborg J,Kanje M

    更新日期：2009-07-01 00:00:00

  • Triple co-culture of human alveolar epithelium, endothelium and macrophages for studying the interaction of nanocarriers with the air-blood barrier.

    abstract：:Predictive in vitro models are valuable alternatives to animal experiments for evaluating the transport of molecules and (nano)particles across biological barriers. In this work, an improved triple co-culture of air-blood barrier was set-up, being exclusively constituted by human cell lines that allowed to perform exp...

    journal_title：Acta biomaterialia

    pub_type： 杂志文章

    doi：10.1016/j.actbio.2019.04.037

    authors： Costa A,de Souza Carvalho-Wodarz C,Seabra V,Sarmento B,Lehr CM

    更新日期：2019-06-01 00:00:00

  • Electrospun thermosensitive hydrogel scaffold for enhanced chondrogenesis of human mesenchymal stem cells.

    abstract：:Hydrogels have shown great potential for cartilage tissue engineering applications due to their capability to encapsulate cells within biomimetic, 3-dimensional (3D) microenvironments. However, the multi-step fabrication process that is necessary to produce cell/scaffold constructs with defined dimensions, limits thei...

    journal_title：Acta biomaterialia

    pub_type： 杂志文章

    doi：10.1016/j.actbio.2017.11.020

    authors： Brunelle AR,Horner CB,Low K,Ico G,Nam J

    更新日期：2018-01-15 00:00:00

  • A tyrosine-rich amelogenin peptide promotes neovasculogenesis in vitro and ex vivo.

    abstract：:The formation of new blood vessels has been shown to be fundamental in the repair of many damaged tissues, and we have recently shown that the adult human periodontal ligament contains multipotent stem/progenitor cells that are capable of undergoing vasculogenic and angiogenic differentiation in vitro and ex vivo. Ena...

    journal_title：Acta biomaterialia

    pub_type： 杂志文章

    doi：10.1016/j.actbio.2013.11.027

    authors： Amin HD,Olsen I,Knowles J,Dard M,Donos N

    更新日期：2014-05-01 00:00:00

  • Influence of cyclic fatigue in water on the load-bearing capacity of dental bridges made of zirconia.

    abstract：:The humid atmosphere and permanent occurrence of chewing forces in the oral environment lead to degradation of ceramics used for prosthetic restorations. The aim of this in vitro study was to evaluate the influence of artificial aging on the load-bearing capacity of four-unit bridges, with both undamaged and predamage...

    journal_title：Acta biomaterialia

    pub_type： 杂志文章

    doi：10.1016/j.actbio.2008.04.012

    authors： Kohorst P,Dittmer MP,Borchers L,Stiesch-Scholz M

    更新日期：2008-09-01 00:00:00

  • Interaction force measurements for the design of tissue adhesives.

    abstract：:Synthesis of tissue adhesives had been carried out in various laboratories in the past decades but the development is currently stalled. One of the key reasons, it is believed, is that researchers have not fully understood and resolved the role of the functional groups that are responsible for good adhesion to biologi...

    journal_title：Acta biomaterialia

    pub_type： 杂志文章

    doi：10.1016/j.actbio.2008.08.001

    authors： Lim KP,Tan LP

    更新日期：2009-01-01 00:00:00

  • Cell-laden and orthogonal-multilayer tissue-engineered corneal stroma induced by a mechanical collagen microenvironment and transplantation in a rabbit model.

    abstract：:The development of functional therapies for corneal repair and regeneration is a pressing issue. Corneal stroma provides the principal functions of the cornea. However, because of the highly organized nature of the stromal matrix, the attempts to reproduce corneal stroma might follow a scar model. Here, we have develo...

    journal_title：Acta biomaterialia

    pub_type： 杂志文章

    doi：10.1016/j.actbio.2018.06.005

    authors： Cui Z,Zeng Q,Liu S,Zhang Y,Zhu D,Guo Y,Xie M,Mathew S,Cai D,Zhang J,Chen J

    更新日期：2018-07-15 00:00:00

  • Quantitative ultrasound imaging of cell-laden hydrogels and printed constructs.

    abstract：:In the present work we have revisited the application of quantitative ultrasound imaging (QUI) to cellular hydrogels, by using the reference phantom method (RPM) in combination with a local attenuation compensation algorithm. The investigated biological samples consisted of cell-laden collagen hydrogels with PC12 neur...

    journal_title：Acta biomaterialia

    pub_type： 杂志文章

    doi：10.1016/j.actbio.2019.04.055

    authors： Ruland A,Gilmore KJ,Daikuara LY,Fay CD,Yue Z,Wallace GG

    更新日期：2019-06-01 00:00:00

  • Porous diopside (CaMgSi(2)O(6)) scaffold: A promising bioactive material for bone tissue engineering.

    abstract：:Diopside (CaMgSi(2)O(6)) powders and dense ceramics have been shown to be bioactive biomaterials for bone repair. The aim of this study is to prepare bioactive diopside scaffolds and examine their physicochemical and biological properties. X-ray diffraction, scanning electron microscopy (SEM), micro-computerized tomog...

    journal_title：Acta biomaterialia

    pub_type： 杂志文章

    doi：10.1016/j.actbio.2009.12.022

    authors： Wu C,Ramaswamy Y,Zreiqat H

    更新日期：2010-06-01 00:00:00