Flt1 peptide-hyaluronate conjugate micelle-like nanoparticles encapsulating genistein for the treatment of ocular neovascularization.

abstract：:In humans, high level of collagen remodeling is seen during normal physiological events such as bone renewal, as well as in pathological conditions, such as arthritis, tumor growth and other chronic wounds. Our lab recently discovered that collagen mimetic peptide (CMP) is able to hybridize with denatured collagens at...

journal_title：Acta biomaterialia

authors： Chan TR,Stahl PJ,Li Y,Yu SM

更新日期：2015-03-01 00:00:00

abstract：:Nickel-titanium shape memory alloys (NiTi-SMAs) exhibit mechanical and chemical properties which make them attractive candidate materials for various types of biomedical applications. However, the high nickel content of NiTi-SMAs may result in adverse tissue reactions, especially when they are considered for load-bear...

journal_title：Acta biomaterialia

authors： Habijan T,Glogowski T,Kühn S,Pohl M,Wittsiepe J,Greulich C,Eggeler G,Schildhauer TA,Köller M

更新日期：2011-06-01 00:00:00

abstract：:A methacrylic terpolymer system with non-fouling interfacial properties was synthesized by the random copolymerization of hexyl methacrylate, methyl methacrylate and sulfobetaine methacrylate (a monomer bearing a zwitterionic pendant group). Polymers were synthesized from feeds containing 0-15 mol.% of the zwitterion-...

journal_title：Acta biomaterialia

authors： Heath DE,Cooper SL

更新日期：2012-08-01 00:00:00

abstract：:Diopside (CaMgSi(2)O(6)) powders and dense ceramics have been shown to be bioactive biomaterials for bone repair. The aim of this study is to prepare bioactive diopside scaffolds and examine their physicochemical and biological properties. X-ray diffraction, scanning electron microscopy (SEM), micro-computerized tomog...

journal_title：Acta biomaterialia

authors： Wu C,Ramaswamy Y,Zreiqat H

更新日期：2010-06-01 00:00:00

abstract：:Decellularized nerve, or acellular nerve allografts (ANAs), are an increasingly used alternative to nerve autografts to repair nerve gaps to facilitate regeneration. The adaptive immune system, specifically T cells, plays a role in promoting regeneration upon these ANA scaffolds. However, how T cells promote regenerat...

journal_title：Acta biomaterialia

authors： Pan D,Hunter DA,Schellhardt L,Fuchs A,Halevi AE,Snyder-Warwick AK,Mackinnon SE,Wood MD

更新日期：2020-08-01 00:00:00

abstract：UNLABELLED:Many chorioretinal diseases are chronic and need sustained drug delivery systems to keep therapeutic drug level at the disease site. Many intravitreal drug delivery systems under developing do not have mechanism incorporated for a non-invasive monitoring of drug release. The current study prepared rugate por...

journal_title：Acta biomaterialia

authors： Hou H,Nieto A,Belghith A,Nan K,Li Y,Freeman WR,Sailor MJ,Cheng L

更新日期：2015-09-01 00:00:00

abstract：:Multifunctional nanoplatforms offering simultaneous imaging and therapeutic functions have been recognized as a highly promising strategy for personalized nanomedicine. In this work, we synthesized a farnesylthiosalicylate (FTS, a nontoxic Ras antagonist) based triblock copolymer POEG-b-PVBA-b-PFTS (POVF) composed of ...

journal_title：Acta biomaterialia

authors： Sun J,Sun L,Li J,Xu J,Wan Z,Ouyang Z,Liang L,Li S,Zeng D

更新日期：2018-07-15 00:00:00

abstract：:The proliferation epidermal growth factor (EGF) is known to acquire contradictory apoptotic activities upon conjugation with gold nanoparticles (GNPs) through hitherto unknown mechanisms. Here, we identified an essential role of membrane rafts in the drastic activity switching of EGF-GNPs through the following intrace...

journal_title：Acta biomaterialia

authors： Yamamoto S,Iwamaru Y,Shimizu Y,Ueda Y,Sato M,Yamaguchi K,Nakanishi J

更新日期：2019-04-01 00:00:00

abstract：:Bacteria have inherent properties of self-propelled navigation and specific infiltration into solid tumors. In the current study, we investigate a novel type of bacterial microbots for delivery of hybrid micelles to promote the synergistic antitumor efficacy. Escherichia coli Nissle 1917 (EcN) is used as a bacterial c...

journal_title：Acta biomaterialia

authors： Xie S,Chen M,Song X,Zhang Z,Zhang Z,Chen Z,Li X

更新日期：2018-09-15 00:00:00

abstract：:As efficient drug carriers, stimuli-responsive mesoporous silica nanoparticles are at the forefront of research on drug delivery systems. An acid-responsive system based on silyl ether has been applied to deliver a hybrid prodrug. Thiol-ene click chemistry has been successfully utilized for tethering this prodrug to m...

journal_title：Acta biomaterialia

authors： Yan Y,Fu J,Wang T,Lu X

更新日期：2017-03-15 00:00:00

abstract：UNLABELLED:Injectable biomaterials have been evaluated as potential new therapies for myocardial infarction (MI) and heart failure. These materials have improved left ventricular (LV) geometry and ejection fraction, yet there remain concerns that biomaterial injection may create a substrate for arrhythmia. Since studie...

journal_title：Acta biomaterialia

authors： Suarez SL,Rane AA,Muñoz A,Wright AT,Zhang SX,Braden RL,Almutairi A,McCulloch AD,Christman KL

更新日期：2015-10-01 00:00:00

abstract：:Novel Mg-Zr-Sr alloys have recently been developed for use as biodegradable implant materials. The Mg-Zr-Sr alloys were prepared by diluting Mg-Zr and Mg-Sr master alloys with pure Mg. The impact of Zr and Sr on the mechanical and biological properties has been thoroughly examined. The microstructures and mechanical p...

journal_title：Acta biomaterialia

authors： Li Y,Wen C,Mushahary D,Sravanthi R,Harishankar N,Pande G,Hodgson P

更新日期：2012-08-01 00:00:00

abstract：:To improve the corrosion resistance and biological performance of commercially pure titanium (cp-Ti) substrates, potassium hydroxide was employed to modify the surfaces of titanium substrates, followed by biomimetic deposition of apatite on the substrates in a simulated body fluid. The morphologies of native and treat...

journal_title：Acta biomaterialia

authors： Cai K,Lai M,Yang W,Hu R,Xin R,Liu Q,Sung KL

更新日期：2010-06-01 00:00:00

abstract：UNLABELLED:The regeneration of hyaline cartilage remains clinically challenging. Here, we evaluated the therapeutic effects of using cell-free porous poly(lactic-co-glycolic acid) (PLGA) graft implants (PGIs) along with early loading exercise to repair a full-thickness osteochondral defect. Rabbits were randomly alloca...

journal_title：Acta biomaterialia

authors： Chang NJ,Lin CC,Shie MY,Yeh ML,Li CF,Liang PI,Lee KW,Shen PH,Chu CJ

更新日期：2015-12-01 00:00:00

abstract：:Antibody-mediated osseous regeneration (AMOR) has been proved as a promising strategy for osteogenic differentiation of induced pluripotent stem cells derived MSCs (iMSCs). The key characteristic of antibody that determines the AMOR potential is largely unknown. The glycosylation profile of immunoglobulin G (IgG) repr...

journal_title：Acta biomaterialia

authors： Wu Q,Yang Y,Xie D,Li S,Liu Y,Shu L,Fu G,Xu Y,Ji P

更新日期：2020-09-15 00:00:00

abstract：:In this study, the Cu-doping mechanism of Biphasic Calcium Phosphate (BCP) was thoroughly investigated, as was its ionic release behavior, in order to elucidate cytotoxicity features of these bioceramics. BCP are composed of hydroxyapatite (Ca10(PO4)6(OH)2) and β-TCP (Ca3(PO4)2). The two phases present two different d...

journal_title：Acta biomaterialia

authors： Gomes S,Vichery C,Descamps S,Martinez H,Kaur A,Jacobs A,Nedelec JM,Renaudin G

更新日期：2018-01-01 00:00:00

abstract：:Surface modification of titanium implants to improve their fixation in bone tissue is of great interest. We present a novel approach to enhance implant performance by applying important principles of bone mineralization to biomedical coatings. As an attempt to mimic the biphasic biomineralization process, both the enz...

journal_title：Acta biomaterialia

authors： de Jonge LT,van den Beucken JJ,Leeuwenburgh SC,Hamers AA,Wolke JG,Jansen JA

更新日期：2009-09-01 00:00:00

abstract：:Poly(ethylene glycol) PEG-based hydrogels are promising for cell encapsulation and tissue engineering, but are known to elicit a foreign body response (FBR) in vivo. The goal of this study was to investigate the impact of the FBR, and specifically the presence of inflammatory macrophages, on encapsulated cells and the...

journal_title：Acta biomaterialia

authors： Saleh LS,Carles-Carner M,Bryant SJ

更新日期：2018-04-15 00:00:00

abstract：:Turtle shell is a multi-scale bio-composite in which the components are arranged in various spatial patterns, leading to an unusually strong and durable structure. The keratin-coated dorsal shell, termed the carapace, exhibits a flat bone, sandwich-like structure made up of two exterior cortices enclosing a cancellous...

journal_title：Acta biomaterialia

authors： Achrai B,Wagner HD

更新日期：2013-04-01 00:00:00

abstract：:The Mg-Ca alloy system has been proposed as a potential new kind of degradable biomaterial with possible application within bone. Here microarc oxidation (MAO) coatings were fabricated on top of a Mg-Ca alloy using different applied voltages and the effect of applied voltage on the surface morphology and phase constit...

journal_title：Acta biomaterialia

authors： Gu XN,Li N,Zhou WR,Zheng YF,Zhao X,Cai QZ,Ruan L

更新日期：2011-04-01 00:00:00

abstract：:There is an increasing clinical need to design novel dental materials that combine regenerative and antibacterial properties. In this work the characterization of a recently developed sol-gel-derived bioactive glass ceramic containing silver ions (Ag-BG) is presented. The microstructural characteristics, ion release p...

journal_title：Acta biomaterialia

authors： Chatzistavrou X,Fenno JC,Faulk D,Badylak S,Kasuga T,Boccaccini AR,Papagerakis P

更新日期：2014-08-01 00:00:00

abstract：:Bioactive ions released from bioceramics play important roles in bone regeneration; however, it is unclear how each ionic composition in complex bioceramics exerts its specific effect on bone regeneration. The aim of this study is to elucidate the functional effects of Sr and Si ions in bioceramics on the regeneration...

journal_title：Acta biomaterialia

authors： Mao L,Xia L,Chang J,Liu J,Jiang L,Wu C,Fang B

更新日期：2017-10-01 00:00:00

abstract：:The objective of this study is to design the manner of ephrinB2 immobilized onto polyacrylamide (PAAm) hydrogels with varied elasticity and evaluate the effect of hydrogels elasticity and the immobilized manner of ephrinB2 on the Runx2 expression of human mesenchymal stem cells (hMSC). The PAAm hydrogels were prepared...

journal_title：Acta biomaterialia

authors： Toda H,Yamamoto M,Uyama H,Tabata Y

更新日期：2017-08-01 00:00:00

abstract：:Understanding the composition of the adsorbed protein layer on a biomaterial surface is of an extreme importance as it directs the primary biological response. Direct detection using labeled proteins and indirect detection based on enzymatic assays or changes to mass, refractive index or density of a surface have been...

journal_title：Acta biomaterialia

authors： Sarem M,Vonwil D,Lüdeke S,Shastri VP

更新日期：2017-07-15 00:00:00

abstract：UNLABELLED:The generation of tissue-engineered blood vessel substitutes remains an ongoing challenge for cardiovascular tissue engineering. Full biocompatibility and immediate availability have emerged as central issues for clinical use. To address these issues, we developed a technique that allows the generation of hi...

journal_title：Acta biomaterialia

authors： Aper T,Wilhelmi M,Gebhardt C,Hoeffler K,Benecke N,Hilfiker A,Haverich A

更新日期：2016-01-01 00:00:00

abstract：:To reduce the biocorrosion rate by surface modification, Mg-Ca alloy (1.4wt.% Ca content) was soaked in three alkaline solutions (Na(2)HPO(4), Na(2)CO(3) and NaHCO(3)) for 24h, respectively, and subsequently heat treated at 773K for 12h. Scanning electron microscopy and energy-dispersive spectroscopy results revealed ...

journal_title：Acta biomaterialia

authors： Gu XN,Zheng W,Cheng Y,Zheng YF

更新日期：2009-09-01 00:00:00

abstract：:The aim of this work was to study the phase transformation during the setting reaction of two calcium phosphate bone cements based on either alpha tricalcium phosphate (alpha-TCP) or tetracalcium phosphate (TetCP) initial solid phase, and a magnesium carbonate-phosphoric acid solution as the hardening liquid. Low mole...

journal_title：Acta biomaterialia

authors： Rau JV,Generosi A,Smirnov VV,Ferro D,Rossi Albertini V,Barinov SM

更新日期：2008-07-01 00:00:00

abstract：:Titanium (Ti) based tissue engineering scaffolds can be used to repair damaged bone. However, successful orthopedic applications of these scaffolds rely on their ability to mimic the mechanical properties of trabecular bone. Selective laser melting (SLM) was used to manufacture scaffolds of a new β-Ti35Zr28Nb alloy fo...

journal_title：Acta biomaterialia

authors： Li Y,Ding Y,Munir K,Lin J,Brandt M,Atrens A,Xiao Y,Kanwar JR,Wen C

更新日期：2019-03-15 00:00:00

abstract：:A simple, degradable poly(ethylene glycol) (PEG) microsphere system formed from a water-in-water emulsion process is presented. Microsphere network degradation and erosion were controlled by adjusting the number of hydrolytically labile sites, by varying the PEG molecular weight, and by adjusting the emulsion conditio...

journal_title：Acta biomaterialia

authors： Parlato M,Johnson A,Hudalla GA,Murphy WL

更新日期：2013-12-01 00:00:00

abstract：:Thin film nitinol has unique mechanical properties (e.g., superelasticity), excellent biocompatibility, and ultra-smooth surface, as well as shape memory behavior. All these features along with its low-profile physical dimension (i.e., a few micrometers thick) make this material an ideal candidate in developing low-pr...

journal_title：Acta biomaterialia

authors： Shayan M,Chun Y

更新日期：2015-07-01 00:00:00