The RNA-binding protein RBM3 is required for cell proliferation and protects against serum deprivation-induced cell death.

abstract：BACKGROUND:To investigate the relationship between unexplained indirect hyperbilirubinemia of Vietnamese newborns and the polymorphism of the promoter TATA box and exon 1 of bilirubin uridine diphosphate glucuronosyltransferase (UGT1A1) gene. METHODS:A total of 149 neonates were divided into the hyperbilirubinemia gro...

journal_title：Pediatric research

authors： Nguyen TT,Zhao W,Yang X,Zhong DN

更新日期：2020-12-01 00:00:00

abstract：:A strongly positive tuberculin skin reaction (> 1.5 cm2) was observed during the acute phase of the illness in 11 children with Kawasaki disease (KD), but not in control pediatric patients with other febrile infections (41 patients) or diseases similar to KD (9 patients). The cutaneous sensitivity to intermediate stre...

journal_title：Pediatric research

authors： Bertotto A,Spinozzi F,Vagliasindi C,Radicioni M,De Rosa O,Vaccaro R

更新日期：1997-04-01 00:00:00

abstract：:The newborn immune system differs quantitatively and functionally from that of adults. Development of the immune system has important implications for childhood diseases. The immaturity of the immune system in the first years of life may contribute to failure of tolerance induction and in the development of allergic d...

journal_title：Pediatric research

authors： Koning H,Baert MR,Oranje AP,Savelkoul HF,Neijens HJ

更新日期：1996-09-01 00:00:00

abstract：:Previous studies have reported differences in muscle function and metabolism between patients with cystic fibrosis (CF) and healthy controls (HC), but it is currently unknown whether these abnormalities are specific to CF or also seen in other airway diseases. In this study, we used magnetic resonance spectroscopy (MR...

journal_title：Pediatric research

authors： Wells GD,Wilkes DL,Schneiderman JE,Rayner T,Elmi M,Selvadurai H,Dell SD,Noseworthy MD,Ratjen F,Tein I,Coates AL

更新日期：2011-01-01 00:00:00

abstract：:Ca2+ transients were examined in embryonic chick hearts with an experimentally induced cardiac neural crest-related outflow tract defect known as persistent truncus arteriosus (PTA). In all of the animal models of neural crest-related heart defects, prenatal mortality is too high to be attributed to structural defects...

journal_title：Pediatric research

authors： Creazzo TL,Brotto MA,Burch J

更新日期：1997-12-01 00:00:00

abstract：BACKGROUND:The objective was to determine the association between perioperative risk factors and brain imaging abnormalities on neurologic outcome in neonates with hypoplastic left heart syndrome (HLHS) or d-Transposition of the great arteries (d-TGA) who underwent cardiac surgery including cardiopulmonary bypass. MET...

journal_title：Pediatric research

authors： Kuhn VA,Carpenter JL,Zurakowski D,Reitz JG,Tague L,Donofrio MT,Murnick J,Axt-Fliedner R,Limperopoulos C,Yerebakan C

更新日期：2020-07-25 00:00:00

abstract：OBJECTIVES:(1) Examine associations of a branched-chain amino acid (BCAA) metabolite pattern with metabolic risk across adolescence; (2) use Least Absolute Shrinkage and Selection Operator (LASSO) to identify novel metabolites of metabolic risk. METHODS:We used linear regression to examine associations of a BCAA score...

journal_title：Pediatric research

authors： Perng W,Tang L,Song PXK,Tellez-Rojo MM,Cantoral A,Peterson KE

更新日期：2019-02-01 00:00:00

abstract：:Although tyrosine is considered indispensable during the neonatal period, its poor solubility has limited its inclusion in parenteral amino acid solutions to less than 1% of total amino acids. Dipeptides of tyrosine are highly soluble, have been shown to be well used and safe in animal models and humans, and, therefor...

journal_title：Pediatric research

authors： Roberts SA,Ball RO,Moore AM,Filler RM,Pencharz PB

更新日期：2001-01-01 00:00:00

abstract：:Conversion of adenosine to inosine is decreased in adenosine deaminase (ADA)-deficient fibroblasts at all concentrations of adenosine tested. Adenosine is not differentially toxic to ADA-deficient fibroblasts except at very high (5 X 10(-4) -1 X 10(-3) M) adenosine levels. Conversion of [14C] adenosine to GTP is not d...

journal_title：Pediatric research

authors： Benke PJ,Dittmar D

更新日期：1976-07-01 00:00:00

abstract：BACKGROUND:Appearance of sleep cycling has been associated with good outcome in term and preterm infants, but the normal time of its appearance has not been determined. The objectives of this study were, to correlate the time of sleep cycling appearance and the length of quiet sleep in neonates with different degrees o...

journal_title：Pediatric research

authors： Abramsky R,Stavsky M,Novack V,Shany E

更新日期：2020-03-01 00:00:00

abstract：:To investigate the difference in ventilatory response to exercise between children and young adults, we administered a treadmill progressive exercise test to seven boys (aged 8 to 11 y [group A]) and six male young adults (aged 14 to 21 y [group B]), who had a history of Kawasaki disease without significant coronary a...

journal_title：Pediatric research

authors： Ohuchi H,Kato Y,Tasato H,Arakaki Y,Kamiya T

更新日期：1999-03-01 00:00:00

abstract：:Pyritinol-HCl was tested for its impact on the cognitive functions of children with learning disabilities. This study is a contribution to scientific discussion on the complicated methodologic problems in evaluating the clinical efficacy of psychopharmacologic agents. Sixty-seven pupils of slow learner classes between...

journal_title：Pediatric research

authors： Wälti U,Kuenzler M,Schild J,Vassella F,Pavlincova E,Bircher J,Herschkowitz N

更新日期：1975-09-01 00:00:00

abstract：INTRODUCTION:To examine the immune-modulatory effects of probiotics during early infancy, Bifidobacterium breve M-16V (B. breve) was administered to rat pups during the newborn or weaning period, and the expression of inflammatory genes was investigated using a cDNA microarray and real-time PCR. RESULTS:After B. breve...

journal_title：Pediatric research

authors： Ohtsuka Y,Ikegami T,Izumi H,Namura M,Ikeda T,Ikuse T,Baba Y,Kudo T,Suzuki R,Shimizu T

更新日期：2012-01-01 00:00:00

abstract：:Intrauterine growth restriction (IUGR) is a recognized risk factor for neurologic deficits later in life. Abnormal fetal blood flow in the presence of fetal growth retardation helps to distinguish true fetal growth impairment from small but normally grown infants. The present study aimed to investigate the influence o...

journal_title：Pediatric research

authors： Ley D,Marsal K,Dahlgren J,Hellstrom A

更新日期：2004-07-01 00:00:00

abstract：:The zeta subunit of the CD3 T-cell receptor complex and the major histocompatibility complex class 1 (MHC-I) are important not only for the immune response to antigens, they also function as signal molecules in the brain, where they play a role in the postnatal maturation process. The expression of these molecules can...

journal_title：Pediatric research

authors： Sourial-Bassillious N,Eklöf AC,Scott L,Aperia A,Zelenin S

更新日期：2006-10-01 00:00:00

abstract：:Nitric Oxide (NO) can be cytotoxic or cytoprotective depending on amount and location of its generation. eNOS is important in modulating blood flow and is allosterically regulated. Inducible NOS (iNOS) tends to produce large quantities of NO leading to cell injury. We studied the role and regulation of NOS in carbon t...

journal_title：Pediatric research

authors： Liu H,Subramony C,Nowicki M

更新日期：2008-06-01 00:00:00

abstract：BACKGROUND:Biliary atresia (BA) is an infantile disorder characterized by progressive sclerosing cholangiopathy leading to biliary obstruction. First-line treatment of BA is hepatoportoenterostomy, the prognosis of which is related to age at surgery and to histological variables such as extent of fibrosis and ductular ...

journal_title：Pediatric research

authors： de Souza AF,Meurer L,da Silveira TR,Gregório C,Reus N,Uribe C,Matte U,dos Santos JL

更新日期：2014-01-01 00:00:00

abstract：:Pulmonary surfactant is inactivated in meconium aspiration syndrome and neonatal pneumonia. Development of an exogenous surfactant less sensitive to inactivation might be useful for treating these diseases. We investigated in vitro whether addition of the cationic cyclic membrane cross-linking peptide polymyxin B (PxB...

journal_title：Pediatric research

authors： Stichtenoth G,Jung P,Walter G,Johansson J,Robertson B,Curstedt T,Herting E

更新日期：2006-03-01 00:00:00

abstract：:BackgroundThe mechanisms underlying aberrant activation of intestinal Toll-like receptor 4 (TLR4) signaling in necrotizing enterocolitis (NEC) remain unclear. In this study, we examined the role of single-immunoglobulin interleukin-1 receptor-related molecule (SIGIRR), an inhibitor of TLR signaling, in modulating expe...

journal_title：Pediatric research

authors： Fawley J,Cuna A,Menden HL,McElroy S,Umar S,Welak SR,Gourlay DM,Li X,Sampath V

更新日期：2018-01-01 00:00:00

abstract：:Plasma, amniotic fluid, and tissue concentrations of IGF-I were examined in nutritionally deprived, growth-retarded fetal rats to determine whether IGF-I concentration serves as a marker for nutritional status. Growth retardation was induced by 72 h of maternal fasting. Twenty-three control and 17 growth-retarded fetu...

journal_title：Pediatric research

authors： Bernstein IM,DeSouza MM,Copeland KC

更新日期：1991-08-01 00:00:00

abstract：:There is evidence that an elevated erythropoietin (EPO) concentration is associated with signs of iron deficient erythropoiesis. The aim of this study was to evaluate the iron status by means of novel cellular indices and serum iron markers and to determine whether these are associated with EPO and pH in the venous co...

journal_title：Pediatric research

authors： Ervasti M,Sankilampi U,Heinonen S,Punnonen K

更新日期：2008-08-01 00:00:00

abstract：:Leukotrienes C4 and D4 and thromboxane A2 are potent vasoconstrictors that may mediate pulmonary vasoconstriction in many clinical situations. There is a complex interaction among leukotrienes and thromboxane A2, because inhibition of thromboxane synthesis prevents some of the hemodynamic effects of exogenous leukotri...

journal_title：Pediatric research

authors： Soifer SJ,Schreiber MD,Heymann MA

更新日期：1989-08-01 00:00:00

abstract：BACKGROUND:Early recognition of patients at risk for sepsis is paramount to improve clinical outcomes. We hypothesized that subtle signatures of illness are present in physiological and biochemical time series of pediatric-intensive care unit (PICU) patients in the early stages of sepsis. METHODS:We developed multivar...

journal_title：Pediatric research

authors： Spaeder MC,Moorman JR,Tran CA,Keim-Malpass J,Zschaebitz JV,Lake DE,Clark MT

更新日期：2019-11-01 00:00:00

abstract：BACKGROUND:Later life metabolic dysfunction is a well-recognized consequence of being born small for gestational age (SGA). This study has applied metabolomics to identify whether there are changes in these pathways in prepubertal short SGA children and aimed to compare the intracellular and extracellular metabolome in...

journal_title：Pediatric research

authors： Murray PG,Butcher I,Dunn WB,Stevens A,Perchard R,Hanson D,Whatmore A,Westwood M,Clayton PE

更新日期：2016-08-01 00:00:00

abstract：:It is customary to estimate the uteroplacental function in singletons by defining appropriateness of birth weight by gestational age. Such a measure, however, is not available for the entire multiple pregnancy set. We evaluate a new index, total triplet birth weight, expressed as multiples of the median (MOM) birth we...

journal_title：Pediatric research

authors： Blickstein I,Salihu HM,Keith LG,Alexander GR

更新日期：2006-04-01 00:00:00

abstract：:Although the pathogenesis of necrotizing enterocolitis remains uncertain, ischemia appears to be an important contributing factor to the development of this disorder. Reperfusion plays a major role in ischemia-related injury, and oxygen free radicals produced during reperfusion most likely contribute to the injury. Th...

journal_title：Pediatric research

authors： Papparella A,DeLuca FG,Oyer CE,Pinar H,Stonestreet BS

更新日期：1997-08-01 00:00:00

abstract：:Evidence is inconsistent or poorly understood for links between polychlorinated biphenyls (PCBs), 1,1'-dichloro-2,2'-bis(4-chlorophenyl)ethylene (DDE), and organophosphate (OP) pesticides and adverse pregnancy outcomes, although they are known developmental toxicants. We measured biomarkers of maternal exposure to DDE...

journal_title：Pediatric research

authors： Wolff MS,Engel S,Berkowitz G,Teitelbaum S,Siskind J,Barr DB,Wetmur J

更新日期：2007-02-01 00:00:00

abstract：:In Brazil, similar intrauterine growth restriction (IUGR) rates were observed between cities with distinct levels of socioeconomic development, challenging the current knowledge that higher rates of IUGR would necessarily be observed in poorer areas than in wealthier ones. Ribeirão Preto, a city located in the most de...

journal_title：Pediatric research

authors： De Farias Aragão VM,Barbieri MA,Moura Da Silva AA,Bettiol H,Ribeiro VS

更新日期：2005-05-01 00:00:00

abstract：BACKGROUND:Therapeutic hypothermia (HT) is the only intervention that improves outcomes in neonatal hypoxic-ischemic encephalopathy (HIE). However, the multifactorial mechanisms by which HT impacts HIE are incompletely understood. The complement system plays a major role in the pathogenesis of ischemia-reperfusion inju...

journal_title：Pediatric research

authors： Shah TA,Nejad JE,Pallera HK,Lattanzio FA,Farhat R,Kumar PS,Hair PS,Bass WT,Krishna NK

更新日期：2017-04-01 00:00:00

abstract：:In dissociated whole brain cell cultures from newborn mice, we have previously shown that during glucose deprivation under normoxia, D-beta-hydroxybutyrate and oleic acid are increasingly used for energy production. We now asked whether this glucose dependency of the utilization of D-beta-hydroxybutyrate and oleic aci...

journal_title：Pediatric research

authors： Bossi E,Kohler E,Herschkowitz N

更新日期：1989-11-01 00:00:00