Psychiatric disorder in two siblings with hallervorden-spatz disease.

Abstract:

:Hallervorden-Spatz disease (HSD) is a rare autosomal-recessive hereditary disorder characterized by the early onset of progressive movement alterations, including dystonia, rigidity, choreoathetosis, and mental deterioration. HSD is also associated with a variety of psychiatric symptoms, primarily depression and mental deterioration. However, psychosis has rarely been reported as a major symptom of HSD. We report two siblings who presented psychiatric symptoms as major clinical presentations, accompanied by ataxic and spastic gait, dysarthria, and typical neuroimaging findings of HSD. A 14-year-old girl presented complex motor tics, stereotypic behavior and anxiety symptoms. Her older brother, a 16-year-old boy, presented prominent auditory hallucinations, persecutory delusions and social withdrawal symptoms. Psychiatric symptoms were improved after atypical antipsychotic treatment. HSD is a rare disease but should be carefully considered in the diagnosis of patients with both motor disorder and various psychiatric symptoms.

journal_name

Psychiatry Investig

journal_title

Psychiatry investigation

authors

Sunwoo YK,Lee JS,Kim WH,Shin YB,Lee MJ,Cho IH,Ock SM

doi

10.4306/pi.2009.6.3.226

subject

Has Abstract

pub_date

2009-09-01 00:00:00

pages

226-9

issue

3

eissn

1738-3684

issn

1976-3026

journal_volume

6

pub_type

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