Abstract:
:Hallervorden-Spatz disease (HSD) is a rare autosomal-recessive hereditary disorder characterized by the early onset of progressive movement alterations, including dystonia, rigidity, choreoathetosis, and mental deterioration. HSD is also associated with a variety of psychiatric symptoms, primarily depression and mental deterioration. However, psychosis has rarely been reported as a major symptom of HSD. We report two siblings who presented psychiatric symptoms as major clinical presentations, accompanied by ataxic and spastic gait, dysarthria, and typical neuroimaging findings of HSD. A 14-year-old girl presented complex motor tics, stereotypic behavior and anxiety symptoms. Her older brother, a 16-year-old boy, presented prominent auditory hallucinations, persecutory delusions and social withdrawal symptoms. Psychiatric symptoms were improved after atypical antipsychotic treatment. HSD is a rare disease but should be carefully considered in the diagnosis of patients with both motor disorder and various psychiatric symptoms.
journal_name
Psychiatry Investigjournal_title
Psychiatry investigationauthors
Sunwoo YK,Lee JS,Kim WH,Shin YB,Lee MJ,Cho IH,Ock SMdoi
10.4306/pi.2009.6.3.226subject
Has Abstractpub_date
2009-09-01 00:00:00pages
226-9issue
3eissn
1738-3684issn
1976-3026journal_volume
6pub_type
杂志文章abstract:OBJECTIVE:The synaptosomal-associated protein of 25 kDa (SNAP-25) gene is a presynaptic plasma membrane protein and an integral component of the vesicle docking and fusion machinery mediating secretion of neurotransmitters. Previously, several studies reported association between SNAP-25 and attention deficit hyperacti...
journal_title:Psychiatry investigation
pub_type: 杂志文章
doi:10.4306/pi.2014.11.4.476
更新日期:2014-10-01 00:00:00
abstract:OBJECTIVE:Oxidative metabolism is impaired in several medical conditions including psychiatric disorders, and this imbalance may be involved in the etiology of these diseases. The present study evaluated oxidative balance in pediatric and adolescent patients with attention deficit hyperactivity disorder (ADHD). METHOD...
journal_title:Psychiatry investigation
pub_type: 杂志文章
doi:10.4306/pi.2015.12.3.361
更新日期:2015-07-01 00:00:00
abstract:OBJECTIVE:Associations of thyroid dysfunction with cognitive impairment and depression in late-life have been described but remain controversial. This study aimed to investigate the associations of serum thyroid stimulating hormone (TSH) levels with cognitive impairment and depression after controlling for potential co...
journal_title:Psychiatry investigation
pub_type: 杂志文章
doi:10.4306/pi.2010.7.4.264
更新日期:2010-12-01 00:00:00
abstract:OBJECTIVE:In the current study, we investigated whether there are relations among depressive symptoms, cognitive performance and serum BDNF levels in the patients with chronic kidney disease (CKD). METHODS:Sixty patients with CKD and 65 healthy controls participated. Depressive symptoms were evaluated with Beck depres...
journal_title:Psychiatry investigation
pub_type: 杂志文章
doi:10.30773/pi.2017.03.09
更新日期:2018-02-01 00:00:00
abstract:OBJECTIVE:Adjustment disorder (ADJ) is a common diagnosis. However, it is difficult to distinguish ADJ from other major Axis I disorders, such as major depressive disorder (MDD). The aim of this study was to determine the distinguishing neurophysiological characteristics between ADJ and MDD using quantitative analysis ...
journal_title:Psychiatry investigation
pub_type: 杂志文章
doi:10.4306/pi.2013.10.1.62
更新日期:2013-03-01 00:00:00
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journal_title:Psychiatry investigation
pub_type: 杂志文章
doi:10.4306/pi.2012.9.2.111
更新日期:2012-06-01 00:00:00
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journal_title:Psychiatry investigation
pub_type: 杂志文章
doi:10.30773/pi.2018.01.10
更新日期:2018-05-01 00:00:00
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journal_title:Psychiatry investigation
pub_type: 杂志文章
doi:10.4306/pi.2016.13.5.580
更新日期:2016-09-01 00:00:00
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journal_title:Psychiatry investigation
pub_type: 杂志文章
doi:10.30773/pi.2020.0323
更新日期:2020-09-01 00:00:00
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journal_title:Psychiatry investigation
pub_type: 杂志文章
doi:10.30773/pi.2019.0326
更新日期:2020-09-01 00:00:00
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journal_title:Psychiatry investigation
pub_type: 杂志文章
doi:10.4306/pi.2017.14.3.314
更新日期:2017-05-01 00:00:00
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journal_title:Psychiatry investigation
pub_type: 杂志文章
doi:10.30773/pi.2019.02.14
更新日期:2019-05-01 00:00:00
abstract:OBJECTIVE:Family and twin studies have suggested genetic liability for panic disorder (PD) and therefore we sought to determine the role of noradrenergic and serotonergic candidate genes for susceptibility for PD in a Japanese population. METHODS:In this age- and gender-matched case-control study involving 119 PD pati...
journal_title:Psychiatry investigation
pub_type: 杂志文章
doi:10.4306/pi.2017.14.1.86
更新日期:2017-01-01 00:00:00
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journal_title:Psychiatry investigation
pub_type: 杂志文章
doi:10.4306/pi.2017.14.4.513
更新日期:2017-07-01 00:00:00
abstract:OBJECTIVE:To investigate the altitude, immigration and suicide rates association in Turkey. METHODS:Suicide and immigration rates of 81 provinces and their elevation data were obtained. RESULTS:There were not significant correlations between country elevation, immigration and mean suicide rate. CONCLUSION:The findin...
journal_title:Psychiatry investigation
pub_type: 杂志文章
doi:10.4306/pi.2013.10.1.89
更新日期:2013-03-01 00:00:00
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journal_title:Psychiatry investigation
pub_type: 杂志文章
doi:10.30773/pi.2018.08.31
更新日期:2018-11-01 00:00:00
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journal_title:Psychiatry investigation
pub_type: 杂志文章
doi:10.4306/pi.2016.13.2.196
更新日期:2016-03-01 00:00:00
abstract:OBJECTIVE:We examined a functional model of acquired capability for suicide, which was elaborated from the "Interpersonal-Psychological Theory of Suicide". METHODS:A total of 6,027 Korean community subjects were recruited from The Korean Epidemiologic Catchment Area study conducted in 2011. The subjects were assessed ...
journal_title:Psychiatry investigation
pub_type: 杂志文章
doi:10.4306/pi.2016.13.6.601
更新日期:2016-11-01 00:00:00
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journal_title:Psychiatry investigation
pub_type: 杂志文章
doi:10.4306/pi.2015.12.2.197
更新日期:2015-04-01 00:00:00
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journal_title:Psychiatry investigation
pub_type: 杂志文章
doi:10.4306/pi.2018.15.1.84
更新日期:2018-01-01 00:00:00
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journal_title:Psychiatry investigation
pub_type: 杂志文章
doi:10.30773/pi.2016.10.24
更新日期:2018-06-01 00:00:00
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journal_title:Psychiatry investigation
pub_type: 杂志文章
doi:10.4306/pi.2016.13.4.468
更新日期:2016-07-01 00:00:00
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journal_title:Psychiatry investigation
pub_type: 杂志文章
doi:10.30773/pi.2019.01.16
更新日期:2019-03-01 00:00:00
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journal_title:Psychiatry investigation
pub_type: 杂志文章
doi:10.4306/pi.2014.11.2.152
更新日期:2014-04-01 00:00:00
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journal_title:Psychiatry investigation
pub_type: 杂志文章
doi:10.30773/pi.2019.0324
更新日期:2020-09-01 00:00:00
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journal_title:Psychiatry investigation
pub_type: 杂志文章
doi:10.4306/pi.2013.10.2.131
更新日期:2013-06-01 00:00:00
abstract::Transcranial direct current stimulation (tDCS), a non-invasive neuromodulation technique, has been increasingly used to treat bipolar depression. Researchers recently noticed the risk of tDCS-emergent mania/hypomania in depressed patients and started to evaluate this risk by launching a meta-analysis. Here we present ...
journal_title:Psychiatry investigation
pub_type: 杂志文章
doi:10.30773/pi.2018.08.11.1
更新日期:2018-09-01 00:00:00
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journal_title:Psychiatry investigation
pub_type: 杂志文章
doi:10.4306/pi.2015.12.3.288
更新日期:2015-07-01 00:00:00
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journal_title:Psychiatry investigation
pub_type: 杂志文章
doi:10.4306/pi.2012.9.1.17
更新日期:2012-03-01 00:00:00
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journal_title:Psychiatry investigation
pub_type: 杂志文章
doi:10.4306/pi.2015.12.1.81
更新日期:2015-01-01 00:00:00