Abstract:
:Neural precursor cells (NPCs) in the mammalian olfactory bulb give rise to local inhibitory neurons that integrate into existing circuitry throughout adult life. However, the functional properties of neurotransmitter receptors expressed by NPCs are not well understood. In this study, we use patch-clamp recording and calcium imaging to explore the properties of glutamate receptors expressed by NPCs in the olfactory bulb subependymal layer. We find that calcium-permeable AMPA receptors (AMPARs) are the major receptor type underlying glutamatergic signaling in olfactory bulb NPCs. We also show that when transmitter uptake is reduced, glutamate spillover from distant nerve terminals in the olfactory bulb can activate nonsynaptic NPC AMPARs and generate increases in intracellular calcium. Together, these results suggest that Ca(2+) influx via AMPARs may contribute to calcium-dependent processes that govern NPC differentiation and maturation.
journal_name
J Neurophysioljournal_title
Journal of neurophysiologyauthors
Darcy DP,Isaacson JSdoi
10.1152/jn.00821.2009subject
Has Abstractpub_date
2010-03-01 00:00:00pages
1431-7issue
3eissn
0022-3077issn
1522-1598pii
00821.2009journal_volume
103pub_type
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