Calcium-permeable AMPA receptors mediate glutamatergic signaling in neural precursor cells of the postnatal olfactory bulb.

Abstract:

:Neural precursor cells (NPCs) in the mammalian olfactory bulb give rise to local inhibitory neurons that integrate into existing circuitry throughout adult life. However, the functional properties of neurotransmitter receptors expressed by NPCs are not well understood. In this study, we use patch-clamp recording and calcium imaging to explore the properties of glutamate receptors expressed by NPCs in the olfactory bulb subependymal layer. We find that calcium-permeable AMPA receptors (AMPARs) are the major receptor type underlying glutamatergic signaling in olfactory bulb NPCs. We also show that when transmitter uptake is reduced, glutamate spillover from distant nerve terminals in the olfactory bulb can activate nonsynaptic NPC AMPARs and generate increases in intracellular calcium. Together, these results suggest that Ca(2+) influx via AMPARs may contribute to calcium-dependent processes that govern NPC differentiation and maturation.

journal_name

J Neurophysiol

authors

Darcy DP,Isaacson JS

doi

10.1152/jn.00821.2009

subject

Has Abstract

pub_date

2010-03-01 00:00:00

pages

1431-7

issue

3

eissn

0022-3077

issn

1522-1598

pii

00821.2009

journal_volume

103

pub_type

杂志文章
  • Mechanisms and time course of vocal learning and consolidation in the adult songbird.

    abstract::In songbirds, the basal ganglia outflow nucleus LMAN is a cortical analog that is required for several forms of song plasticity and learning. Moreover, in adults, inactivating LMAN can reverse the initial expression of learning driven via aversive reinforcement. In the present study, we investigated how LMAN contribut...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00311.2011

    authors: Warren TL,Tumer EC,Charlesworth JD,Brainard MS

    更新日期:2011-10-01 00:00:00

  • Inflammatory mediators at acidic pH activate capsaicin receptors in cultured sensory neurons from newborn rats.

    abstract::Whole cell membrane currents induced by the inflammatory mediators, bradykinin, 5-hydroxytryptamine (5-HT) and prostaglandin E2, were investigated in capsaicin-sensitive dorsal root ganglion (DRG) neurons from newborn rats grown on a monolayer of hippocampal glia without nerve growth factor (NGF). When firmly attached...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1998.79.2.670

    authors: Vyklický L,Knotková-Urbancová H,Vitásková Z,Vlachová V,Kress M,Reeh PW

    更新日期:1998-02-01 00:00:00

  • Summation of effective synaptic currents and firing rate modulation in cat spinal motoneurons.

    abstract::The aim of this study was to examine how cat spinal motoneurons integrate the synaptic currents generated by the concurrent activation of large groups of presynaptic neurons. We obtained intracellular recordings from cat triceps surae motoneurons and measured the effects of repetitive activity in different sets of pre...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.2000.83.1.483

    authors: Powers RK,Binder MD

    更新日期:2000-01-01 00:00:00

  • Eye movements when observing predictable and unpredictable actions.

    abstract::We previously showed that, when observers watch an actor performing a predictable block-stacking task, the coordination between the observer's gaze and the actor's hand is similar to the coordination between the actor's gaze and hand. Both the observer and the actor direct gaze to forthcoming grasp and block landing s...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00227.2006

    authors: Rotman G,Troje NF,Johansson RS,Flanagan JR

    更新日期:2006-09-01 00:00:00

  • Selection of head and whisker coordination strategies during goal-oriented active touch.

    abstract::In the rodent whisker system, a key model for neural processing and behavioral choices during active sensing, whisker motion is increasingly recognized as only part of a broader motor repertoire employed by rodents during active touch. In particular, recent studies suggest whisker and head motions are tightly coordina...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00465.2015

    authors: Schroeder JB,Ritt JT

    更新日期:2016-04-01 00:00:00

  • Mechanoafferent neuron with an inexcitable somatic region: consequences for the regulation of spike propagation and afferent transmission.

    abstract::In the Aplysia mechanoafferent B21, afferent transmission is in part regulated via the control of active spike propagation. When B21 is peripherally activated at its resting membrane potential, spikes fail to propagate to an output process, and afferent transmission does not occur. In this report, we show that the pro...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.01341.2006

    authors: Evans CG,Ludwar BCh,Cropper EC

    更新日期:2007-04-01 00:00:00

  • Increased cerebral blood flow supports a single-bout postexercise benefit to executive function: evidence from hypercapnia.

    abstract::A single bout of aerobic exercise improves executive function; however, the mechanism for the improvement remains unclear. One proposal asserts that an exercise-mediated increase in cerebral blood flow (CBF) enhances the efficiency of executive-related cortical structures. To examine this, participants completed separ...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00240.2020

    authors: Tari B,Vanhie JJ,Belfry GR,Shoemaker JK,Heath M

    更新日期:2020-09-01 00:00:00

  • Discharge properties of abductor hallucis before, during, and after an isometric fatigue task.

    abstract::Abductor hallucis is the largest muscle in the arch of the human foot and comprises few motor units relative to its physiological cross-sectional area. It has been described as a postural muscle, aiding in the stabilization of the longitudinal arch during stance and gait. The purpose of this study was to describe the ...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00944.2012

    authors: Kelly LA,Racinais S,Cresswell AG

    更新日期:2013-08-01 00:00:00

  • Structural modularity and grid activity in the medial entorhinal cortex.

    abstract::Following the groundbreaking discovery of grid cells, the medial entorhinal cortex (MEC) has become the focus of intense anatomical, physiological, and computational investigations. Whether and how grid activity maps onto cell types and cortical architecture is still an open question. Fundamental similarities in micro...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章,评审

    doi:10.1152/jn.00574.2017

    authors: Naumann RK,Preston-Ferrer P,Brecht M,Burgalossi A

    更新日期:2018-06-01 00:00:00

  • Neuronal transmission through hippocampal pathways dependent on behavior.

    abstract::1. In chronically prepared, freely moving rats, electrical stimulation was applied to the angular bundle, and responses were recorded extracellularly at a variety of sites in the ipsilateral hippocampal formation. At each recording site the stimulus-response relationship was tested during four different behavioral sta...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1978.41.3.716

    authors: Winson J,Abzug C

    更新日期:1978-05-01 00:00:00

  • Presynaptic and extrasynaptic regulation of posterior nucleus of thalamus.

    abstract::The posterior nucleus of thalamus (PO) is a higher-order nucleus involved in sensorimotor processing, including nociception. An important characteristic of PO is its wide range of activity profiles that vary across states of arousal, thought to underlie differences in somatosensory perception subject to attention and ...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00862.2016

    authors: Park A,Li Y,Masri R,Keller A

    更新日期:2017-07-01 00:00:00

  • Using fMRI to study reward processing in humans: past, present, and future.

    abstract::Functional magnetic resonance imaging (fMRI) is a noninvasive tool used to probe cognitive and affective processes. Although fMRI provides indirect measures of neural activity, the advent of fMRI has allowed for1) the corroboration of significant animal findings in the human brain, and2) the expansion of models to inc...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章,评审

    doi:10.1152/jn.00333.2015

    authors: Wang KS,Smith DV,Delgado MR

    更新日期:2016-03-01 00:00:00

  • Developmental time course distinguishes changes in spontaneous and light-evoked retinal ganglion cell activity in rd1 and rd10 mice.

    abstract::In a subset of hereditary retinal diseases, early photoreceptor degeneration causes rapidly progressive blindness in children. To better understand how retinal development may interact with degenerative processes, we compared spontaneous and light-evoked activity among retinal ganglion cells in rd1 and rd10 mice, stra...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00704.2010

    authors: Stasheff SF,Shankar M,Andrews MP

    更新日期:2011-06-01 00:00:00

  • Representation of pleasant and aversive taste in the human brain.

    abstract::In this study, the representation of taste in the orbitofrontal cortex was investigated to determine whether or not a pleasant and an aversive taste have distinct or overlapping representations in this region. The pleasant stimulus used was sweet taste (1 M glucose), and the unpleasant stimulus was salt taste (0.1 M N...

    journal_title:Journal of neurophysiology

    pub_type: 临床试验,杂志文章

    doi:10.1152/jn.2001.85.3.1315

    authors: O'Doherty J,Rolls ET,Francis S,Bowtell R,McGlone F

    更新日期:2001-03-01 00:00:00

  • Drugs affecting phospholipase C-mediated signal transduction block the olfactory cyclic nucleotide-gated current of adult zebrafish.

    abstract::Amino acid and bile salt odorants are detected by zebrafish with relatively independent odorant receptors, but the transduction cascade(s) subsequently activated by these odorants remains unknown. Electro-olfactogram recording methods were used to determine the effects of two drugs, reported to affect phospholipase C ...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1998.79.3.1183

    authors: Ma L,Michel WC

    更新日期:1998-03-01 00:00:00

  • Potentiation in the first visual synapse of the fly compound eye.

    abstract::In the first visual synapse of the insect compound eye, both the presynaptic and postsynaptic signals are graded, nonspiking changes in membrane voltage. The synapse exhibits tonic transmitter release (even in dark) and strong adaptation to long-lasting light backgrounds, leading to changes also in the dynamics of sig...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.2000.83.4.2103

    authors: Uusitalo RO,Weckström M

    更新日期:2000-04-01 00:00:00

  • Induction of hippocampal LTD requires nitric-oxide-stimulated PKG activity and Ca2+ release from cyclic ADP-ribose-sensitive stores.

    abstract::Long-term depression (LTD) of synaptic transmission can be induced by several mechanisms, one thought to involve Ca2+-dependent activation of postsynaptic nitric oxide (NO) synthase and subsequent diffusion of NO to the presynaptic terminal. We used the stable NO donor S-nitroso-N-acetylpenicillamine (SNAP) to study t...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1999.82.3.1569

    authors: Reyes-Harde M,Potter BV,Galione A,Stanton PK

    更新日期:1999-09-01 00:00:00

  • Temporally irregular mnemonic persistent activity in prefrontal neurons of monkeys during a delayed response task.

    abstract::An important question in neuroscience is whether and how temporal patterns and fluctuations in neuronal spike trains contribute to information processing in the cortex. We have addressed this issue in the memory-related circuits of the prefrontal cortex by analyzing spike trains from a database of 229 neurons recorded...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00949.2002

    authors: Compte A,Constantinidis C,Tegner J,Raghavachari S,Chafee MV,Goldman-Rakic PS,Wang XJ

    更新日期:2003-11-01 00:00:00

  • Human perception of whole body roll-tilt orientation in a hypogravity analog: underestimation and adaptation.

    abstract::Overestimation of roll tilt in hypergravity ("G-excess" illusion) has been demonstrated, but corresponding sustained hypogravic conditions are impossible to create in ground laboratories. In this article we describe the first systematic experimental evidence that in a hypogravity analog, humans underestimate roll tilt...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00140.2018

    authors: Galvan-Garza RC,Clark TK,Sherwood D,Diaz-Artiles A,Rosenberg M,Natapoff A,Karmali F,Oman CM,Young LR

    更新日期:2018-12-01 00:00:00

  • N-methyl-D-aspartate receptors of ganglion cells in rabbit retina.

    abstract::1. Intracellular and extracellular recordings were obtained from ganglion cells in the rabbit retina. The effect of N-methyl-DL-aspartate (NMDLA) and N-methyl-D-aspartate (NMDA) antagonists were studied with the use of a perfusion method for drug application. 2. NMDLA excited all ganglion cell types and caused a chara...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1990.63.1.16

    authors: Massey SC,Miller RF

    更新日期:1990-01-01 00:00:00

  • Abnormal visual gain control and excitotoxicity in early-onset Parkinson's disease Drosophila models.

    abstract::The excitotoxic theory of Parkinson's disease (PD) hypothesizes that a pathophysiological degeneration of dopaminergic neurons stems from neural hyperactivity at early stages of disease, leading to mitochondrial stress and cell death. Recent research has harnessed the visual system of Drosophila PD models to probe thi...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00681.2017

    authors: Himmelberg MM,West RJH,Elliott CJH,Wade AR

    更新日期:2018-03-01 00:00:00

  • Differential effects of corticosterone on the slow afterhyperpolarization in the basolateral amygdala and CA1 region: possible role of calcium channel subunits.

    abstract::The stress hormone corticosterone increases the amplitude of the slow afterhyperpolarization (sAHP) in CA1 pyramidal neurons, without affecting resting membrane potential, input resistance, or action potential characteristics. We here examined how corticosterone affects these properties in the basolateral amygdala (BL...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.01137.2007

    authors: Liebmann L,Karst H,Sidiropoulou K,van Gemert N,Meijer OC,Poirazi P,Joëls M

    更新日期:2008-02-01 00:00:00

  • Motor cost affects the decision of when to shift gaze for guiding movement.

    abstract::Frequent gait modifications are often required to navigate our world. These can involve long or wide steps or changes in direction. People generally prefer to minimize the motor cost (or effort) of a movement, although with changes in gait this is not always possible. The decision of when and where to shift gaze is cr...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00027.2019

    authors: Domínguez-Zamora FJ,Marigold DS

    更新日期:2019-07-01 00:00:00

  • Frequency organization of delay-sensitive neurons in the auditory cortex of the FM bat, Myotis lucifugus.

    abstract::1. The little brown bat, Myotis lucifugus, employs biosonar pulses containing broadband frequency-modulated (FM) sounds of only one harmonic during the initial phases of echolocation. Neurons throughout the auditory cortex exhibit delay-dependent facilitation to artificial pulses and echoes at particular echo delays. ...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1994.72.1.366

    authors: Paschal WG,Wong D

    更新日期:1994-07-01 00:00:00

  • Modest increase in extracellular potassium unmasks effect of recurrent mossy fiber growth.

    abstract::The recurrent mossy fiber pathway of the dentate gyrus expands dramatically in many persons with temporal lobe epilepsy. The new connections among granule cells provide a novel mechanism of synchronization that could enhance the participation of these cells in seizures. Despite the presence of robust recurrent mossy f...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.2000.84.5.2380

    authors: Hardison JL,Okazaki MM,Nadler JV

    更新日期:2000-11-01 00:00:00

  • Reflex and intended responses in motor cortex pyramidal tract neurons of monkey.

    abstract::1. Monkeys were trained to react to an arm perturbation according to an instruction delivered prior to the perturbation. There were two possible instructions (push or pull), and monkeys learned to respond accordingly regardless of the direction (push or pull) of the triggering perturbation. 2. Pyramidal tract neurons ...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1976.39.5.1069

    authors: Evarts EV,Tanji J

    更新日期:1976-09-01 00:00:00

  • Mechanosensitive properties of gastric vagal afferent fibers in the rat.

    abstract::Single, teased fiber recordings were made from the decentralized right cervical vagus nerve (hyponodal) of the rat. A total of 67 afferent fibers that responded to gastric distension (GD) were studied: 9 fibers were stimulated by phasic balloon GD, 58 by more natural fluid GD. All balloon GD-responsive fibers had rest...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1999.82.5.2210

    authors: Ozaki N,Sengupta JN,Gebhart GF

    更新日期:1999-11-01 00:00:00

  • Multiple postsynaptic actions of GABA via GABAB receptors on CA1 pyramidal cells of rat hippocampal slices.

    abstract::1. The effects of gamma-aminobutyric acid (GABA) on non-GABAA receptors were investigated with intracellular recordings in CA1 pyramidal cells of rat hippocampal slices in the presence of antagonists of GABAA receptors (50 microM bicuculline and 50 microM picrotoxin), N-methyl-D-aspartate (NMDA) and non-NMDA receptors...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1996.76.1.69

    authors: Pham TM,Lacaille JC

    更新日期:1996-07-01 00:00:00

  • Nonselective cation channels coupled with tachykinin receptors in rat sensory neurons.

    abstract::1. Effects of substance P (SP) and other tachykinins on membrane currents were investigated using whole cell voltage clamp in cultured sensory neurons isolated from rat dorsal root ganglia. 2. SP (100 nM) evoked an inward current in two-thirds of the cells at negative potentials. In most of the cells that generated th...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1995.73.2.736

    authors: Inoue K,Nakazawa K,Inoue K,Fujimori K

    更新日期:1995-02-01 00:00:00

  • Integration of biphasic synaptic input by electrotonically coupled neuroendocrine caudodorsal cells in the pond snail.

    abstract::The ovulation hormone-producing caudodorsal cells (CDCs) of the pond snail Lymnaea stagnalis form two clusters of electrotonically coupled cells, each containing a few specialized (ventral) cells that connect the clusters. The hormone is secreted during a pacemaker-driven discharge. The CDCs receive a biphasic choline...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1983.49.6.1392

    authors: ter Maat A,Roubos EW,Lodder JC,Buma P

    更新日期:1983-06-01 00:00:00