Efficacy and Safety of Corticosteroid Implants in Non-infectious Uveitis: A Systematic Review with Network Meta-analysis.

Abstract:

BACKGROUND/AIMS:To compare different existent implants for noninfectious uveitis. METHODS:We performed a systematic review of randomized clinical trials (RCTs), searching in five electronic databases and screening reference lists of included studies and relevant reviews. We performed network meta-analysis to compare 0.18 mg fluocinolone acetonide implants, 0.70 mg and 0.35 mg dexamethasone implants, and sham procedures. RESULTS:Eight RCTs were included in this systematic review, of which three articles from two studies (n = 358 patients) were included in network meta-analysis. The 0.70 mg dexamethasone implant (at 1.5 months) was associated with better results than the 0.18 mg fluocinolone acetonide implant (at 1 month) at improving vitreous haze grading (RR = 2.96; 95%CI = 1.23-7.07), and with less frequently development of cataracts at 12 (RR = 0.36; 95%CI = 0.17; 0.79) and 36 months (RR = 0.37; 95%CI = 0.20; 0.71). CONCLUSIONS:In the short term, the 0.70 mg dexamethasone implant is superior at improving vitreous haze, and shows lower risk of cataracts. However, additional RCTs with standardized outcomes are needed.

journal_name

Ocul Immunol Inflamm

authors

Vieira R,Sousa-Pinto B,Figueira L

doi

10.1080/09273948.2020.1787463

subject

Has Abstract

pub_date

2020-08-18 00:00:00

pages

1-8

eissn

0927-3948

issn

1744-5078

pub_type

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