Childhood onset vulvar lichen sclerosus does not resolve at puberty: a prospective case series.

Abstract:

:When vulvar lichen sclerosus occurs in prepubertal children it is widely believed that it is likely to remit at puberty. However when it occurs in adult women it is accepted that remission is unlikely and that in addition untreated or inadequately treated disease may be complicated by significant disturbance of vulvar architecture and less commonly squamous cell carcinoma. Our database reveals 18 girls who developed lichen sclerosus prior to puberty who are now adolescents or young adults. Twelve have remained under surveillance and the other six patients have been lost to follow-up. We report a prospective series of these 12 patients. Three patients have achieved complete remission sustained for three or more years, all prior to menarche. Nine patients, or 75% of the cohort, who still had active lichen sclerosus at puberty continue to require maintenance therapy after menarche. Of the 12, six have had significant disturbance of vulvar architecture. The concept that prepubertal lichen sclerosus resolves at puberty would appear not to be true in the majority of patients. Even when diagnosed early and treated effectively, childhood onset lichen sclerosus may be complicated by distortion of vulvar architecture.

journal_name

Pediatr Dermatol

journal_title

Pediatric dermatology

authors

Smith SD,Fischer G

doi

10.1111/j.1525-1470.2009.01022.x

subject

Has Abstract

pub_date

2009-11-01 00:00:00

pages

725-9

issue

6

eissn

0736-8046

issn

1525-1470

pii

PDE1022

journal_volume

26

pub_type

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