Childhood pemphigus vulgaris treated with dapsone: a case report.

Abstract:

:A 5-year-old boy developed hemorrhagic mucocutaneous blisters on various parts of the body leading to fetor, dysphagia, dysuria, anal pruritus, pain on defecation, and weight loss. The histopathology showed the classic features of pemphigus vulgaris, and direct immunofluorescence showed intercellular deposition of IgG and C3 in the epidermis. Circulating pemphigus antibodies were also detected. He was treated with a combination of systemic prednisone and dapsone which induced a rapid remission and controlled the disease well. He has been in remission for 1 year and 7 months with no immunosuppressive therapy except for the use of topical agents for the oral lesions. An adjuvant to corticosteroids has been used only once before in children with pemphigus vulgaris under the age of 12 years. This is the third and the youngest child in the literature treated in this fashion.

journal_name

Pediatr Dermatol

journal_title

Pediatric dermatology

authors

Bjarnason B,Skoglund C,Flosadóttir E

doi

10.1046/j.1525-1470.1998.1998015381.x

subject

Has Abstract

pub_date

1998-09-01 00:00:00

pages

381-3

issue

5

eissn

0736-8046

issn

1525-1470

journal_volume

15

pub_type

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