A case of cutaneous mastocytosis in a child with prominent Langerhans cell infiltration.

Abstract:

:We recently encountered a 2-year-old boy with slightly infiltrative brown papules on the face, trunk, and extremities. Stroking of one of the papules produced an urticarial wheal (positive Darier's sign). Histopathologic tests revealed a dense infiltration of mast cells containing numerous granules and showing metachromasia under Toluidine blue staining. Immunohistochemical tests revealed that these cells were positive for CD68 and for c-kit. In addition, dermal dendritic cells that were positive for S100 and CD1a immunostaining were intermingled with the mast cells. We confirmed through electron microscopy that the dermal dendritic cells that were observed adjacent to the infiltration of mast cells had Birbeck granules in their cytoplasm, namely Langerhans cells. However, because of the greater numbers of mast cells than Langerhans cells, and because of the absence of both monomorphic LC proliferation and systemic symptoms of Langerhans cell histiocytosis, the present case favors a diagnosis of cutaneous mastocytosis in a child with Langerhans cell infiltration.

journal_name

Pediatr Dermatol

journal_title

Pediatric dermatology

authors

Mitsuya J,Hara H,Fukuda N,Terui T

doi

10.1111/j.1525-1470.2010.01205.x

subject

Has Abstract

pub_date

2011-07-01 00:00:00

pages

412-5

issue

4

eissn

0736-8046

issn

1525-1470

pii

PDE1205

journal_volume

28

pub_type

杂志文章
  • Goodbye warts, hello vitiligo: Candida antigen-induced depigmentation.

    abstract::Depigmentation after the use of topical immune modulators is a rare but reported event. Herein we present what is to our knowledge the first case of vitiligo at a site of Candida antigen injection. ...

    journal_title:Pediatric dermatology

    pub_type: 杂志文章

    doi:10.1111/pde.12049

    authors: Wilmer EN,Burkhart CN,Morrell DS

    更新日期:2013-11-01 00:00:00

  • Midline congenital cervical cleft mimicking linear scleroderma.

    abstract::Midline congenital cervical cleft is an extremely uncommon anomaly of the neck. Fewer than 100 cases have been reported. It is usually described as a cervical scar-like skin defect. We present a case of midline cervical cleft mimicking linear morphea and treated with topical steroids for 2 years. This is an unusual pr...

    journal_title:Pediatric dermatology

    pub_type: 杂志文章

    doi:10.1111/pde.12021

    authors: Méndez-Gallart R,Martinez EE,Rodríguez-Barca P,Nallib IA,Bautista-Casasnovas A

    更新日期:2013-07-01 00:00:00

  • Xanthomas and the inherited hyperlipoproteinemias in children and adolescents.

    abstract::Early recognition of the hyperlipoproteinemias is a crucial element in preventing premature coronary artery disease. Xanthomas provide a cutaneous marker of the silent, underlying pathology. Identifying them, and understanding their relation to the inherited hyperlipoproteinemias may facilitate early diagnosis of hype...

    journal_title:Pediatric dermatology

    pub_type: 杂志文章,评审

    doi:10.1111/j.1525-1470.1990.tb00275.x

    authors: Maher-Wiese VL,Marmer EL,Grant-Kels JM

    更新日期:1990-09-01 00:00:00

  • Diaper dermatitis prevalence and severity: Global perspective on the impact of caregiver behavior.

    abstract:OBJECTIVES:To compare prevalence and severity of diaper dermatitis (DD) in infants and toddlers (babies) across three countries (China, USA, and Germany), including diapered skin measures and caregiver practices. METHODS:A cross-sectional study of 1791 babies (~600 from each country) was recruited at each clinical sit...

    journal_title:Pediatric dermatology

    pub_type: 杂志文章

    doi:10.1111/pde.14047

    authors: Carr AN,DeWitt T,Cork MJ,Eichenfield LF,Fölster-Holst R,Hohl D,Lane AT,Paller A,Pickering L,Taieb A,Cui TY,Xu ZG,Wang X,Brink S,Niu Y,Ogle J,Odio M,Gibb RD

    更新日期:2020-01-01 00:00:00

  • Distal extremity necrosis as a manifestation of cutaneous polyarteritis nodosa: case report and review of the acute management of a pediatric patient.

    abstract::We present the case of an 8-year-old girl who presented with distal extremity necrosis of the hands, feet, nose, and ears as an acute manifestation of cutaneous polyarteritis nodosa (CPAN). She was emergently managed with intravenous steroids, nifedipine, sildenafil, pentoxifylline, nitroglycerin paste, aspirin, low-m...

    journal_title:Pediatric dermatology

    pub_type: 杂志文章,评审

    doi:10.1111/j.1525-1470.2011.01515.x

    authors: Williams VL,Guirola R,Flemming K,Modi GM,Rosales C,DeGuzman MM

    更新日期:2012-07-01 00:00:00

  • Ichthyosis: mechanisms of disease.

    abstract::The disorders of cornification (ichthyoses) comprise acquired and inherited disorders characterized clinically by generalized scaling and histologically by hyperkeratosis. They may arise through defects in the production or maintenance of a normal cornified cell compartment, or both. The stratum corneum is composed of...

    journal_title:Pediatric dermatology

    pub_type: 杂志文章,评审

    doi:10.1111/j.1525-1470.1992.tb00632.x

    authors: Williams ML

    更新日期:1992-12-01 00:00:00

  • Fetal Alcohol Exposure and PHACE Syndrome: A Case and Autopsy Report.

    abstract::This report describes the clinical, radiologic, and autopsy findings of a newborn with PHACE syndrome (posterior fossa malformations, hemangioma, arterial anomalies, cardiac defects, and eye anomalies) and fetal alcohol spectrum disorder. To our knowledge, the concurrence of these conditions has not been reported in t...

    journal_title:Pediatric dermatology

    pub_type:

    doi:10.1111/pde.12837

    authors: Oza VS,Feigenbaum DF,Jacquot C,Hess CP,Siegel D,Frieden IJ

    更新日期:2016-05-01 00:00:00

  • A patient with trisomy 13 mosaicism with an unusual skin pigmentary pattern and prolonged survival.

    abstract::Trisomy 13, or Patau syndrome, is a chromosomal disorder that can occur in complete, partial, or mosaic forms. Mosaicism is observed in 6% of individuals with trisomy 13 and, in contrast to the complete form, has wide phenotypic variability, longer survival, and in some patients an unusual skin pigmentary pattern simi...

    journal_title:Pediatric dermatology

    pub_type: 杂志文章

    doi:10.1111/pde.12339

    authors: González-del Angel A,Estandia-Ortega B,Gaviño-Vergara A,Sáez-de-Ocariz M,Velasco-Hernández Mde L,Salas-Labadía C

    更新日期:2014-09-01 00:00:00

  • Fibro-Osseous Pseudotumor of the Digits Mimicking Pyogenic Granuloma.

    abstract::Fibro-osseous pseudotumor of the digits is a benign neoplasm that originates in the soft tissue adjacent to the short bones of the hands and feet. We present a case in a 13-year-old girl that was initially misdiagnosed as pyogenic granuloma. Familiarity with this entity and imaging and histologic studies are necessary...

    journal_title:Pediatric dermatology

    pub_type: 杂志文章

    doi:10.1111/pde.13087

    authors: Gómez-Zubiaur A,Pericet-Fernández L,Vélez-Velázquez MD,Cabrera-Hernández A,Piteiro-Bermejo AB,Beá-Ardebol S,Medina-Montalvo S,Trasobares-Marugán L

    更新日期:2017-05-01 00:00:00

  • Familial Uncombable Hair Syndrome: Ultrastructural Hair Study and Response to Biotin.

    abstract::We report a family affected to the fourth generation by uncombable hair syndrome. This syndrome is characterized by unruly, dry, blond hair with a tangled appearance. The family pedigree strongly supports the hypothesis of autosomal dominant inheritance; some members of the family had, apart from uncombable hair, mino...

    journal_title:Pediatric dermatology

    pub_type: 杂志文章

    doi:10.1111/j.1525-1470.2007.00385.x

    authors: Boccaletti V,Zendri E,Giordano G,Gnetti L,De Panfilis G

    更新日期:2007-05-01 00:00:00

  • Papulolinear collagenoma with arborizing arrangement: report of a case.

    abstract::Connective tissue nevi of collagen type are now classified in four major subtypes. In addition to the clinicopathological features of papulolinear collagenoma, which is considered as a variant of isolated collagen harmatoma, the case we present has a unique arborizing pattern. ...

    journal_title:Pediatric dermatology

    pub_type: 杂志文章

    doi:10.1111/j.1525-1470.2008.00842.x

    authors: Lo LK,Tsai TF,Chen YF,Hung CM,Ko WC

    更新日期:2009-01-01 00:00:00

  • Familial progressive hypermelanosis in Indian monozygotic twins.

    abstract::Familial hyperpigmentation, or melanosis universalis hereditaria, is a rare hyperpigmentary disorder with onset in infancy. Here, we describe monozygotic twins with similar pattern of progressive hyperpigmentation with onset in early neonatal period without any family history. Histopathological examination showed incr...

    journal_title:Pediatric dermatology

    pub_type: 杂志文章

    doi:10.1111/j.1525-1470.2010.01361.x

    authors: Gupta N,Sharma MC,Ramam M,Kabra M

    更新日期:2011-01-01 00:00:00

  • Differential diagnoses of diaper dermatitis.

    abstract::Diaper dermatitis is the most common contact eczema present in early childhood. The main cause is an irritant reaction to urine and feces, which is facilitated by the occlusive conditions under the diaper, leading to hyperhydration of the stratum corneum (diaper dermatitis). In addition, diaper pressure and friction c...

    journal_title:Pediatric dermatology

    pub_type: 杂志文章,评审

    doi:10.1111/pde.13484

    authors: Fölster-Holst R

    更新日期:2018-03-01 00:00:00

  • Dramatic improvement of pyoderma gangrenosum with infliximab in a patient with PAPA syndrome.

    abstract::Infliximab, a chimeric antitumor necrosis factor alpha monoclonal antibody (anti-TNF alpha), has been recently shown to have a beneficial effect on pyoderma gangrenosum associated with inflammatory bowel disease. Patients with the syndromic triad of pyogenic sterile arthritis, pyoderma gangrenosum, and acne, an autoin...

    journal_title:Pediatric dermatology

    pub_type: 杂志文章

    doi:10.1111/j.1525-1470.2005.22320.x

    authors: Stichweh DS,Punaro M,Pascual V

    更新日期:2005-05-01 00:00:00

  • Perniosis in association with anorexia nervosa.

    abstract::Several dermatologic abnormalities have been described in anorexia nervosa, but only rare associations have been made with perniosis. We recently saw two teenage girls and one woman with anorexia nervosa who had symptoms of perniosis. We suggest that altered thermoregulation and a hyperreactive peripheral vascular res...

    journal_title:Pediatric dermatology

    pub_type: 杂志文章

    doi:10.1111/j.1525-1470.1994.tb00063.x

    authors: White KP,Rothe MJ,Milanese A,Grant-Kels JM

    更新日期:1994-03-01 00:00:00

  • Infantile toxic epidermal necrolysis: Successful treatment of an 8-week-old with intravenous immunoglobulin and amniotic membrane transplant.

    abstract::Stevens-Johnson syndrome and toxic epidermal necrolysis comprise a spectrum of severe mucocutaneous hypersensitivity reactions. A paucity of data limits current understanding of the etiology, treatment options, and prognosis of this entity in the infantile population compared to that in the adult and pediatric literat...

    journal_title:Pediatric dermatology

    pub_type:

    doi:10.1111/pde.14376

    authors: Nassim JS,Karim SA,Grenier PO,Schmidt B,Jones KM

    更新日期:2020-10-30 00:00:00

  • Verruciform xanthoma in a patient with recessive dystrophic epidermolysis bullosa: Case report and literature review.

    abstract::Verruciform xanthoma (VX) is a rare finding thought to be caused by epidermal damage from trauma or inflammation and has been reported in a limited number of patients with recessive dystrophic epidermolysis bullosa (RDEB). Herein, we describe a 20-year-old woman with RDEB who developed a large, verrucous, pink plaque ...

    journal_title:Pediatric dermatology

    pub_type: 杂志文章

    doi:10.1111/pde.14079

    authors: Stephens M,Rubin AI,Perman MJ

    更新日期:2020-03-01 00:00:00

  • Sacral hemangioma with sinus tract in an infant.

    abstract::Congenital midline cutaneous lesions should always alert the clinician to the possibility of spinal dysraphism. These lesions can take many different forms. The physician should be cognizant of such lesions in order to avoid potential neurologic complications. We present a patient with a midline sacral hemangioma asso...

    journal_title:Pediatric dermatology

    pub_type: 杂志文章

    doi:10.1046/j.1525-1470.2003.20307.x

    authors: Winstanley D,Graham B,Blair M,Linfesty R,Tomita S,Matthews J

    更新日期:2003-05-01 00:00:00

  • Propranolol-resistant infantile hemangioma successfully treated with sirolimus.

    abstract::Infantile hemangiomas are the most common benign vascular tumors in childhood. Propranolol is the first-line treatment for infantile hemangiomas, but failures may occur. Sirolimus, an mTOR inhibitor, is a promising drug for the treatment of vascular malformations and vascular tumors. We present the case of a child wit...

    journal_title:Pediatric dermatology

    pub_type:

    doi:10.1111/pde.14163

    authors: Dávila-Osorio VL,Iznardo H,Roé E,Puig L,Baselga E

    更新日期:2020-07-01 00:00:00

  • Rothmund-Thomson syndrome with myelodysplasia.

    abstract::Rothmund-Thomson syndrome (RTS) is a rare autosomal recessive disorder that is caused by a DNA repair defect. It is characterized mainly by skin, eye, and skeletal abnormalities. Cutaneous changes appear at between 3 and 6 months of age and include poikiloderma, photosensitivity, scaling, hyperkeratosis, and disturban...

    journal_title:Pediatric dermatology

    pub_type: 杂志文章

    doi:10.1046/j.1525-1470.2001.018003210.x

    authors: Narayan S,Fleming C,Trainer AH,Craig JA

    更新日期:2001-05-01 00:00:00

  • Eccrine angiomatous hamartoma: a report of symmetric and painful lesions of the wrists.

    abstract::Eccrine angiomatous hamartoma (EAH) is a rare, benign cutaneous lesion histologically defined as a proliferation of eccrine glands within a closely associated vascular stroma. Typically EAH presents as a solitary flesh-colored, hyperhidrotic, painful papule or plaque appearing at birth or during childhood. Only two pr...

    journal_title:Pediatric dermatology

    pub_type: 杂志文章,评审

    doi:10.1046/j.1525-1470.2001.018002117.x

    authors: Morrell DS,Ghali FE,Stahr BJ,McCauliffe DP

    更新日期:2001-03-01 00:00:00

  • Perianal striated muscle hamartoma associated with hemangioma.

    abstract::Striated muscle hamartoma is a rare entity which was described only recently. It is a congenital malformation characterized by the presence of striated, mature muscle fibers in the reticular dermis and hypodermis. We describe a striated muscle hamartoma of the perianal region in a female infant associated with an hema...

    journal_title:Pediatric dermatology

    pub_type: 杂志文章,评审

    doi:10.1046/j.1525-1470.1998.1998015274.x

    authors: Scrivener Y,Petiau P,Rodier-Bruant C,Cribier B,Heid E,Grosshans E

    更新日期:1998-07-01 00:00:00

  • Endemic pemphigus foliaceus in Venezuela: report of two children.

    abstract::Two native Yanomami children from the Venezuelan Amazonia with erythroderma were hospitalized on our service. Clinical, histologic, and immunofluorescence studies diagnosed endemic pemphigus foliaceous. Human leukocyte antigen class II showed DRB1*04 subtype *0411, which has not been previously associated with this di...

    journal_title:Pediatric dermatology

    pub_type: 杂志文章

    doi:10.1111/j.1525-1470.2006.00197.x

    authors: González F,Sáenz AM,Cirocco A,Tacaronte IM,Fajardo JE,Calebotta A

    更新日期:2006-03-01 00:00:00

  • Accessory tragus: Report of a case in a rare location on the nasal vestibule.

    abstract::A case of an accessory tragus located on the nasal vestibule is reported. This represents the third case of this entity located outside of a derivative of a branchial arch. All three of these cases were located in the nose/glabella region. ...

    journal_title:Pediatric dermatology

    pub_type: 杂志文章

    doi:10.1111/pde.14090

    authors: Moradi S,Castiglione C,Ehrig T

    更新日期:2020-03-01 00:00:00

  • Congenital nevocytic nevi: follow-up of a Swedish birth register sample regarding etiologic factors, discomfort, and removal rate.

    abstract::Congenital nevi both small and large are frequently removed. We attempted to study the removal rate and etiologic aspects of congenital nevi as well as their psychosocial effects through the use of a quality test. A questionnaire sent to a sample population of individuals with congenital nevocytic nevi (n=192) collect...

    journal_title:Pediatric dermatology

    pub_type: 杂志文章

    doi:10.1046/j.1525-1470.2002.00086.x

    authors: Berg P,Lindelöf B

    更新日期:2002-07-01 00:00:00

  • Clinical and Laboratory Characteristics of a Tinea Capitis Outbreak Among Novice Buddhist Monks.

    abstract::Sixty novice Buddhist monks with tinea capitis confirmed according to clinical presentation and mycological laboratory finding were included in this study. Mixed-type clinical presentation was observed in approximately half of all cases, together with scarring alopecia (95%) and superficial fungal skin infection at lo...

    journal_title:Pediatric dermatology

    pub_type: 杂志文章

    doi:10.1111/pde.13102

    authors: Bunyaratavej S,Leeyaphan C,Rujitharanawong C,Muanprasat C,Matthapan L

    更新日期:2017-05-01 00:00:00

  • Erythema nodosum in association with celiac disease.

    abstract::We present a 16-year-old girl with a 4-year history of chronic persistent erythema nodosum. Recurrently low serum iron values suggested the possibility of a malabsorption syndrome. The presence of antitransglutaminase and antiendomysium antibodies and the jejunal biopsy specimen findings showed an underlying celiac di...

    journal_title:Pediatric dermatology

    pub_type: 杂志文章

    doi:10.1111/j.0736-8046.2004.21307.x

    authors: Bartyik K,Várkonyi A,Kirschner A,Endreffy E,Túri S,Karg E

    更新日期:2004-05-01 00:00:00

  • Fixed drug eruption in the genital area in 15 boys.

    abstract::Fixed drug eruption (FDE) is manifested as localized, circumscribed, round or oval plaques that characteristically recur in the same site with each use of the offending drug. The drugs most commonly implicated are phenolphthalein, barbiturates, antibiotics, salicylates, contraceptives, and anticonvulsants. FDE can app...

    journal_title:Pediatric dermatology

    pub_type: 杂志文章

    doi:10.1046/j.1525-1470.2002.00078.x

    authors: Nussinovitch M,Prais D,Ben-Amitai D,Amir J,Volovitz B

    更新日期:2002-05-01 00:00:00

  • Psoriasiform acral dermatitis: a peculiar clinical presentation of psoriasis in children.

    abstract::Recently an unusual chronic dermatosis, considered a new clinical entity and closely resembling psoriasis, has been described in the literature under the term psoriasiform acral dermatitis (PAD). It is characterized by cutaneous involvement of the digits without nail dystrophy. We describe three young patients, ages 6...

    journal_title:Pediatric dermatology

    pub_type: 杂志文章,评审

    doi:10.1046/j.1525-1470.1999.00099.x

    authors: Patrizi A,Bardazzi F,Neri I,Fanti PA

    更新日期:1999-11-01 00:00:00

  • Levels of interleukin-18 and endothelin-1 in children with Henoch-Schönlein purpura: a study from northern India.

    abstract::Henoch-Schönlein purpura (HSP) is an acute systemic vasculitis with unknown etiology, although several studies have found HSP to be related to cytokines such as tumor necrosis factor α, interleukin (IL)-1, and adhesion molecules. In the present study we determined the levels of cytokines such as IL-18 and endothelin-1...

    journal_title:Pediatric dermatology

    pub_type: 杂志文章

    doi:10.1111/pde.12222

    authors: Mahajan N,Kapoor D,Bisht D,Singh S,Minz RW,Dhawan V

    更新日期:2013-11-01 00:00:00