Dramatic improvement of pyoderma gangrenosum with infliximab in a patient with PAPA syndrome.

Abstract:

:Infliximab, a chimeric antitumor necrosis factor alpha monoclonal antibody (anti-TNF alpha), has been recently shown to have a beneficial effect on pyoderma gangrenosum associated with inflammatory bowel disease. Patients with the syndromic triad of pyogenic sterile arthritis, pyoderma gangrenosum, and acne, an autoinflammatory process caused by mutations in the CD2 binding protein-1 (CD2BP1) gene, can have severe pyoderma gangrenosum. We describe a 14-year-old patient with this syndrome who was unresponsive to multiple therapies. A dramatic improvement in his pyoderma gangrenosum was observed after one infusion of infliximab, and a second infusion led to its resolution. Our observation extends the therapeutic use of infliximab to this component of PAPA syndrome.

journal_name

Pediatr Dermatol

journal_title

Pediatric dermatology

authors

Stichweh DS,Punaro M,Pascual V

doi

10.1111/j.1525-1470.2005.22320.x

subject

Has Abstract

pub_date

2005-05-01 00:00:00

pages

262-5

issue

3

eissn

0736-8046

issn

1525-1470

pii

PDE22320

journal_volume

22

pub_type

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