Profile and outcome of childhood mycosis fungoides in Singapore.

Abstract:

:Mycosis fungoides (MF) is the most common form of cutaneous T-cell lymphoma. It usually occurs in middle-aged and elderly persons, although several reports have described its occurrence in young children. The aim of this study was to review the profile and outcome of childhood MF in Singapore from 1989 to 1998. A total of nine patients (six males and three females) were diagnosed with MF before the age of 21 years. There were four Chinese, four Malay, and one Indian. The age at the time of histologic diagnosis ranged from 6 to 20 years (mean 14.3 years). Eight of the nine patients presented with hypopigmented patches and plaques. According to TNM staging, three were in stage 1A and six in stage 1B. The treatment modalities included psoralen plus ultraviolet A (PUVA) (n = 5), UVB (n = 2), and potent topical steroids (n = 2). We found that PUVA induced a faster clinical remission, but maintenance PUVA was required to prolong the relapse-free interval. This study also highlighted the need to consider MF in the differential diagnosis of hypopigmented dermatoses in dark-skinned individuals, especially if they occur on the buttocks.

journal_name

Pediatr Dermatol

journal_title

Pediatric dermatology

authors

Tan E,Tay YK,Giam YC

doi

10.1046/j.1525-1470.2000.017005352.x

subject

Has Abstract

pub_date

2000-09-01 00:00:00

pages

352-6

issue

5

eissn

0736-8046

issn

1525-1470

journal_volume

17

pub_type

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