Streptococcal exanthem in a blaschkolinear pattern: clinical evidence for genetic mosaicism in hypomelanosis of ito.

Abstract:

:Due to the presence of two different clones of cells in early embryogenesis, numerous congenital and acquired dermatoses have a linear distribution following the lines of Blaschko. Acquired inflammatory skin diseases are rarely observed in linear patterns. Our patient was born with macrocephaly, left eye glaucoma, and a left facial and contralateral corporal hemihypertrophy, cerebral dysgenesis, and skeletal abnormalities. Hypopigmented S-shaped linear macules on the trunk and linear streaks on the arms and legs were compatible with hypomelanosis of Ito. At 5 years of age the patient presented with an erythematous follicular exanthem compatible with scarlet fever exclusively in the lines of Blaschko. This fact suggests a genetic mosaicism.

journal_name

Pediatr Dermatol

journal_title

Pediatric dermatology

authors

Durán-McKinster C,Moises C,Rodríguez-Jurado R,Tamayo-Sánchez L,Orozco-Covarrubias L,Ruiz-Maldonado R

doi

10.1046/j.1525-1470.2002.00119.x

subject

Has Abstract

pub_date

2002-09-01 00:00:00

pages

423-5

issue

5

eissn

0736-8046

issn

1525-1470

pii

0119

journal_volume

19

pub_type

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