Abstract:
:Childhood lichen sclerosus (LS) is a rare and often misdiagnosed inflammatory dermatitis with an unpredictable course. The complications of LS are architectural changes of the vulva; malignant transformation is possible. The objective of our study was to define the background and the long-term course of childhood LS. A registery study identified 44 children with LS treated at Tampere University Hospital, Tampere, Finland, from 1982 to 2010. A questionnaire was sent to the identified patients and 15 responded. The clinical depiction of LS varied significantly. LS was diagnosed in only 16% of the patients at the referring unit. Autoimmune disorders were observed in 6 of the 44 patients. High prevalences of Turner's syndrome (2/44) and kidney disease (2/44) were noted. The majority of the patients were treated with topical corticosteroids. Eight developed architectural changes of the vulva. The questionnaire revealed that three of six patients who were asymptomatic at the end of the registery study follow-up experienced a recurrence of symptoms. None of them were undergoing follow-up. Nine of the 15 patients reported reduced quality of life. Childhood LS is a heterogeneous disease with a remarkable effect on quality of life. The misdiagnosis of childhood LS is common. The association between LS and autoimmune diseases should be noted. The high prevalence of Turner's syndrome raises questions regarding the influence of low estrogen levels on the development of LS. The prognosis cannot be predicted, so long-term follow-up is recommended. New tools for diagnosis and surveillance are needed.
journal_name
Pediatr Dermatoljournal_title
Pediatric dermatologyauthors
Lagerstedt M,Karvinen K,Joki-Erkkilä M,Huotari-Orava R,Snellman E,Laasanen SLdoi
10.1111/pde.12109subject
Has Abstractpub_date
2013-07-01 00:00:00pages
444-50issue
4eissn
0736-8046issn
1525-1470journal_volume
30pub_type
杂志文章abstract::A 2-year-old boy had hundreds of discrete, small, flat yellow to brown colored papules distributed over the face, neck, and trunk. Biopsy revealed a well-demarcated infiltrate within the papillary dermis composed of histiocytes and some Touton giant cells and eosinophils. The cells were negative for protein S-100 and ...
journal_title:Pediatric dermatology
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abstract::Congenital nevi both small and large are frequently removed. We attempted to study the removal rate and etiologic aspects of congenital nevi as well as their psychosocial effects through the use of a quality test. A questionnaire sent to a sample population of individuals with congenital nevocytic nevi (n=192) collect...
journal_title:Pediatric dermatology
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doi:10.1046/j.1525-1470.2002.00086.x
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journal_title:Pediatric dermatology
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journal_title:Pediatric dermatology
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更新日期:1997-05-01 00:00:00
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journal_title:Pediatric dermatology
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abstract::This article reviews skin changes occurring in diabetic children. Skin changes may be related to metabolic alterations associated with diabetes. Others may be manifestations of macro or microvascular disease. Insulin injections, required for management of most diabetes in the pediatric age group, may also cause cutane...
journal_title:Pediatric dermatology
pub_type: 杂志文章,评审
doi:10.1111/j.1525-1470.1985.tb01047.x
更新日期:1985-03-01 00:00:00
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journal_title:Pediatric dermatology
pub_type: 杂志文章
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abstract::A male infant with skin lesions was born to a 28-year-old mother who was under treatment for pemphigus vulgaris (PV), diagnosed eight years earlier. Circulating IgG class pemphigus antibody was found in the infant's blood, and deposition of IgG in the intercellular spaces of the epidermis was seen. The infant's lesion...
journal_title:Pediatric dermatology
pub_type: 杂志文章
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journal_title:Pediatric dermatology
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journal_title:Pediatric dermatology
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journal_title:Pediatric dermatology
pub_type: 杂志文章
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更新日期:1994-09-01 00:00:00
abstract::Lichen planus is an uncommonly encountered dermatosis in children. In the present study of 50 children the limbs were the most common site of involvement (70.0%). A majority of the children (60.0%) presented with the classic form of the disease. Hypertrophic lesions were present in 26.0% of children while linear lesio...
journal_title:Pediatric dermatology
pub_type: 杂志文章,评审
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更新日期:1999-09-01 00:00:00
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doi:10.1111/j.1525-1470.2007.00433.x
更新日期:2007-07-01 00:00:00
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journal_title:Pediatric dermatology
pub_type: 杂志文章
doi:10.1111/j.1525-1470.2011.01665.x
更新日期:2013-03-01 00:00:00
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journal_title:Pediatric dermatology
pub_type: 杂志文章
doi:10.1111/pde.13920
更新日期:2020-01-01 00:00:00
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journal_title:Pediatric dermatology
pub_type: 杂志文章,评审
doi:10.1111/pde.13652
更新日期:2018-11-01 00:00:00
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journal_title:Pediatric dermatology
pub_type: 杂志文章
doi:10.1111/j.1525-1470.2011.01507.x
更新日期:2012-09-01 00:00:00
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journal_title:Pediatric dermatology
pub_type: 杂志文章,评审
doi:10.1111/j.1525-1470.2008.00669.x
更新日期:2008-05-01 00:00:00
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journal_title:Pediatric dermatology
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journal_title:Pediatric dermatology
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journal_title:Pediatric dermatology
pub_type: 杂志文章
doi:10.1111/j.1525-1470.1993.tb00368.x
更新日期:1993-09-01 00:00:00
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journal_title:Pediatric dermatology
pub_type: 杂志文章
doi:10.1111/j.1525-1470.1985.tb00474.x
更新日期:1985-07-01 00:00:00
abstract:BACKGROUND/OBJECTIVES:Loose anagen syndrome (LAS) is a disorder of abnormal anchorage of the hair to the scalp. Its symptoms include an inability to grow hair long and hair that is easily pulled out. METHODS:We conducted a retrospective chart review of patients with LAS over the last 10 years at the Children's Hospita...
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pub_type: 杂志文章
doi:10.1111/pde.12912
更新日期:2016-09-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2000-09-01 00:00:00
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pub_type: 杂志文章,评审
doi:10.1111/pde.12007
更新日期:2014-05-01 00:00:00
abstract::Loose anagen hair syndrome (LAHS) is an uncommonly reported autosomal dominant hair disorder with incomplete penetrance that primarily affects children but is occasionally seen in adults. LAHS is characterized by the ability to easily and painlessly extract unsheathed anagen hairs from the scalp with gentle traction. ...
journal_title:Pediatric dermatology
pub_type: 杂志文章
doi:10.1111/pde.12208
更新日期:2013-09-01 00:00:00