Abstract:
:1. Intracellular recordings were made in 427 phrenic motoneurons from kittens (in four stages of postnatal development, ranging from 2 to 14 wk) and in 72 motoneurons from adult cats. These experiments were performed to determine how the pattern of spontaneous discharge changes in phrenic motoneurons during development and how these changes might be influenced by alterations in the electrophysiological properties of these neurons. 2. The mean axonal conduction velocity increased significantly (P less than 0.0001) throughout this period of development, with the most rapid increase occurring between weeks 2 and 5 (18.5 +/- 5.4 and 32.4 +/- 5.6 m/s, respectively, mean +/- SD). 3. There was no change in the magnitude of the membrane potential, antidromic action potential, or positive overshoot; whereas there was a decrease in the half-width of the action potential from 2 (652 +/- 184 ms) to 14 (525 +/- 116 ms) wk postnatal. 4. The mean duration of the afterhyperpolarization (AHPdur) decreased from 69 +/- 20 ms at 2 wk to 60 +/- 16 ms by 9 wk, then increased to 66 +/- 18 ms by 14 wk of age and to 75 +/- 21 ms in the adult. The mean amplitude of the afterhyperpolarization (AHPamp) in the 2-wk-old group (4.9 +/- 1.8 mV) was larger than that at weeks 5 (3.9 +/- 1.7 mV) and 9 (3.9 +/- 1.6 mV), whereas the mean AHPamp of the adult (3.1 +/- 1.2 mV) was significantly smaller than the mean of any younger group. A significant negative correlation was found between AHPdur and axonal conduction velocity in all age groups studied, including the adult.(ABSTRACT TRUNCATED AT 250 WORDS)
journal_name
J Neurophysioljournal_title
Journal of neurophysiologyauthors
Cameron WE,Jodkowski JS,Fang H,Guthrie RDdoi
10.1152/jn.1991.65.3.671subject
Has Abstractpub_date
1991-03-01 00:00:00pages
671-9issue
3eissn
0022-3077issn
1522-1598journal_volume
65pub_type
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