Abstract:
OBJECTIVE:Previous studies have suggested that diabetes increases the risk of Parkinson disease (PD); however, this has not been conclusively established. We analyzed the risk of PD based on baseline glucose tolerance status in a large-scale cohort representative of the general Korean population. RESEARCH DESIGN AND METHODS:This analysis was performed in a cohort of 15,168,021 adults aged ≥40 years who underwent health checkups under the National Health Insurance Service between January 2009 and December 2010. The clinical course of subjects was monitored until December 2016. Subjects were classified into the following groups: no diabetes, impaired fasting glucose (IFG), diabetes duration <5 years, and diabetes duration ≥5 years. We analyzed the adjusted hazard ratio of PD for each group. RESULTS:During the observation period of 49,076,148.74 person-years, PD occurred in 31,577 patients. Compared with the nondiabetes group, the adjusted hazard ratio was 1.038 (95% CI, 1.009-1.067) in the IFG group, 1.185 (95% CI, 1.143-1.229) in the diabetes duration <5 years group, and 1.618 (95% CI, 1.566-1.672) in the diabetes duration ≥5 years group. These results were consistent with those of the subgroup analysis, and the presence of diabetes further increased the risk of PD regardless of comorbidities such as cardiovascular, cerebrovascular, and chronic kidney diseases. CONCLUSIONS:This population-based cohort study suggests that diabetes is an independent risk factor for PD.
journal_name
Diabetes Carejournal_title
Diabetes careauthors
Rhee SY,Han KD,Kwon H,Park SE,Park YG,Kim YH,Yoo SJ,Rhee EJ,Lee WYdoi
10.2337/dc19-0760subject
Has Abstractpub_date
2020-09-01 00:00:00pages
2169-2175issue
9eissn
0149-5992issn
1935-5548pii
dc19-0760journal_volume
43pub_type
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