Abstract:
:Neural degeneration in glaucoma involves retinal ganglion cells and neurons of their major target, the lateral geniculate nucleus (LGN). Dendrites of relay LGN neurons projecting to the visual cortex were studied by immunocytochemical and quantitative Sholl analysis in combination with confocal microscopy and 3D-morphometry. In non-human adult primate glaucoma, relay LGN neurons showed reduced dendrite complexity and length, and these changes were modified by NMDA receptor blockade. Dendrite plasticity of LGN relay neurons in adult primate glaucoma has implications for potential disease modification by treatment interventions.
journal_name
Vision Resjournal_title
Vision researchauthors
Ly T,Gupta N,Weinreb RN,Kaufman PL,Yücel YHdoi
10.1016/j.visres.2010.08.003subject
Has Abstractpub_date
2011-01-28 00:00:00pages
243-50issue
2eissn
0042-6989issn
1878-5646pii
S0042-6989(10)00377-9journal_volume
51pub_type
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