Dendrite plasticity in the lateral geniculate nucleus in primate glaucoma.

Abstract:

:Neural degeneration in glaucoma involves retinal ganglion cells and neurons of their major target, the lateral geniculate nucleus (LGN). Dendrites of relay LGN neurons projecting to the visual cortex were studied by immunocytochemical and quantitative Sholl analysis in combination with confocal microscopy and 3D-morphometry. In non-human adult primate glaucoma, relay LGN neurons showed reduced dendrite complexity and length, and these changes were modified by NMDA receptor blockade. Dendrite plasticity of LGN relay neurons in adult primate glaucoma has implications for potential disease modification by treatment interventions.

journal_name

Vision Res

journal_title

Vision research

authors

Ly T,Gupta N,Weinreb RN,Kaufman PL,Yücel YH

doi

10.1016/j.visres.2010.08.003

subject

Has Abstract

pub_date

2011-01-28 00:00:00

pages

243-50

issue

2

eissn

0042-6989

issn

1878-5646

pii

S0042-6989(10)00377-9

journal_volume

51

pub_type

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