Aspartate-induced dissociation of proximal from distal retinal activity in the mudpuppy.

Abstract:

:The effects of aspartate (Asp) on the ERG and on neuronal, glial, and K+ responses were monitored continuously in the superfused mudpuppy eyecup. Asp induced a time-dependent sequence of events which may be divided into three stages: Stage 1, initially, light-evoked responses throughout the retina are depressed; Stage 2, distal responses (horizontal, bipolar, and K+ responses) return to near pre-drug amplitudes and there is a simultaneous ERG enhancement, but responses in the proximal retina remain suppressed; Stage 3, a second depression of retinal responses leads to a-wave isolation. The dissociation of distal from proximal responses observed during Stage 2 strongly supports the hypothesis that the ERG b-wave results from events arising in the distal retinal network.

journal_name

Vision Res

journal_title

Vision research

authors

Shimazaki H,Karwoski CJ,Proenza LM

doi

10.1016/0042-6989(84)90113-5

subject

Has Abstract

pub_date

1984-01-01 00:00:00

pages

587-95

issue

6

eissn

0042-6989

issn

1878-5646

pii

0042-6989(84)90113-5

journal_volume

24

pub_type

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