Focal cone ERGs of rhodopsin Pro347Leu transgenic rabbits.

Abstract:

:A rhodopsin P347L transgenic (Tg) rabbit, a model of retinitis pigmentosa, has been generated in our laboratory. The purpose of this study was to determine the properties of focal areas of the retina in this rabbit model during the course of retinal degeneration. To accomplish this, we recorded focal ERGs from wild-type (WT) and Tg rabbits at ages 3, 6, and 12 months. A 15° stimulus spot was used to elicit the focal ERGs from the center of the visual streak and from four surrounding areas. We found that the amplitudes of the focal cone ERG b-waves and oscillatory potentials (OPs) of the Tg rabbits in the five areas decreased progressively with increasing age and became almost non-recordable at 12 months. There were no significant regional differences in the b-waves of Tg rabbits recorded from the 5 areas. The amplitudes of the OPs were better preserved than the b-waves and the OPs/b-wave ratio was higher than that in WT rabbits at every recording area. The summed OPs amplitudes, which most likely originate from the amacrine and/or ganglion cells, recorded from the area superior to the optic disc was significantly larger than that from other areas at 3- and 6-months-old. This indicated that the inner retinal neurons were not altered equally after photoreceptor degeneration in this rabbit model.

journal_name

Vision Res

journal_title

Vision research

authors

Ueno S,Koyasu T,Kominami T,Sakai T,Kondo M,Yasuda S,Terasaki H

doi

10.1016/j.visres.2013.08.006

subject

Has Abstract

pub_date

2013-10-18 00:00:00

pages

118-23

eissn

0042-6989

issn

1878-5646

pii

S0042-6989(13)00215-0

journal_volume

91

pub_type

杂志文章
  • Working memory can guide pop-out search.

    abstract::Top-down feedback from working memory (WM) can exert an early and involuntary influence on visual selection for targets that are relatively difficult to discriminate [Soto, D., Heinke, D., Humphreys, G. W., & Blanco, M. J. (2005) Journal of Experimental Psychology: Human Perception and Performance, 31, 248]. Here, we ...

    journal_title:Vision research

    pub_type: 杂志文章

    doi:10.1016/j.visres.2005.09.008

    authors: Soto D,Humphreys GW,Heinke D

    更新日期:2006-03-01 00:00:00

  • Comparing the retinal structures and functions in two species of gulls (Larus delawarensis and Larus modestus) with significant nocturnal behaviours.

    abstract::Ring-billed gulls (Larus delawarensis) and gray gulls (Larus modestus) are two species active both by day and night. We have investigated the retinal adaptations that allow the diurnal and nocturnal behaviours of these two species. Electroretinograms and histological analyses show that both species have a duplex retin...

    journal_title:Vision research

    pub_type: 杂志文章

    doi:10.1016/j.visres.2006.02.023

    authors: Emond MP,McNeil R,Cabana T,Guerra CG,Lachapelle P

    更新日期:2006-09-01 00:00:00

  • Cellular pattern formation during retinal regeneration: a role for homotypic control of cell fate acquisition.

    abstract::A dominant mechanism of cellular patterning in the growing fish retina is control of cell fate acquisition by negative feedback signals arising from differentiated cells. We tested the ability of a computational model of this pattern formation mechanism to simulate cellular patterns in regenerated goldfish retina. The...

    journal_title:Vision research

    pub_type: 杂志文章

    doi:10.1016/j.visres.2006.08.025

    authors: Tyler MJ,Cameron DA

    更新日期:2007-02-01 00:00:00

  • Psychophysics of reading. XVIII. The effect of print size on reading speed in normal peripheral vision.

    abstract::Reading in peripheral vision is slow and requires large print, posing substantial difficulty for patients with central scotomata. The purpose of this study was to evaluate the effect of print size on reading speed at different eccentricities in normal peripheral vision. We hypothesized that reading speeds should remai...

    journal_title:Vision research

    pub_type: 杂志文章

    doi:10.1016/s0042-6989(98)00072-8

    authors: Chung ST,Mansfield JS,Legge GE

    更新日期:1998-10-01 00:00:00

  • "Lens mitochondria" in the retinal cones of the tree-shrew Tupaia belangeri.

    abstract::In all mammals, the mitochondria of the cones of the retina are concentrated in the inner segment. Uniquely in tree-shrews (Tupaia, Scandentia, Mammalia), a "megamitochondrion" exhibiting highly specialized systems of densely packed cristae and a very electron dense matrix, is located apically in the inner segment. Th...

    journal_title:Vision research

    pub_type: 杂志文章

    doi:10.1016/s0042-6989(96)00199-x

    authors: Knabe W,Skatchkov S,Kuhn HJ

    更新日期:1997-02-01 00:00:00

  • ON and OFF field potentials in the rat superior colliculus during development.

    abstract::The present investigation is aimed at characterizing the development of ON and OFF visually evoked responses in the rat superior colliculus from postnatal day 13 (P13) to postnatal day 25. Depth profiles of field potentials reveal that ON and OFF long latency biphasic field potentials are already present when collicul...

    journal_title:Vision research

    pub_type: 杂志文章

    doi:10.1016/s0042-6989(97)00145-4

    authors: Fortin S,Itaya SK,Chemtob S,Molotchnikoff S

    更新日期:1997-11-01 00:00:00

  • Factors limiting the postnatal development of visual acuity in the monkey.

    abstract::A major factor underlying the prolonged postnatal improvement of visual acuity in primates is an increase in the sampling limit imposed by the photoreceptor mosaic, which may be as much as 5-fold. Further factors operating peripheral to neurons of the lateral geniculate nucleus, which might include changes in neural c...

    journal_title:Vision research

    pub_type: 杂志文章

    doi:10.1016/0042-6989(88)90104-6

    authors: Jacobs DS,Blakemore C

    更新日期:1988-01-01 00:00:00

  • Perceived motion in depth.

    abstract::We examine how various sources of information contribute to the percept of motion in depth. Subjects were presented with targets moving in depth, and were asked to judge their velocities and final positions. On each presentation, the target's position relative to the two eyes (target vergence), the size of the target'...

    journal_title:Vision research

    pub_type: 杂志文章

    doi:10.1016/0042-6989(95)00146-8

    authors: Brenner E,Van Den Berg AV,Van Damme WJ

    更新日期:1996-03-01 00:00:00

  • Irrational contour synthesis.

    abstract::The mechanisms responsible for generating illusory contours are thought to fulfil an adaptive role in providing estimates of missing contour fragments generated by partial camouflage. One striking apparent counter-example to this view was described in Current Biology 21 (2011) 492-496, which showed that illusory conto...

    journal_title:Vision research

    pub_type: 杂志文章

    doi:10.1016/j.visres.2019.02.014

    authors: Anderson BL,Tan K,Marlow PJ

    更新日期:2019-05-01 00:00:00

  • Nothing more than a pair of curvatures: A common mechanism for the detection of both radial and non-radial frequency patterns.

    abstract::Radial frequency (RF) patterns, which are sinusoidal modulations of a radius in polar coordinates, are commonly used to study shape perception. Previous studies have argued that the detection of RF patterns is either achieved globally by a specialized global shape mechanism, or locally using as cue the maximum tangent...

    journal_title:Vision research

    pub_type: 杂志文章

    doi:10.1016/j.visres.2017.03.005

    authors: Schmidtmann G,Kingdom FAA

    更新日期:2017-05-01 00:00:00

  • Contrast masking in strabismic amblyopia: attenuation, noise, interocular suppression and binocular summation.

    abstract::To investigate amblyopic contrast vision at threshold and above we performed pedestal-masking (contrast discrimination) experiments with a group of eight strabismic amblyopes using horizontal sinusoidal gratings (mainly 3c/deg) in monocular, binocular and dichoptic configurations balanced across eye (i.e. five conditi...

    journal_title:Vision research

    pub_type: 杂志文章

    doi:10.1016/j.visres.2008.04.017

    authors: Baker DH,Meese TS,Hess RF

    更新日期:2008-07-01 00:00:00

  • The aperture problem--I. Perception of nonrigidity and motion direction in translating sinusoidal lines.

    abstract::To examine how local velocities from different regions of the visual field combine to form a coherent motion percept, we subjected a sinusoidal line stimulus to translational motion. Horizontal movement of a sinewave line along its axial direction is perceived as nonrigid if the angle at the zero crossing is smaller t...

    journal_title:Vision research

    pub_type: 杂志文章

    doi:10.1016/0042-6989(88)90052-1

    authors: Nakayama K,Silverman GH

    更新日期:1988-01-01 00:00:00

  • Population coding under normalization.

    abstract::A common computation in visual cortex is the divisive normalization of responses by a pooled signal of the activity of cells within its neighborhood. From a geometrical point of view, normalization constraints the population response to high-contrast stimuli to lie on the surface of a high-dimensional sphere. Here we ...

    journal_title:Vision research

    pub_type: 杂志文章

    doi:10.1016/j.visres.2009.12.007

    authors: Ringach DL

    更新日期:2010-10-28 00:00:00

  • The effect of various anaesthetics on the spatial tuning of two major wave peaks in the transient pattern electroretinogram of the cat: evidence for pattern and luminance components.

    abstract::The main PERG component of the transient contrast reversal pattern electroretinogram (PERG) in cats was a negative wave (3.5 microV average, SD 1.7 microV) peaking at about 130 msec (N130) with a spatial resolution above 5.5 c/deg, close to behavioural estimates. The early positivity (P35) was more variable, smaller a...

    journal_title:Vision research

    pub_type: 杂志文章

    doi:10.1016/0042-6989(90)90021-c

    authors: Vaegan,Arora A,Crewther SG,Millar TJ

    更新日期:1990-01-01 00:00:00

  • Effects of regular aerobic exercise on visual perceptual learning.

    abstract::This study investigated the influence of five days of moderate intensity aerobic exercise on the acquisition and consolidation of visual perceptual learning using a motion direction discrimination (MDD) task. The timing of exercise relative to learning was manipulated by administering exercise either before or after p...

    journal_title:Vision research

    pub_type: 杂志文章

    doi:10.1016/j.visres.2017.08.007

    authors: Connell CJW,Thompson B,Green H,Sullivan RK,Gant N

    更新日期:2018-11-01 00:00:00

  • Modulation of motion aftereffect by surround motion and its dependence on stimulus size and eccentricity.

    abstract::As a mechanism to detect differential motion, we have proposed a model of 'a motion contrast detector' and have shown that it can explain the perceptual change from motion capture to induced motion with increasing stimulus size and decreasing eccentricity. To further test the feasibility of the model, we examined the ...

    journal_title:Vision research

    pub_type: 杂志文章

    doi:10.1016/0042-6989(94)00269-r

    authors: Murakami I,Shimojo S

    更新日期:1995-07-01 00:00:00

  • Luminance mechanisms mediate the motion of red-green isoluminant gratings: the role of "temporal chromatic aberration".

    abstract::In this paper we use a dynamic noise-masking paradigm to explore the nature of the mechanisms mediating the motion perception of drifting isoluminant red-green gratings. We compare contrast thresholds for the detection and direction discrimination of drifting gratings (1.5 cpd), over a range of temporal frequencies (0...

    journal_title:Vision research

    pub_type: 杂志文章

    doi:10.1016/s0042-6989(03)00115-9

    authors: Mullen KT,Yoshizawa T,Baker CL Jr

    更新日期:2003-05-01 00:00:00

  • Preattentive equivalence of multicomponent Gabor textures in the central and peripheral visual field.

    abstract::Similarity ratings were obtained to determine the minimum number of Gabor components that would produce a comparison texture that appeared preattentively similar to a 64-component standard texture. All textures were chosen to be both specifiable by a relatively small number of localized spectral components and suffici...

    journal_title:Vision research

    pub_type: 杂志文章

    doi:10.1016/0042-6989(94)00128-9

    authors: Geri GA,Lyon DR,Zeevi Y

    更新日期:1995-02-01 00:00:00

  • Horizontal cell dynamics: what are the main factors?

    abstract::The factors potentially determining the dynamics of horizontal cell (HC) responses are: (1) the rate of transmitter release (including its transient component) and removal; (2) the voltage non-linearity of HC non-synaptic membrane combined with its capacitance; and (3) the dynamics of feedback from HCs to photorecepto...

    journal_title:Vision research

    pub_type: 杂志文章

    doi:10.1016/s0042-6989(96)00130-7

    authors: Maximov VV,Byzov AL

    更新日期:1996-12-01 00:00:00

  • On the search for an appropriate metric for reaction time to suprathreshold increments and decrements.

    abstract::Weber contrast, DeltaL/L, is a widely used contrast metric for aperiodic stimuli. Zele, Cao & Pokorny [Zele, A. J., Cao, D., & Pokorny, J. (2007). Threshold units: A correct metric for reaction time? Vision Research, 47, 608-611] found that neither Weber contrast nor its transform to detection-threshold units equates ...

    journal_title:Vision research

    pub_type: 杂志文章,随机对照试验

    doi:10.1016/j.visres.2008.12.010

    authors: Vassilev A,Murzac A,Zlatkova MB,Anderson RS

    更新日期:2009-03-01 00:00:00

  • Asymmetry of perceived motion smear during head and eye movements: evidence for a dichotomous neural categorization of retinal image motion.

    abstract::We measured perceived motion smear when retinal image motion was created either by a physically moving object or by movement of the eyes or head. Consistent with previous reports, the extent of perceived motion smear during an eye or head movement is less than that produced by physical object motion when the eyes are ...

    journal_title:Vision research

    pub_type: 杂志文章

    doi:10.1016/j.visres.2004.12.004

    authors: Tong J,Patel SS,Bedell HE

    更新日期:2005-06-01 00:00:00

  • Speeding rod recovery improves temporal resolution in the retina.

    abstract::The temporal resolution of the visual system progressively increases with light intensity. Under scotopic conditions, temporal resolution is relatively poor, and may be limited by both retinal and cortical processes. Rod photoresponses themselves are quite slow because of the slowly deactivating biochemical cascade ne...

    journal_title:Vision research

    pub_type: 杂志文章

    doi:10.1016/j.visres.2015.02.011

    authors: Fortenbach CR,Kessler C,Peinado Allina G,Burns ME

    更新日期:2015-05-01 00:00:00

  • Metrics of saccade responses to visual double stimuli: two different modes.

    abstract::Earlier studies using visual double stimuli along the horizontal axis have revealed a strong averaging tendency in the saccadic system. This study shows averaging also for equally eccentric double stimuli with a modest difference in direction (delta phi = 30 deg). When the difference is enlarged (delta phi = 90 deg) t...

    journal_title:Vision research

    pub_type: 杂志文章

    doi:10.1016/0042-6989(84)90172-x

    authors: Ottes FP,Van Gisbergen JA,Eggermont JJ

    更新日期:1984-01-01 00:00:00

  • Discriminating depth in corrugated stereo surfaces: facilitation by a pedestal is explained by removal of uncertainty.

    abstract::With luminance gratings, psychophysical thresholds for detecting a small increase in the contrast of a weak 'pedestal' grating are 2-3 times lower than for detection of a grating when the pedestal is absent. This is the 'dipper effect'--a reliable improvement whose interpretation remains controversial. Analogies betwe...

    journal_title:Vision research

    pub_type: 杂志文章

    doi:10.1016/j.visres.2008.07.009

    authors: Georgeson MA,Yates TA,Schofield AJ

    更新日期:2008-09-01 00:00:00

  • Contrast matching of two-dimensional compound gratings.

    abstract::The contrast of a two-dimensional compound grating consisting of 2, 3 or 4 components with the same spatial frequency but different orientations was matched to the contrast of a simple cosine grating. At all spatial frequencies and contrast levels studied the stimuli which matched in apparent contrast had nearly equal...

    journal_title:Vision research

    pub_type: 杂志文章

    doi:10.1016/0042-6989(94)90298-4

    authors: Tiippana K,Näsänen R,Rovamo J

    更新日期:1994-05-01 00:00:00

  • Nonlocal interactions in color perception: nonlinear processing of chromatic signals from remote inducers.

    abstract::The perceived color of an object depends on the chromaticity of its immediate background. But color appearance is also influenced by remote chromaticities. To quantify these influences, the effects of remote color fields on the appearance of a fixated 2 degrees test field were measured using a forced-choice method. Ch...

    journal_title:Vision research

    pub_type: 杂志文章

    doi:10.1016/s0042-6989(01)00017-7

    authors: Wachtler T,Albright TD,Sejnowski TJ

    更新日期:2001-05-01 00:00:00

  • Irrelevant peripheral visual stimuli impair manual reaction times in Parkinson's disease.

    abstract::In three experiments, the effects of irrelevant visual information on the time to initiate and to complete a simple movement of the hand in response to a visual signal were studied in patients with a diagnosis of Parkinson's disease, and in age-matched normal controls. Subjects gazed at the centre of a TV monitor and ...

    journal_title:Vision research

    pub_type: 杂志文章

    doi:10.1016/S0042-6989(97)00188-0

    authors: McDowell SA,Harris J

    更新日期:1997-12-01 00:00:00

  • Disparity tuning in mechanisms of human stereopsis.

    abstract::The change in sensitivity across some stimulus dimension which follows adaptation to a particular stimulus can reveal a great deal about the tuning characteristics of underlying sensory/perceptual mechanisms. In this study, a psychophysical adaptation paradigm was employed to characterize the disparity tuning of perce...

    journal_title:Vision research

    pub_type: 杂志文章

    doi:10.1016/0042-6989(92)90161-b

    authors: Stevenson SB,Cormack LK,Schor CM,Tyler CW

    更新日期:1992-09-01 00:00:00

  • Optic flow and scene structure do not always contribute to the control of human walking.

    abstract::Using displacing prisms to dissociate the influence of optic flow and egocentric direction, previous research (Current Biology 8 (1998) 1191) showed that people primarily use egocentric direction to control their locomotion on foot, rather than optic flow. When wearing displacing prisms, participants followed the curv...

    journal_title:Vision research

    pub_type: 杂志文章

    doi:10.1016/s0042-6989(02)00066-4

    authors: Harris JM,Bonas W

    更新日期:2002-06-01 00:00:00

  • The effect of complex motion pattern on speed perception.

    abstract::We recently reported a new motion illusion where dots in expanding random dot patterns appear to move faster than those in rotation patterns despite having the same physical speed distributions. In the current paper, we compared expansion and rotation motion to translational motion and found that the perceived dot spe...

    journal_title:Vision research

    pub_type: 杂志文章

    doi:10.1016/s0042-6989(97)00279-4

    authors: Geesaman BJ,Qian N

    更新日期:1998-05-01 00:00:00