Abstract:
:A rhodopsin P347L transgenic (Tg) rabbit, a model of retinitis pigmentosa, has been generated in our laboratory. The purpose of this study was to determine the properties of focal areas of the retina in this rabbit model during the course of retinal degeneration. To accomplish this, we recorded focal ERGs from wild-type (WT) and Tg rabbits at ages 3, 6, and 12 months. A 15° stimulus spot was used to elicit the focal ERGs from the center of the visual streak and from four surrounding areas. We found that the amplitudes of the focal cone ERG b-waves and oscillatory potentials (OPs) of the Tg rabbits in the five areas decreased progressively with increasing age and became almost non-recordable at 12 months. There were no significant regional differences in the b-waves of Tg rabbits recorded from the 5 areas. The amplitudes of the OPs were better preserved than the b-waves and the OPs/b-wave ratio was higher than that in WT rabbits at every recording area. The summed OPs amplitudes, which most likely originate from the amacrine and/or ganglion cells, recorded from the area superior to the optic disc was significantly larger than that from other areas at 3- and 6-months-old. This indicated that the inner retinal neurons were not altered equally after photoreceptor degeneration in this rabbit model.
journal_name
Vision Resjournal_title
Vision researchauthors
Ueno S,Koyasu T,Kominami T,Sakai T,Kondo M,Yasuda S,Terasaki Hdoi
10.1016/j.visres.2013.08.006subject
Has Abstractpub_date
2013-10-18 00:00:00pages
118-23eissn
0042-6989issn
1878-5646pii
S0042-6989(13)00215-0journal_volume
91pub_type
杂志文章相关文献
VISION RESEARCH文献大全abstract::Top-down feedback from working memory (WM) can exert an early and involuntary influence on visual selection for targets that are relatively difficult to discriminate [Soto, D., Heinke, D., Humphreys, G. W., & Blanco, M. J. (2005) Journal of Experimental Psychology: Human Perception and Performance, 31, 248]. Here, we ...
journal_title:Vision research
pub_type: 杂志文章
doi:10.1016/j.visres.2005.09.008
更新日期:2006-03-01 00:00:00
abstract::Ring-billed gulls (Larus delawarensis) and gray gulls (Larus modestus) are two species active both by day and night. We have investigated the retinal adaptations that allow the diurnal and nocturnal behaviours of these two species. Electroretinograms and histological analyses show that both species have a duplex retin...
journal_title:Vision research
pub_type: 杂志文章
doi:10.1016/j.visres.2006.02.023
更新日期:2006-09-01 00:00:00
abstract::A dominant mechanism of cellular patterning in the growing fish retina is control of cell fate acquisition by negative feedback signals arising from differentiated cells. We tested the ability of a computational model of this pattern formation mechanism to simulate cellular patterns in regenerated goldfish retina. The...
journal_title:Vision research
pub_type: 杂志文章
doi:10.1016/j.visres.2006.08.025
更新日期:2007-02-01 00:00:00
abstract::Reading in peripheral vision is slow and requires large print, posing substantial difficulty for patients with central scotomata. The purpose of this study was to evaluate the effect of print size on reading speed at different eccentricities in normal peripheral vision. We hypothesized that reading speeds should remai...
journal_title:Vision research
pub_type: 杂志文章
doi:10.1016/s0042-6989(98)00072-8
更新日期:1998-10-01 00:00:00
abstract::In all mammals, the mitochondria of the cones of the retina are concentrated in the inner segment. Uniquely in tree-shrews (Tupaia, Scandentia, Mammalia), a "megamitochondrion" exhibiting highly specialized systems of densely packed cristae and a very electron dense matrix, is located apically in the inner segment. Th...
journal_title:Vision research
pub_type: 杂志文章
doi:10.1016/s0042-6989(96)00199-x
更新日期:1997-02-01 00:00:00
abstract::The present investigation is aimed at characterizing the development of ON and OFF visually evoked responses in the rat superior colliculus from postnatal day 13 (P13) to postnatal day 25. Depth profiles of field potentials reveal that ON and OFF long latency biphasic field potentials are already present when collicul...
journal_title:Vision research
pub_type: 杂志文章
doi:10.1016/s0042-6989(97)00145-4
更新日期:1997-11-01 00:00:00
abstract::A major factor underlying the prolonged postnatal improvement of visual acuity in primates is an increase in the sampling limit imposed by the photoreceptor mosaic, which may be as much as 5-fold. Further factors operating peripheral to neurons of the lateral geniculate nucleus, which might include changes in neural c...
journal_title:Vision research
pub_type: 杂志文章
doi:10.1016/0042-6989(88)90104-6
更新日期:1988-01-01 00:00:00
abstract::We examine how various sources of information contribute to the percept of motion in depth. Subjects were presented with targets moving in depth, and were asked to judge their velocities and final positions. On each presentation, the target's position relative to the two eyes (target vergence), the size of the target'...
journal_title:Vision research
pub_type: 杂志文章
doi:10.1016/0042-6989(95)00146-8
更新日期:1996-03-01 00:00:00
abstract::The mechanisms responsible for generating illusory contours are thought to fulfil an adaptive role in providing estimates of missing contour fragments generated by partial camouflage. One striking apparent counter-example to this view was described in Current Biology 21 (2011) 492-496, which showed that illusory conto...
journal_title:Vision research
pub_type: 杂志文章
doi:10.1016/j.visres.2019.02.014
更新日期:2019-05-01 00:00:00
abstract::Radial frequency (RF) patterns, which are sinusoidal modulations of a radius in polar coordinates, are commonly used to study shape perception. Previous studies have argued that the detection of RF patterns is either achieved globally by a specialized global shape mechanism, or locally using as cue the maximum tangent...
journal_title:Vision research
pub_type: 杂志文章
doi:10.1016/j.visres.2017.03.005
更新日期:2017-05-01 00:00:00
abstract::To investigate amblyopic contrast vision at threshold and above we performed pedestal-masking (contrast discrimination) experiments with a group of eight strabismic amblyopes using horizontal sinusoidal gratings (mainly 3c/deg) in monocular, binocular and dichoptic configurations balanced across eye (i.e. five conditi...
journal_title:Vision research
pub_type: 杂志文章
doi:10.1016/j.visres.2008.04.017
更新日期:2008-07-01 00:00:00
abstract::To examine how local velocities from different regions of the visual field combine to form a coherent motion percept, we subjected a sinusoidal line stimulus to translational motion. Horizontal movement of a sinewave line along its axial direction is perceived as nonrigid if the angle at the zero crossing is smaller t...
journal_title:Vision research
pub_type: 杂志文章
doi:10.1016/0042-6989(88)90052-1
更新日期:1988-01-01 00:00:00
abstract::A common computation in visual cortex is the divisive normalization of responses by a pooled signal of the activity of cells within its neighborhood. From a geometrical point of view, normalization constraints the population response to high-contrast stimuli to lie on the surface of a high-dimensional sphere. Here we ...
journal_title:Vision research
pub_type: 杂志文章
doi:10.1016/j.visres.2009.12.007
更新日期:2010-10-28 00:00:00
abstract::The main PERG component of the transient contrast reversal pattern electroretinogram (PERG) in cats was a negative wave (3.5 microV average, SD 1.7 microV) peaking at about 130 msec (N130) with a spatial resolution above 5.5 c/deg, close to behavioural estimates. The early positivity (P35) was more variable, smaller a...
journal_title:Vision research
pub_type: 杂志文章
doi:10.1016/0042-6989(90)90021-c
更新日期:1990-01-01 00:00:00
abstract::This study investigated the influence of five days of moderate intensity aerobic exercise on the acquisition and consolidation of visual perceptual learning using a motion direction discrimination (MDD) task. The timing of exercise relative to learning was manipulated by administering exercise either before or after p...
journal_title:Vision research
pub_type: 杂志文章
doi:10.1016/j.visres.2017.08.007
更新日期:2018-11-01 00:00:00
abstract::As a mechanism to detect differential motion, we have proposed a model of 'a motion contrast detector' and have shown that it can explain the perceptual change from motion capture to induced motion with increasing stimulus size and decreasing eccentricity. To further test the feasibility of the model, we examined the ...
journal_title:Vision research
pub_type: 杂志文章
doi:10.1016/0042-6989(94)00269-r
更新日期:1995-07-01 00:00:00
abstract::In this paper we use a dynamic noise-masking paradigm to explore the nature of the mechanisms mediating the motion perception of drifting isoluminant red-green gratings. We compare contrast thresholds for the detection and direction discrimination of drifting gratings (1.5 cpd), over a range of temporal frequencies (0...
journal_title:Vision research
pub_type: 杂志文章
doi:10.1016/s0042-6989(03)00115-9
更新日期:2003-05-01 00:00:00
abstract::Similarity ratings were obtained to determine the minimum number of Gabor components that would produce a comparison texture that appeared preattentively similar to a 64-component standard texture. All textures were chosen to be both specifiable by a relatively small number of localized spectral components and suffici...
journal_title:Vision research
pub_type: 杂志文章
doi:10.1016/0042-6989(94)00128-9
更新日期:1995-02-01 00:00:00
abstract::The factors potentially determining the dynamics of horizontal cell (HC) responses are: (1) the rate of transmitter release (including its transient component) and removal; (2) the voltage non-linearity of HC non-synaptic membrane combined with its capacitance; and (3) the dynamics of feedback from HCs to photorecepto...
journal_title:Vision research
pub_type: 杂志文章
doi:10.1016/s0042-6989(96)00130-7
更新日期:1996-12-01 00:00:00
abstract::Weber contrast, DeltaL/L, is a widely used contrast metric for aperiodic stimuli. Zele, Cao & Pokorny [Zele, A. J., Cao, D., & Pokorny, J. (2007). Threshold units: A correct metric for reaction time? Vision Research, 47, 608-611] found that neither Weber contrast nor its transform to detection-threshold units equates ...
journal_title:Vision research
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.visres.2008.12.010
更新日期:2009-03-01 00:00:00
abstract::We measured perceived motion smear when retinal image motion was created either by a physically moving object or by movement of the eyes or head. Consistent with previous reports, the extent of perceived motion smear during an eye or head movement is less than that produced by physical object motion when the eyes are ...
journal_title:Vision research
pub_type: 杂志文章
doi:10.1016/j.visres.2004.12.004
更新日期:2005-06-01 00:00:00
abstract::The temporal resolution of the visual system progressively increases with light intensity. Under scotopic conditions, temporal resolution is relatively poor, and may be limited by both retinal and cortical processes. Rod photoresponses themselves are quite slow because of the slowly deactivating biochemical cascade ne...
journal_title:Vision research
pub_type: 杂志文章
doi:10.1016/j.visres.2015.02.011
更新日期:2015-05-01 00:00:00
abstract::Earlier studies using visual double stimuli along the horizontal axis have revealed a strong averaging tendency in the saccadic system. This study shows averaging also for equally eccentric double stimuli with a modest difference in direction (delta phi = 30 deg). When the difference is enlarged (delta phi = 90 deg) t...
journal_title:Vision research
pub_type: 杂志文章
doi:10.1016/0042-6989(84)90172-x
更新日期:1984-01-01 00:00:00
abstract::With luminance gratings, psychophysical thresholds for detecting a small increase in the contrast of a weak 'pedestal' grating are 2-3 times lower than for detection of a grating when the pedestal is absent. This is the 'dipper effect'--a reliable improvement whose interpretation remains controversial. Analogies betwe...
journal_title:Vision research
pub_type: 杂志文章
doi:10.1016/j.visres.2008.07.009
更新日期:2008-09-01 00:00:00
abstract::The contrast of a two-dimensional compound grating consisting of 2, 3 or 4 components with the same spatial frequency but different orientations was matched to the contrast of a simple cosine grating. At all spatial frequencies and contrast levels studied the stimuli which matched in apparent contrast had nearly equal...
journal_title:Vision research
pub_type: 杂志文章
doi:10.1016/0042-6989(94)90298-4
更新日期:1994-05-01 00:00:00
abstract::The perceived color of an object depends on the chromaticity of its immediate background. But color appearance is also influenced by remote chromaticities. To quantify these influences, the effects of remote color fields on the appearance of a fixated 2 degrees test field were measured using a forced-choice method. Ch...
journal_title:Vision research
pub_type: 杂志文章
doi:10.1016/s0042-6989(01)00017-7
更新日期:2001-05-01 00:00:00
abstract::In three experiments, the effects of irrelevant visual information on the time to initiate and to complete a simple movement of the hand in response to a visual signal were studied in patients with a diagnosis of Parkinson's disease, and in age-matched normal controls. Subjects gazed at the centre of a TV monitor and ...
journal_title:Vision research
pub_type: 杂志文章
doi:10.1016/S0042-6989(97)00188-0
更新日期:1997-12-01 00:00:00
abstract::The change in sensitivity across some stimulus dimension which follows adaptation to a particular stimulus can reveal a great deal about the tuning characteristics of underlying sensory/perceptual mechanisms. In this study, a psychophysical adaptation paradigm was employed to characterize the disparity tuning of perce...
journal_title:Vision research
pub_type: 杂志文章
doi:10.1016/0042-6989(92)90161-b
更新日期:1992-09-01 00:00:00
abstract::Using displacing prisms to dissociate the influence of optic flow and egocentric direction, previous research (Current Biology 8 (1998) 1191) showed that people primarily use egocentric direction to control their locomotion on foot, rather than optic flow. When wearing displacing prisms, participants followed the curv...
journal_title:Vision research
pub_type: 杂志文章
doi:10.1016/s0042-6989(02)00066-4
更新日期:2002-06-01 00:00:00
abstract::We recently reported a new motion illusion where dots in expanding random dot patterns appear to move faster than those in rotation patterns despite having the same physical speed distributions. In the current paper, we compared expansion and rotation motion to translational motion and found that the perceived dot spe...
journal_title:Vision research
pub_type: 杂志文章
doi:10.1016/s0042-6989(97)00279-4
更新日期:1998-05-01 00:00:00