Abstract:
:Parainfluenza virus (PIV) infection is a significant cause of morbidity and mortality, especially in hematologic malignancy patients including hematopoietic stem cell transplantation (HCT) recipients. However, limited information is available for risk stratification in PIV-infected patients with hematologic malignancy with or without HCT. Patients with hematologic malignancy diagnosed with PIV from January 2009 to December 2018 were retrospectively included in a tertiary care hospital in Seoul, South Korea. Upper respiratory tract infection (URTI) was defined as the detection of PIV in a nasopharyngeal sample with URTI symptoms without new pulmonary infiltrates. Lower respiratory tract infection (LRTI) was defined as detection of PIV in either upper or lower respiratory tract samples with new pulmonary infiltrates, with or without hypoxia. PIV-associated mortality was defined as death with respiratory failure and persistent LRTI within 90 days after diagnosis. The study included 143 adult patients. Of these, 55 (38%) progressed to or initially presented with LRTI. Among these, 22 (40%) died from PIV-associated mortality. An immunodeficiency risk score was developed from associated risk factors using a multivariable Cox regression model. Patients were stratified into low (0-2), moderate (3-5), and high risk (6-8) groups with PIV-associated mortalities of 0%, 9%, and 67%, respectively (p < 0.005, Harrell's C-index = 0.84). PIV infection can result in substantial mortality in patients with hematologic malignancy if it progresses to LRTI. The immunodeficiency risk score presented here may be useful for distinguishing moderate and high risk groups that might benefit from antiviral therapy.
journal_name
Ann Hematoljournal_title
Annals of hematologyauthors
Lee J,Jung J,Kim MJ,Chong YP,Lee SO,Choi SH,Kim YS,Woo JH,Choi EJ,Park HS,Lee JH,Lee JH,Lee KH,Kim SHdoi
10.1007/s00277-020-03996-6subject
Has Abstractpub_date
2020-06-01 00:00:00pages
1231-1239issue
6eissn
0939-5555issn
1432-0584pii
10.1007/s00277-020-03996-6journal_volume
99pub_type
杂志文章abstract::Despite recent advances made in its treatment, multiple myeloma (MM) remains an incurable B cell malignancy. Thus, the objective for treating these patients is to prolong overall survival (OS) and preserve patients' quality of life. We have analyzed data from 264 consecutive MM patients who had their initial visit bet...
journal_title:Annals of hematology
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journal_title:Annals of hematology
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journal_title:Annals of hematology
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doi:10.1007/s00277-008-0633-2
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journal_title:Annals of hematology
pub_type: 杂志文章
doi:10.1007/s00277-009-0895-3
更新日期:2010-04-01 00:00:00
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journal_title:Annals of hematology
pub_type: 临床试验,杂志文章
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更新日期:2008-05-01 00:00:00
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journal_title:Annals of hematology
pub_type: 杂志文章
doi:10.1007/s002770050589
更新日期:2000-05-01 00:00:00
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journal_title:Annals of hematology
pub_type: 杂志文章
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更新日期:1997-01-01 00:00:00
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journal_title:Annals of hematology
pub_type: 杂志文章
doi:10.1007/s002770050582
更新日期:2000-04-01 00:00:00
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journal_title:Annals of hematology
pub_type: 杂志文章
doi:10.1007/s002770100311
更新日期:2001-08-01 00:00:00
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journal_title:Annals of hematology
pub_type: 杂志文章,多中心研究
doi:10.1007/s00277-016-2682-2
更新日期:2016-06-01 00:00:00
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journal_title:Annals of hematology
pub_type: 杂志文章
doi:10.1007/s00277-004-0862-y
更新日期:2004-06-01 00:00:00
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journal_title:Annals of hematology
pub_type: 杂志文章,多中心研究
doi:10.1007/s00277-016-2815-7
更新日期:2016-12-01 00:00:00
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journal_title:Annals of hematology
pub_type: 杂志文章
doi:10.1007/s002779900136
更新日期:2000-06-01 00:00:00
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journal_title:Annals of hematology
pub_type: 杂志文章
doi:10.1007/BF01695918
更新日期:1994-01-01 00:00:00
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pub_type: 杂志文章
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pub_type: 杂志文章,多中心研究
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journal_title:Annals of hematology
pub_type: 杂志文章,评审
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journal_title:Annals of hematology
pub_type: 临床试验,杂志文章,随机对照试验
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journal_title:Annals of hematology
pub_type: 杂志文章
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更新日期:1998-12-01 00:00:00
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pub_type: 临床试验,杂志文章
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pub_type: 杂志文章
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pub_type: 杂志文章
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更新日期:2014-06-01 00:00:00
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