Abstract：
:The effects of age on the neurotoxicity of phenobarbital and its anticonvulsant effect were examined in female BDF1 mice of different ages by means of a rotorod test and the pentylenetetrazole (PTZ)-induced maximal seizure, respectively. The minimal neurotoxic concentrations (MTCs) of phenobarbital in both plasma and brain evaluated by a rotorod test were 50% lower (p less than 0.05) in old (24-months-old) mice compared with the respective values in young (6-months-old) mice, while 12-months values were the highest of the three groups. Mice given some dosages of phenobarbital, particularly old (24-months-old) mice, died within the 15-min observation period after an i.p. injection of PTZ (150 mg/kg) without demonstrating a hindlimb extensor component (HLE) of maximal seizure. When these animals were classified as responders with regard to the anticonvulsant effect of phenobarbital, the minimal effective concentrations (MECs) in plasma and brain required for abolishing the PTZ-induced maximal seizure in old mice were only 10-20% those of young mice. Present results coupled with our past studies using electroshock seizure suggest that both the neurotoxicity and the efficacy of phenobarbital increase with age in mice.
journal_name
Arch Gerontol Geriatrjournal_title
Archives of gerontology and geriatricsauthors
Kitani K,Sato Y,Kanai S,Ohta M,Nokubo M,Masuda Ydoi
10.1016/0167-4943(88)90009-xsubject
Has Abstractpub_date
1988-12-01 00:00:00pages
261-71issue
4eissn
0167-4943issn
1872-6976pii
016749438890009Xjournal_volume
7pub_type
杂志文章abstract：OBJECTIVES:To investigate the prevalence of potentially inappropriate prescribing (PIP) of central nervous system and psychotropic (CNS-PS) drugs to the Korean elderly population, and to identify PIP-associated factors. METHODS:Ambulatory care visits were identified from the 2013 National Aged Patient Sample (HIRA-APS...
journal_title：Archives of gerontology and geriatrics
pub_type： 杂志文章
doi：10.1016/j.archger.2017.08.013
更新日期：2018-01-01 00:00:00
abstract：:The dynamics of self-organized systems are characterized by irreversible processes in which the exchange of matter, energy and signals among genetic, metabolic and environmental patterns are nonlinear; reversible events (i.e., at equilibrium) occur only in special cases. The adaptations of complex systems to the envir...
journal_title：Archives of gerontology and geriatrics
pub_type： 杂志文章
doi：10.1016/s0167-4943(05)80055-x
更新日期：1994-01-01 00:00:00
abstract：AIM:This study aimed to compare the effects of two exercise programs on balance and risk of falls in older women with age-related visual dysfunction. METHODS:Participants living in a residential home were randomly allocated to Group I (n=21) receiving a progressive, tailored multimodal exercise program in addition to ...
journal_title：Archives of gerontology and geriatrics
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.archger.2012.01.009
更新日期：2012-09-01 00:00:00
abstract：:The purpose of this study was to describe and compare QoL and its determinants in two groups of patients with AD that differed in place of residence: community or nursing home. This study covered 200 patients with AD (mean age 79.3 ± 8.2 years, 74% female). Fifty-four per cent of the subjects were living in a nursing ...
journal_title：Archives of gerontology and geriatrics
pub_type： 杂志文章
doi：10.1016/j.archger.2013.04.013
更新日期：2013-11-01 00:00:00
abstract：:The evaluation of intima-media thickening (IMT) of carotid artery is an important parameter in preclinical diagnosis of atherosclerosis and stroke risk in hypertensive patients. Measurements of carotid wall thickness via Doppler were considered to be valuable in prediction of risk of brain damage and future stroke due...
journal_title：Archives of gerontology and geriatrics
pub_type： 杂志文章
doi：10.1016/j.archger.2007.01.044
更新日期：2007-01-01 00:00:00
abstract：:This random double-blind trial compares psychological well-being and perceived quality of life in 60 subjects (18 M, 42 F), mean age 61 years, with age-associated memory impairment (AAMI), who were administered a standardised ginseng-containing vitamin complex or placebo for 9 months. We evaluated psychological well-b...
journal_title：Archives of gerontology and geriatrics
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/0167-4943(95)00659-9
更新日期：1995-11-01 00:00:00
abstract：:We studied the change in personal ability to perform the activities of daily living (P-ADL) one year after hospitalization (T2) of patients at least 65 years old at baseline (T1). The study included 363 (175 men) medical inpatients with age range 65-98 (mean 80.2, SD 7.5) years. Information was collected at baseline a...
journal_title：Archives of gerontology and geriatrics
pub_type： 杂志文章
doi：10.1016/j.archger.2013.05.008
更新日期：2013-11-01 00:00:00
abstract：BACKGROUND:Chronic and lifestyle-related diseases and social status were reported to be associated with long-term care (LTC). The social factors should be treated as social sub-groups of which characteristics show social profiles. However, few previous studies considered that. The present study aimed to investigate the...
journal_title：Archives of gerontology and geriatrics
pub_type： 杂志文章
doi：10.1016/j.archger.2018.12.010
更新日期：2019-01-01 00:00:00
abstract：:The onset of delirium is frequent in elderly patients who sustain hip fractures. The purpose of this study was to characterize different patterns of preoperative and postoperative delirium, to study factors associated with preoperative delirium and to evaluate the possible different outcome of these patients. This ret...
journal_title：Archives of gerontology and geriatrics
pub_type： 杂志文章
doi：10.1016/s0167-4943(02)00058-4
更新日期：2003-01-01 00:00:00
abstract：:We studied the factors influencing the choice of admission to Geriatrics units, instead of other acute hospital units after an emergency visit. We report the results from a cohort of 1283 randomly selected patients aged >75 years hospitalized in emergency and representative of the French University hospital system. Al...
journal_title：Archives of gerontology and geriatrics
pub_type： 杂志文章
doi：10.1016/j.archger.2010.01.018
更新日期：2011-01-01 00:00:00
abstract：:There is little empirical data about the impact of digital inclusion on cognition among older adults. This paper aimed at investigating the effects of a digital inclusion program in the cognitive performance of older individuals who participated in a computer learning workshop named "Idosos On-Line" (Elderly Online). ...
journal_title：Archives of gerontology and geriatrics
pub_type： 杂志文章
doi：10.1016/j.archger.2010.11.007
更新日期：2011-09-01 00:00:00
abstract：:In times of the modern global societies, concern for QoL is a priority for gerontology, being an interdisciplinary field. The aim of this study was to assess the QoL of students of the U3A based on socio-demographic factors, subjectively reported diseases and/or discomfort, and well-being. The study comprised 257 stud...
journal_title：Archives of gerontology and geriatrics
pub_type： 杂志文章
doi：10.1016/j.archger.2010.09.003
更新日期：2011-09-01 00:00:00
abstract：:Physical training was performed by 22 women aged between 63 and 84 yr and 4 men aged between 74 and 86 yr twice a week for 10 mths. Some subjects had moderate disorders but all of them lived in their own homes. Apart from using body weight and elastic bands, no special equipment was used as resistance. Emphasis was la...
journal_title：Archives of gerontology and geriatrics
pub_type： 杂志文章
doi：10.1016/0167-4943(84)90024-4
更新日期：1984-10-01 00:00:00
abstract：:Dehydroepiandrosterone sulfate (DHEAS) is the most abundant circulating steroid hormone in humans and can readily be converted to its parent steroid DHEA by tissue sulfatases. Yet, a biologic function for these steroids has not been defined. The link between DHEA and aging has been raised by: (1) its well documented a...
journal_title：Archives of gerontology and geriatrics
pub_type： 杂志文章
doi：10.1016/s0167-4943(96)00761-3
更新日期：1997-05-01 00:00:00
abstract：:Experimental animal studies carried out over the past 40 years have unequivocally shown that neurogenic mechanisms are involved in the pathogenesis of hypertension. The results of these studies also suggest that neural factors are important not only in the development but also in the maintenance of the high blood pres...
journal_title：Archives of gerontology and geriatrics
pub_type： 杂志文章
doi：10.1016/0167-4943(94)00609-b
更新日期：1995-01-01 00:00:00
abstract：:The demands of long-term care facilities (LTCFs) residents are complex which usually require a range of professionals and caregivers to provide treatment and care. To reduce this fragmentation of care, integrated care models are developed in modern health care system, and a gradual change from traditional LTCF care to...
journal_title：Archives of gerontology and geriatrics
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.archger.2009.05.004
更新日期：2010-05-01 00:00:00
abstract：:Aim of the study was to investigate the replicability and reliability of the multi-dimensional health assessment questionnaire (MDHAQ) and visual analog scale (VAS) in young and elderly individuals with chronic pain. Ambulatory patients, 20 of them aged above 65 years and complaining about chronic pain and 20 patients...
journal_title：Archives of gerontology and geriatrics
pub_type： 杂志文章
doi：10.1016/j.archger.2010.10.017
更新日期：2011-07-01 00:00:00
abstract：PURPOSE:Chronic obstructive pulmonary disease (COPD) is often associated with malnutrition, which is in turn associated with poor outcomes. Accordingly, in COPD patients adequate nutrition might improve several clinical and functional outcomes. Nevertheless, information about nutrient intake of older populations with C...
journal_title：Archives of gerontology and geriatrics
pub_type： 杂志文章
doi：10.1016/j.archger.2016.01.006
更新日期：2016-05-01 00:00:00
abstract：:Alzheimer Disease (AD) is an age-related dementia that is going to assume the characteristics of a health emergency. A reliable diagnosis of AD, especially at the very onset, is complicated. Moreover, it is known that about 20% of patients in hospital for Alzheimer-type dementia have unusual clinical symptoms and some...
journal_title：Archives of gerontology and geriatrics
pub_type： 杂志文章
doi：10.1016/s0167-4943(98)00017-x
更新日期：1998-07-01 00:00:00
abstract：:The management of advanced cancer in the older person is variable. In some patients with common malignancies chemotherapy may palliate symptoms and prolong survival, while in other patients chemotherapy is a cause of overwhelming toxicity and supportive care is the preferred form of treatment. We explored the principl...
journal_title：Archives of gerontology and geriatrics
pub_type： 杂志文章
doi：10.1016/0167-4943(90)90015-x
更新日期：1990-03-01 00:00:00
abstract：:The aims were to evaluate the cognitive performance and clinical diagnosis in patients (<75 years) seeking help for subjective memory complaints, to determine the prevalence of certain psychiatric symptoms and to conduct follow-up examinations. At baseline 41% showed normal cognitive performance (subjective memory imp...
journal_title：Archives of gerontology and geriatrics
pub_type： 杂志文章
doi：10.1016/j.archger.2010.02.009
更新日期：2010-11-01 00:00:00
abstract：:Independent mobility is a key factor in predicting morbidity and determining hospital discharge readiness for older patients. The main objective was identify and appraise relevant instruments for the measurement of mobility of hospitalized geriatric patients. A systematic review was performed in two consecutive steps....
journal_title：Archives of gerontology and geriatrics
pub_type： 杂志文章,评审
doi：10.1016/j.archger.2017.05.009
更新日期：2017-09-01 00:00:00
abstract：:There is increasing evidence for an association between WMH and large-artery atherosclerosis. We evaluated 268 patients with acute ischemic stroke to assess the relationship between intracranial (IC) atherosclerosis and WMH. The patients were classified into three groups according to the location of the stenosis; IC, ...
journal_title：Archives of gerontology and geriatrics
pub_type： 杂志文章
doi：10.1016/j.archger.2010.07.008
更新日期：2011-09-01 00:00:00
abstract：OBJECTIVE:CVD are the leading causes of death and disability in the world. Since there are no published data about the knowledge of CVD risk factors among Croatian older adults, this was the primary aim of this study. Another aim was to determine relationship between actual CVD risk (total cholesterol - TC and triglyce...
journal_title：Archives of gerontology and geriatrics
pub_type： 杂志文章
doi：10.1016/j.archger.2015.04.001
更新日期：2015-07-01 00:00:00
abstract：:Family caregiving is prevalent and may have adverse impacts on health, particularly for elder caregivers who tend to have chronic health conditions which need ongoing self-management. Interventions that empower family caregivers to take care of themselves are needed. This study examined the impact on caregivers of par...
journal_title：Archives of gerontology and geriatrics
pub_type： 临床试验,杂志文章
doi：10.1016/j.archger.2007.02.009
更新日期：2008-01-01 00:00:00
abstract：:Leisure time represents an important part of the so-called 'successful aging' and contributes to overcome the problems related to the reduction of the social roles, favoring a better subjective adaptation to old age. In this work we observed the elderly population frequenting our Day Hospital, by estimating the affect...
journal_title：Archives of gerontology and geriatrics
pub_type： 杂志文章
doi：10.1016/s0167-4943(01)00111-x
更新日期：2001-09-01 00:00:00
abstract：:This article has been withdrawn at the request of the author(s) and/or editor. The Publisher apologizes for any inconvenience this may cause. The full Elsevier Policy on Article Withdrawal can be found at http://www.elsevier.com/locate/withdrawalpolicy. ...
journal_title：Archives of gerontology and geriatrics
pub_type： 杂志文章
doi：10.1016/j.archger.2015.01.012
更新日期：2015-01-31 00:00:00
abstract：:Two hundred and fifty-six carers of elderly people aged 70 and over were questioned on their attitudes towards their caring role and their preferences for their own future care. Despite the fact that most were providing assistance at high personal cost, most cares were highly committed to their caring role. However, t...
journal_title：Archives of gerontology and geriatrics
pub_type： 杂志文章
doi：10.1016/0167-4943(92)90050-e
更新日期：1992-03-01 00:00:00
abstract：:The objective of this study was to evaluate the health status and associated factors of the elderly Chinese population. A cross-sectional survey was administered to 849 elderly people aged 60 years and over living in a certain district of Nanjing, China. A health rating scale based on the characteristics of the elderl...
journal_title：Archives of gerontology and geriatrics
pub_type： 杂志文章
doi：10.1016/j.archger.2012.10.001
更新日期：2013-01-01 00:00:00
abstract：:The influence of dementia on the prevalence of urinary and faecal incontinence was investigated in a random sample (n = 485) of the total population of 85-year-olds from the city of Gothenburg, Sweden. The subjects were assessed by a psychiatric interview, physical examinations, computed tomography of the head and ana...
journal_title：Archives of gerontology and geriatrics
pub_type： 杂志文章
doi：10.1016/0167-4943(94)90021-3
更新日期：1994-07-01 00:00:00
