Abstract:
:Vitellogenin (VTG) is a precursor of egg-yolk protein and is therefore present at high concentrations in the plasma of female fish. In male fish, VTG concentrations are usually undetectable or low but can be induced upon exposure to estrogenic substances either via the water or the diet. This work was performed to determine the reason for the apparently elevated VTG concentrations in unexposed stock male fathead minnow maintained in our laboratory. The results showed clearly that some of the food given to the fish was estrogenic and that replacement of this with nonestrogenic food led to a significant reduction in the basal VTG levels measured in male fish after a six-month period. This reduction in male VTG concentrations drastically increased the sensitivity of the VTG test in further studies carried out with these fish. Moreover, a review of published concentrations of VTG in unexposed male fathead minnow suggests that this problem may exist in other laboratories. The fathead minnow is a standard ecotoxicological fish test species, so these findings will be of interest to any laboratory carrying out fish tests on endocrine-disrupting chemicals.
journal_name
Environ Toxicol Chemjournal_title
Environmental toxicology and chemistryauthors
Beresford N,Brian JV,Runnalls TJ,Sumpter JP,Jobling Sdoi
10.1002/etc.479subject
Has Abstractpub_date
2011-05-01 00:00:00pages
1139-45issue
5eissn
0730-7268issn
1552-8618journal_volume
30pub_type
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