Abstract:
:We measured concentrations of polychlorinated biphenyls (PCBs), polychlorinated dibenzo-p-dioxins (PCDDs), and polychlorinated dibenzofurans (PCDFs) in northern leopard frogs collected from the Green Bay ecosystem and explored the catalytic activity of hepatic cytochrome P450-associated monooxygenase (P450 enzyme) as a biomarker for exposure to aryl hydrocarbon receptor (AhR) agonists. The two hypotheses tested were PCH concentrations in northern leopard frogs would be positively correlated with sediment polychlorinated hydrocarbon (PCH) levels in wetland habitats along a contamination gradient and hepatic ethoxyresorufin-O-deethylase (EROD) activity of northern leopard frogs, which is presumably mediated by aryl hydrocarbon receptor (AhR), would be positively correlated with PCH concentrations in frog carcasses (whole body minus liver) from different collection sites. In 1994 to 1995, frogs from seven sites along the lower Fox River and Green Bay, USA, were assayed for hepatic EROD activities and whole carcass concentrations of PCBs, PCDDs, and PCDFs. Tissue total PCB concentrations ranging from 3 to 154 ng/g were significantly correlated with sediment PCB levels. Only one PCDD and two PCDFs at concentrations of 6 to 8 pg/g were found in the frogs collected from one of the sites. The EROD activity in frogs ranging from 186 to 270 pmol/min/mg protein was not significantly correlated with frog body weight and was similar among sites except for Peter's Marsh. No significant correlation was found between EROD activity and carcass PCB concentration. This result was consistent with the fact that the frogs collected from the Green Bay ecosystem had relatively low PCB concentrations compared with what was required for induction in the laboratory (ED50 for EROD is between 700 and 2,300 ng/g).
journal_name
Environ Toxicol Chemjournal_title
Environmental toxicology and chemistryauthors
Huang YW,Karasov WH,Patnode KA,Jefcoate CRdoi
10.1002/etc.5620181002subject
Has Abstractpub_date
1999-10-01 00:00:00pages
2123-2130issue
10eissn
0730-7268issn
1552-8618journal_volume
18pub_type
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