Continuous intravertebral injection of fasudil hydrochloride in the treatment of cerebral vasospasm.

Abstract:

BACKGROUND AND OBJECTIVE:Cerebral vasospasm is a serious complication of subarachnoid hemorrhage (SAH) and is associated with clinical deterioration and mortality. The objective of this study is to investigate the effect of continuous intravertebral artery (cIVA) injection of fasudil hydrochloride on delayed cerebral vasospasm (CVS). MATERIAL AND METHODS:Forty white rabbits were alloted into groups: (i) seven-day (cIVA injection of fasudil hydrochloride for seven days after injection of blood) group, (ii) five-day (cIVA injection of fasudil hydrochloride for five days from the third day after injection of blood) group, (iii) intravenous treatment (intravenous infusion of fasudil hydrochloride after the first blood injection twice a day) group, and (iv) control group. All the rabbits in all the four groups underwent selective vertebrobasilar angiography. The pathological changes in the basal artery were observed by light and electron microscopy. Fasudil hydrochloride injection (2ml:30mg) was provided by Tianjin Chase Sun Pharmaceutical Company Limited. RESULTS:Severe CVS occurred after subarachnoid hemorrhage (SAH) in the control group, whereas, it was significantly lower after intravertebral artery and intravenous injection of fasudil hydrochloride. The difference between the intravenous and intravertebral artery groups was statistically significant on the seventh day. CONCLUSIONS:The effect of cIVA injection of fasudil hydrochloride in treating delayed CVS due to SAH at different time points was better than intravenous administration.

journal_name

Neurol India

journal_title

Neurology India

authors

Liu P,Liao X,Xiang J,Pan L,Ma L

doi

10.4103/0028-3886.79127

subject

Has Abstract

pub_date

2011-03-01 00:00:00

pages

161-7

issue

2

eissn

0028-3886

issn

1998-4022

pii

ni_2011_59_2_161_79127

journal_volume

59

pub_type

杂志文章
  • Intracranial plasma cell granuloma.

    abstract::We report two rare cases of primary intracranial plasma cell granuloma. The tumors probably arose from the dura and involved the cerebral parenchyma. These patients presented with clinical features of raised intracranial pressure and there was focal neurological deficit. The management issues are discussed. ...

    journal_title:Neurology India

    pub_type: 杂志文章,评审

    doi:

    authors: Shenoy SN,Raja A

    更新日期:2004-06-01 00:00:00

  • Analysis of dystrophin gene deletions by multiplex PCR in eastern India.

    abstract::The most common genetic neuromuscular disease of childhood, Duchenne and Becker muscular dystrophy (DMD/BMD) is caused by deletion, duplication or point mutation of the dystrophin gene located at Xp 21.2. In the present study DNA from seventy unrelated patients clinically diagnosed as having DMD/BMD referred from diff...

    journal_title:Neurology India

    pub_type: 杂志文章

    doi:10.4103/0028-3886.27164

    authors: Basak J,Dasgupta UB,Banerjee TK,Senapati AK,Das SK,Mukherjee SC

    更新日期:2006-09-01 00:00:00

  • Steroid-induced myopathy following a single oral dose of prednisolone.

    abstract::This report describes a case of acute steroid-induced myopathy following a single dose of oral prednisolone. A 55-year-old man presented with an acute exacerbation of chronic obstructive pulmonary disease, which was treated with prednisolone 40 mg daily in addition to bronchodilators. He developed features of myopathy...

    journal_title:Neurology India

    pub_type: 杂志文章

    doi:

    authors: Kumar S

    更新日期:2003-12-01 00:00:00

  • Massive pontine hemorrhagic transformation associated with an anticoagulant for basilar artery occlusion.

    abstract::Symptomatic hemorrhagic transformation is common in supratentorial and cerebellar infarction, but is rare in brainstem infarction. It is seldom reported in basilar artery occlusion. Although early arterial recanalization by thrombolytic agent has became the new trend of treatment, for some neurologists anticoagulant i...

    journal_title:Neurology India

    pub_type: 杂志文章

    doi:10.4103/0028-3886.28123

    authors: Hsiao MC,Lee JD,Lee M,Weng HH

    更新日期:2006-12-01 00:00:00

  • Parkinsonism with newly diagnosed flare-up rheumatoid arthritis mimicking progressive supranuclear palsy.

    abstract::In order to make a correct diagnosis of idiopathic Parkinson's disease (PD), it is essential to exclude atypical parkinsonian features, such as early dementia, fall, and autonomic dysfunction. Rheumatoid arthritis (RA), which is a systemic inflammatory disorder, although most patients present in a polyarticular manner...

    journal_title:Neurology India

    pub_type:

    doi:10.4103/0028-3886.284382

    authors: Lee KW,Chien CF,Wu MN,Lai CL,Liou LM

    更新日期:2020-03-01 00:00:00

  • Surgical management of selected pituitary macroadenomas using extended endoscopic endonasal transsphenoidal approach: early experience.

    abstract:BACKGROUND AND OBJECTIVES:The endoscopic transsphenoidal approach is commonly used surgical approach for pituitary adenomas. However, adenomas with dumbbell configuration, pure suprasellar location, and fibrous consistency are difficult to remove by this approach. Recently, the extended endoscopic endonasal approach (E...

    journal_title:Neurology India

    pub_type: 杂志文章

    doi:10.4103/0028-3886.111114

    authors: Sankhla SK,Jayashankar N,Khan GM

    更新日期:2013-03-01 00:00:00

  • Spectrum of mutations in sarcoglycan genes in the Mumbai region of western India: high prevalence of 525del T.

    abstract:BACKGROUND:While the clinical and immunocytochemical features of sarcoglycanopathies have been reported from India, genetic aspects have not been studied. There is large variation in the sarcoglycan mutations among the studied populations. AIM:To study the spectrum of mutations in sarcoglycan genes (SG). MATERIALS AN...

    journal_title:Neurology India

    pub_type: 杂志文章

    doi:10.4103/0028-3886.55603

    authors: Khadilkar SV,Singh RK,Hegde M,Urtizberea A,Love DR,Chong B

    更新日期:2009-07-01 00:00:00

  • Pregabalin and lamotrigine in central poststroke pain: A pilot study.

    abstract:BACKGROUND:Comparative study of Class I drugs in central poststroke pain (CPSP) is lacking. OBJECTIVE:To evaluate the safety and efficacy of pregabalin and lamotrigine in patients with CPSP. SETTING:Tertiary care teaching referral hospital. METHODS:We included consecutive patients with CPSP having ≥50 mm score on Vi...

    journal_title:Neurology India

    pub_type: 杂志文章,随机对照试验

    doi:10.4103/neuroindia.NI_45_16

    authors: Kalita J,Chandra S,Misra UK

    更新日期:2017-05-01 00:00:00

  • Cognition in advanced normal pressure hydrocephalus: A pilot study from South India.

    abstract:BACKGROUND:Literature on cognition in normal pressure hydrocephalus (NPH) is sparse and more so on cognition in advanced NPH. OBJECTIVE:To study the cognitive profile in a hospital-based cohort of cognitively-advanced NPH. SETTINGS AND DESIGN:This was a prospective cross-sectional study. The patients included those a...

    journal_title:Neurology India

    pub_type: 杂志文章

    doi:10.4103/neuroindia.NI_1219_15

    authors: Mathew R,Pavithran S

    更新日期:2017-07-01 00:00:00

  • Once daily baclofen sustained release or gastro-retentive system are acceptable alternatives to thrice daily baclofen immediate release at same daily dosage in patients.

    abstract:BACKGROUND:Baclofen, a GABA-agonist, is currently available as an immediate release (IR) formulation for relieving neurogenic spasticity in a variety of disorders. Baclofen IR requires to be administered three times a day which inadvertently increases the chances of medication noncompliance among patients and is also a...

    journal_title:Neurology India

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.4103/0028-3886.53284

    authors: Sampat NG,Kulkarni RV,Sase N,Joshi NH,Vora PB,Bhattacharya AK,Lakhani JD,Bhowmik SS

    更新日期:2009-05-01 00:00:00

  • Conditional downregulation of brain- derived neurotrophic factor and tyrosine kinase receptor B blocks epileptogenesis in the human temporal lobe epilepsy hippocampus.

    abstract:BACKGROUND:Brain-derived neurotrophic factor (BDNF) has been implicated as a potential therapeutic target in temporal lobe epilepsy (TLE). However, whether BDNF exerts an epileptogenic or antiepileptogenic function remains controversial. MATERIALS AND METHODS:BDNF/tyrosine kinase receptor B (trkB) expression levels we...

    journal_title:Neurology India

    pub_type: 杂志文章

    doi:10.4103/0028-3886.60392

    authors: Hou X,Wang X,Zhang L

    更新日期:2010-01-01 00:00:00

  • Functional recovery in ischemic stroke.

    abstract::Functional outcome at three months was studied in 72 patients with ischemic stroke. The Canadian Neurological Scale was used to assess the severity of stroke at admission and functional outcome at 3 months was assessed using modified Rankin scale. The size and site of the infarct was noted from the initial CT. Risk fa...

    journal_title:Neurology India

    pub_type: 杂志文章

    doi:

    authors: Paithankar MM,Dabhi RD

    更新日期:2003-09-01 00:00:00

  • Prevalence and risk factors of asymptomatic carotid artery stenosis in Indian population: An 8-year follow-up study.

    abstract:BACKGROUND:Asymptomatic carotid artery stenosis (ACAS) is a marker for cerebrovascular disease, coronary atherosclerosis, and death. AIM:To investigate the prevalence of ACAS in the Indian population, and to correlate ACAS with other vascular risk factors. MATERIALS AND METHODS:We prospectively recruited 1500 individ...

    journal_title:Neurology India

    pub_type: 杂志文章

    doi:10.4103/neuroindia.NI_523_16

    authors: Kaul S,Alladi S,Mridula KR,Bandaru VC,Umamashesh M,Anjanikumar D,Lalitha P,Chandrasekhar R

    更新日期:2017-03-01 00:00:00

  • Cryptococcal meningitis in HIV infected: experience from a North Indian tertiary center.

    abstract:BACKGROUND:Cryptococcal meningitis is a common opportunistic infection in Human Immunodeficiency Virus (HIV)-infected individuals. There is little information specifically addressing cryptococcal meningitis in HIV-infected patients from North India. AIMS:To determine clinical presentation, hospital course, response to...

    journal_title:Neurology India

    pub_type: 杂志文章

    doi:

    authors: Kumar S,Wanchu A,Chakrabarti A,Sharma A,Bambery P,Singh S

    更新日期:2008-10-01 00:00:00

  • Evidence-based guidelines for the management of epilepsy.

    abstract::Approximately 50 million people live with epilepsy worldwide. The aim of this review is to present an overview of the current evidence and management recommendations for evaluation and treatment of patients with epilepsy. Systematic literature reviews were undertaken. A review of contemporary published evidence-based ...

    journal_title:Neurology India

    pub_type: 杂志文章,评审

    doi:10.4103/neuroindia.NI_1027_16

    authors: Singh SP,Sankaraneni R,Antony AR

    更新日期:2017-01-01 00:00:00

  • Neurological Manifestations Do not Affect Cumulative Survival in Indian Patients with Antineutrophil Cytoplasmic Antibody Associated Vasculitis.

    abstract:Background:Neurological manifestations are an important cause of morbidity in antineutrophil cytoplasmic antibody (ANCA) associated vasculitis (AAV). It is not clear whether or not they are indicative of a severe disease course with multiple organ involvement and shortened survival. Aims and Objectives:To characterize...

    journal_title:Neurology India

    pub_type: 杂志文章

    doi:10.4103/0028-3886.266234

    authors: Sharma A,Rajan R,Modi M,Pinto B,Dhooria A,Rathi M,Mittal T,Kumar S,Sharma K,Dhir V,Nada R,Minz RW,Singh S

    更新日期:2019-07-01 00:00:00

  • Calvarial tuberculosis: A report of eleven patients.

    abstract:BACKGROUND:Tuberculosis is endemic in developing countries. However, calvarial tuberculosis is rare, even in areas where tuberculosis is endemic. In the literature, only few case series of calvarial tuberculosis have been reported. AIM:To report a case series of 11 patients with calvarial tuberculosis, and discuss the...

    journal_title:Neurology India

    pub_type: 杂志文章

    doi:10.4103/0028-3886.57814

    authors: Diyora B,Kumar R,Modgi R,Sharma A

    更新日期:2009-09-01 00:00:00

  • Diagnosing residual or recurrent cerebral aneurysms after clipping by computed tomographic angiography: Meta-analysis.

    abstract:BACKGROUND:A cerebral aneurysm with incomplete treatment may re-grow and cause new bleeding. This meta-analysis calculates the sensitivity and specificity of computed tomographic angiography (CTA) in the detection of the residual or recurrent cerebral aneurysms after clipping, in comparison with digital subtraction ang...

    journal_title:Neurology India

    pub_type: 杂志文章,meta分析

    doi:10.4103/0028-3886.107942

    authors: Sun H,Ma J,Liu Y,Lan Z,You C

    更新日期:2013-01-01 00:00:00

  • Paroxysmal occipital discharges suppressed by eye opening: spectrum of clinical and imaging features at a tertiary care center in India.

    abstract:BACKGROUND:Paroxysmal occipital discharges (PODs) demonstrating the phenomena of fixation-off sensitivity have classically been described in childhood epilepsies with occipital paroxysms. AIM:We attempted to delineate the demographic, clinical and imaging characteristics of patients whose interictal electroencephalogr...

    journal_title:Neurology India

    pub_type: 杂志文章

    doi:10.4103/0028-3886.103183

    authors: Kaul B,Shukla G,Goyal V,Srivastava A,Behari M

    更新日期:2012-09-01 00:00:00

  • Meningioma associated with contralateral chronic subdural haematoma: a short report.

    abstract::Two unusual cases of meningiomas associated with opposite chronic subdural haematoma are presented. ...

    journal_title:Neurology India

    pub_type: 杂志文章

    doi:

    authors: Sinha VD,Dharker SR

    更新日期:2001-06-01 00:00:00

  • Miller-Fisher syndrome associated with chronic lymphocytic leukemia.

    abstract::Chronic lymphocytic leukemia (CLL) is a frequent hematological malignancy, with meningeal or peripheral nerve infiltrations being the most commonly encountered neurological complications. In this report, we describe a CLL patient with Miller-Fisher syndrome (MFS) who responded to immune modulation with plasmapheresis....

    journal_title:Neurology India

    pub_type: 杂志文章

    doi:10.4103/0028-3886.42003

    authors: Aki Z,Aksoy O,Sucak G,Kuruoğlu R,Yağci M

    更新日期:2008-04-01 00:00:00

  • Hirayama disease/cervical flexion-induced myelopathy progressing to spastic paraparesis: A report on three cases with literature review.

    abstract::Hirayama disease (HD)/cervical flexion-induced myelopathy (CFIM) is a lower motor neuron disease conventionally affecting a single upper extremity. We describe three men progressing after a long stable period to develop severe spastic paraparesis and bladder disturbances as a protracted implication of HD. The age at o...

    journal_title:Neurology India

    pub_type: 杂志文章,评审

    doi:10.4103/0028-3886.236966

    authors: Preethish-Kumar V,Polavarapu K,Nashi S,Bhattacharya K,Saini J,Vengalil S,Pruthi N,Bhat DI,Nalini A

    更新日期:2018-07-01 00:00:00

  • Lift-up laminoplasty for myelopathy caused by ossification of the posterior longitudinal ligament of the cervical spine.

    abstract:BACKGROUND AND AIMS:We have utilized lift-up laminoplasty to treat patients with myelopathy caused by ossification of the posterior longitudinal ligament (OPLL) of the cervical spine. The preliminary surgical outcome with computer-assisted morphological assessment is presented. MATERIAL AND METHODS:The surgical techni...

    journal_title:Neurology India

    pub_type: 杂志文章

    doi:

    authors: Takami T,Ohata K,Goto T,Nishikawa M,Nishio A,Tsuyuguchi N,Hara M

    更新日期:2004-03-01 00:00:00

  • Sarcoglycanopathies: a clinicopathological study of 13 cases [corrected].

    abstract:BACKGROUND:Limb girdle muscular dystrophy (LGMD) is a phenotypic expression of a heterogeneous group of diseases and sarcoglycanopathy is one of the causes of LGMD. There is only one study on sarcoglycanopathies in the Indian literature. No data is available from northern India. MATERIALS AND METHODS:All cases of musc...

    journal_title:Neurology India

    pub_type: 杂志文章

    doi:

    authors: Sharma MC,Mannan R,Singh NG,Gulati S,Kalra V,Sarkar C

    更新日期:2004-12-01 00:00:00

  • Development of neuropsychological evaluation screening tool: An education-free cognitive screening instrument.

    abstract:Background:Due to the paucity of quick, cognitive screening tools available in India that are independent of cultural and educational influences, a 6-item paper and pencil test, covering areas of memory, executive functioning, attention, and visuospatial ability domains - the Neuropsychological Evaluation Screening Too...

    journal_title:Neurology India

    pub_type: 杂志文章

    doi:10.4103/0028-3886.227304

    authors: Chopra S,Kaur H,Pandey RM,Nehra A

    更新日期:2018-03-01 00:00:00

  • Cerebral amyloid angiopathy presenting as a posterior leukoencephalopathy: a case report and review of the literature.

    abstract::Cerebral amyloid angiopathy (CAA) is well known to present with lobar intracerebral hemorrhage, dementia or transient neurological events. White matter changes with CAA have only been recently described and can be seen with either sporadic or familial CAA. We present a 50-year-old man with rapidly progressive dementia...

    journal_title:Neurology India

    pub_type: 杂志文章

    doi:

    authors: Maramattom BV,Maramattom LV

    更新日期:2004-12-01 00:00:00

  • Intraarterial nimodipine for the treatment of symptomatic vasospasm after aneurysmal subarachnoid hemorrhage: a preliminary study.

    abstract:OBJECTIVE:Despite dramatic advances in all medical era, cerebral vasospasm is still the major complication in patients with subarachnoid hemorrhage (SAH). The purpose of this study was to assess the influence of intraarterial (IA) nimodipine in the treatment of symptomatic vasospasm and in preventing neurological disab...

    journal_title:Neurology India

    pub_type: 杂志文章

    doi:10.4103/0028-3886.91356

    authors: Dehdashti AR,Binaghi S,Uske A,Regli L

    更新日期:2011-11-01 00:00:00

  • Is infantile spinal muscular atrophy a disease of maturation arrest or a dynamic neurogenic atrophy of the skeletal muscle?

    abstract::Spinal muscular atrophy constitutes one of the major disease entities amongst infantile neuro-muscular disorders. On the basis of morphological evidence, it had been suggested that the infantile spinal muscular atrophy (ISMA) is due to maturation arrest of the myofibres at 20 weeks gestation. Therefore, in the present...

    journal_title:Neurology India

    pub_type: 杂志文章

    doi:

    authors: Gayathri N,Das S,Gourie-Devi M,Ramamohan Y,Sarala D

    更新日期:1998-07-01 00:00:00

  • Comparative study of electrophysiological changes in snake bites.

    abstract:AIMS:To study and compare the electrophysiological changes in neuroparalytic or vasculotoxic snakebites. MATERIALS AND METHODS:40 patients who had a definite history of snakebite, either vasculotoxic or neuroparalytic, were selected. They were grouped as Group A, 20 patients having a neuroparalytic snakebite with defi...

    journal_title:Neurology India

    pub_type: 杂志文章

    doi:10.4103/0028-3886.158214

    authors: Panduranga P,Sangle SA,Mane AA,Doshi S,Kadam DB

    更新日期:2015-05-01 00:00:00

  • Spontaneous resolution of chronic subdural haematoma secondary to chronic idiopathic thrombocytopenic purpura.

    abstract::Chronic subdural haematoma (SDH) complicating chronic idiopathic thrombocytopenic purpura (ITP), in an adult is extremely rare. There are only four such case reports available in the literature and all these patients had surgical evacuation of the haematoma. We report an elderly female with chronic ITP presenting with...

    journal_title:Neurology India

    pub_type: 杂志文章

    doi:

    authors: Gupta SK,Khosla VK,Verma SC

    更新日期:1997-04-01 00:00:00