Abstract:
BACKGROUND:Brain-derived neurotrophic factor (BDNF) has been implicated as a potential therapeutic target in temporal lobe epilepsy (TLE). However, whether BDNF exerts an epileptogenic or antiepileptogenic function remains controversial. MATERIALS AND METHODS:BDNF/tyrosine kinase receptor B (trkB) expression levels were comparatively assessed in the hippocampal tissue of TLE patients with (HS group) and without hippocampal sclerosis (non-HS group) as well as from non-epileptic controls. RESULTS:Immunohistochemistry and immunoblot analysis revealed a marked increase in BDNF/trkB expression in the dentate gyrus and CA3 regions of HS and non-HS groups. The lack of any differences in expression levels was observed between HS and non-HS patients. Meanwhile, treatment with VPA (Valproic acid, anti-epileptic drug) resulted in a significant down-regulation of BDNF/trkB protein expression in sclerotic and non-sclerotic hippocampus (P < 0.001). In contrast, no marked change was noticed in VPA-untreated and OA-treated groups (sodium octanoate). CONCLUSION:These results suggest that the up-regulation of BDNF/trkB pathway might be at least in part responsible for the epileptogenesis.
journal_name
Neurol Indiajournal_title
Neurology Indiaauthors
Hou X,Wang X,Zhang Ldoi
10.4103/0028-3886.60392subject
Has Abstractpub_date
2010-01-01 00:00:00pages
29-34issue
1eissn
0028-3886issn
1998-4022pii
ni_2010_58_1_29_60392journal_volume
58pub_type
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