Cerebral amyloid angiopathy presenting as a posterior leukoencephalopathy: a case report and review of the literature.

Abstract:

:Cerebral amyloid angiopathy (CAA) is well known to present with lobar intracerebral hemorrhage, dementia or transient neurological events. White matter changes with CAA have only been recently described and can be seen with either sporadic or familial CAA. We present a 50-year-old man with rapidly progressive dementia in whom MRI brain showed symmetrical white matter changes in the parieto-occipital regions. Brain biopsy revealed changes of CAA along with features of Alzheimer's disease. Immunohistochemistry revealed amyloid beta protein. The subcortical lesions were thought to occur from hypoperfusion of the distal white matter. The role of amyloid in the pathogenesis of CAA and the mechanism of leukoencephalopathy are discussed.

journal_name

Neurol India

journal_title

Neurology India

authors

Maramattom BV,Maramattom LV

subject

Has Abstract

pub_date

2004-12-01 00:00:00

pages

487-8

issue

4

eissn

0028-3886

issn

1998-4022

journal_volume

52

pub_type

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