Miller-Fisher syndrome associated with chronic lymphocytic leukemia.

Abstract:

:Chronic lymphocytic leukemia (CLL) is a frequent hematological malignancy, with meningeal or peripheral nerve infiltrations being the most commonly encountered neurological complications. In this report, we describe a CLL patient with Miller-Fisher syndrome (MFS) who responded to immune modulation with plasmapheresis. A 47-year-old man diagnosed as B-cell CLL admitted with neutropenic fever. He complained of diplopia and numbness of both arms. Neurological examination revealed a bilateral external ophthalmoplegia, dysphagia, dysarthria, mild shoulder girdle muscle weakness and gait ataxia, accompanied by absent tendon reflexes. Nerve conduction studies were indicative of a predominantly axonal sensori-motor peripheral neuropathy. This association of CLL with MFS had not been previously reported in the literature.

journal_name

Neurol India

journal_title

Neurology India

authors

Aki Z,Aksoy O,Sucak G,Kuruoğlu R,Yağci M

doi

10.4103/0028-3886.42003

subject

Has Abstract

pub_date

2008-04-01 00:00:00

pages

198-200

issue

2

eissn

0028-3886

issn

1998-4022

journal_volume

56

pub_type

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