Abstract:
Background:The clinical phenotypes of myelin oligodendrocyte glycoprotein (MOG) antibody disease, its disease course, and treatment are poorly understood and much work needs to be done towards this. Objective:To characterize the clinico-radiologic spectrum and treatment outcomes of MOG antibody disease and differentiate it from aquaporin-4 (AQP-4) antibody positive neuromyelitis optica spectrum disorders (NMO-SD). Methods:A single-center, observational study from Western India during 2017-2019, of 48 patients with either MOG antibody positive (21 patients) or AQP-4 antibody positive (27 patients) central nervous system demyelination. Results:MOG antibody group had median age 32.2 years, no gender bias, median disease duration 40 months, relapses in 9 patients (43%), and median 2.5 (1-16) episodes per patient. Onset phenotypes included isolated bilateral optic neuritis (ON) (43%), isolated unilateral ON (19%), acute brainstem syndrome (19%), simultaneous ON with myelitis (9%), isolated myelitis (5%), and acute disseminated encephalomyelitis optic neuritis (ADEM-ON) (5%). Characteristic neuroimaging abnormalities were anterior segment longitudinally extensive ON, upper brainstem, and thoracic cord involvement (both short and long segment lesions). Most patients (86%) responded well to steroids, only 3/21 required rescue immunotherapy. In total, 6 out of 46 eyes affected developed permanent visual disability, while one patient had motor disability. The features differentiating MOG from AQP-4 antibody group were: no female predilection, preferential optic nerve involvement, characteristic neuroimaging abnormalities, and favorable therapeutic response and outcome. Conclusions:MOG disease commonly presents as severe ON, myelitis, acute brainstem syndrome, ADEM or their combinations. Early identification, treatment, and maintenance immunosuppression are necessary. It can easily be differentiated from NMO-SD using clinico-radiological features and therapeutic response.
journal_name
Neurol Indiajournal_title
Neurology Indiaauthors
Ojha PT,Aglave VB,Soni G,Jagiasi KA,Singh RK,Singh RK,Nagendra Sdoi
10.4103/0028-3886.294831subject
Has Abstractpub_date
2020-09-01 00:00:00pages
1106-1114issue
5eissn
0028-3886issn
1998-4022pii
ni_2020_68_5_1106_294831journal_volume
68pub_type
杂志文章相关文献
NEUROLOGY INDIA文献大全abstract::The Department of Neurological Sciences at Christian Medical College (CMC), Vellore was the first department to start neurosurgical and neurological services in India. Jacob Chandy started the department in 1949 against several odds. He started a formal training program in neurosurgery in 1958, for the first time in I...
journal_title:Neurology India
pub_type: 历史文章,杂志文章
doi:10.4103/0028-3886.177625
更新日期:2016-03-01 00:00:00
abstract:Background:Fluid management during intracranial surgery is an important concern. The type of fluid used can have biochemical and metabolic effects during intraoperative management. However, it is yet to be known whether biochemical and metabolic effects have an influence on the clinical outcome of a patient. Objective...
journal_title:Neurology India
pub_type: 杂志文章,随机对照试验
doi:10.4103/0028-3886.258047
更新日期:2019-03-01 00:00:00
abstract::There are more than 10 million persons with epilepsy (PWE) in India. Despite availability of antiepileptic drugs (AEDs), there is a large treatment gap varying from 50 to 70% among PWE. For treatable epilepsy, this gap can be attributed to poor education, poverty, cultural beliefs, stigma, and poor healthcare infrastr...
journal_title:Neurology India
pub_type: 杂志文章
doi:10.4103/neuroindia.NI_1070_16
更新日期:2017-01-01 00:00:00
abstract:BACKGROUND:Neuropathy is often an associated feature woth long-standing type II diabetes mellitus. Neuropathy may occur even in subjects with impaired glucose tolerance. OBJECTIVE:To study the prevalence of neuropathy using different electrophysiological techniques in subjects with impaired glucose tolerance (IGT) and...
journal_title:Neurology India
pub_type: 杂志文章
doi:10.4103/0028-3886.149393
更新日期:2014-11-01 00:00:00
abstract::The issue of stroke in young in India has long been of interest to neurologists in the country. The age group for stroke in young has been variable between different studies but perhaps should be restricted to 15-49 years as this age group tends to have a unique set of causes and risk factors. There is no evidence ind...
journal_title:Neurology India
pub_type: 杂志文章,评审
doi:10.4103/0028-3886.65531
更新日期:2010-05-01 00:00:00
abstract::Positron emission tomography (PET) is the study of human physiology by electronic detection of positron-emitting radiopharmaceuticals. It is one of the noninvasive technologies that can measure the metabolic and functional activity of living tissue. Positron emission tomography finds its clinical applications in broad...
journal_title:Neurology India
pub_type: 杂志文章,评审
doi:10.4103/0028-3886.16395
更新日期:2005-06-01 00:00:00
abstract:BACKGROUND:Literature on cognition in normal pressure hydrocephalus (NPH) is sparse and more so on cognition in advanced NPH. OBJECTIVE:To study the cognitive profile in a hospital-based cohort of cognitively-advanced NPH. SETTINGS AND DESIGN:This was a prospective cross-sectional study. The patients included those a...
journal_title:Neurology India
pub_type: 杂志文章
doi:10.4103/neuroindia.NI_1219_15
更新日期:2017-07-01 00:00:00
abstract:Objectives:Aspirin is a drug that has been found to be useful in reducing the incidence of infarctions. This systemic is aimed at review evaluating the benefits of aspirin in the management of tuberculous meningitis. Methods:A systematic literature search was performed using PubMed, Cochrane Central Register of Contro...
journal_title:Neurology India
pub_type: 杂志文章,meta分析
doi:10.4103/0028-3886.266232
更新日期:2019-07-01 00:00:00
abstract:OBJECTIVE:The objective of this study was to conduct a retrospective analysis of the clinical characteristics of 20 individuals with intramedullary cavernous angiomas (ICA) presented with serious pain complaints. This study was to investigate the efficacy of short- and long-term pain relief following surgical resection...
journal_title:Neurology India
pub_type: 杂志文章
doi:10.4103/0028-3886.141477
更新日期:2014-07-01 00:00:00
abstract::The services of clinical psychology (neuro) were established in 1969 under the tutelage of Dr. Surya Gupta. The unit has now established itself as a core group in the Neurosciences Centre, providing services to various other departments. The research and clinical services in Clinical Neuropsychology have substantially...
journal_title:Neurology India
pub_type: 杂志文章
doi:10.4103/0028-3886.193822
更新日期:2016-11-01 00:00:00
abstract::The application of molecular diagnostic techniques has greatly improved the diagnosis, carrier detection, prenatal testing and genetic counseling for families with Duchenne and Becker muscular dystrophy (D/BMD) in India. The prediction of Duchenne muscular dystrophy (DMD) patients to have out-framed deletions and Beck...
journal_title:Neurology India
pub_type: 杂志文章,评审
doi:10.4103/0028-3886.43442
更新日期:2008-07-01 00:00:00
abstract::Epilepsy surgery currently offers the best treatment for patients with drug-refractory epilepsy (DRE). Resective surgery, in the presence of a well-localized epileptogenic focus, remains the best modality towards achieving seizure freedom. However, localization of the focus may not be possible in all the cases of DRE,...
journal_title:Neurology India
pub_type: 杂志文章
doi:10.4103/0028-3886.302475
更新日期:2020-11-01 00:00:00
abstract::The clinical, electrophysiological and pathological features of 16 patients with vasculitic neuropathy were evaluated. Vasculitic neuropathy accounted for 5.3 of biopsy proven cases of various neuropathies. They included 7 cases of systemic vasculitic neuropathy (SVN) and 9 cases of nonsystemic vasculitic neuropathy (...
journal_title:Neurology India
pub_type: 杂志文章
doi:
更新日期:1998-01-01 00:00:00
abstract::Delayed carpal tunnel syndrome is rare. We describe the electrophysiological findings in a patient with Colle's fracture, who developed carpal tunnel syndrome 22 years after a wrist injury. ...
journal_title:Neurology India
pub_type: 杂志文章
doi:
更新日期:2003-03-01 00:00:00
abstract::Approximately 50 million people live with epilepsy worldwide. The aim of this review is to present an overview of the current evidence and management recommendations for evaluation and treatment of patients with epilepsy. Systematic literature reviews were undertaken. A review of contemporary published evidence-based ...
journal_title:Neurology India
pub_type: 杂志文章,评审
doi:10.4103/neuroindia.NI_1027_16
更新日期:2017-01-01 00:00:00
abstract::Based on the evidence that hyperglycaemia aggravates ischaemic cerebral injury, it has been suggested that blood glucose levels be kept within 200 mg/dL during intracranial neurosurgery. Hypoglycaemia, however, can be a serious problem if glucose-containing solutions are avoided during the first four hours, as suggest...
journal_title:Neurology India
pub_type: 杂志文章
doi:
更新日期:2001-12-01 00:00:00
abstract::Women in India are greatly discriminated against if they happen to have epilepsy. Engagements are often cancelled. The parents of epileptic girls have to give heavy dowry at the time of marriage, even if the boy is handicapped. As a result, many girls do not disclose their problem before marriage. They take the medici...
journal_title:Neurology India
pub_type:
doi:
更新日期:2000-06-01 00:00:00
abstract::Patients with severe head injury with bilateral dilated unreactive pupils are considered to have a grave prognosis. Hence proper planning and aggressive management becomes mandatory for achieving good results. We present the outcome of consecutive 166 patients with severe head injury, admitted between January 1996 and...
journal_title:Neurology India
pub_type: 杂志文章
doi:
更新日期:2002-12-01 00:00:00
abstract::In this paper we report an 18 year old woman with an intradural extramedullary tuberculoma mimicking en plaque meningioma located in the thoracic region. The patient was operated via thoracic laminoplasty and tumor was totally resected. On the follow-up examination the magnetic resonance imaging demonstrated the total...
journal_title:Neurology India
pub_type: 杂志文章
doi:10.4103/0028-3886.51300
更新日期:2009-03-01 00:00:00
abstract::Clinical symptoms and radiologic characteristics of gliomatosis cerebri (GC) are non-specific and the condition may be confused with other central nervous system diseases. We report three patients with GC; all the three patients had involvement of more than three lobes and the deep white matter, as well as bilateral i...
journal_title:Neurology India
pub_type: 杂志文章
doi:10.4103/0028-3886.76892
更新日期:2011-01-01 00:00:00
abstract:Background:Anatomy of the temporal region is complex with controversy over the relationship of fascial planes with the upper division of the facial nerve. Objective:This study aimed to identify the safe surgical landmarks to preserve the frontotemporal branch of the facial nerve during surgery and define the safest ap...
journal_title:Neurology India
pub_type: 杂志文章
doi:10.4103/0028-3886.304113
更新日期:2020-11-01 00:00:00
abstract:BACKGROUND:Baclofen, a GABA-agonist, is currently available as an immediate release (IR) formulation for relieving neurogenic spasticity in a variety of disorders. Baclofen IR requires to be administered three times a day which inadvertently increases the chances of medication noncompliance among patients and is also a...
journal_title:Neurology India
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.4103/0028-3886.53284
更新日期:2009-05-01 00:00:00
abstract::Enterogenous cyst is extremely rare in the supratentorial compartment. Two adult patients with histologically variefied supratentorial entrogenous cyst are described. Light microscopy and immunohistochemistry examination revealed the endodermal origin of the cyst. Enterogenous cyst should be considered in the differen...
journal_title:Neurology India
pub_type: 杂志文章,评审
doi:10.4103/0028-3886.72200
更新日期:2010-09-01 00:00:00
abstract::Accessory nerve schwannoma are extremely rare. The preoperative consideration of this diagnosis will lead to appropriate surgical management with preservation of motor nerve function. In this article we review the literature and report a case treated successfully based on preoperative MRI findings. ...
journal_title:Neurology India
pub_type: 杂志文章
doi:10.4103/0028-3886.16941
更新日期:2005-09-01 00:00:00
abstract::Intracranial epidermoids are generally seen as hypodense nonenhancing lesions on computed tomography scans; and, as T1 hypointense and T2 hyperintense lesions on magnetic resonance imaging (MRI). Unusual radiological findings have been reported earlier. The authors present the case of a 54-year old male patient who ha...
journal_title:Neurology India
pub_type:
doi:10.4103/0028-3886.232336
更新日期:2018-05-01 00:00:00
abstract::Lateral sacral lipomyelomeningocele is a rare spinal developmental anomaly. In the case under report, the fat attached to the neural placode was blending with the gluteal fat externally. The cord was tethered at this level. Multiple bony anomalies and diastematomyelia were associated findings. A case of lateral sacral...
journal_title:Neurology India
pub_type: 杂志文章
doi:
更新日期:2002-06-01 00:00:00
abstract:BACKGROUND:Instrumentation in patients with osteoporosis is challenging. Bone cement-augmented fenestrated pedicle screw fixation is a new procedure for fixation in the osteoporotic bone; and, applying minimally invasive techniques to the above is a challenging and novel concept. AIMS:To evaluate the clinical and radi...
journal_title:Neurology India
pub_type: 杂志文章
doi:10.4103/0028-3886.222826
更新日期:2018-01-01 00:00:00
abstract:BACKGROUND:Earthquake is one of the most devastating natural disasters that threaten human lives. Worldwide more than 3 million deaths have been caused by earthquakes in recent 20 years. AIM:To analyze clinical features of head injuries after Sichuan earthquake. MATERIALS AND METHODS:From May 12 to June 12, 2008, Dep...
journal_title:Neurology India
pub_type: 杂志文章
doi:10.4103/0028-3886.60406
更新日期:2010-01-01 00:00:00
abstract::Benign gliomas of the brain show decreased uptake of 18F fluorodeoxyglucose (FDG) on positron emission tomography (PET). Malignant transformation is usually manifested by an increase of 18FDG uptake. A 45-year-old female has been followed up since 1987 by means of 18FDG-PET for a right hemispheric World Health Organiz...
journal_title:Neurology India
pub_type: 杂志文章
doi:10.4103/0028-3886.15076
更新日期:2005-03-01 00:00:00
abstract::Two hundred and sixty four transsphenoidal procedure for excision for pituitary adenomas were performed in the Christian Medical College Hospital at Vellore between 1983 and 1994. These were reviewed to evaluate the complications and their management. There were four operative deaths (1.5). Major morbidity included ce...
journal_title:Neurology India
pub_type: 杂志文章
doi:
更新日期:1997-10-01 00:00:00