Abstract:
:There are more than 10 million persons with epilepsy (PWE) in India. Despite availability of antiepileptic drugs (AEDs), there is a large treatment gap varying from 50 to 70% among PWE. For treatable epilepsy, this gap can be attributed to poor education, poverty, cultural beliefs, stigma, and poor healthcare infrastructure; whereas for chronic epilepsy, this gap can be attributed to lack of proper diagnosis and treatment. To prevent, treat, and cure epilepsy, researchers worldwide have made exciting advances across all areas of epilepsy research. Studies carried out in India have also shown substantial progress; however, most of them are focused on the epidemiological aspects of epilepsy, genetic associations, identification, and validation of new AEDs in animal models of epilepsy.Very few studies are reported on understanding the process of epileptogenesis, a dynamic process by which neurons begin to display abnormal firing patterns that cause epileptic seizures. Animal epilepsy models can be used for in depth studies; however, studies conducted on resected brain tissues from epilepsy patients are clinically relevant. Finally, more funding support from government and collaborations among basic research institutes, medical institutes, as well as industries is required to raise the standards of epilepsy research in India.This review focuses on the evaluation of the current status of epilepsy research in India and the need to identify potential anti-epileptogenic interventions.
journal_name
Neurol Indiajournal_title
Neurology Indiaauthors
Dixit AB,Banerjee J,Chandra PS,Tripathi Mdoi
10.4103/neuroindia.NI_1070_16subject
Has Abstractpub_date
2017-01-01 00:00:00pages
S83-S92issue
Supplementeissn
0028-3886issn
1998-4022pii
ni_2017_65_7_83_201663journal_volume
65pub_type
杂志文章相关文献
NEUROLOGY INDIA文献大全abstract::This study was undertaken to find out the profile of intractable epilepsy (IE) in a tertiary referral centre. 100 patients (males 67; females 33) with IE attending the epilepsy clinic were evaluated. Detailed history, examination, investigations like EEG and CT scan and details regarding pharmacotherapy were analysed....
journal_title:Neurology India
pub_type: 杂志文章
doi:
更新日期:2000-12-01 00:00:00
abstract:BACKGROUND AND AIM:To determine the quality of life and its relationship with socio-demographic and medical factors in patients with stroke. SETTING AND DESIGN:Seventy patients with stroke seen in the neurology clinic on a follow-up visit; at least a period of 3 months of follow-up was included. MATERIALS AND METHODS...
journal_title:Neurology India
pub_type: 杂志文章
doi:10.4103/0028-3886.72165
更新日期:2010-09-01 00:00:00
abstract::Peripheral nerve and brachial plexus injuries typically cause severe impairment in the affected limb. The incidence of neuropathic pain is high, reaching up to 95% of cases, especially if cervical root avulsion has occurred. Neuropathic pain results from damage to the somatosensory system, and its progression towards ...
journal_title:Neurology India
pub_type: 杂志文章,评审
doi:10.4103/0028-3886.250699
更新日期:2019-01-01 00:00:00
abstract::Intracranial epidermoids are generally seen as hypodense nonenhancing lesions on computed tomography scans; and, as T1 hypointense and T2 hyperintense lesions on magnetic resonance imaging (MRI). Unusual radiological findings have been reported earlier. The authors present the case of a 54-year old male patient who ha...
journal_title:Neurology India
pub_type:
doi:10.4103/0028-3886.232336
更新日期:2018-05-01 00:00:00
abstract::Prescription writing has to be properly addressed with regard to its correctness and appropriateness. Any errors in the procedure have to be eliminated. Electronic prescribing has abolished most of typographical prescription errors but the rationality involved in prescription of drugs is more of a thought process, whi...
journal_title:Neurology India
pub_type: 杂志文章,评审
doi:10.4103/0028-3886.236960
更新日期:2018-07-01 00:00:00
abstract::Rosai Dorfman disease (RDD), also known as sinus histiocytosis with massive lymphadenopathy, is a benign histiocytic proliferative disorder mainly affecting the lymph nodes. Although several cases of extra-nodal involvement have been reported previously, central nervous system involvement, particularly in the absence ...
journal_title:Neurology India
pub_type: 杂志文章
doi:10.4103/0028-3886.82770
更新日期:2011-05-01 00:00:00
abstract:Objective:To investigate the application value of using dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) with extended Tofts linear model for relapsing-remitting multiple sclerosis (RRMS) and its correlation with expanded disability status scale (EDSS) scores and disease duration. Materials and Methods:T...
journal_title:Neurology India
pub_type: 杂志文章
doi:10.4103/0028-3886.232324
更新日期:2018-05-01 00:00:00
abstract::Dermatomal somatosensory evoked potentials (DSSEP) from C5-T1 dermatomes were recorded in 20 normal healthy adult volunteers as controls and 61 patients with neck pain. The patients were divided into three groups. Group I : symptomatic patients withclinical signs of C5-T1 radiculopathy and radiological evidence of cer...
journal_title:Neurology India
pub_type: 杂志文章
doi:
更新日期:1998-04-01 00:00:00
abstract::Hirayama disease (HD)/cervical flexion-induced myelopathy (CFIM) is a lower motor neuron disease conventionally affecting a single upper extremity. We describe three men progressing after a long stable period to develop severe spastic paraparesis and bladder disturbances as a protracted implication of HD. The age at o...
journal_title:Neurology India
pub_type: 杂志文章,评审
doi:10.4103/0028-3886.236966
更新日期:2018-07-01 00:00:00
abstract:BACKGROUND:Pain-related studies have mainly been performed through traditional methods, which lack the rigorous analysis of anatomical locations. Functional magnetic resonance imaging (fMRI) is a noninvasive method detecting neural activity, and has the ability to precisely locate related activations in vivo. Moreover,...
journal_title:Neurology India
pub_type: 杂志文章
doi:10.4103/0028-3886.73748
更新日期:2010-11-01 00:00:00
abstract::The present report highlights an unusual presentation of vitamin B12 deficiency--recurrent seizures in a 26-year-old man. His symptoms responded to parenteral vitamin B12 therapy. The relevant literature is reviewed. ...
journal_title:Neurology India
pub_type: 杂志文章
doi:
更新日期:2004-03-01 00:00:00
abstract:BACKGROUND:Neuropathy is often an associated feature woth long-standing type II diabetes mellitus. Neuropathy may occur even in subjects with impaired glucose tolerance. OBJECTIVE:To study the prevalence of neuropathy using different electrophysiological techniques in subjects with impaired glucose tolerance (IGT) and...
journal_title:Neurology India
pub_type: 杂志文章
doi:10.4103/0028-3886.149393
更新日期:2014-11-01 00:00:00
abstract::Opinion is still divided over a standard surgical procedure to decompress lumbar canal stenosis. Both, laminectomy with or without facetectomy and foraminotomy and interlaminar fenestration have been advocated. In the present communication interlaminar decompression in lumbar canal stenosis has been discussed. Sixteen...
journal_title:Neurology India
pub_type: 临床试验,杂志文章
doi:
更新日期:1999-12-01 00:00:00
abstract::Women in India are greatly discriminated against if they happen to have epilepsy. Engagements are often cancelled. The parents of epileptic girls have to give heavy dowry at the time of marriage, even if the boy is handicapped. As a result, many girls do not disclose their problem before marriage. They take the medici...
journal_title:Neurology India
pub_type:
doi:
更新日期:2000-06-01 00:00:00
abstract::Bilateral optic nerve injury is a rare condition and is reported in 5-6 percent of all optic nerve injuries. However, there is no published series on bilateral optic nerve injury. Analysis of 31 cases of bilateral optic nerve involvement seen amongst 275 patients with optic nerve injury (11.5 percent) is discussed. Ro...
journal_title:Neurology India
pub_type: 杂志文章
doi:
更新日期:1999-06-01 00:00:00
abstract:PURPOSE:To summarize our experience in treating patients with spinal angiolipomas. MATERIALS AND METHODS:We conducted a retrospective review of the case records of patients with spinal angiolipoma who underwent surgery between March 1992 and March 2013. RESULTS:Of the 12 patients seen during the study period, 10 pati...
journal_title:Neurology India
pub_type: 杂志文章
doi:10.4103/0028-3886.141232
更新日期:2014-07-01 00:00:00
abstract:BACKGROUND:While operating intracranial meningiomas, neurosurgeons commonly drill the hyperostotic bone and put the bone flap back. OBJECTIVE:To determine whether bony changes seen in meningioma are due to tumor invasion or reactionary changes. MATERIALS AND METHODS:This prospective study, conducted over 10 months (O...
journal_title:Neurology India
pub_type: 杂志文章
doi:10.4103/0028-3886.93589
更新日期:2012-01-01 00:00:00
abstract:BACKGROUND AND OBJECTIVE:Cerebral vasospasm is a serious complication of subarachnoid hemorrhage (SAH) and is associated with clinical deterioration and mortality. The objective of this study is to investigate the effect of continuous intravertebral artery (cIVA) injection of fasudil hydrochloride on delayed cerebral v...
journal_title:Neurology India
pub_type: 杂志文章
doi:10.4103/0028-3886.79127
更新日期:2011-03-01 00:00:00
abstract:BACKGROUND:Evidence from small case series suggests that the intrasinus thrombolysis (IST) is relatively safe and effective in rapid recanalization of thrombosed sinuses and reversal of neurological deficits in patients with cerebral venous and sinus thrombosis (CVST) However, in the absence of randomized controlled tr...
journal_title:Neurology India
pub_type: 杂志文章
doi:10.4103/0028-3886.63800
更新日期:2010-03-01 00:00:00
abstract::The exact diagnosis of demyelinating diseases is an enigma even in the best neurological centres. In the present study, the potential role of differential CSF proteins has been critically evaluated in differentiating multiple sclerosis (MS) and acute disseminated encephalomyelitis (ADEM). Cellulose acetate electrophor...
journal_title:Neurology India
pub_type: 杂志文章
doi:
更新日期:2002-03-01 00:00:00
abstract:BACKGROUND:Symptomatic neurosyphilis (NS) can have varied syndromic presentations: Meningitis, meningovascular and parenchymatous involvement. AIMS:To evaluate the different types of clinical syndrome of NS in a tertiary care hospital. MATERIAL AND METHODS:This was a study of clinical profile of 16 patients with NS, ...
journal_title:Neurology India
pub_type: 杂志文章
doi:10.4103/0028-3886.82719
更新日期:2011-05-01 00:00:00
abstract:BACKGROUND:Earthquake is one of the most devastating natural disasters that threaten human lives. Worldwide more than 3 million deaths have been caused by earthquakes in recent 20 years. AIM:To analyze clinical features of head injuries after Sichuan earthquake. MATERIALS AND METHODS:From May 12 to June 12, 2008, Dep...
journal_title:Neurology India
pub_type: 杂志文章
doi:10.4103/0028-3886.60406
更新日期:2010-01-01 00:00:00
abstract:Background:Due to the paucity of quick, cognitive screening tools available in India that are independent of cultural and educational influences, a 6-item paper and pencil test, covering areas of memory, executive functioning, attention, and visuospatial ability domains - the Neuropsychological Evaluation Screening Too...
journal_title:Neurology India
pub_type: 杂志文章
doi:10.4103/0028-3886.227304
更新日期:2018-03-01 00:00:00
abstract::Although the conventional hematoxylin and eosin (H and E) staining is vital for the histological diagnosis of lesions, the role of immunohistochemistry (IHC) is undeniable in surgical pathology. Morphology, which looks more or less similar on H and E staining, can be further differentiated by merely doing IHC. This, i...
journal_title:Neurology India
pub_type: 杂志文章
doi:10.4103/0028-3886.181547
更新日期:2016-05-01 00:00:00
abstract::78 autopsy proven cases of infective endocarditis (IE) seen during 1983 to 1995 were retrospectively reviewed. The brain was available for examination in 44 cases. In the remaining cases, brain was not examined because examination of it was not requested due to lack of neurological findings. Brain lesions were observe...
journal_title:Neurology India
pub_type: 杂志文章
doi:
更新日期:2001-03-01 00:00:00
abstract::Headaches are commonly associated with various psychiatric disorders. The comorbidity of migraine and psychiatric disorders has been well documented. Here we present a case of schizophrenia with comorbid headache treated with clozapine. The patient's headache fulfilled the diagnostic criteria for cluster headache (CH)...
journal_title:Neurology India
pub_type: 杂志文章
doi:
更新日期:2006-06-01 00:00:00
abstract:BACKGROUND:'Wearing off' refers to the phenomenology of movement disorders in Parkinson's disease (PD) that appears early and is much commoner than generally believed. It may be present in the form of either motor symptoms or non-motor symptoms. AIM:To investigate the utility of wearing-off questionnaire (WOQ-19, Ital...
journal_title:Neurology India
pub_type: 杂志文章
doi:10.4103/0028-3886.217959
更新日期:2017-11-01 00:00:00
abstract:BACKGROUND:The conventional laminectomy may precipitate numerous long-term complications such as the development of kypho-scoliosis, spinal instability, epidural fibrosis and loss of bony shield over the spinal cord, thus increasing the risk of a subsequent myelopathy. The present study evaluates the efficacy of a unil...
journal_title:Neurology India
pub_type: 杂志文章
doi:10.4103/0028-3886.156289
更新日期:2015-03-01 00:00:00
abstract:BACKGROUND:Colloid cysts are not common brain lesions and account for 0.2-2.0% of all brain lesions. Transcallosal, transforaminal approach is a safe route and the most direct path to excise third ventricular colloid cyst, without dependence on hydrocephalus. AIM:To assess the surgical outcome of patients with colloid...
journal_title:Neurology India
pub_type: 杂志文章
doi:10.4103/0028-3886.84334
更新日期:2011-07-01 00:00:00
abstract::Scedosporium apiospermum is a filamentous fungus causing a broad spectrum of clinical diseases especially in those who are immunocompromised. The common sites involved are lungs, skin, sinuses, eyes, bones, joints, and central nervous system (CNS). CNS is involved in invasive Scedosporiosis in the form of a cerebral a...
journal_title:Neurology India
pub_type:
doi:10.4103/0028-3886.293486
更新日期:2020-07-01 00:00:00