Pregabalin and lamotrigine in central poststroke pain: A pilot study.

Abstract:

BACKGROUND:Comparative study of Class I drugs in central poststroke pain (CPSP) is lacking. OBJECTIVE:To evaluate the safety and efficacy of pregabalin and lamotrigine in patients with CPSP. SETTING:Tertiary care teaching referral hospital. METHODS:We included consecutive patients with CPSP having ≥50 mm score on Visual Analog Scale (VAS) and randomized them to receive either oral pregabalin or oral lamotrigine. Their clinical findings, serum chemistry, and cranial magnetic resonance imaging findings were noted. The severity of CPSP was assessed by VAS while the allodynia was assessed on a 0-10 scale. The hospital anxiety and depression (HAD) score was also recorded. The primary outcome was> 50% reduction in the VAS score while the secondary outcome was> 50% reduction in the severity of allodynia and improvement in HAD score at 3 months. Adverse reactions were noted in both the groups. RESULTS:There were 30 patients with CPSP with a median age of 54.5 years (Male:Female = 36:4). While both pregabalin (P < 0.0001) and lamotrigine (P < 0.0001) resulted in significant improvement in the VAS score (63.3% vs. 53.3%), allodynia (66.7% vs. 75%), and HAD score (80% vs. 81.8%) compared to the baseline, the was no significant intergroup difference. Lamotrigine had to be withdrawn in three patients due to skin rash. CONCLUSIONS:Both pregabalin and lamotrigine are equally effective in CPSP, but significant side effects leading to drug withdrawal occured with lamotrigine administration.

journal_name

Neurol India

journal_title

Neurology India

authors

Kalita J,Chandra S,Misra UK

doi

10.4103/neuroindia.NI_45_16

subject

Has Abstract

pub_date

2017-05-01 00:00:00

pages

506-511

issue

3

eissn

0028-3886

issn

1998-4022

pii

ni_2017_65_3_506_205930

journal_volume

65

pub_type

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