Abstract:
OBJECTIVE:This meta-analysis was conducted to assess the relationship between interleukin-10-1082 G/A single nucleotide polymorphism with atherosclerosis (AS) risk. MATERIALS AND METHODS:The databases of PubMed, EMBASE, Chinese National Knowledge Infrastructure and Wan-Fang were searched from January 2000 to January 2014. 16 studies (involving 7779 cases and 7271 controls) were finally included. Each eligible study was scored for quality assessment. We adopted the most probably appropriate genetic model (recessive model) after carefully calculation. Between study heterogeneity was explored by subgroup analysis and publication bias was estimated by Begg's funnel plot and Egger's regression test. RESULTS:Statistically significant association was observed between AA genotype with overall AS risk, being mainly in coronary heart disease and stroke subgroups among Asian population, and peripheral artery disease (PAD) subgroup among Caucasians. CONCLUSIONS:Interleukin-10-1082 AA genotype is associated with increased overall AS risk. AA carriers of Asians seem to be more susceptible to coronary artery disease and stroke, and Caucasians are more susceptible to PAD.
journal_name
Neurol Indiajournal_title
Neurology Indiaauthors
Chao L,Lei H,Fei Jdoi
10.4103/0028-3886.132323subject
Has Abstractpub_date
2014-03-01 00:00:00pages
130-6issue
2eissn
0028-3886issn
1998-4022pii
ni_2014_62_2_130_132323journal_volume
62pub_type
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