A meta-analysis of interleukin-10-1082 promoter genetic polymorphism associated with atherosclerotic risk.

Abstract:

OBJECTIVE:This meta-analysis was conducted to assess the relationship between interleukin-10-1082 G/A single nucleotide polymorphism with atherosclerosis (AS) risk. MATERIALS AND METHODS:The databases of PubMed, EMBASE, Chinese National Knowledge Infrastructure and Wan-Fang were searched from January 2000 to January 2014. 16 studies (involving 7779 cases and 7271 controls) were finally included. Each eligible study was scored for quality assessment. We adopted the most probably appropriate genetic model (recessive model) after carefully calculation. Between study heterogeneity was explored by subgroup analysis and publication bias was estimated by Begg's funnel plot and Egger's regression test. RESULTS:Statistically significant association was observed between AA genotype with overall AS risk, being mainly in coronary heart disease and stroke subgroups among Asian population, and peripheral artery disease (PAD) subgroup among Caucasians. CONCLUSIONS:Interleukin-10-1082 AA genotype is associated with increased overall AS risk. AA carriers of Asians seem to be more susceptible to coronary artery disease and stroke, and Caucasians are more susceptible to PAD.

journal_name

Neurol India

journal_title

Neurology India

authors

Chao L,Lei H,Fei J

doi

10.4103/0028-3886.132323

subject

Has Abstract

pub_date

2014-03-01 00:00:00

pages

130-6

issue

2

eissn

0028-3886

issn

1998-4022

pii

ni_2014_62_2_130_132323

journal_volume

62

pub_type

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