Abstract:
:Diagnostic tests are usually evaluated in terms of simple qualitative measures of sensitivity and specificity. When comparing different quantitative assays such as ELISAs, it is often more useful to deal with actual values (sample optical density/cut-off optical density ratio (OD ratio] rather than the qualitative relationship to the cut-off, i.e. positive or negative. This allows for a statistical approach to the questions of sensitivity and specificity. The National HIV Reference Laboratory of Australia has developed an approach for determining statistical estimates of sensitivity and specificity in terms of delta (delta). Delta is defined as the distance of the mean OD ratio of the sample population from the cut-off measured in standard deviation units. This paper discusses the derivation of this measurement and its usefulness when evaluating ELISA tests.
journal_name
J Virol Methodsjournal_title
Journal of virological methodsauthors
Crofts N,Maskill W,Gust IDdoi
10.1016/0166-0934(88)90087-0subject
Has Abstractpub_date
1988-10-01 00:00:00pages
51-9issue
1eissn
0166-0934issn
1879-0984pii
0166-0934(88)90087-0journal_volume
22pub_type
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