Cohort Differences in the Associations of Selected Candidate Genes With Risk of All-Cause Mortality at Advanced Ages.

Abstract:

:Considerable efforts have been made to identify the genetic basis of human longevity, with only limited progress. One important drawback of current genetic studies is the limited knowledge of gene-environment interaction. Using 2 cohorts of long-lived individuals born in 1905 and 1915 in Denmark, we performed survival analysis to estimate risk of mortality for major candidate genes of aging and longevity and their cohort effects. Through statistical modeling that combines individual genetic and survival information with cohort-specific survival data, we estimated the relative risks of mortality from ages 95 to 103 years associated with genetic variants in apolipoprotein E (APOE), forkhead box class O3a, clusterin, and phosphatidylinositol binding clathrin assembly protein. Our analysis estimated a decreased risk of carrying the APOE$\varepsilon $4 allele (change in risk = -0.403, 95% confidence interval (CI): -0.831, 0.021; P = 0.040) in men of the later cohort, although the allele itself was harmful to survival across sexes (relative risk = 1.161, 95% CI: 1.027, 1.345; P = 0.026). We also estimated a cohort effect of increased risk for the minor allele of rs3851179 in phosphatidylinositol binding clathrin assembly protein with borderline significance (change in risk = 0.165, 95% CI: -0.010, 0.331; P = 0.052) in women. Our estimated significant cohort effect on APOE$\varepsilon $4 is indicative of the interplay between the gene and the changing environment that modulates survival at extreme ages.

journal_name

Am J Epidemiol

authors

Tan Q,Jacobsen R,Nygaard M,Soerensen M,Mengel-From J,Christiansen L,Christensen K

doi

10.1093/aje/kwaa007

subject

Has Abstract

pub_date

2020-07-01 00:00:00

pages

708-716

issue

7

eissn

0002-9262

issn

1476-6256

pii

5714865

journal_volume

189

pub_type

杂志文章
  • The effect of a control program for enzootic bovine leukosis. Changes in herd prevalence in Denmark, 1969-1978.

    abstract::As part of the Danish control program for enzootic bovine leukosis, three hematologic screenings of all cattle herds in Denmark were performed in the period 1969-1978. Herds with multiple cases of persistent lymphocytosis and/or leukotic tumors were classified as "leukosis herds." During nationwide blood testing, 369 ...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.aje.a115505

    authors: Gottschau A,Willeberg P,Franti CE,Flensburg JC

    更新日期:1990-02-01 00:00:00

  • Self-reported life satisfaction and 20-year mortality in healthy Finnish adults.

    abstract::The authors investigated the role of self-reported life satisfaction in mortality with a prospective cohort study (1976-1995). A nationwide sample of healthy adults (18-64 years, n = 22,461) from the Finnish Twin Cohort responded to a questionnaire about life satisfaction and known predictors of mortality in 1975. A s...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/aje/152.10.983

    authors: Koivumaa-Honkanen H,Honkanen R,Viinamäki H,Heikkilä K,Kaprio J,Koskenvuo M

    更新日期:2000-11-15 00:00:00

  • Assessment of Quadrivalent Human Papillomavirus Vaccine Safety Using the Self-Controlled Tree-Temporal Scan Statistic Signal-Detection Method in the Sentinel System.

    abstract::The self-controlled tree-temporal scan statistic-a new signal-detection method-can evaluate whether any of a wide variety of health outcomes are temporally associated with receipt of a specific vaccine, while adjusting for multiple testing. Neither health outcomes nor postvaccination potential periods of increased ris...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/aje/kwy023

    authors: Yih WK,Maro JC,Nguyen M,Baker MA,Balsbaugh C,Cole DV,Dashevsky I,Mba-Jonas A,Kulldorff M

    更新日期:2018-06-01 00:00:00

  • Parent-offspring body mass index associations in the Norwegian Mother and Child Cohort Study: a family-based approach to studying the role of the intrauterine environment in childhood adiposity.

    abstract::In the present study, the authors investigated the role of the intrauterine environment in childhood adiposity by comparing the maternal-offspring body mass index (BMI) association with the paternal-offspring BMI association when the offspring were 3 years of age, using parental prepregnancy BMI (measured as weight in...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/aje/kws134

    authors: Fleten C,Nystad W,Stigum H,Skjaerven R,Lawlor DA,Davey Smith G,Naess O

    更新日期:2012-07-15 00:00:00

  • Incidence and risk factors for concussion in high school athletes, North Carolina, 1996-1999.

    abstract::A prospective cohort study was used to quantify risk factors for sports concussions. Analysis was based on a stratified cluster sample of North Carolina high school athletes followed during 1996-1999. Clustering was by school and sport, and the sample included 15,802 athletes with 1-8 seasons of follow-up per athlete....

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/aje/kwh304

    authors: Schulz MR,Marshall SW,Mueller FO,Yang J,Weaver NL,Kalsbeek WD,Bowling JM

    更新日期:2004-11-15 00:00:00

  • Natural history of bone loss over 6 years among premenopausal and early postmenopausal women.

    abstract::The aims of this prospective cohort study were to determine rates of premenopausal and early postmenopausal bone loss, age at onset of bone loss, and whether rates of bone loss depend on baseline bone mineral density (BMD). The cohort of 614 women aged 24-44 years at baseline from the longitudinal Michigan Bone Health...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/aje/kwf049

    authors: Bainbridge KE,Sowers MF,Crutchfield M,Lin X,Jannausch M,Harlow SD

    更新日期:2002-09-01 00:00:00

  • Body mass index at different adult ages, weight change, and colorectal cancer risk in the National Institutes of Health-AARP Cohort.

    abstract::The authors investigated the relations of body mass index at different ages and adult weight change to incident colorectal cancer risk in the prospective National Institutes of Health-AARP Diet and Health Study (1995-1996), using a subcohort with repeated recall weights (273,679 participants; mean baseline age = 62.8 ...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/aje/kws192

    authors: Renehan AG,Flood A,Adams KF,Olden M,Hollenbeck AR,Cross AJ,Leitzmann MF

    更新日期:2012-12-15 00:00:00

  • When will nondifferential misclassification of an exposure preserve the direction of a trend?

    abstract::Dosemeci et al. (Am J Epidemiol 1990; 132:746-8) gave examples in which nondifferential misclassification of exposure reversed the direction of a trend. Gilbert (Am J Epidemiol 1991; 134:440-1) proposed that these examples occurred because the errors in exposure were systematic, and she pointed out that the relation b...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.aje.a117283

    authors: Weinberg CR,Umbach DM,Greenland S

    更新日期:1994-09-15 00:00:00

  • Occupational risks of bladder cancer among white women in the United States.

    abstract::The relation between occupation and bladder cancer in women was examined based on data collected during the National Bladder Cancer Study, a population-based, case-control study conducted in 10 areas of the United States. Occupational hazards among women have received little attention in previous bladder cancer studie...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.aje.a115680

    authors: Silverman DT,Levin LI,Hoover RN

    更新日期:1990-09-01 00:00:00

  • A validation of two motion sensors in the prediction of child and adult physical activity levels.

    abstract::The authors sought to assess the reliability and validity of two motion activity sensors in the prediction of observed physical activity levels in adults and children by means of two studies at North Dakota State University in Fargo, North Dakota. In study 1, 50 adults were observed in fall 1984 for one hour of recrea...

    journal_title:American journal of epidemiology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1093/oxfordjournals.aje.a114121

    authors: Klesges RC,Klesges LM,Swenson AM,Pheley AM

    更新日期:1985-09-01 00:00:00

  • Longitudinal association of C-reactive protein and lung function over 13 years: The EPIC-Norfolk study.

    abstract::Chronic obstructive pulmonary disease is known to be associated with systemic inflammation. We examined the longitudinal association of C-reactive protein (CRP) and lung function in a cohort of 18,110 men and women from the European Prospective Investigation Into Cancer in Norfolk who were 40-79 years of age at baseli...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/aje/kwt208

    authors: Ahmadi-Abhari S,Kaptoge S,Luben RN,Wareham NJ,Khaw KT

    更新日期:2014-01-01 00:00:00

  • Hepatitis Ain Greenland: importance of specific antibody testing in epidemiologic surveillance.

    abstract::An epidemic of viral hepatitis type A in an arctic area is described. From 1970-1974, 4961 clinical cases of hepatitis were reported in Greenland, corresponding to 11 per cent of the total population. Epidemiologic surveillance indicated person-to-person transmission of the disease, apparently by the oralfecal route. ...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.aje.a112366

    authors: Skinhoj P,Mikkelsen F,Hollinger FB

    更新日期:1977-02-01 00:00:00

  • Body fat distribution and osteoarthritis.

    abstract::The association of body fat distribution with single and combined site osteoarthritis was investigated using data from the US Health Examination Survey I, 1960-1962 (HES I) and the first National Health and Nutrition Examination Survey I, 1971-1975 (NHANES I). The study included 1,636 adults aged 35-79 years from HES ...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.aje.a115711

    authors: Davis MA,Neuhaus JM,Ettinger WH,Mueller WH

    更新日期:1990-10-01 00:00:00

  • Occupational exposure to whole-body vibration and Parkinson's disease: results from a population-based case-control study.

    abstract::Mechanical stress producing head injury is associated with Parkinson's disease, suggesting that relations with other physical hazards such as whole-body vibration (WBV) should be tested. In this study, the authors evaluated the relation between occupational exposure to WBV and Parkinson's disease. A population-based c...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/aje/kws017

    authors: Harris MA,Marion SA,Spinelli JJ,Tsui JK,Teschke K

    更新日期:2012-08-15 00:00:00

  • Associations of Maternal Vitamin B12 Concentration in Pregnancy With the Risks of Preterm Birth and Low Birth Weight: A Systematic Review and Meta-Analysis of Individual Participant Data.

    abstract::Vitamin B12 (hereafter referred to as B12) deficiency in pregnancy is prevalent and has been associated with both lower birth weight (birth weight <2,500 g) and preterm birth (length of gestation <37 weeks). Nevertheless, current evidence is contradictory. We performed a systematic review and a meta-analysis of indivi...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章,meta分析,评审

    doi:10.1093/aje/kww212

    authors: Rogne T,Tielemans MJ,Chong MF,Yajnik CS,Krishnaveni GV,Poston L,Jaddoe VW,Steegers EA,Joshi S,Chong YS,Godfrey KM,Yap F,Yahyaoui R,Thomas T,Hay G,Hogeveen M,Demir A,Saravanan P,Skovlund E,Martinussen MP,Jacobsen G

    更新日期:2017-02-01 00:00:00

  • Use of diuretics and other antihypertensive medications in relation to the risk of renal cell cancer.

    abstract::In a population-based case-control study of the association between use of diuretics and renal cell cancer, 120 white men whose cancer was diagnosed during the years 1980-1991 and 86 white women diagnosed in 1960-1991 were identified among members of the Kaiser Permanente Northwest health plan. Controls were plan memb...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.aje.a117328

    authors: Weinmann S,Glass AG,Weiss NS,Psaty BM,Siscovick DS,White E

    更新日期:1994-11-01 00:00:00

  • Pharyngeal carriage and acquisition of anticapsular antibody to Haemophilus influenzae type b in a high-risk population in southwestern Alaska.

    abstract::Haemophilus influenzae type b disease in Alaskan Eskimos is characterized by greatly increased disease incidence at younger ages. This suggests that Eskimo infants have increased exposure to the disease. Exposure was studied in 1982-1983 in children less than age three years who lived in four Eskimo villages, as well ...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.aje.a114758

    authors: Hall DB,Lum MK,Knutson LR,Heyward WL,Ward JI

    更新日期:1987-12-01 00:00:00

  • Sample size requirements for association studies of gene-gene interaction.

    abstract::In the study of complex diseases, it may be important to test hypotheses related to gene-gene (G x G) interaction. The success of such studies depends critically on obtaining adequate sample sizes. In this paper, the author investigates sample size requirements for studies of G x G interaction, focusing on four study ...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/aje/155.5.478

    authors: Gauderman WJ

    更新日期:2002-03-01 00:00:00

  • Low-dose exposure to asbestos and lung cancer: dose-response relations and interaction with smoking in a population-based case-referent study in Stockholm, Sweden.

    abstract::This population-based case-referent study investigated the lung cancer risk associated with occupational exposure to asbestos, focusing on dose-response relations and the interaction with tobacco smoking. Incident cases of lung cancer among males aged 40-75 years in Stockholm County, Sweden, were identified from 1985 ...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/aje/155.11.1016

    authors: Gustavsson P,Nyberg F,Pershagen G,Schéele P,Jakobsson R,Plato N

    更新日期:2002-06-01 00:00:00

  • Identifying genetic susceptibilities to diabetes-related complications among individuals at low risk of complications: An application of tree-structured survival analysis.

    abstract::The authors hypothesized that genetic predisposition to diabetes complications would be more evident among low-risk individuals and aimed to identify genes related to developing complications (confirmed distal symmetric polyneuropathy, overt nephropathy, or coronary artery disease) in low-risk groups. Participants in ...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/aje/kwj287

    authors: Costacou T,Chang Y,Ferrell RE,Orchard TJ

    更新日期:2006-11-01 00:00:00

  • Exploring the role of diet in modifying the effect of known disease determinants: application to risk factors of liver cirrhosis.

    abstract::The analysis of the combined effects of nutritional factors with other putative disease determinants in log-linear or logistic models is methodologically complicated by the strong multicollinearity between nutritional factors, resulting in poor precision in estimating the parameters. Furthermore, the generally used mu...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.aje.a117572

    authors: Corrao G,Ferrari PA,Galatola G

    更新日期:1995-12-01 00:00:00

  • Social support and mortality in an elderly community population.

    abstract::A community sample made in the fall of 1972 in Durham County, North Carolina, and that consisted of 331 persons 65 years of age and older was assessed for adequacy of social support along three parameters: roles and available attachments, perceived social support, and frequency of social interaction. This approach to ...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.aje.a113351

    authors: Blazer DG

    更新日期:1982-05-01 00:00:00

  • Impact of smoking and smoking cessation on lung cancer mortality in the Asia-Pacific region.

    abstract::Cigarette smoking is becoming increasingly common in Asia while quitting remains rare, in part because of a lack of knowledge about the risks of smoking. This study compared the risk of death from lung cancer associated with smoking habits in Australia and New Zealand and in Asia by using data from the Asia Pacific Co...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章,多中心研究

    doi:10.1093/aje/kwm002

    authors: Huxley R,Jamrozik K,Lam TH,Barzi F,Ansary-Moghaddam A,Jiang CQ,Suh I,Woodward M,Asia Pacific Cohort Studies Collaboration.

    更新日期:2007-06-01 00:00:00

  • Ethnic status and participation in longitudinal health surveys.

    abstract::Ethnic differences in survey participation and their effects on self-reported physical and psychiatric health status measures were examined in a longitudinal health study in Alameda County, California, in 1978 following two time intervals. Blacks and Mexican-Americans were more likely than whites to refuse to particip...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.aje.a113731

    authors: Vernon SW,Roberts RE,Lee ES

    更新日期:1984-01-01 00:00:00

  • Validating survey responses to questions about gun ownership among owners of registered handguns.

    abstract::While survey-based data on firearm ownership are essential for epidemiologic studies of the relation between gun ownership and injuries, the validity of respondent answers to questions about gun ownership has not been confirmed. In order to assess the accuracy of interview data about firearms, in June to August 1987, ...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.aje.a115600

    authors: Kellermann AL,Rivara FP,Banton J,Reay D,Fligner CL

    更新日期:1990-06-01 00:00:00

  • Index for US state tobacco control initial outcomes.

    abstract::Public health tobacco control efforts have increasingly targeted communities in addition to individuals. Before population smoking decreases, effectiveness might be detected from initial outcomes reflecting these efforts, such as higher cigarette prices or more workplace and home smoking restrictions. Presumably, thes...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/aje/152.8.727

    authors: Gilpin EA,Stillman FA,Hartman AM,Gibson JT,Pierce JP

    更新日期:2000-10-15 00:00:00

  • The time interval between death and next-of-kin contact and its effects on response rates and data quality.

    abstract::The relation of the interval of time between death and next-of-kin contact to outcome variables including response rates and data quality was examined in a nationally representative sample of 17,713 deaths of persons 25 years of age or older that occurred in the United States in 1986. For most of the outcome variables...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.aje.a116051

    authors: Poe GS,McLaughlin JK,Powell-Griner E,Parsons CR,Robinson K

    更新日期:1991-12-15 00:00:00

  • Dietary boron and hormone replacement therapy as risk factors for lung cancer in women.

    abstract::Hormone replacement therapy (HRT) may reduce lung cancer risk. Dietary boron may have actions similar to those of HRT; however, no previous study has reported the associations between dietary boron intake and lung cancer risk or the joint effects of boron intake and HRT use on lung cancer risk. The authors examined th...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/aje/kwn021

    authors: Mahabir S,Spitz MR,Barrera SL,Dong YQ,Eastham C,Forman MR

    更新日期:2008-05-01 00:00:00

  • Plasma vitamin D biomarkers and leukocyte telomere length.

    abstract::Vitamin D may reduce telomere shortening through anti-inflammatory and anti-cell proliferation mechanisms. In the present study, we examined the association between vitamin D and relative leukocyte telomere length by using both plasma 25-hydroxyvitamin D (25(OH)D) and 1,25-dihydroxyvitamin D (1,25(OH)2D) biomarkers. V...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/aje/kws435

    authors: Liu JJ,Prescott J,Giovannucci E,Hankinson SE,Rosner B,Han J,De Vivo I

    更新日期:2013-06-15 00:00:00

  • Health Disparities Research Among Small Tribal Populations: Describing Appropriate Criteria for Aggregating Tribal Health Data.

    abstract::In response to community concerns, we used the Tribal Participatory Research framework in collaboration with 5 American-Indian communities in Washington, Idaho, and Montana to identify the appropriate criteria for aggregating health data on small tribes. Across tribal sites, 10 key informant interviews and 10 focus gr...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/aje/kwv334

    authors: Van Dyke ER,Blacksher E,Echo-Hawk AL,Bassett D,Harris RM,Buchwald DS

    更新日期:2016-07-01 00:00:00