Abstract:
:Vitamin B12 (hereafter referred to as B12) deficiency in pregnancy is prevalent and has been associated with both lower birth weight (birth weight <2,500 g) and preterm birth (length of gestation <37 weeks). Nevertheless, current evidence is contradictory. We performed a systematic review and a meta-analysis of individual participant data to evaluate the associations of maternal serum or plasma B12 concentrations in pregnancy with offspring birth weight and length of gestation. Twenty-two eligible studies were identified (11,993 observations). Eighteen studies were included in the meta-analysis (11,216 observations). No linear association was observed between maternal B12 levels in pregnancy and birth weight, but B12 deficiency (<148 pmol/L) was associated with a higher risk of low birth weight in newborns (adjusted risk ratio = 1.15, 95% confidence interval (CI): 1.01, 1.31). There was a linear association between maternal levels of B12 and preterm birth (per each 1-standard-deviation increase in B12, adjusted risk ratio = 0.89, 95% CI: 0.82, 0.97). Accordingly, B12 deficiency was associated with a higher risk of preterm birth (adjusted risk ratio = 1.21, 95% CI: 0.99, 1.49). This finding supports the need for randomized controlled trials of vitamin B12 supplementation in pregnancy.
journal_name
Am J Epidemioljournal_title
American journal of epidemiologyauthors
Rogne T,Tielemans MJ,Chong MF,Yajnik CS,Krishnaveni GV,Poston L,Jaddoe VW,Steegers EA,Joshi S,Chong YS,Godfrey KM,Yap F,Yahyaoui R,Thomas T,Hay G,Hogeveen M,Demir A,Saravanan P,Skovlund E,Martinussen MP,Jacobsen Gdoi
10.1093/aje/kww212subject
Has Abstractpub_date
2017-02-01 00:00:00pages
212-223issue
3eissn
0002-9262issn
1476-6256pii
kww212journal_volume
185pub_type
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