Abstract:
:Recent work has implicated low-frequency (<20 Hz) neuronal phase information as important for both auditory (<10 Hz) and speech [theta (∼4-8 Hz)] perception. Activity on the timescale of theta corresponds linguistically to the average length of a syllable, suggesting that information within this range has consequences for segmentation of meaningful units of speech. Longer timescales that correspond to lower frequencies [delta (1-3 Hz)] also reflect important linguistic features-prosodic/suprasegmental-but it is unknown whether the patterns of activity in this range are similar to theta. We investigate low-frequency activity with magnetoencephalography (MEG) and mutual information (MI), an analysis that has not yet been applied to noninvasive electrophysiological recordings. We find that during speech perception each frequency subband examined [delta (1-3 Hz), theta(low) (3-5 Hz), theta(high) (5-7 Hz)] processes independent information from the speech stream. This contrasts with hypotheses that either delta and theta reflect their corresponding linguistic levels of analysis or each band is part of a single holistic onset response that tracks global acoustic transitions in the speech stream. Single-trial template-based classifier results further validate this finding: information from each subband can be used to classify individual sentences, and classifier results that utilize the combination of frequency bands provide better results than single bands alone. Our results suggest that during speech perception low-frequency phase of the MEG signal corresponds to neither abstract linguistic units nor holistic evoked potentials but rather tracks different aspects of the input signal. This study also validates a new method of analysis for noninvasive electrophysiological recordings that can be used to formally characterize information content of neural responses and interactions between these responses. Furthermore, it bridges results from different levels of neurophysiological study: small-scale multiunit recordings and local field potentials and macroscopic magneto/electrophysiological noninvasive recordings.
journal_name
J Neurophysioljournal_title
Journal of neurophysiologyauthors
Cogan GB,Poeppel Ddoi
10.1152/jn.00075.2011subject
Has Abstractpub_date
2011-08-01 00:00:00pages
554-63issue
2eissn
0022-3077issn
1522-1598pii
jn.00075.2011journal_volume
106pub_type
杂志文章,随机对照试验abstract::Rewards in the natural environment are rarely predicted with complete certainty. Uncertainty relating to future rewards has typically been defined as the variance of the potential outcomes. However, the asymmetry of predicted reward distributions, known as skewness, constitutes a distinct but neuroscientifically under...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00471.2011
更新日期:2011-11-01 00:00:00
abstract::Although the patterns of activity produced by neocortical networks are now better understood, how these states are activated, sustained, and terminated still remains unclear. Negative feedback by the endogenous neuromodulator adenosine may potentially play an important role, as it can be released by activity and there...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00620.2014
更新日期:2015-02-01 00:00:00
abstract::Pioneering studies demonstrated that novel degrees of freedom could be controlled individually by directly encoding the firing rate of single motor cortex neurons, without regard to each neuron's role in controlling movement of the native limb. In contrast, recent brain-computer interface work has emphasized decoding ...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00373.2013
更新日期:2014-09-15 00:00:00
abstract::Neurons of the motor nerve net of the jellyfish Cyanea were impaled with microelectrodes for intracellular recordings. The cells have conventional, negative resting potentials and produce variable-amplitude action potentials with complex waveforms. The variability and complexity of these spikes is due to the superimpo...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1983.50.3.671
更新日期:1983-09-01 00:00:00
abstract::Processing of temporal information is key in auditory processing. In this study, we recorded single-unit activity from rat auditory cortex while they performed an interval-discrimination task. The animals had to decide whether two auditory stimuli were separated by either 150 or 300 ms and nose-poke to the left or to ...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00381.2013
更新日期:2013-11-01 00:00:00
abstract::1. Using an optical method for measuring membrane potential, we have been able to monitor action-potential activity simultaneously in 14 neurons of the supraesophageal ganglion of the barnacle. 2. Under favorable conditions, 4-mV synaptic potentials could also be detected optically. ...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1977.40.6.1281
更新日期:1977-11-01 00:00:00
abstract::In the spinal cord, the monoamine neurotransmitter norepinephrine, which is released mainly from fibers descending from the dorsal pons, has major modulatory effects on nociception and locomotor rhythms. To map the spatial and temporal patterns of this release, changes in monoamine level were examined in laminae I-VII...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00608.2002
更新日期:2003-06-01 00:00:00
abstract::Previous behavioral work has shown the existence of both anticipatory and reactive grip force responses to predictable load perturbations, but how the brain implements anticipatory control remains unclear. Here we recorded electroencephalographs while participants were subjected to predictable and unpredictable extern...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.01112.2006
更新日期:2008-02-01 00:00:00
abstract::1. The little brown bat, Myotis lucifugus, employs biosonar pulses containing broadband frequency-modulated (FM) sounds of only one harmonic during the initial phases of echolocation. Neurons throughout the auditory cortex exhibit delay-dependent facilitation to artificial pulses and echoes at particular echo delays. ...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1994.72.1.366
更新日期:1994-07-01 00:00:00
abstract::The responses of low-frequency, primary-like neurons of the ventral cochlear nucleus were measured as a function of signal-to-noise ratio for gated tonal signals and noise maskers that were varied in bandwidth and duration. For a given signal-to-noise ratio, each of the maskers is known to produce the same amount of m...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1983.50.6.1516
更新日期:1983-12-01 00:00:00
abstract::Many neurons within prefrontal cortex exhibit a tonic discharge between visual stimulation and motor response. This delay activity may contribute to movement, memory, and vision. We studied delay activity sent from the frontal eye field (FEF) in prefrontal cortex to the superior colliculus (SC). We evaluated whether t...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.2001.85.4.1673
更新日期:2001-04-01 00:00:00
abstract::Sopite syndrome, centered around the drowsiness, lethargy, and irritability associated with motion sickness, can be induced by exposure to low-frequency motion. It is known that the vestibular apparatus plays an important role in the pathogenesis of motion sickness, which features several autonomic responses, and we h...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00177.2020
更新日期:2020-12-01 00:00:00
abstract::Organization of spinal motor output has become of interest for investigating differential activation of lumbar and sacral motor pools during locomotor tasks. Motor pools are associated with functional grouping of motoneurons of the lower limb muscles. Here we examined how the spatiotemporal organization of lumbar and ...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00167.2019
更新日期:2019-08-01 00:00:00
abstract::1. A generalized three-dimensional state space model of visual vestibular interaction was developed. Matrix and dynamical system operators associated with inputs from the semicircular canals, otolith velocity estimator, and the visual system have been incorporated into the model, which focus on their relationship to t...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1991.66.4.1410
更新日期:1991-10-01 00:00:00
abstract::Recent evidence implicates the superior colliculus (SC) in cognitive processes, such as target selection and control of spatial attention, in addition to the execution of saccadic eye movements. We report here the presence of a cognitive response in some cells in the SC in a task that requires the long-term associatio...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.01071.2005
更新日期:2006-06-01 00:00:00
abstract::The hearing ability of five Japanese macaques (Macaca fuscata) was assessed following two-stage bilateral auditory cortex lesions. The animals were tested using a shock-avoidance procedure with a conditioned-suppression procedure used for comparison in two cases. The animals initially were unable to respond to sound, ...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1986.55.2.256
更新日期:1986-02-01 00:00:00
abstract::The widespread noradrenergic innervation in the brain promotes arousal and learning by molecular mechanisms that remain largely undefined. Recent work shows that the β(2)-adrenergic receptor (β(2)AR) is linked to the AMPA-type glutamate receptor subunit GluA1 via stargazin and PSD-95 (Joiner ML, Lise MF, Yuen EY, Kam ...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00374.2011
更新日期:2012-05-01 00:00:00
abstract::We have found new evidence for gamma-aminobutyric acid (GABA)-induced intrinsic optical changes associated with a voltage-sensitive dye signal in the early embryonic chick brain stem slice. The slices were prepared from 8-day-old embryos, and they were stained with a voltage-sensitive dye (NK2761). Pressure ejection o...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1998.79.4.2208
更新日期:1998-04-01 00:00:00
abstract::1. Previous studies indicate that after transection of the rostral spinal cord, larval lamprey begin to recover locomotor behavior 2 wk posttransection and recovery is complete at approximately 8 wk. To examine the mechanisms underlying behavioral recovery after spinal cord transection, in the present study the time c...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1994.72.2.847
更新日期:1994-08-01 00:00:00
abstract::1. To test whether the cerebellum is involved in compensating for orbital nonlinearities, we recorded discharges of saccadic burst neurons in the fastigial oculomotor region (FOR) during both centrifugal and centripetal saccades in two trained macaque monkeys. 2. We also investigated the metrics of centrifugal and cen...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1994.71.5.1976
更新日期:1994-05-01 00:00:00
abstract::We previously reported that neurons in the mediodorsal thalamic nucleus (MD) are topographically organized and express spatial and nonspatial coding properties similar to those of the prefrontal areas with which they are connected. In the course of mapping the dorsal thalamus, we also studied neurons in a subset of th...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00969.2003
更新日期:2005-01-01 00:00:00
abstract::Silencing-induced homeostatic plasticity is usually expressed as a change in the amplitude or the frequency of miniature postsynaptic currents. Here we report that, prolonged (approximately 24 h) silencing of mature (20-22 days in vitro) cultured hippocampal neurons using the voltage-gated sodium channel blocker tetro...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.90378.2008
更新日期:2008-08-01 00:00:00
abstract::Retinal Müller cells are highly permeable to potassium as a consequence of their intrinsic membrane properties. Therefore these cells are able to play an important role in maintaining potassium homeostasis in the vertebrate retina during light-induced neuronal activity. Polyamines and other factors present in Müller c...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.2001.85.4.1357
更新日期:2001-04-01 00:00:00
abstract::Two-Photon Processor (TPP) is a versatile, ready-to-use, and freely available software package in MATLAB to process data from in vivo two-photon calcium imaging. TPP includes routines to search for cell bodies in full-frame (Search for Neural Cells Accelerated; SeNeCA) and line-scan acquisition, routines for calcium s...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00087.2013
更新日期:2013-07-01 00:00:00
abstract::Reach-to-grasp movements require information about the distance and size of target objects. Calibration of this information could be achieved via feedback information (visual and/or haptic) regarding terminal accuracy when target objects are grasped. A number of reports suggest that the nervous system alters reach-to-...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00112.2013
更新日期:2013-12-01 00:00:00
abstract::Successful navigation requires a constantly updated neural representation of directional heading, which is conveyed by head direction (HD) cells. The HD signal is predominantly controlled by visual landmarks, but when familiar landmarks are unavailable, self-motion cues are able to control the HD signal via path integ...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.01041.2010
更新日期:2011-06-01 00:00:00
abstract::We simultaneously compared the sensitivity of single primary afferent neurons supplying the glabrous skin of the hand and the psychophysical amplitude discrimination thresholds in human subjects for a set of vibrotactile stimuli delivered to the receptive field. All recorded afferents had a dynamic range narrower than...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00482.2014
更新日期:2014-11-15 00:00:00
abstract::Divergence of the Shaker superfamily of voltage-gated (Kv) ion channels early in metazoan evolution created numerous electrical phenotypes that were presumably selected to produce a wide range of excitability characteristics in neurons, myocytes, and other cells. A comparative approach that emphasizes this early radia...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00858.2005
更新日期:2006-05-01 00:00:00
abstract::Fast-spiking (FS) interneurons provide the main route of feedforward inhibition from cortex to spiny projection neurons in the striatum. A steep current-firing frequency curve and a dense local axonal arbor suggest that even small excitatory inputs could translate into powerful feedforward inhibition, although such an...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00063.2005
更新日期:2006-01-01 00:00:00
abstract::Visual tracking of moving objects requires prediction to compensate for visual delays and minimize mismatches between eye and target position and velocity. In everyday life, objects often disappear behind an occluder, and prediction is required to align eye and target at reappearance. Earlier studies investigating eye...
journal_title:Journal of neurophysiology
pub_type: 临床试验,杂志文章
doi:10.1152/jn.00596.2005
更新日期:2006-01-01 00:00:00