Abstract:
OBJECTIVE:To appraise the process of development and clinical content of national human immunodeficiency virus (HIV) clinical practice guidelines of countries in the eastern Mediterranean and to formulate recommendations for future guideline development and adaptation. METHODS:Twenty-three countries in the World Health Organization (WHO) Eastern Mediterranean and United Nations Children's Fund Middle East and North Africa regions were invited to submit national HIV clinical practice guidelines for review. The guideline development methodology was assessed using an adaptation of the Appraisal of Guidelines Research and Evaluation (AGREE) instrument and guideline content, using a checklist to evaluate concordance with WHO 2006 generic guidelines. FINDINGS:Twelve countries submitted 20 guidelines developed between 2004 and 2009. Median scores were poor (i.e. < 0.6) for the methodological quality domains of rigour of development, stakeholder involvement and applicability and flexibility. Scores were better for the domains of scope and purpose (median: 0.82, interquartile range, IQR: 0.58-0.89) and clarity and presentation (median: 0.67, IQR: 0.50-0.78). Concerning guideline content, recommended first-line treatment and eligibility criteria for antiretroviral therapy (ART) in adults were in line with WHO recommendations in most guidelines. However, recommendations on antiretroviral prophylaxis for the prevention of vertical HIV transmission, diagnosis and treatment of HIV infection in infants, monitoring patients on ART, treatment failure and co-morbidities were often lacking. CONCLUSION:The large majority of national HIV clinical practice guidelines had methodological weaknesses and content inaccuracies. Countries require assistance with the adaptation process to ensure that guidelines are valid and up to date and accurately reflect WHO global clinical care recommendations for patients with HIV.
journal_name
Bull World Health Organjournal_title
Bulletin of the World Health Organizationauthors
De Weggheleire A,Bortolotti V,Zolfo M,Crowley S,Colebunders R,Riedner G,Lynen Ldoi
10.2471/BLT.10.083790subject
Has Abstractpub_date
2011-06-01 00:00:00pages
442-50issue
6eissn
0042-9686issn
1564-0604pii
BLT.10.083790journal_volume
89pub_type
杂志文章abstract::Strains of Vibrio cholerae-1156 from various parts of the world-were examined by standardized antibiotic sensitivity tests in one centre, to determine the global incidence of antibiotic resistance in this organism and to assess the extent to which differences in methods of sensitivity testing might be responsible for ...
journal_title:Bulletin of the World Health Organization
pub_type: 杂志文章
doi:
更新日期:1976-01-01 00:00:00
abstract::The association between oral leukoplakia and possible etiological factors in patients at a Bombay hospital was analysed by a new multivariate computer analysis based on information theory. It was found that the most important etiological factors were bidi smoking and age. The well known sex-leukoplakia relationship wa...
journal_title:Bulletin of the World Health Organization
pub_type: 杂志文章
doi:
更新日期:1972-01-01 00:00:00
abstract::This paper deals with the medico-legal aspects of death certification, the inadequate attention accorded to these aspects in most of the present death certificate forms, and the consequences resulting from this circumstance. A description is also given of the revision of the national system of medical certification of...
journal_title:Bulletin of the World Health Organization
pub_type: 杂志文章
doi:
更新日期:1960-01-01 00:00:00
abstract::Until about 10 years ago heparin was prepared from ox lungs and was regarded as a homogeneous polymer (of a sulfated mucopolysaccharide) with a relatively constant biological activity of about 100 IU/mg. The mucus and mucosa of the intestine of hog, sheep and ox have now become the main industrial source of bulk start...
journal_title:Bulletin of the World Health Organization
pub_type: 杂志文章
doi:
更新日期:1970-01-01 00:00:00
abstract:Objective:To evaluate the changes in sugar and energy labelling of carbonated sugar-sweetened soft drinks after the implementation of a tax on sugar-sweetened drinks in the United Kingdom of Great Britain and Northern Ireland. Methods:We visited nine main supermarkets before (May 2014) and after (April 2018) the tax c...
journal_title:Bulletin of the World Health Organization
pub_type: 杂志文章
doi:10.2471/BLT.19.234542
更新日期:2019-12-01 00:00:00
abstract::The international unit of colistin methane sulfonate has been defined by collaborative assay as the activity contained in 0.00007874 mg of the international reference preparation. The definition was based on results from 7 laboratories in 5 countries which carried out assays against their existing national standards. ...
journal_title:Bulletin of the World Health Organization
pub_type: 杂志文章
doi:
更新日期:1973-01-01 00:00:00
abstract::Reported is an enzyme-linked immunosorbent assay (ELISA) that has been optimized and validated for the determination of chloroquine in urine or dried blood spots. The assay employs antisera raised in sheep to a chloroquine derivative conjugated to keyhole limpet haemocyanin and chloroquine conjugated to porcine thyrog...
journal_title:Bulletin of the World Health Organization
pub_type: 杂志文章
doi:
更新日期:1988-01-01 00:00:00
abstract::The effects of flea control on the prevalence of (Pasteurella) pestis antibody rates in the California vole, Microtus californicus, were studied in San Mateo County, California, USA. In this area, which had shown antibody prevalence rates of 50% or more during epizootics in previous years, continuous flea control meas...
journal_title:Bulletin of the World Health Organization
pub_type: 杂志文章
doi:
更新日期:1971-01-01 00:00:00
abstract:OBJECTIVE:To investigate physical activity during leisure time and commuting among persons aged 15-69 years in the urban population of Tianjin, China, and to assess its associations with demographic and health-related characteristics. METHODS:In 1996 a cross-sectional survey of 2002 males and 1974 females provided inf...
journal_title:Bulletin of the World Health Organization
pub_type: 杂志文章
doi:
更新日期:2002-01-01 00:00:00
abstract::For several years after the First World War calcium oxide was the main compound used in the control of Oncomelania nosophora in Japan. This was generally replaced in 1944 by calcium cyanamide; since 1952 the prefectural authorities in areas of endemic bilharziasis have increasingly turned to the use of sodium pentachl...
journal_title:Bulletin of the World Health Organization
pub_type: 杂志文章
doi:
更新日期:1961-01-01 00:00:00
abstract::Although no full-scale survey of the prevalence of bilharziasis in Swaziland has been carried out, examinations of schoolchildren have revealed S. mansoni infection rates of up to 49% in some areas, and S. haematobium infection rates ranging from 3% to 75%. The highest prevalence occurs in areas where there are thickl...
journal_title:Bulletin of the World Health Organization
pub_type: 杂志文章
doi:
更新日期:1958-01-01 00:00:00
abstract::The ParaSight(R)-F test is a qualitative diagnostic test of Plasmodium falciparum, which is based on the detection by a monoclonal antibody of a species-specific soluble antigen (histidine-rich protein (HRP-II)) in whole blood and which can be performed without special equipment. A visual reading is given by a polyclo...
journal_title:Bulletin of the World Health Organization
pub_type: 临床试验,杂志文章,随机对照试验
doi:
更新日期:1995-01-01 00:00:00
abstract::Previous studies have shown that when mice and monkeys are infected with bovine schistosomes they develop a considerable degree of heterologous immunity against subsequent challenge with Schistosoma mansoni. The present report describes a study on the reverse effect in which calves were first exposed to cercariae of S...
journal_title:Bulletin of the World Health Organization
pub_type: 杂志文章
doi:
更新日期:1970-01-01 00:00:00
abstract:PROBLEM:In 1999, a tuberculosis (TB) crisis was declared in the Western Pacific Region. APPROACH:In response, WHO established the Stop TB Special Project, which sought to halve 2000 levels of TB prevalence and mortality by 2010 through first reaching the global 2005 TB targets. LOCAL SETTING:Particular issues in the ...
journal_title:Bulletin of the World Health Organization
pub_type: 杂志文章
doi:10.2471/blt.06.038521
更新日期:2007-05-01 00:00:00
abstract::An outbreak of spastic paraparesis which mostly affected women and children occurred in a northern province of Mozambique in 1981. The epidemic was related to chronic cyanide intoxication associated with a diet consisting almost exclusively of cassava. A prolonged drought in the area had exhausted all food resources e...
journal_title:Bulletin of the World Health Organization
pub_type: 杂志文章
doi:
更新日期:1984-01-01 00:00:00
abstract::Four cases of Plasmodium ovale malaria are reported among US servicemen stationed in Viet-Nam between January 1966 and March 1969. Taken together with other cases cited by the authors, these provide strong evidence of the existence (sometimes disputed) of this Plasmodium in continental South-East Asia.None of the men ...
journal_title:Bulletin of the World Health Organization
pub_type: 杂志文章
doi:
更新日期:1970-01-01 00:00:00
abstract:OBJECTIVE:To examine the association between maternal smoking and non-syndromic orofacial clefts in infants. METHODS:A meta-analysis of the association between maternal smoking during pregnancy was carried out using data from 24 case-control and cohort studies. FINDINGS:Consistent, moderate and statistically signific...
journal_title:Bulletin of the World Health Organization
pub_type: 杂志文章,meta分析
doi:
更新日期:2004-03-01 00:00:00
abstract::Tamiami virus produces a lethal encephalitis in suckling mice, and the illness is mediated, at least in part, by cellular immunity. Infection of extraneural organs, including lymphoid organs, is limited. The same virus produces a widespread infection in its natural host, the cotton rat, but neither symptomatic illness...
journal_title:Bulletin of the World Health Organization
pub_type: 杂志文章
doi:
更新日期:1975-01-01 00:00:00
abstract::In the early summer of 1993, an outbreak of Rift Valley fever (RVF) was reported among both humans and animals in Aswan Governorate, Upper Egypt. To determine whether RVF infection had spread to the Nile delta region of the country, we carried out a cross-sectional survey of 1181 occupationally exposed abattoir worker...
journal_title:Bulletin of the World Health Organization
pub_type: 杂志文章
doi:
更新日期:1996-01-01 00:00:00
abstract:OBJECTIVE:To estimate the validity (sensitivity, specificity, and positive and negative predictive values) of a clinical algorithm as used by community health workers (CHWs) to detect and classify neonatal illness during routine household visits in rural Bangladesh. METHODS:CHWs evaluated breastfeeding and symptoms an...
journal_title:Bulletin of the World Health Organization
pub_type: 杂志文章
doi:10.2471/blt.07.050666
更新日期:2009-01-01 00:00:00
abstract::Pacific islanders face up to the dire health effects of global warming. Atasa Moceituba and Monique Tsang report. ...
journal_title:Bulletin of the World Health Organization
pub_type: 新闻
doi:10.2471/BLT.15.021115
更新日期:2015-11-01 00:00:00
abstract::A new straightforward photometric method for the assay of the antimalarial drug chloroquine and its metabolites in urine is described. The method involves an ion-pair extraction procedure with dichloromethane using the acid-base indicator bromthymol blue as counter-ion. The ion pair formed with chloroquine in the orga...
journal_title:Bulletin of the World Health Organization
pub_type: 杂志文章
doi:
更新日期:1985-01-01 00:00:00
abstract::Early identification of children at high risk of diarrhoea-associated dehydration would be of great value to health care workers in developing countries. To identify prognostic factors for life-threatening dehydration, we carried out a case-control study among under-2-year-olds in Porto Alegre, Brazil. Cases were 192 ...
journal_title:Bulletin of the World Health Organization
pub_type: 杂志文章
doi:
更新日期:1992-01-01 00:00:00
abstract:OBJECTIVE:To analyse national data on asbestos use and related diseases in the European Region of the World Health Organization (WHO). METHODS:For each of the 53 countries, per capita asbestos use (kg/capita/year) and age-adjusted mortality rates (deaths/million persons/year) due to mesothelioma and asbestosis were ca...
journal_title:Bulletin of the World Health Organization
pub_type: 杂志文章
doi:10.2471/BLT.13.132118
更新日期:2014-11-01 00:00:00
abstract::Lyophilized cells for the passive (formerly indirect) haemagglutination test for malaria were tested in a small field trial. A comparison was made with results obtained with samples from the same persons by another method in another laboratory (Center for Disease Control, Atlanta, GA, USA). The use of lyophilized cell...
journal_title:Bulletin of the World Health Organization
pub_type: 杂志文章
doi:
更新日期:1975-01-01 00:00:00
abstract::A survey of the sandfly population of Iran was conducted in the interests of providing further knowledge of the biology of these vectors of leishmaniasis, sandfly fever and kalaazar. The search for specimens was carried out in the Tabriz, Sarab, Caspian Sea, Teheran and Kazerun areas, both inside buildings and in natu...
journal_title:Bulletin of the World Health Organization
pub_type: 杂志文章
doi:
更新日期:1961-01-01 00:00:00
abstract::The authors have compared the value of multiple doses of duck-embryo and HEP Flury vaccine with that of pooled 5% sheep-brain vaccine in experimental rabies infection in guinea-pigs. They found that the duck-embryo vaccine given in a dosage corresponding to 14 ml of 10% vaccine (the dosage recommended for human treatm...
journal_title:Bulletin of the World Health Organization
pub_type: 杂志文章
doi:
更新日期:1963-01-01 00:00:00
abstract::With an increasing number of malaria eradication programmes approaching or entering the consolidation phase, the epidemiological features of disappearing malaria are getting better known and defined. At the same time, the old classical methods of measuring malaria prevalence have become inadequate and new methods for ...
journal_title:Bulletin of the World Health Organization
pub_type: 杂志文章
doi:
更新日期:1960-01-01 00:00:00
abstract::Registration of births, recording deaths by age, sex and cause, and calculating mortality levels and differentials are fundamental to evidence-based health policy, monitoring and evaluation. Yet few of the countries with the greatest need for these data have functioning systems to produce them despite legislation prov...
journal_title:Bulletin of the World Health Organization
pub_type: 杂志文章
doi:/S0042-96862005000800015
更新日期:2005-08-01 00:00:00
abstract::A two-year study was undertaken to establish the incidence and possible viral etiology of acute respiratory diseases among the child population of a shanty town in Rio de Janeiro, Brazil. The results demonstrated that nearly half of all the illnesses seen were respiratory infections, 10% of them affecting the lower re...
journal_title:Bulletin of the World Health Organization
pub_type: 杂志文章
doi:
更新日期:1983-01-01 00:00:00