Abstract：
:Reported is an enzyme-linked immunosorbent assay (ELISA) that has been optimized and validated for the determination of chloroquine in urine or dried blood spots. The assay employs antisera raised in sheep to a chloroquine derivative conjugated to keyhole limpet haemocyanin and chloroquine conjugated to porcine thyroglobulin adsorbed onto the wells of a microtitration plate. The competitive binding of the antiserum to the wells was monitored using an alkaline-phosphatase-conjugated second antibody and a specific substrate. The assay exhibits no cross-reactivity with known chloroquine metabolites, other antimalarials, and commonly used drugs. The method was used to determine chloroquine in dried blood spot extracts and urine from a patient who was receiving a prescribed prophylactic chloroquine regimen. The drug was detected in the urine for 17 weeks and in the dried blood spots for 4 weeks after termination of the therapy.
journal_name
Bull World Health Organjournal_title
Bulletin of the World Health Organizationauthors
Rowell V,Rowell FJ,Baker A,Laurie D,Sidki AMsubject
Has Abstractpub_date
1988-01-01 00:00:00pages
211-7issue
2eissn
0042-9686issn
1564-0604journal_volume
66pub_type
杂志文章abstract：:Low back pain is the leading cause of years lived with disability globally. In 2018, an international working group called on the World Health Organization to increase attention on the burden of low back pain and the need to avoid excessively medical solutions. Indeed, major international clinical guidelines now recog...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：10.2471/BLT.18.226050
更新日期：2019-06-01 00:00:00
abstract：OBJECTIVE:To describe mortality from neglected tropical diseases (NTDs) in Brazil, 2000-2011. METHODS:We extracted information on cause of death, age, sex, ethnicity and place of residence from the nationwide mortality information system at the Brazilian Ministry of Health. We selected deaths in which the underlying c...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：10.2471/BLT.15.152363
更新日期：2016-02-01 00:00:00
abstract：:The authors describe some experiments carried out to determine the effect of moisture, temperature, and pressure on the suspensibility of DDT water-dispersible powders.It was found that the removal of moisture brought about a slight increase in suspensibility; that heating for one hour at temperatures below 70 degrees...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：
更新日期：1959-01-01 00:00:00
abstract：OBJECTIVE:To determine how much influenza contributes to severe acute respiratory illness (SARI), a leading cause of death in children, among people of all ages in Bangladesh. METHODS:Physicians obtained nasal and throat swabs to test for influenza virus from patients who were hospitalized within 7 days of the onset o...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：10.2471/BLT.11.090209
更新日期：2012-01-01 00:00:00
abstract：:Four cases of Plasmodium ovale malaria are reported among US servicemen stationed in Viet-Nam between January 1966 and March 1969. Taken together with other cases cited by the authors, these provide strong evidence of the existence (sometimes disputed) of this Plasmodium in continental South-East Asia.None of the men ...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：
更新日期：1970-01-01 00:00:00
abstract：OBJECTIVE:To assess the implications of implementing the World Health Organization (WHO) 2010 guidelines for antiretroviral therapy (ART) initiation in adults and adolescents with human immunodeficiency virus (HIV) infection, which recommend initiating ART at a CD4+ T lymphocyte (CD4+) threshold of ≤ 350 cells/mm(3) in...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章,多中心研究
doi：10.2471/BLT.11.089599
更新日期：2012-09-01 00:00:00
abstract：:Haemagglutination (HA) has been used frequently for the titration of tetanus antitoxin but published results have varied in relation to the "unitage" determined by the mouse toxin-neutralization test (TN). This report gives the results of the titration of a group of sera by haemagglutination and compares them with the...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：
更新日期：1970-01-01 00:00:00
abstract：:The availability of affordable medicines is a major barrier to providing high-quality health care in many countries. Fatima Suleman talks to Fiona Fleck. ...
journal_title：Bulletin of the World Health Organization
pub_type： 传,历史文章,新闻
doi：10.2471/BLT.17.031217
更新日期：2017-12-01 00:00:00
abstract：:DDE and the o,p' and p,p' isomers of DDT were assayed in 94 human biopsy fat samples from hospitals in Delhi by gas chromatography. DDT was present in all except 2 samples at concentrations from 0.17 to 176.5 mg per kg of body fat. The average total DDT content was 21.8+/-2.9 mg/kg, of which 45.9% was DDE. The average...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：
更新日期：1973-01-01 00:00:00
abstract：:DEC (diethylcarbamazine)-medicated salt, at a concentration of 0.1 to 0.2 mg per 100 mg, was given to the entire population of Karaikal (119 978) in South India for a 4-year period from 1982. The per capita consumption of DEC in medicated salt was 13.3 grams for the entire period. The prevalence of microfilaraemia dec...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：
更新日期：1996-01-01 00:00:00
abstract：:The author reviews the agricultural use of night-soil, sewage, and sewage sludge from two points of view: the purely agricultural and the sanitary.Knowledge of the chemistry and bacteriology of human faecal matter is still rather scant, and much further work has to be done to find practical ways of digesting night-soi...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：
更新日期：1954-01-01 00:00:00
abstract：:In 39 randomly selected villages and towns in Tumkur District, South India, approximately 2000 persons, tuberculosis cases and matched controls, were interviewed in order to determine how many had symptoms suggestive of tuberculosis. Approximately 70% of the bacteriologically confirmed cases and over half the radiolog...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：
更新日期：1963-01-01 00:00:00
abstract：:Epidemiological studies of the cardiovascular characteristics of three typically rural communities in the Gambia, Jamaica, and the United Republic of Tanzania were carried out by means of standardized methodology. This paper reports comparisons of arterial blood pressure distribution and electrocardiographic findings ...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：
更新日期：1979-01-01 00:00:00
abstract：:A number of drugs and drug combinations were tested both in vitro and in vivo against pathogens causing actinomycetoma and maduromycetoma. Of 144 patients with actinomycetoma treated, 63.2% were cured, 21.5% showed great improvement in their condition, and 11.1% showed some improvement. Treatment was successful even w...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：
更新日期：1976-01-01 00:00:00
abstract：:The systematic position of the so-called "species" of Leishmania is examined and an attempt made to determine their phylogenetic relationships. The morphology of the organisms as seen by light- and electron-microscopy is described; neither method provides useful criteria for the determination of species. The behaviour...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：
更新日期：1971-01-01 00:00:00
abstract：:Until very recently, rabies research had made few notable advances since the time of Pasteur, but during the past few years the use of modern virological techniques has led to rapid progress in research on the rabies virus. This article summarizes the present state of knowledge of pathogenesis, immunology, cultivation...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：
更新日期：1968-01-01 00:00:00
abstract：:Registration of births, recording deaths by age, sex and cause, and calculating mortality levels and differentials are fundamental to evidence-based health policy, monitoring and evaluation. Yet few of the countries with the greatest need for these data have functioning systems to produce them despite legislation prov...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：/S0042-96862005000800015
更新日期：2005-08-01 00:00:00
abstract：:Few experiments have been reported on immunity to reinfection in domestic stock. The degree of resistance to reinfection with S. mattheei was studied in cattle and sheep. On the basis of the results, the only evidence of acquired immunity in calves and sheep is a reduction in the length of adult worms. ...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：
更新日期：1974-01-01 00:00:00
abstract：:Reported are the results of a randomized, double-masked, placebo-controlled trial of annual ivermectin dosing in 34 rural communities, Kaduna State, northern Nigeria, where guinea savanna onchocerciasis is mesoendemic. A total of 939 individuals underwent Friedmann field analysis at the first examination and saw at le...
journal_title：Bulletin of the World Health Organization
pub_type： 临床试验,杂志文章,多中心研究,随机对照试验
doi：
更新日期：1997-01-01 00:00:00
abstract：:The Millennium Development Goals depend critically on scaling up public health investments in developing countries. As a matter of urgency, developing-country governments must present detailed investment plans that are sufficiently ambitious to meet the goals, and the plans must be inserted into existing donor process...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：/S0042-96862004001200012
更新日期：2004-12-01 00:00:00
abstract：:Since 1970, WHO has conducted a collaborative study on the use of "excess mortality" from respiratory diseases (that is, the number of deaths actually recorded in excess of the number expected on the basis of past seasonal experience) in order to assess in 13 different countries the severity of influenza epidemics. Th...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：
更新日期：1973-01-01 00:00:00
abstract：:In Iran, microscopic examination of skin scrapings from 2202 individuals with clinically diagnosed cutaneous leishmaniasis (CL) lesions revealed the presence of amastigotes in 1123 cases (51.0%). Bacteriological examinations of the lesions indicated that 788 individuals (35.7%) were also infected with one or more path...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：
更新日期：1990-01-01 00:00:00
abstract：:With a view to developing a schedule for the ambulatory treatment of Schistosoma haematobium infection with sodium antimony dimercaptosuccinate (TWSb), a trial was conducted in Tanzania of the comparative effectiveness of daily and weekly injections of TWSb in schoolchildren. In-patients received five daily injections...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：
更新日期：1965-01-01 00:00:00
abstract：:James Chau talks to Ana Lesher Treviño about the challenges faced in communicating about public health. ...
journal_title：Bulletin of the World Health Organization
pub_type： 新闻
doi：10.2471/BLT.19.030819
更新日期：2019-08-01 00:00:00
abstract：OBJECTIVE:To quantify long-term health service use (HSU) following non-fatal injury in adults. METHODS:A retrospective, population-based, matched cohort study identified an inception cohort (1988-91) of injured people who had been hospitalized (ICD-9-CM 800-995) aged 18-64 years (n = 21 032) and a matched non-injured ...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：10.2471/blt.06.030833
更新日期：2006-10-01 00:00:00
abstract：:Although none of the currently available methods of contraception can be considered ideal for use by adolescents, many come reasonably close. The present article reviews the relative benefits and risks associated with each method. Oral contraceptives (OCs) appear to bear few specific risks for adolescents. Pills co...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：
更新日期：1984-01-01 00:00:00
abstract：:A test procedure involving simply-constructed, portable test-equipment has been developed for detecting resistance to DDT residual applications by adult mosquitos. The procedure involves timed exposures of adult female mosquitos to DDT residues in chambers made of paper and screen wire, and the determination of the su...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：
更新日期：1953-01-01 00:00:00
abstract：:In an attempt to prepare highly specific antiserum to variola virus, a chimpanzee was inoculated with a virulent human strain of this virus. Three uninoculated chimpanzees were housed in the same room; two of these developed clinical disease with seroconversion, while the third developed no evidence of infection and n...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：
更新日期：1979-01-01 00:00:00
abstract：:This paper gives a comprehensive account of the first six years of operation of an onchocerciasis control pilot project in an area of over 3000 km(2) in the Abuja Emirate, Northern Nigeria. Control was attempted by the use of DDT against the larvae of the vector, Simulium damnosum. For the first two years technical DD...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：
更新日期：1962-01-01 00:00:00
abstract：:The minimal inhibitory concentration (MIC) values of penicillin, ampicillin, tetracycline, chloramphenicol, and streptomycin for 500 gonococcal strains were studied for product-moment coefficient correlations. The strains were isolated from male patients with acute gonococcal urethritis attending the Venereal Disease ...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：
更新日期：1980-01-01 00:00:00
