Low serum miR-223 expression predicts poor outcome in patients with acute myeloid leukemia.

Abstract:

BACKGROUND:Identification of biomarkers for acute myeloid leukemia (AML) is important for treating this malignancy. Recent studies have reported that microRNAs (miRNAs) are stably detectable in the blood/plasma and can be used as biomarkers for various types of cancer including AML. The aim of this study was to analyze miR-223 level in serum as a potential indicator for AML diagnosis and prognosis prediction. METHODS:Quantitative reverse transcription-polymerase chain reaction (qRT-PCR) was used to detect the levels of miR-223 in the serum samples from 131 patients and 70 healthy individuals. RESULTS:The results revealed that serum miR-223 was underexpressed in AML patients, particularly those in intermediate and unfavorable cytogenetic risk groups. Further analysis revealed that serum miR-223 could yield a receiver operating characteristic (ROC) area under the curve (AUC) of 0.849 with 83.2% sensitivity and 81.4% specificity. Moreover, a significant increase in serum miR-223 level was observed in AML subjects after their treatment. Reduced serum miR-223 level was highly associated with aggressive clinical variables and shorter survival of patients. Furthermore, miR-223 expression was identified to be an independent prognostic predictor of worse overall survival. CONCLUSION:In conclusion, miR-223 may be a reliable diagnostic and prognostic biomarker for AML.

journal_name

J Clin Lab Anal

authors

Yu G,Yin Z,He H,Zheng Z,Chai Y,Xuan L,Lin R,Wang Q,Li J,Xu D

doi

10.1002/jcla.23096

subject

Has Abstract

pub_date

2020-03-01 00:00:00

pages

e23096

issue

3

eissn

0887-8013

issn

1098-2825

journal_volume

34

pub_type

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