Advancing drug discovery for schizophrenia.

abstract：:Our studies of Ca2+ release have shown that three classes of compounds--quercetin, which inhibits Ca2+ release by reversal of the Ca2+ pump, H+ ionophores and DCCD, which affect proton gradients, and lipophilic anions, which act to oppose a separation of membrane surface charges--all have potential in probing the mech...

journal_title：Annals of the New York Academy of Sciences

authors： MacLennan DH,Shoshan V,Wood DS

更新日期：1982-01-01 00:00:00

abstract：:Rehabilitation aims to lessen the physical and cognitive impairments and disabilities of patients with stroke, multiple sclerosis, spinal cord or brain injury, and other neurologic diseases. Conventional approaches beyond compensatory adjustments to disability may be augmented by applying some of the myriad experiment...

journal_title：Annals of the New York Academy of Sciences

authors： Dobkin BH

更新日期：2004-12-01 00:00:00

abstract：:The underlying etiology and pathogenesis of Gulf War veterans' illnesses continue to be under intense investigation. Reports have suggested the basis for these illnesses may be an altered immune system, but compelling evidence is lacking. We sought to determine whether in vitro immune responses were abnormal in sympto...

journal_title：Annals of the New York Academy of Sciences

authors： Everson MP,Shi K,Aldridge P,Bartolucci AA,Blackburn WD

更新日期：2002-06-01 00:00:00

abstract：:In recent years calcium channel blockers have emerged as a new class of antiarrhythmic agents for the control of certain supraventricular and ventricular arrhythmias. Electrophysiologically, they are heterogeneous but their main action is mediated through a depressant effect on the slow calcium channel in cardiac musc...

journal_title：Annals of the New York Academy of Sciences

authors： Nademanee K,Singh BN

更新日期：1988-01-01 00:00:00

abstract：:Women are four to eight times more likely to be affected by fibromyalgia syndrome (FMS). A lack of cortisol, potentially due to an adrenocortical deficit is postulated in FMS. The cause of such adrenal insufficiency is unknown. It could be assumed that stress exposure during critical periods contributes to vulnerabili...

journal_title：Annals of the New York Academy of Sciences

authors： Klingmann PO,Kugler I,Steffke TS,Bellingrath S,Kudielka BM,Hellhammer DH

更新日期：2008-12-01 00:00:00

abstract：:Hematopoietic development in the mammal can be represented as a numerically expanding hierarchy of cell populations that are progressively restricted in their self-renewal and differentiation abilities. Classical functional studies have now been extended to provide exact physical descriptions of various stages in the ...

journal_title：Annals of the New York Academy of Sciences

authors： Lemischka I

更新日期：1999-04-30 00:00:00

abstract：:Major trauma, shock, sepsis, and other conditions can lead to the acute respiratory distress syndrome (ARDS), which may progress to the highly lethal multiple organ dysfunction syndrome (MODS). Although a number of therapeutic strategies have been initiated, their success has been limited largely due to an incomplete ...

journal_title：Annals of the New York Academy of Sciences

authors： Deitch EA

更新日期：2010-10-01 00:00:00

abstract：:RAS interacts with multiple targets in the cell and controls at least two signaling pathways, one regulating extracellular signal-regulated kinase (ERK) activation and the other controlling membrane ruffling formation. These two pathways appear to act synergistically to cause transformation. Human smooth muscle alpha-...

journal_title：Annals of the New York Academy of Sciences

authors： Kumar CC,Ohashi K,Nagata K,Walsh A,Bar-Sagi D,Mizuno K

更新日期：1999-01-01 00:00:00

abstract：:Our studies have indicated that normal human placental cytosol contains a complex mixture of nucleoside kinase enzymes, some of which conform to previously characterized activities. Deoxyadenosine is phosphorylated by deoxycytidine kinase, adenosine kinase, and two as yet uncharacterized activities. Deoxyguanosine pho...

journal_title：Annals of the New York Academy of Sciences

authors： Hurley MC,Fox IH

更新日期：1985-01-01 00:00:00

abstract：:The effects of TCDD exposure on the developing immune system were investigated in Wistar/Fischer hybrid or Fischer rats. Fetal and neonatal rats were exposed to TCDD through maternal dosing (5 muk/kg) on day 18 of gestation and on days 0, 7, and 14 of postnatal life (group 1). Another group of neonatal rats was expose...

journal_title：Annals of the New York Academy of Sciences

authors： Luster MI,Faith RE,Clark G

更新日期：1979-05-31 00:00:00

abstract：:Previous research on development of the Xenopus olfactory bulb from our laboratory has shown that mitral cells begin to differentiate after olfactory axons make contact with the olfactory bulb, and the number of olfactory axons is correlated with the number of mitral cells throughout development. In embryos, removal o...

journal_title：Annals of the New York Academy of Sciences

authors： Burd GD,Sein V

更新日期：1998-11-30 00:00:00

abstract：:Over several years our group has sought to synthesize and identify selective ligands for imidazoline (I) receptors, in particular the I2 binding site. As a consequence, [3H]2-(2-benzofuranyl)-2-imidazoline (2BFI) has proved extremely useful for binding and autoradiographic studies. More recently we have synthesized a ...

journal_title：Annals of the New York Academy of Sciences

authors： Hudson AL,Gough R,Tyacke R,Lione L,Lalies M,Lewis J,Husbands S,Knight P,Murray F,Hutson P,Nutt DJ

更新日期：1999-06-21 00:00:00

abstract：:During viewing of a near target, the gain of the visually modulated vestibulo-ocular reflex (vVOR) exceeds 1.0. We investigated whether retinal image slip contributes to this gain increase by measuring responses during strobe illumination. Subjects showed greater gain values during normal versus strobe illumination of...

journal_title：Annals of the New York Academy of Sciences

authors： Han YH,Kumar AN,Somers JT,Reschke MF,Leigh RJ

更新日期：2005-04-01 00:00:00

abstract：:Cities modify their local climate, and at the same time they suffer from the local impacts of climate change. Our paper discusses the progress and obstacles in three active research topics that contribute to increasing the capability within the urban climate research community for transferring local climate knowledge ...

journal_title：Annals of the New York Academy of Sciences

authors： Hidalgo J,Lemonsu A,Masson V

更新日期：2019-01-01 00:00:00

abstract：:Results obtained from projects in which self-organizing musical structures spontaneously arise through electrical interface between the brain and generative musical systems are surveyed. This provides a springboard for examining important paradigm shifts taking place in our thinking about what musical forms can be and...

journal_title：Annals of the New York Academy of Sciences

authors： Rosenboom D

更新日期：2003-11-01 00:00:00

abstract：:Relaxin causes renal hyperfiltration, natriuresis, and diuresis in male rats. This study determined the effect of recombinant human relaxin (rhRLX) on renal function in the female rat. After 7 days of rhRLX treatment (0.4 microg/h) urinary excretion of sodium and chloride were significantly lower in the rhRLX-treated ...

journal_title：Annals of the New York Academy of Sciences

authors： Bogzil AH,Ashton N

更新日期：2009-04-01 00:00:00

abstract：:Explicit memory refers to the conscious retrieval of past information or experiences, whereas implicit memory refers to an unintentional or nonconscious form of retrieval. Much of the literature in cognitive psychology and cognitive neuroscience has focused on differences between explicit and implicit memory, and the ...

journal_title：Annals of the New York Academy of Sciences

authors： Dew ITZ,Cabeza R

更新日期：2011-04-01 00:00:00

abstract：:The perceptions of coccidioidomycosis as a medical problem has undergone sequential and dramatic metamorphoses since its first description more than a century ago. First thought to be rare and lethal, coccidioidomycosis was subsequently found to be common and often mild. During World War II, its overall impact upon la...

journal_title：Annals of the New York Academy of Sciences

authors： Galgiani JN

更新日期：2007-09-01 00:00:00

abstract：:This paper represents recent results on the development of optimal analytic solutions to the variation problem of trajectory optimization and their application in the construction of on-board guidance laws. The importance of employing the analytically integrated trajectories in a mission design is discussed. It is ass...

journal_title：Annals of the New York Academy of Sciences

authors： Azimov D,Bishop R

更新日期：2005-12-01 00:00:00

abstract：:The emission factors for indoor straw combustion are a major data gap for estimating the polycyclic aromatic hydrocarbon (PAH) emissions in China. The emission factors for open-fire straw burning were borrowed from our previous study and a rough estimate was developed. As one of the most important emission sources in ...

journal_title：Annals of the New York Academy of Sciences

authors： Zhang Y,Dou H,Chang B,Wei Z,Qiu W,Liu S,Liu W,Tao S

更新日期：2008-10-01 00:00:00

abstract：:In a placebo-controlled double-blinded study, the effect of 8 weeks of grape juice was compared to the effect of isocaloric placebo juice. Volunteers with a systolic blood pressure > 130 mmHg and diastolic blood pressure > 90 mmHg were recruited. A total of 40 healthy subjects were randomized to receive isocaloric jui...

journal_title：Annals of the New York Academy of Sciences

authors： Park YK,Lee SH,Park E,Kim JS,Kang MH

更新日期：2009-08-01 00:00:00

abstract：:We have generated a transgenic rat model of Charcot-Marie-Tooth disease type 1A (CMT1A) providing formal proof that this neuropathy can be caused by increased expression of peripheral myelin protein-22 (PMP22). Heterozygous PMP22-transgenic rats develop muscle weakness and gait abnormalities as well as reduced nerve c...

journal_title：Annals of the New York Academy of Sciences

authors： Niemann S,Sereda MW,Rossner M,Stewart H,Suter U,Meinck HM,Griffiths IR,Nave KA

更新日期：1999-09-14 00:00:00

abstract：:The mechanisms controlling ATP generation in the transition from normal resting conditions to either high work states or ischemia are poorly understood. ATP generation depends upon compartmentation between the mitochondria and cytosol of metabolic pathways and key energy transfer species that cannot be easily assessed...

journal_title：Annals of the New York Academy of Sciences

authors： Zhou L,Yu X,Cabrera ME,Stanley WC

更新日期：2006-10-01 00:00:00

abstract：:Hereditary episodic ataxia (EA) syndromes are rare monogenic disorders that are phenotypically and genetically heterogeneous. The number of identified EA phenotypes is expanding. So far, mutations have been identified in four genes, all coding for membrane proteins including ion channels and transporters. The study of...

journal_title：Annals of the New York Academy of Sciences

authors： Jen JC

更新日期：2008-10-01 00:00:00

abstract：:In a prospective investigation of perioperative cardiac edema formation requiring a delayed sternal closure, we identified thrombin increase combined with a simultaneous decrease of factor XIII as a probable cause. After experimental studies additionally revealed that factor XIII could protect endothelial barrier func...

journal_title：Annals of the New York Academy of Sciences

authors： Wozniak G,Noll T,Akintürk H,Thul J,Müller M

更新日期：2001-01-01 00:00:00

abstract：:Odorant signals are detected by binding of odor molecules to odorant receptors. These belong to the G protein-coupled receptor family. They in turn couple to G proteins, most of which induce cAMP production. This second messenger activates ion channels to depolarize the olfactory sensory neuron, thus providing a signa...

journal_title：Annals of the New York Academy of Sciences

authors： Wicher D,Schäfer R,Bauernfeind R,Stensmyr MC,Heller R,Heinemann SH,Hansson BS

更新日期：2009-07-01 00:00:00

abstract：:According to the fetal origin of adult diseases hypothesis, the intrauterine environment through developmental plasticity may permanently influence long-term health and disease. Therefore, intrauterine growth restriction (IUGR), due either to maternal, placental, or genetic factors, may permanently alter the endocrine...

journal_title：Annals of the New York Academy of Sciences

authors： Kanaka-Gantenbein C

更新日期：2010-09-01 00:00:00

abstract：:This study explores the mechanisms dominating the regulation of the biochemical energy consumption and the mechanical output of the actin-myosin motor units, the crossbridges (Xbs), in the cardiac sarcomere. Our analytical model, which couples Xbs cycling dynamics with the kinetics of the free Ca(2+) binding to tropon...

journal_title：Annals of the New York Academy of Sciences

authors： Landesberg A,Levy C,Yaniv Y,Sideman S

更新日期：2004-05-01 00:00:00

abstract：:Expectation of reward facilitates motor behaviors that enable the animal to approach a location in space where the reward is expected. It is now known that the same expectation of reward profoundly modifies sensory, motor, and cognitive information processing in the brain. However, it is still unclear which brain regi...

journal_title：Annals of the New York Academy of Sciences

authors： Hikosaka O

更新日期：2007-05-01 00:00:00

abstract：UNLABELLED:This article suggests eight high-level concepts that can promote convergence by identifying analogies across fields of science and engineering. CONSERVATION: Many properties are conserved, through symmetries, parity laws, and feedback-regulated stabilities in complex adaptive systems. INDECISION: Inconsisten...

journal_title：Annals of the New York Academy of Sciences

authors： Bainbridge WS

更新日期：2006-12-01 00:00:00