Abstract：
:There is no therapy for chronic fibroproliferative diseases, in spite of the fact that current health statistics suggest that these (which include cardiovascular disease, pulmonary fibrosis, diabetic nephropathy, liver cirrhosis and systemic sclerosis) have been estimated to cause approximately 45% of the deaths in the developed world. Recently, many studies have shown that mitogen activated protein kinases (MAPKs) are activated in response to fibrogenic agents and contribute to the formation and function of the myofibroblast, the critical cell type responsible for excessive scarring. A recent report by Madala and colleagues (Am J Respir Cell Mol Biol, 2011) has provided a proof-of-concept study showing that the specific MEK inhibitor ARRY-142886 (ARRY) can both suppress the progression of fibrosis and reverse an animal model of lung fibrosis. Thus MEK inhibition could be a valuable method to treat lung fibrosis.
journal_name
J Cell Commun Signaljournal_title
Journal of cell communication and signalingauthors
Leask Adoi
10.1007/s12079-011-0156-9subject
Has Abstractpub_date
2012-03-01 00:00:00pages
59-60issue
1eissn
1873-9601issn
1873-961Xjournal_volume
6pub_type
杂志文章abstract：:Periostin is a secretory protein with a multi-domain structure, comprising an amino-terminal cysteine-rich EMI domain, four internal FAS 1 domains, and a carboxyl-terminal hydrophilic domain. These adjacent domains bind to extracellular matrix proteins (type I collagen, fibronectin, tenascin-C, and laminin γ2), and BM...
journal_title：Journal of cell communication and signaling
pub_type： 杂志文章,评审
doi：10.1007/s12079-017-0422-6
更新日期：2018-03-01 00:00:00
abstract：:Tumor cells release extracellular vesicles (EVs) into the tumor microenvironment that may facilitate malignant progression and metastasis. Breast carcinoma EVs express high levels of the thrombospondin-1 and signal regulatory protein-α receptor CD47, which is the target of several experimental therapeutics currently i...
journal_title：Journal of cell communication and signaling
pub_type： 杂志文章
doi：10.1007/s12079-017-0428-0
更新日期：2018-03-01 00:00:00
abstract：:Lung immaturity is the major cause of morbidity and mortality in premature infants, especially those born <28 weeks of gestation. These infants are at high risk of developing respiratory distress syndrome (RDS), a lung disease caused by insufficient surfactant production and immaturity of saccular/alveolar type II epi...
journal_title：Journal of cell communication and signaling
pub_type： 杂志文章
doi：10.1007/s12079-017-0443-1
更新日期：2018-03-01 00:00:00
abstract：:The discovery of the gap junction structure, its functions and the family of the "connexin" genes, has been basically ignored by the major biological disciplines. These connexin genes code for proteins that organize to form membrane-associated hemi-channels, "connexons", co-join with the connexons of neighboring cells...
journal_title：Journal of cell communication and signaling
pub_type： 杂志文章
doi：10.1007/s12079-010-0108-9
更新日期：2011-03-01 00:00:00
abstract：:Extracellular molecules coordinate the multiple signaling pathways spatiotemporally to exchange information between cells during development. Understanding the regulation of these signal molecule-dependent pathways elucidates the mechanism of intercellular crosstalks. CCN2/CTGF is one of the CCN family members that bi...
journal_title：Journal of cell communication and signaling
pub_type： 杂志文章
doi：10.1007/s12079-018-0487-x
更新日期：2019-03-01 00:00:00
abstract：:Non-alcoholic fatty liver disease (NAFLD) is a condition in which fat accumulates in the liver of patients without a prior history of alcohol abuse. The most severe form, nonalcoholic steatohepatitis (NASH), often leads to hepatic fibrosis and cirrhosis with ensuing complications. To date, there is no pharmacologic tr...
journal_title：Journal of cell communication and signaling
pub_type： 杂志文章
doi：10.1007/s12079-017-0432-4
更新日期：2018-03-01 00:00:00
abstract：:Because of differences in the downstream signaling patterns of its pathways, the role of the human epidermal growth factor family of receptors (HER) in promoting cell growth and survival is cell line and context dependent. Using two model cell lines, we have studied how the regulatory interaction network among the key...
journal_title：Journal of cell communication and signaling
pub_type： 杂志文章
doi：10.1007/s12079-017-0389-3
更新日期：2017-12-01 00:00:00
abstract：:Hepatoblastoma (HB) is one of the most common liver malignancies in children, while the molecular basis of the disease is largely unknown. Therefore, this study aims to explore the key genes and molecular mechanisms of the pathogenesis of HB using a bioinformatics approach. The gene expression dataset GSE131329 was us...
journal_title：Journal of cell communication and signaling
pub_type： 杂志文章
doi：10.1007/s12079-020-00584-1
更新日期：2020-10-13 00:00:00
abstract：:The lectin from Canavalia ensiformis (Concanavalin-A, ConA), one of the most abundant lectins known, enables one to mimic biological lectin/carbohydrate interactions that regulate extracellular matrix protein recognition. As such, ConA is known to induce membrane type-1 matrix metalloproteinase (MT1-MMP) which express...
journal_title：Journal of cell communication and signaling
pub_type： 杂志文章
doi：10.1007/s12079-009-0084-0
更新日期：2010-03-01 00:00:00
abstract：:We have recently identified several novel ATP-independent inhibitors that target the extracellular signal-regulated kinase-2 (ERK2) protein and inhibit substrate phosphorylation. To further characterize these compounds, we describe the use of C. elegans as a model organism. C. elegans is recognized as a versatile and ...
journal_title：Journal of cell communication and signaling
pub_type： 杂志文章
doi：10.1007/s12079-008-0034-2
更新日期：2008-12-01 00:00:00
abstract：:Pancreatitis is an inflammatory condition of the pancreas which, in its chronic form, involves tissue destruction, exocrine and endocrine insufficiency, increased risk of pancreatic cancer, and an extensive fibrotic pathology which is due to unrelenting collagen deposition by pancreatic stellate cells (PSC). In respon...
journal_title：Journal of cell communication and signaling
pub_type： 杂志文章
doi：10.1007/s12079-014-0220-3
更新日期：2014-06-01 00:00:00
abstract：:The aim of this study was to investigate the effects of homocysteine (Hcy), a risk factor for cardiovascular diseases, hypertension, stroke and obesity, on expression of CD36 that regulates uptake of oxidized low-density lipoprotein (Ox-LDL) by adipocytes and differentiation of 3T3-L1 cells to adipocytes. Cell viabili...
journal_title：Journal of cell communication and signaling
pub_type： 杂志文章
doi：10.1007/s12079-015-0316-4
更新日期：2016-03-01 00:00:00
abstract：:The expression of the CCN family of matricellular proteins is highly dysregulated in connective tissue pathologies such as fibrosis and highly metastatic cancers. Strategies targeting members of this family, especially CCN2, are under development as novel therapeutic approaches to highly metastatic cancers such as pan...
journal_title：Journal of cell communication and signaling
pub_type： 杂志文章,评审
doi：10.1007/s12079-016-0321-2
更新日期：2016-06-01 00:00:00
abstract：:PEGylation is a biochemical modification process of bioactive molecules with polyethylene glycol (PEG), which lends several desirable properties to proteins/peptides, antibodies, and vesicles considered to be used for therapy or genetic modification of cells. However, PEGylation of proteins is a complex process and ca...
journal_title：Journal of cell communication and signaling
pub_type： 杂志文章,评审
doi：10.1007/s12079-018-0492-0
更新日期：2019-09-01 00:00:00
abstract：:Key pathways like insulin signaling, AMP activated kinase (AMPK) activation and inflammatory signaling are involved in the complex pathological network of hepatic insulin resistance. Our aim is to investigate whether grape seed proanthocyanidins (GSP) and metformin (MET) target any of these pathways in insulin resista...
journal_title：Journal of cell communication and signaling
pub_type： 杂志文章
doi：10.1007/s12079-013-0210-x
更新日期：2014-03-01 00:00:00
abstract：:CCN3 is a member of the CCN family of cell growth and differentiation regulators that play key roles during embryonic development, and are associated with severe human pathologies. The level of CCN genes' expression is of prognostic value in several types of tumors. In the present manuscript, we report the isolation a...
journal_title：Journal of cell communication and signaling
pub_type： 杂志文章
doi：10.1007/s12079-007-0009-8
更新日期：2007-09-01 00:00:00
abstract：:Research over the past few years has highlighted the ability of the unfolded protein response (UPR) to minimize the deleterious effects of accumulated misfolded proteins under both physiological and pathological conditions. The endoplasmic reticulum (ER) adapts to endogenous and exogenous stressors by expanding its pr...
journal_title：Journal of cell communication and signaling
pub_type： 杂志文章
doi：10.1007/s12079-014-0251-9
更新日期：2014-12-01 00:00:00
abstract：:Interferon gamma (IFN-ɣ) is a pleiotropic cytokine which plays dual contrasting roles in cancer. Although IFN-ɣ has been clinically used to treat various malignancies, it was recently shown to have protumorigenic activities. Reactive oxygen species (ROS) are overproduced in cancer cells, mainly due to NADPH oxidase ac...
journal_title：Journal of cell communication and signaling
pub_type： 杂志文章
doi：10.1007/s12079-016-0362-6
更新日期：2017-03-01 00:00:00
abstract：:Transforming growth factor beta (TGF-beta) and connective tissue growth factor (CTGF) have been described to induce the production of extracellular matrix (ECM) proteins and have been reported to be increased in different fibrotic disorders. Skeletal muscle fibrosis is a common feature of Duchenne muscular dystrophy (...
journal_title：Journal of cell communication and signaling
pub_type： 杂志文章
doi：10.1007/s12079-008-0018-2
更新日期：2007-12-01 00:00:00
abstract：:The growth regulating factor CTGF/CCN-2 is an integral factor in growth and development, connective tissue maintenance, wound repair and cell cycle regulation. It has recently been reported that CTGF/CCN-2 is involved in very early development having been detected in early notochord formation in zebrafish using CTGF/C...
journal_title：Journal of cell communication and signaling
pub_type： 杂志文章
doi：10.1007/s12079-008-0031-5
更新日期：2008-12-01 00:00:00
abstract：:The ubiquitin proteasome pathway plays a critical role in regulating many processes in the cell which are important for tumour cell growth and survival. Inhibition of proteasome function has emerged as a powerful strategy for anti-cancer therapy. Clinical validation of the proteasome as a therapeutic target was achiev...
journal_title：Journal of cell communication and signaling
pub_type： 杂志文章
doi：10.1007/s12079-011-0121-7
更新日期：2011-06-01 00:00:00
abstract：:Glutamate metabolism plays a vital role in biosynthesis of nucleic acids and proteins. It is also associated with a number of different stress responses. Deficiency of enzymes involved in glutamate metabolism is associated with various disorders including gyrate atrophy, hyperammonemia, hemolytic anemia, γ-hydoxybutyr...
journal_title：Journal of cell communication and signaling
pub_type： 杂志文章
doi：10.1007/s12079-015-0315-5
更新日期：2016-03-01 00:00:00
abstract：:Fibrotic diseases are a significant cause of mortality. It is being increasingly appreciated that the cellular microenvironment plays a key role in promoting pathological fibrosis. A previous Bits and Bytes described an elegant series of experiments published by Bruce Riser and colleagues (Am J Pathol. 2009: 174:1725-...
journal_title：Journal of cell communication and signaling
pub_type： 杂志文章
doi：10.1007/s12079-015-0281-y
更新日期：2015-03-01 00:00:00
abstract：:CCN proteins play crucial roles in development, angiogenesis, cell motility, matrix turnover, proliferation, and other fundamental cell processes. Early embryonic lethality in CCN5 knockout and over-expressing mice led us to characterize CCN5 distribution in early development. Previous papers in this series showed tha...
journal_title：Journal of cell communication and signaling
pub_type： 杂志文章
doi：10.1007/s12079-012-0176-0
更新日期：2012-12-01 00:00:00
abstract：:Hepatocyte exosomes (ExoHep) are proposed to mediate physiological or pathophysiological signaling in a variety of hepatic target cells. ExoHep were purified from the medium of primary mouse hepatocytes or AML12 cells and characterized as ~100 nm nanovesicles that were positive for proteins commonly found in exosomes ...
journal_title：Journal of cell communication and signaling
pub_type： 杂志文章
doi：10.1007/s12079-017-0421-7
更新日期：2018-03-01 00:00:00
abstract：:The Fifth International Workshop on the CCN Family of Genes was held in Toronto October 18-22, 2008. This bi-annual workshop provides a unique opportunity for the presentation and discussion of cutting edge research in the CCN field. The CCN family members have emerged as extracellular matrix associated proteins which...
journal_title：Journal of cell communication and signaling
pub_type： 杂志文章
doi：10.1007/s12079-009-0036-8
更新日期：2008-12-01 00:00:00
abstract：:It is well-established that the expression of CCN family of matricellular proteins is altered in essentially all cancers and, hence, targeting these proteins may be a novel therapeutic approach to treating these diseases. For example, CCN6 (WISP3) is downregulated in aggressive breast cancers, and this phenomenon appe...
journal_title：Journal of cell communication and signaling
pub_type： 杂志文章
doi：10.1007/s12079-012-0189-8
更新日期：2013-06-01 00:00:00
abstract：:Fibroblast growth factor 1 (FGF-1) is the first FGF family member, and it induces proliferation of fibroblasts and other types of the cells. However, recent studies are uncovering unexpected functions of this molecule. Our previous study redefined this growth factor as a catabolic molecule produced in cartilage upon m...
journal_title：Journal of cell communication and signaling
pub_type： 杂志文章
doi：10.1007/s12079-020-00600-4
更新日期：2021-01-04 00:00:00
abstract：:UNC-5 Homolog B (UNC5B) is a member of the dependence receptor family. This family of receptors can induce two opposite intracellular signaling cascades depending on the presence or absence of the ligand and is thus capable of driving two opposing processes. UNC5B signaling has been implicated in several cancers, wher...
journal_title：Journal of cell communication and signaling
pub_type： 杂志文章
doi：10.1007/s12079-018-0485-z
更新日期：2019-03-01 00:00:00
abstract：:In June 2015, Thomson Reuters informed our publisher Springer that the Journal of Cell Communication and Signaling, the official journal of the International CCN Society, « had been selected for coverage in Thomson Reuter's products and services. Beginning with V. 1 (1) 2007, this publication would be indexed and abst...
journal_title：Journal of cell communication and signaling
pub_type： 杂志文章
doi：10.1007/s12079-015-0306-6
更新日期：2015-09-01 00:00:00
